CA2801946A1 - Methods for manufacturing a dual biosensor test strip - Google Patents
Methods for manufacturing a dual biosensor test strip Download PDFInfo
- Publication number
- CA2801946A1 CA2801946A1 CA2801946A CA2801946A CA2801946A1 CA 2801946 A1 CA2801946 A1 CA 2801946A1 CA 2801946 A CA2801946 A CA 2801946A CA 2801946 A CA2801946 A CA 2801946A CA 2801946 A1 CA2801946 A1 CA 2801946A1
- Authority
- CA
- Canada
- Prior art keywords
- electrode sets
- layer
- continuous
- electrode
- reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000012360 testing method Methods 0.000 title claims abstract description 152
- 238000000034 method Methods 0.000 title claims abstract description 49
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 35
- 230000009977 dual effect Effects 0.000 title abstract description 4
- 239000000758 substrate Substances 0.000 claims abstract description 115
- 238000005520 cutting process Methods 0.000 claims abstract description 19
- 210000001124 body fluid Anatomy 0.000 claims abstract description 7
- 125000006850 spacer group Chemical group 0.000 claims description 50
- 239000003153 chemical reaction reagent Substances 0.000 claims description 42
- 238000000151 deposition Methods 0.000 claims description 15
- 238000010030 laminating Methods 0.000 claims 4
- 239000002699 waste material Substances 0.000 abstract description 2
- 239000010410 layer Substances 0.000 description 134
- 239000012530 fluid Substances 0.000 description 44
- 238000005070 sampling Methods 0.000 description 20
- 239000012790 adhesive layer Substances 0.000 description 14
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- 239000008280 blood Substances 0.000 description 13
- 230000008901 benefit Effects 0.000 description 9
- 238000000608 laser ablation Methods 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
- 238000011049 filling Methods 0.000 description 7
- 239000008103 glucose Substances 0.000 description 7
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- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 239000004642 Polyimide Substances 0.000 description 2
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- 238000002679 ablation Methods 0.000 description 2
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- 230000001771 impaired effect Effects 0.000 description 2
- 238000007641 inkjet printing Methods 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
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- 238000005259 measurement Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- -1 polyethylene terephthalate Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 229920001721 polyimide Polymers 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
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- 230000003466 anti-cipated effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
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- 239000003114 blood coagulation factor Substances 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000003490 calendering Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
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- 238000001914 filtration Methods 0.000 description 1
- 230000002641 glycemic effect Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 238000009863 impact test Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012153 long-term therapy Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
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- 125000005487 naphthalate group Chemical group 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000003094 perturbing effect Effects 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
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- 210000002966 serum Anatomy 0.000 description 1
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- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0825—Test strips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
- Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
- Y10T156/1084—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing of continuous or running length bonded web
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Electrochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36001010P | 2010-06-30 | 2010-06-30 | |
| US61/360,010 | 2010-06-30 | ||
| PCT/US2011/042574 WO2012003306A1 (en) | 2010-06-30 | 2011-06-30 | Methods for manufacturing a dual biosensor test strip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2801946A1 true CA2801946A1 (en) | 2012-01-05 |
Family
ID=44511683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2801946A Abandoned CA2801946A1 (en) | 2010-06-30 | 2011-06-30 | Methods for manufacturing a dual biosensor test strip |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20130105074A1 (enExample) |
| EP (1) | EP2588857A1 (enExample) |
| JP (1) | JP5580934B2 (enExample) |
| KR (1) | KR20130023287A (enExample) |
| CN (1) | CN103038637A (enExample) |
| CA (1) | CA2801946A1 (enExample) |
| MX (1) | MX2012014620A (enExample) |
| WO (1) | WO2012003306A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11360076B2 (en) | 2012-03-30 | 2022-06-14 | Weavr Health Corp. | Methods and systems to collect a biological sample |
| US20130341207A1 (en) * | 2012-06-21 | 2013-12-26 | Lifescan Scotland Limited | Analytical test strip with capillary sample-receiving chambers separated by stop junctions |
| US8921061B2 (en) | 2012-11-02 | 2014-12-30 | Roche Diagnostics Operations, Inc. | Reagent materials and associated test elements |
| US8920628B2 (en) * | 2012-11-02 | 2014-12-30 | Roche Diagnostics Operations, Inc. | Systems and methods for multiple analyte analysis |
| US11358138B2 (en) | 2013-07-19 | 2022-06-14 | Boston Microfluidics Inc. | Fluid sample collection device |
| US10036709B2 (en) * | 2014-05-20 | 2018-07-31 | Roche Diabetes Care, Inc. | BG meter illuminated test strip |
| WO2016011308A1 (en) * | 2014-07-17 | 2016-01-21 | Siemens Healthcare Diagnostics Inc. | Sensor array |
| EP3216076B1 (en) | 2014-11-03 | 2024-03-06 | F. Hoffmann-La Roche AG | Method of using electrochemical test elements having multiple electrode arrangements |
| WO2017120464A1 (en) * | 2016-01-08 | 2017-07-13 | Siemens Healthcare Diagnostics Inc. | Heating element for sensor array |
| PL3523639T3 (pl) * | 2016-10-05 | 2025-03-17 | F. Hoffmann-La Roche Ag | Odczynniki wykrywające i układy elektrod do elementów diagnostycznych testów wieloanalitowych oraz sposoby ich zastosowania |
| JP7621580B2 (ja) | 2017-10-27 | 2025-01-27 | ナイチンゲール ヘルス オーイーユィ | 液体試料採取装置 |
| US11484877B2 (en) | 2018-05-29 | 2022-11-01 | Weavr Health Corp. | Blood metering device with desiccant and support for storage media and inlay with flange |
| US11772097B2 (en) | 2018-10-19 | 2023-10-03 | Renegadexbio, Pbc | Simultaneous spot test and storage of blood samples |
| GB2595060B (en) | 2018-10-23 | 2022-11-02 | Weavr Health Corp | Funnel with extension tube to augment blood collection device |
| EP4025129A4 (en) * | 2019-09-06 | 2024-02-14 | RenegadeXBio, PBC | Medium with hydrophobic patterns and break lines defining a blood collection volume |
| KR102226295B1 (ko) * | 2019-10-15 | 2021-03-10 | 주식회사 비바이오 | 생체물질 센싱용 스트립 및 그 제조 방법 |
| KR20230040359A (ko) * | 2020-07-17 | 2023-03-22 | 트르스티스 오브 보스톤 유니버시티 | 바이러스 검출 시스템 및 그 용도 |
| TWI852826B (zh) * | 2023-11-03 | 2024-08-11 | 五鼎生物技術股份有限公司 | 生化檢測模組及其製造方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5141868A (en) * | 1984-06-13 | 1992-08-25 | Internationale Octrooi Maatschappij "Octropa" Bv | Device for use in chemical test procedures |
| US5997817A (en) | 1997-12-05 | 1999-12-07 | Roche Diagnostics Corporation | Electrochemical biosensor test strip |
| US20050103624A1 (en) * | 1999-10-04 | 2005-05-19 | Bhullar Raghbir S. | Biosensor and method of making |
| EP1167538A1 (de) * | 2000-06-30 | 2002-01-02 | Schibli Engineering GmbH | Biosensor und Herstellverfahren dafür |
| US6800488B2 (en) * | 2000-12-13 | 2004-10-05 | Lifescan, Inc. | Methods of manufacturing reagent test strips |
| US8071030B2 (en) * | 2003-06-20 | 2011-12-06 | Roche Diagnostics Operations, Inc. | Test strip with flared sample receiving chamber |
| ES2675787T3 (es) * | 2003-06-20 | 2018-07-12 | F. Hoffmann-La Roche Ag | Método y reactivo para producir tiras reactivas estrechas y homogéneas |
| EP1667581A1 (en) * | 2003-09-01 | 2006-06-14 | Inverness Medical Switzerland GmbH | Sampling device with capillary action |
| CN1875114A (zh) * | 2003-10-29 | 2006-12-06 | 新加坡科技研究局 | 生物传感器 |
| US20050247573A1 (en) * | 2004-03-23 | 2005-11-10 | Hideaki Nakamura | Biosensors |
| US7465597B2 (en) * | 2006-06-29 | 2008-12-16 | Home Diagnostics, Inc. | Method of manufacturing a diagnostic test strip |
| ES2547574T3 (es) * | 2007-09-24 | 2015-10-07 | Bayer Healthcare Llc | Procedimiento de ensayo multielectrodo |
| CN101918822B (zh) * | 2008-03-27 | 2013-04-03 | 松下电器产业株式会社 | 测定装置、测定系统和浓度测定方法 |
-
2011
- 2011-06-30 WO PCT/US2011/042574 patent/WO2012003306A1/en not_active Ceased
- 2011-06-30 CN CN2011800326744A patent/CN103038637A/zh active Pending
- 2011-06-30 JP JP2013518702A patent/JP5580934B2/ja not_active Expired - Fee Related
- 2011-06-30 CA CA2801946A patent/CA2801946A1/en not_active Abandoned
- 2011-06-30 MX MX2012014620A patent/MX2012014620A/es not_active Application Discontinuation
- 2011-06-30 EP EP11731224.9A patent/EP2588857A1/en not_active Withdrawn
- 2011-06-30 KR KR1020127034266A patent/KR20130023287A/ko not_active Abandoned
-
2012
- 2012-12-12 US US13/712,072 patent/US20130105074A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20130105074A1 (en) | 2013-05-02 |
| JP5580934B2 (ja) | 2014-08-27 |
| KR20130023287A (ko) | 2013-03-07 |
| MX2012014620A (es) | 2013-02-07 |
| JP2013530408A (ja) | 2013-07-25 |
| WO2012003306A1 (en) | 2012-01-05 |
| EP2588857A1 (en) | 2013-05-08 |
| CN103038637A (zh) | 2013-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20121206 |
|
| FZDE | Discontinued |
Effective date: 20150416 |