CA2790602C - 10'-fluorinated vinca alkaloids provide enhanced biological activity against mdr cancer cells - Google Patents

10'-fluorinated vinca alkaloids provide enhanced biological activity against mdr cancer cells Download PDF

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Publication number
CA2790602C
CA2790602C CA2790602A CA2790602A CA2790602C CA 2790602 C CA2790602 C CA 2790602C CA 2790602 A CA2790602 A CA 2790602A CA 2790602 A CA2790602 A CA 2790602A CA 2790602 C CA2790602 C CA 2790602C
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mmol
compound
fluoro
equiv
vinca alkaloid
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CA2790602A
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English (en)
French (fr)
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CA2790602A1 (en
Inventor
Dale L. Boger
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Scripps Research Institute
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Scripps Research Institute
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA2790602A 2010-02-22 2011-02-09 10'-fluorinated vinca alkaloids provide enhanced biological activity against mdr cancer cells Active CA2790602C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30678610P 2010-02-22 2010-02-22
US61/306,786 2010-02-22
PCT/US2011/024230 WO2011103007A2 (en) 2010-02-22 2011-02-09 10'-fluorinated vinca alkaloids provide enhanced biological activity against mdr cancer cells

Publications (2)

Publication Number Publication Date
CA2790602A1 CA2790602A1 (en) 2011-08-25
CA2790602C true CA2790602C (en) 2016-12-13

Family

ID=44483528

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2790602A Active CA2790602C (en) 2010-02-22 2011-02-09 10'-fluorinated vinca alkaloids provide enhanced biological activity against mdr cancer cells

Country Status (6)

Country Link
US (1) US8940754B2 (https=)
EP (1) EP2539339B1 (https=)
JP (1) JP5542972B2 (https=)
AU (1) AU2011218391B2 (https=)
CA (1) CA2790602C (https=)
WO (1) WO2011103007A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102363622B (zh) * 2011-11-24 2014-01-29 四川大学 一种化合物及其制备方法和应用
EP2807167A4 (en) * 2012-01-25 2016-01-20 Demerx Inc INDOIND AND BENZO FURANKED ISOCHINUCLIDEN DERIVATIVES AND METHOD FOR THE MANUFACTURE THEREOF
US9611271B2 (en) 2012-12-03 2017-04-04 Scripps Research Institute C20′ urea derivatives of vinca alkaloids
HU230462B1 (hu) * 2013-05-30 2016-07-28 Richter Gedeon Nyrt. Új bisz-indol alkaloidok mint rákellenes gyógyszerek
CA2989550C (en) 2014-06-18 2023-08-08 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
EP3464289B1 (en) 2016-05-31 2021-04-21 The Scripps Research Institute Ultra-potent vinca alkaloids: added molecular complexity further disrupts the tubulin dimer-dimer interface
CN106336419B (zh) * 2016-08-23 2018-10-16 江苏豪森药业集团有限公司 酒石酸长春瑞滨的制备方法
WO2026007326A1 (zh) * 2024-07-01 2026-01-08 四川大学 长春碱衍生物的制备及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU82514A1 (fr) * 1980-06-10 1982-01-20 Omnium Chimique Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
FR2761990B1 (fr) * 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca
US6723338B1 (en) 1999-04-01 2004-04-20 Inex Pharmaceuticals Corporation Compositions and methods for treating lymphoma
WO2005055939A2 (en) * 2003-12-04 2005-06-23 Amr Technology, Inc. Vinca derivatives
FR2905949B1 (fr) 2006-09-20 2008-11-21 Pierre Fabre Medicament Sa Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca

Also Published As

Publication number Publication date
JP2013520499A (ja) 2013-06-06
EP2539339A4 (en) 2013-08-07
US20120329822A1 (en) 2012-12-27
AU2011218391A1 (en) 2012-09-13
AU2011218391B2 (en) 2015-01-22
JP5542972B2 (ja) 2014-07-09
US8940754B2 (en) 2015-01-27
EP2539339A2 (en) 2013-01-02
WO2011103007A3 (en) 2012-01-05
CA2790602A1 (en) 2011-08-25
EP2539339B1 (en) 2014-05-14
WO2011103007A2 (en) 2011-08-25

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