CA2793527A1 - Use of naphthofuran derivatives in the treatment of cancer - Google Patents

Use of naphthofuran derivatives in the treatment of cancer Download PDF

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Publication number
CA2793527A1
CA2793527A1 CA2793527A CA2793527A CA2793527A1 CA 2793527 A1 CA2793527 A1 CA 2793527A1 CA 2793527 A CA2793527 A CA 2793527A CA 2793527 A CA2793527 A CA 2793527A CA 2793527 A1 CA2793527 A1 CA 2793527A1
Authority
CA
Canada
Prior art keywords
compound
polymorph
degrees
peak
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2793527A
Other languages
English (en)
French (fr)
Inventor
Chiang Jia Li
David Leggett
Youzhi Li
Wei Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Oncology Inc
Original Assignee
Boston Biomedical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Biomedical Inc filed Critical Boston Biomedical Inc
Publication of CA2793527A1 publication Critical patent/CA2793527A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2793527A 2010-03-19 2011-03-21 Use of naphthofuran derivatives in the treatment of cancer Abandoned CA2793527A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31589010P 2010-03-19 2010-03-19
US31588610P 2010-03-19 2010-03-19
US61/315,886 2010-03-19
US61/315,890 2010-03-19
US32581410P 2010-04-19 2010-04-19
US61/325,814 2010-04-19
PCT/US2011/029283 WO2011116399A1 (en) 2010-03-19 2011-03-21 Novel methods for targeting cancer stem cells

Publications (1)

Publication Number Publication Date
CA2793527A1 true CA2793527A1 (en) 2011-09-22

Family

ID=47678420

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2793527A Abandoned CA2793527A1 (en) 2010-03-19 2011-03-21 Use of naphthofuran derivatives in the treatment of cancer
CA2946890A Abandoned CA2946890A1 (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2946890A Abandoned CA2946890A1 (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells

Country Status (12)

Country Link
US (2) US9730909B2 (US20070167479A1-20070719-C00034.png)
EP (1) EP2547205B1 (US20070167479A1-20070719-C00034.png)
JP (1) JP2013522326A (US20070167479A1-20070719-C00034.png)
CN (1) CN103025159A (US20070167479A1-20070719-C00034.png)
AU (1) AU2011227023B2 (US20070167479A1-20070719-C00034.png)
BR (1) BR112012023660B8 (US20070167479A1-20070719-C00034.png)
CA (2) CA2793527A1 (US20070167479A1-20070719-C00034.png)
DK (1) DK2547205T3 (US20070167479A1-20070719-C00034.png)
FI (1) FI2547205T3 (US20070167479A1-20070719-C00034.png)
LT (1) LT2547205T (US20070167479A1-20070719-C00034.png)
RU (1) RU2591823C2 (US20070167479A1-20070719-C00034.png)
WO (1) WO2011116399A1 (US20070167479A1-20070719-C00034.png)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10377731B2 (en) 2007-09-10 2019-08-13 Boston Biomedical, Inc. Compositions and methods for cancer treatment

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107721958A (zh) * 2010-03-19 2018-02-23 北京强新生物科技有限公司 靶向癌症干细胞的新的化合物和组合物
SG11201508358RA (en) * 2013-04-09 2015-11-27 Boston Biomedical Inc 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer
WO2015120304A1 (en) 2014-02-07 2015-08-13 Boston Biomedical, Inc. 3-substituted carbonyl-naphtho[2,3-b]furane derivative or pharmaceutically acceptable salt thereof
WO2015190489A1 (ja) 2014-06-09 2015-12-17 京都薬品工業株式会社 新規抗癌剤
EA201792287A1 (ru) 2015-04-17 2018-03-30 Бостон Биомедикал, Инк. Способы лечения рака
EP3283071A1 (en) 2015-04-17 2018-02-21 Boston Biomedical, Inc. Methods for treating cancer
MX2017015618A (es) 2015-06-03 2018-08-15 Boston Biomedical Inc Composiciones que comprenden un inhibidor de la autorrenovación y diferenciación de células madre cancerosas y un agente inmunoterapéutico para su uso en el tratamiento del cáncer.
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
CN109069469A (zh) 2016-01-20 2018-12-21 北京强新生物科技有限公司 治疗癌症的方法
CA3029596A1 (en) 2016-06-28 2018-01-04 Boston Biomedical, Inc. Methods for treating cancer
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
CA3045306A1 (en) 2016-11-29 2018-06-07 Boston Biomedical, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
JP2020520923A (ja) 2017-05-17 2020-07-16 ボストン バイオメディカル， インコーポレイテッド がんを処置するための方法
US10953369B2 (en) * 2018-03-08 2021-03-23 Georgia Tech Research Corporation Spirocentric compounds and polymers thereof
MX2021004151A (es) 2018-10-12 2021-09-08 1Globe Biomedical Co Ltd Nueva solución de combinación para el tratamiento contra cáncer refractario a la quimioterapia.
CN111825644B (zh) * 2019-04-18 2023-07-28 中国医学科学院药物研究所 2,3-二氢萘并[2,3-b]呋喃-4,9-二酮类化合物及其制备方法和用途
CN117350965A (zh) * 2023-10-07 2024-01-05 中国原子能科学研究院 对象内放射性微球的指标预估装置

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0402192A1 (fr) 1989-05-31 1990-12-12 BODET, Jean Augustin Article en carton ou matière analogue et procédé de fabrication
JPH04139177A (ja) 1989-12-28 1992-05-13 Dainippon Ink & Chem Inc フラルベンゾキノン誘導体及びその製造方法並びに制癌剤
JPH1121284A (ja) 1997-06-30 1999-01-26 Kotobuki:Kk フラノナフトキノン誘導体及びこれを含有する医薬
US6174913B1 (en) 1998-06-05 2001-01-16 The University Of North Carolina At Chapel Hill Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents
EP1146869A2 (en) 1999-01-27 2001-10-24 University Of South Florida Inhibition of stat3 signal transduction for human cancer therapy
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
JP3961827B2 (ja) 1999-08-02 2007-08-22 エフ．ホフマン−ラ ロシュ アーゲー 新規な選択的レチノイドアゴニスト
JP2001097860A (ja) * 1999-09-29 2001-04-10 Japan Science & Technology Corp 抗薬剤耐性菌剤と抗クラミジア剤
UA75055C2 (uk) 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
WO2002078617A2 (en) 2001-03-28 2002-10-10 University Of South Florida Materials and methods for treatment of cancer and identification of anti-cancer compounds
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
AU2002357012A1 (en) 2001-11-27 2003-06-10 Transform Pharmaceuticals, Inc. Oral pharmaceutical formulations comprising paclitaxel, derivatives and methods of administration thereof
CN1310652C (zh) 2001-11-29 2007-04-18 特拉科斯有限公司 用体外光提取法和/或凋亡细胞对被试者进行预治疗的方法
DK1344533T3 (da) 2002-03-15 2007-01-08 Natimmune As Farmaceutiske præparater, der omfatter mannosebindende lectin
EP1551392A4 (en) 2002-09-17 2006-09-20 Arqule Inc NOVEL LAPACHO COMPOUNDS AND METHODS OF USE THEREOF
AR042052A1 (es) 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas
IS6633A (is) 2002-11-22 2004-05-23 Omega Farma Ehf. Samsetningar af fínasteríð töflum
AU2004256425A1 (en) 2003-06-09 2005-01-20 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20050049207A1 (en) 2003-09-03 2005-03-03 Kaufmann Doug A. Method of treating and preventing cancer
WO2005033048A2 (en) 2003-09-29 2005-04-14 The Johns Hopkins University Wnt pathway antagonists
KR101170655B1 (ko) 2003-12-11 2012-08-03 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 세포 증식 질환 치료용 화합물
EP1748772A2 (en) 2004-04-09 2007-02-07 University Of South Florida Combination therapies for cancer and proliferative angiopathies
JP2004224802A (ja) 2004-04-21 2004-08-12 Japan Science & Technology Agency 抗菌剤
EP1885352A2 (en) 2004-11-24 2008-02-13 Novartis AG Combinations comprising jak inhibitors and at least one of bcr-abl, flt-3, fak or raf kinase inhibitors
CA2599393A1 (en) 2005-02-25 2006-08-31 The Regents Of The University Of Michigan Small molecule inhibitors of stat3 and the uses thereof
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
CN101142202A (zh) * 2005-03-16 2008-03-12 太日保日本株式会社 抗癌化合物及其中间体和生产方法
JP2006290871A (ja) 2005-03-16 2006-10-26 Taheebo Japan Kk 抗癌性を示す化合物およびその中間体ならびにそれらの製造方法
US20060252073A1 (en) 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
WO2007100640A2 (en) 2006-02-21 2007-09-07 The Regents Of The University Of Michigan Growth hormone receptor antagonist cancer treatment
RU2456265C2 (ru) 2006-03-31 2012-07-20 Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем Биологически доступная для перорального применения кофейная кислота, относящаяся к противоопухолевым лекарственным средствам
US20070238770A1 (en) 2006-04-05 2007-10-11 Bristol-Myers Squibb Company Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
WO2008094321A2 (en) 2006-10-04 2008-08-07 Universtiy Of South Florida Akt sensitization of cancer cells
JP4077863B1 (ja) 2007-05-31 2008-04-23 タヒボジャパン株式会社 抗癌活性を有する光学活性２−（１−ヒドロキシエチル）−５−ヒドロキシナフト［２，３−ｂ］フラン−４，９−ジオンの製法
WO2009036099A1 (en) * 2007-09-10 2009-03-19 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors
US20100298402A1 (en) 2007-11-06 2010-11-25 Orchid Research Laboratories Limited Stilbene derivatives as pstat3/il-6 inhibitors
CN107721958A (zh) * 2010-03-19 2018-02-23 北京强新生物科技有限公司 靶向癌症干细胞的新的化合物和组合物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10377731B2 (en) 2007-09-10 2019-08-13 Boston Biomedical, Inc. Compositions and methods for cancer treatment

Also Published As

Publication number Publication date
FI2547205T3 (fi) 2024-05-27
AU2011227023B2 (en) 2015-05-28
US20130028944A1 (en) 2013-01-31
JP2013522326A (ja) 2013-06-13
EP2547205B1 (en) 2024-03-20
WO2011116399A1 (en) 2011-09-22
BR112012023660A2 (pt) 2015-09-15
DK2547205T3 (da) 2024-05-27
AU2011227023A1 (en) 2012-09-27
BR112012023660B8 (pt) 2021-05-25
CN103025159A (zh) 2013-04-03
RU2012144420A (ru) 2014-04-27
CA2946890A1 (en) 2011-09-22
EP2547205A4 (en) 2013-08-14
LT2547205T (lt) 2024-06-10
EP2547205A1 (en) 2013-01-23
US20170319537A1 (en) 2017-11-09
US9730909B2 (en) 2017-08-15
RU2591823C2 (ru) 2016-07-20
BR112012023660B1 (pt) 2021-05-18

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150804

FZDE Discontinued

Effective date: 20170929