CA2790834C - Plasma mass spectrometry with ion suppression - Google Patents

Plasma mass spectrometry with ion suppression Download PDF

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Publication number
CA2790834C
CA2790834C CA2790834A CA2790834A CA2790834C CA 2790834 C CA2790834 C CA 2790834C CA 2790834 A CA2790834 A CA 2790834A CA 2790834 A CA2790834 A CA 2790834A CA 2790834 C CA2790834 C CA 2790834C
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CA
Canada
Prior art keywords
cell
mode
ions
collision
gas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2790834A
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English (en)
French (fr)
Other versions
CA2790834A1 (en
Inventor
Hamid Badiei
Kaveh Kahen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Revvity Health Sciences Inc
Original Assignee
PerkinElmer Health Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PerkinElmer Health Sciences Inc filed Critical PerkinElmer Health Sciences Inc
Publication of CA2790834A1 publication Critical patent/CA2790834A1/en
Application granted granted Critical
Publication of CA2790834C publication Critical patent/CA2790834C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/06Electron- or ion-optical arrangements
    • H01J49/061Ion deflecting means, e.g. ion gates
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/0027Methods for using particle spectrometers
    • H01J49/0031Step by step routines describing the use of the apparatus
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/004Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/004Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/005Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/004Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0072Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by ion/ion reaction, e.g. electron transfer dissociation, proton transfer dissociation
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/004Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0077Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction specific reactions other than fragmentation
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/10Ion sources; Ion guns
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/24Vacuum systems, e.g. maintaining desired pressures
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/10Ion sources; Ion guns
    • H01J49/105Ion sources; Ion guns using high-frequency excitation, e.g. microwave excitation, Inductively Coupled Plasma [ICP]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CA2790834A 2010-02-26 2011-02-28 Plasma mass spectrometry with ion suppression Active CA2790834C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30867610P 2010-02-26 2010-02-26
US61/308,676 2010-02-26
PCT/US2011/026463 WO2011106768A1 (en) 2010-02-26 2011-02-28 Plasma mass spectrometry with ion suppression

Publications (2)

Publication Number Publication Date
CA2790834A1 CA2790834A1 (en) 2011-09-01
CA2790834C true CA2790834C (en) 2017-11-28

Family

ID=44507256

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2790834A Active CA2790834C (en) 2010-02-26 2011-02-28 Plasma mass spectrometry with ion suppression

Country Status (8)

Country Link
US (1) US8426804B2 (enExample)
EP (1) EP2539915A4 (enExample)
JP (2) JP5792203B2 (enExample)
CN (2) CN203325832U (enExample)
AU (1) AU2011220352B2 (enExample)
CA (1) CA2790834C (enExample)
SG (1) SG183179A1 (enExample)
WO (1) WO2011106768A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9190253B2 (en) 2010-02-26 2015-11-17 Perkinelmer Health Sciences, Inc. Systems and methods of suppressing unwanted ions
EP2539915A4 (en) * 2010-02-26 2016-08-10 Perkinelmer Health Sci Inc PLASMASSASS SPECTROMETRY WITH ION SUPPRESSION
SG10201501031YA (en) * 2010-02-26 2015-04-29 Perkinelmer Health Sci Inc Fluid chromatography injectors and injector inserts
US20140083544A1 (en) 2012-09-21 2014-03-27 Brian Chan Manifolds and methods and systems using them
US9129790B2 (en) * 2013-03-14 2015-09-08 Perkinelmer Health Sciences, Inc. Orthogonal acceleration TOF with ion guide mode
WO2015019461A1 (ja) 2013-08-08 2015-02-12 株式会社島津製作所 三連四重極型質量分析装置
GB201316164D0 (en) * 2013-09-11 2013-10-23 Thermo Fisher Scient Bremen Targeted mass analysis
US10068752B2 (en) * 2013-10-16 2018-09-04 Dh Technologies Development Pte. Ltd. Multiplexed precursor isolation for mass spectrometry
JP6449541B2 (ja) * 2013-12-27 2019-01-09 アジレント・テクノロジーズ・インクAgilent Technologies, Inc. プラズマ質量分析装置用イオン光学システム
US9754774B2 (en) 2014-02-14 2017-09-05 Perkinelmer Health Sciences, Inc. Systems and methods for automated analysis of output in single particle inductively coupled plasma mass spectrometry and similar data sets
WO2015122920A1 (en) * 2014-02-14 2015-08-20 Perkinelmer Health Sciences, Inc. Systems and methods for automated analysis of output in single particle inductively coupled plasma mass spectrometry and similar data sets
EP3105775B1 (en) * 2014-02-14 2019-11-13 PerkinElmer Health Sciences, Inc. Systems and methods for automated optimization of a multi-mode inductively coupled plasma mass spectrometer
EP3598477B1 (en) 2014-05-01 2020-12-30 PerkinElmer Health Sciences, Inc. Methods for detection and quantification of silicon in samples
WO2016022478A1 (en) 2014-08-04 2016-02-11 Fluid Handling Llc Tapered washer shaft jacking arrangement
CA2976763A1 (en) * 2015-04-01 2016-10-06 Dh Technologies Development Pte. Ltd. Rf/dc filter to enhance mass spectrometer robustness
GB2541383B (en) 2015-08-14 2018-12-12 Thermo Fisher Scient Bremen Gmbh Mirror lens for directing an ion beam
US20230230822A1 (en) * 2015-08-14 2023-07-20 Thermo Fisher Scientific (Bremen) Gmbh Collision cell having an axial field
GB2544484B (en) * 2015-11-17 2019-01-30 Thermo Fisher Scient Bremen Gmbh Addition of reactive species to ICP source in a mass spectrometer
GB2546967B (en) * 2016-01-27 2020-04-15 Thermo Fisher Scient Bremen Gmbh Quadrupole mass spectrometer
US10170290B2 (en) 2016-05-24 2019-01-01 Thermo Finnigan Llc Systems and methods for grouping MS/MS transitions
CN107845561A (zh) * 2016-09-18 2018-03-27 江苏可力色质医疗器械有限公司 一种减少交叉干扰的质谱碰撞反应池及分析方法
CN109716484B (zh) * 2016-09-21 2021-02-09 株式会社岛津制作所 质谱分析装置
CA3074351A1 (en) * 2017-09-01 2019-03-07 Perkinelmer Health Sciences Canada, Inc. Systems and methods using a gas mixture to select ions
CN107887251B (zh) * 2017-10-31 2020-04-07 天津大学 一种离子分子反应质谱系统
KR20200125594A (ko) * 2018-01-08 2020-11-04 퍼킨엘머 헬스 사이언스 캐나다 인코포레이티드 질량 분광법을 사용하여 2종 이상의 피분석물을 정량하기 위한 방법 및 시스템
US10290482B1 (en) * 2018-03-13 2019-05-14 Agilent Technologies, Inc. Tandem collision/reaction cell for inductively coupled plasma-mass spectrometry (ICP-MS)
US10854438B2 (en) * 2018-03-19 2020-12-01 Agilent Technologies, Inc. Inductively coupled plasma mass spectrometry (ICP-MS) with improved signal-to-noise and signal-to-background ratios
US11239068B2 (en) * 2018-11-02 2022-02-01 Agilent Technologies, Inc. Inductively coupled plasma mass spectrometer with mass correction
JP7095579B2 (ja) * 2018-12-05 2022-07-05 株式会社島津製作所 質量分析装置
CN110225643B (zh) * 2019-04-23 2021-06-04 中国科学院近代物理研究所 一种鸡尾酒束流制备装置及方法
US12051584B2 (en) 2020-02-04 2024-07-30 Perkinelmer Scientific Canada Ulc ION interfaces and systems and methods using them
CN113871284B (zh) * 2020-06-30 2025-04-25 株式会社岛津制作所 质谱仪
CN112185800B (zh) * 2020-09-27 2021-07-16 复旦大学 一种电感耦合等离子体飞行时间质谱仪
CN112863997B (zh) * 2020-12-31 2024-06-11 杭州谱育科技发展有限公司 具有粒子消除功能的icp-ms
CN115901913A (zh) * 2021-08-17 2023-04-04 南京大学 一种利用多极杆质量分析器的同位素分离富集方法
CH720458B1 (de) * 2023-11-07 2024-08-15 Bruker Switzerland Ag Elektrodenanordnung, Verfahren zur Herstellung einer Elektrodenanordnung und ionenoptisches Instrument.

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5018A (en) * 1847-03-13 Improvement in machinery for combing wool
CA2062629C (en) 1992-03-10 1999-06-15 John Barry French Apparatus and method for liquid sample introduction
US5381008A (en) 1993-05-11 1995-01-10 Mds Health Group Ltd. Method of plasma mass analysis with reduced space charge effects
US5565679A (en) 1993-05-11 1996-10-15 Mds Health Group Limited Method and apparatus for plasma mass analysis with reduced space charge effects
DE69535979D1 (de) * 1994-02-28 2009-08-20 Analytica Of Branford Inc Multipol-ionenleiter für massenspektrometrie
US5684581A (en) 1995-12-11 1997-11-04 Mds Health Group Limited Torch for inductively coupled plasma spectrometry
US6177668B1 (en) * 1996-06-06 2001-01-23 Mds Inc. Axial ejection in a multipole mass spectrometer
WO1998029896A1 (en) 1997-01-03 1998-07-09 Mds Inc. Spray chamber with dryer
US5969352A (en) 1997-01-03 1999-10-19 Mds Inc. Spray chamber with dryer
AUPO557797A0 (en) 1997-03-12 1997-04-10 Gbc Scientific Equipment Pty Ltd A time of flight analysis device
US6140638A (en) * 1997-06-04 2000-10-31 Mds Inc. Bandpass reactive collision cell
USRE39627E1 (en) * 2000-08-30 2007-05-15 Mds Inc. Device and method preventing ion source gases from entering reaction/collision cells in mass spectrometry
CA2317085C (en) * 2000-08-30 2009-12-15 Mds Inc. Device and method for preventing ion source gases from entering reaction/collision cells in mass spectrometry
US7700295B2 (en) 2000-12-28 2010-04-20 Mds Sciex Elemental analysis of tagged biologically active materials
US7135296B2 (en) 2000-12-28 2006-11-14 Mds Inc. Elemental analysis of tagged biologically active materials
US6713757B2 (en) * 2001-03-02 2004-03-30 Mds Inc. Controlling the temporal response of mass spectrometers for mass spectrometry
US6627912B2 (en) * 2001-05-14 2003-09-30 Mds Inc. Method of operating a mass spectrometer to suppress unwanted ions
US7479630B2 (en) 2004-03-25 2009-01-20 Bandura Dmitry R Method and apparatus for flow cytometry linked with elemental analysis
US20050032228A1 (en) 2001-07-19 2005-02-10 Bandura Dmitry R Method for phosporous quantitation
US6791078B2 (en) * 2002-06-27 2004-09-14 Micromass Uk Limited Mass spectrometer
US6835928B2 (en) * 2002-09-04 2004-12-28 Micromass Uk Limited Mass spectrometer
US8110814B2 (en) * 2003-10-16 2012-02-07 Alis Corporation Ion sources, systems and methods
WO2005062883A2 (en) 2003-12-23 2005-07-14 The George Washington University Demountable direct injection high efficiency nebulizer for inductively coupled plasma mass spectrometry
US7317186B2 (en) 2003-12-23 2008-01-08 The George Washington University Short torch design for direct liquid sample introduction using conventional and micro-nebulizers for plasma spectrometry
JP4214925B2 (ja) * 2004-02-26 2009-01-28 株式会社島津製作所 質量分析装置
US7804064B2 (en) 2004-10-01 2010-09-28 The George Washington University In-situ droplet monitoring for self-tuning spectrometers
US7483767B2 (en) 2004-10-14 2009-01-27 The George Washington University Feedback mechanism for smart nozzles and nebulizers
US7528365B2 (en) * 2006-02-07 2009-05-05 Applera Corporation Chemical noise reduction for mass spectrometry
US9105457B2 (en) 2010-02-24 2015-08-11 Perkinelmer Health Sciences, Inc. Cone-shaped orifice arrangement for inductively coupled plasma sample introduction system
EP2539915A4 (en) * 2010-02-26 2016-08-10 Perkinelmer Health Sci Inc PLASMASSASS SPECTROMETRY WITH ION SUPPRESSION
US8373117B2 (en) 2010-02-26 2013-02-12 Dh Technologies Development Pte. Ltd. Gas delivery system for mass spectrometer reaction and collision cells

Also Published As

Publication number Publication date
CN207587694U (zh) 2018-07-06
JP6817201B2 (ja) 2021-01-20
EP2539915A1 (en) 2013-01-02
JP5792203B2 (ja) 2015-10-07
US20120091331A1 (en) 2012-04-19
CN203325832U (zh) 2013-12-04
SG183179A1 (en) 2012-09-27
WO2011106768A1 (en) 2011-09-01
JP2017535040A (ja) 2017-11-24
JP2013521597A (ja) 2013-06-10
CA2790834A1 (en) 2011-09-01
US8426804B2 (en) 2013-04-23
AU2011220352A1 (en) 2012-10-18
EP2539915A4 (en) 2016-08-10
AU2011220352B2 (en) 2015-10-22

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