CA2801781C - Protein kinase c inhibitors and uses thereof - Google Patents

Protein kinase c inhibitors and uses thereof Download PDF

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Publication number
CA2801781C
CA2801781C CA2801781A CA2801781A CA2801781C CA 2801781 C CA2801781 C CA 2801781C CA 2801781 A CA2801781 A CA 2801781A CA 2801781 A CA2801781 A CA 2801781A CA 2801781 C CA2801781 C CA 2801781C
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alkyl
compound
substituted
salt
hydrogen
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French (fr)
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CA2801781A1 (en
Inventor
Sacha Holland
Rao Kolluri
Salvador Alvarez
Matthew Duncton
Rajinder Singh
Jing Zhang
Esteban Masuda
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Rigel Pharmaceuticals Inc
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Rigel Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11013—Protein kinase C (2.7.11.13)

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
CA2801781A 2010-07-21 2011-07-21 Protein kinase c inhibitors and uses thereof Active CA2801781C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36646410P 2010-07-21 2010-07-21
US61/366,464 2010-07-21
PCT/US2011/044824 WO2012012619A1 (en) 2010-07-21 2011-07-21 Protein kinase c inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
CA2801781A1 CA2801781A1 (en) 2012-01-26
CA2801781C true CA2801781C (en) 2018-02-27

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ID=44533110

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2801781A Active CA2801781C (en) 2010-07-21 2011-07-21 Protein kinase c inhibitors and uses thereof

Country Status (5)

Country Link
US (2) US8710223B2 (enExample)
EP (1) EP2595982B1 (enExample)
JP (1) JP6035238B2 (enExample)
CA (1) CA2801781C (enExample)
WO (1) WO2012012619A1 (enExample)

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US20140329842A1 (en) 2014-11-06
WO2012012619A1 (en) 2012-01-26
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US20120022092A1 (en) 2012-01-26
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