CA2788045A1 - Microorganism production of high-valve chemical products, and related compositions, methods and systems - Google Patents

Microorganism production of high-valve chemical products, and related compositions, methods and systems Download PDF

Info

Publication number
CA2788045A1
CA2788045A1 CA2788045A CA2788045A CA2788045A1 CA 2788045 A1 CA2788045 A1 CA 2788045A1 CA 2788045 A CA2788045 A CA 2788045A CA 2788045 A CA2788045 A CA 2788045A CA 2788045 A1 CA2788045 A1 CA 2788045A1
Authority
CA
Canada
Prior art keywords
microorganism
activity
genetically modified
chemical product
coa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2788045A
Other languages
English (en)
French (fr)
Inventor
Michael D. Lynch
Ryan T. Gill
Tanya Warnecke-Lipscomb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OPX Biotechnologies Inc
University of Colorado Denver
Original Assignee
OPX Biotechnologies Inc
University of Colorado Denver
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OPX Biotechnologies Inc, University of Colorado Denver filed Critical OPX Biotechnologies Inc
Publication of CA2788045A1 publication Critical patent/CA2788045A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C12M3/02—Tissue, human, animal or plant cell, or virus culture apparatus with means providing suspensions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P29/00—Preparation of compounds containing a naphthacene ring system, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52—Propionic acid; Butyric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/66—Preparation of oxygen-containing organic compounds containing the quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Sustainable Development (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2788045A 2010-01-27 2011-01-27 Microorganism production of high-valve chemical products, and related compositions, methods and systems Abandoned CA2788045A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US29884410P 2010-01-27 2010-01-27
US61/298,844 2010-01-27
US32148010P 2010-04-06 2010-04-06
US61/321,480 2010-04-06
PCT/US2011/022790 WO2011094457A1 (en) 2010-01-27 2011-01-27 Microorganism production of high-valve chemical products, and related compositions, methods and systems

Publications (1)

Publication Number Publication Date
CA2788045A1 true CA2788045A1 (en) 2011-08-04

Family

ID=44319784

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2788045A Abandoned CA2788045A1 (en) 2010-01-27 2011-01-27 Microorganism production of high-valve chemical products, and related compositions, methods and systems

Country Status (10)

Country Link
US (2) US20130122541A1 (en:Method)
EP (1) EP2529023A4 (en:Method)
KR (1) KR20120136349A (en:Method)
CN (1) CN102822347A (en:Method)
AU (1) AU2011210852B2 (en:Method)
CA (1) CA2788045A1 (en:Method)
GB (1) GB2492256A (en:Method)
IN (1) IN2012DN06617A (en:Method)
MX (1) MX2012008700A (en:Method)
WO (1) WO2011094457A1 (en:Method)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
CN102695799A (zh) 2009-09-27 2012-09-26 Opx生物工艺学公司 用于制备3-羟基丙酸和其它产物的方法
CA2788596A1 (en) 2010-02-11 2011-08-18 Metabolix, Inc. Process for producing a monomer component from a genetically modified polyhydroxyalkanoate biomass
CA2807561C (en) 2010-08-06 2022-04-12 Mascoma Corporation Production of malonyl-coa derived products via anaerobic pathways
MX2013005654A (es) 2010-11-22 2013-07-17 Novozymes Inc Composiciones y metodos para la produccion de acido 3-hidroxipropionico.
CA2881666A1 (en) * 2012-08-10 2014-02-13 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
AU2013352418B2 (en) 2012-11-30 2016-12-08 Novozymes, Inc. 3-Hydroxypropionic Acid production by recombinant yeasts
US9157101B2 (en) 2012-12-21 2015-10-13 Algenol Biotech LLC Cyanobacterium sp. for production of compounds
US8846369B2 (en) 2012-12-21 2014-09-30 Algenol Biofuels Inc. Cyanobacterium sp. host cell and vector for production of chemical compounds in cyanobacterial cultures
KR20150129007A (ko) * 2013-03-15 2015-11-18 카아길, 인코포레이팃드 단일 기능성 mcr + 3-hp 탈수소효소
US9512057B2 (en) 2013-03-15 2016-12-06 Cargill, Incorporated 3-hydroxypropionic acid compositions
US9447438B2 (en) 2013-03-15 2016-09-20 Cargill, Incorporated Acetyl-coA carboxylases
EP2970077B1 (en) 2013-03-15 2018-11-07 Rohm and Haas Company Thermal salt-splitting of (alkyl)ammonium 3-hydroxypropionate
WO2014144400A1 (en) 2013-03-15 2014-09-18 Cargill, Incorporated Recovery of 3-hydroxypropionic acid
US20140273132A1 (en) 2013-03-15 2014-09-18 Algenol Biofuels Inc. Process for Inoculating a Bioreactor with Cyanobacteria
WO2014149285A1 (en) 2013-03-15 2014-09-25 Dow Global Technologies Llc Thermal salt-splitting of ammonium propionate
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
JP6603658B2 (ja) 2013-07-19 2019-11-06 カーギル インコーポレイテッド 脂肪酸及び脂肪酸誘導体の製造のための微生物及び方法
WO2015031504A1 (en) * 2013-08-27 2015-03-05 The Regents Of The University Of California RECOMBINANT PATHWAY AND ORGANISMS FOR MALONYL-CoA SYNTHESIS
US9701610B2 (en) 2013-10-17 2017-07-11 Dow Global Technologies Llc Ammonium bisulfate catalyzed dehydration of beta-hydroxy acids
CN104099307A (zh) * 2014-03-12 2014-10-15 江南大学 一种解除酪氨酸反馈抑制的AroF酶突变体及其应用
WO2015148943A1 (en) * 2014-03-28 2015-10-01 Conjugon, Inc. Preparation of small colony variants of therapeutic bacteria
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
WO2016069155A2 (en) * 2014-09-29 2016-05-06 The Regents Of The University Of California Method for biosynthesis of acetaminophen
WO2016105483A1 (en) 2014-12-23 2016-06-30 Algenol Biotech LLC Methods for increasing the stability of production of compounds in microbial host cells
CA2977593A1 (en) 2015-02-27 2016-09-01 White Dog Labs, Inc. Mixotrophic fermentation method for making acetone, isopropanol, butyric acid and other bioproducts, and mixtures thereof
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
WO2017100376A2 (en) 2015-12-07 2017-06-15 Zymergen, Inc. Promoters from corynebacterium glutamicum
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
KR102636404B1 (ko) * 2016-06-15 2024-02-13 경상국립대학교산학협력단 터펜 알코올 또는 그 유도체의 제조 방법
EP3478833A4 (en) 2016-06-30 2019-10-02 Zymergen, Inc. METHOD FOR PRODUCING A BACTERIAL HEMOGLOBIN LIBRARY AND ITS USE
JP2019519241A (ja) 2016-06-30 2019-07-11 ザイマージェン インコーポレイテッド グルコース透過酵素ライブラリーを生成するための方法およびその使用
US10138489B2 (en) 2016-10-20 2018-11-27 Algenol Biotech LLC Cyanobacterial strains capable of utilizing phosphite
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
EP3577227A4 (en) 2017-02-02 2020-12-30 Cargill Inc. GENETICALLY MODIFIED CELLS PRODUCING C6-C10 FATTY ACID DERIVATIVES
EP3612199A4 (en) * 2017-04-17 2021-01-06 Baylor College of Medicine COMMENSAL BACTERIA AS A NEW TREATMENT FOR DRY EYE AND SJÖGREN'S SYNDROME
DE102018008670A1 (de) * 2018-10-26 2020-04-30 Forschungszentrum Jülich GmbH Bereitstellung von Malonyl-CoA in coryneformen Bakterien sowie Verfahren zur Hestellung von Polyphenolen und Polyketiden mit coryneformen Bakterien
EP3898980A1 (en) * 2018-12-18 2021-10-27 Alderys Malonic semi-aldehyde-producing yeasts
CN112410389B (zh) * 2019-08-23 2023-07-18 中国科学院微生物研究所 支链α-酮酸脱氢酶复合体在制备丙二酸单酰辅酶A中的应用
CN112725251B (zh) * 2019-10-14 2022-07-22 江南大学 一种生产亚精胺的工程菌
CN111675743B (zh) * 2020-06-05 2023-10-27 宁夏泰益欣生物科技股份有限公司 一种从多杀菌素发酵液中提取多杀菌素的方法
KR102696014B1 (ko) * 2020-11-05 2024-08-16 주식회사 엘지화학 3-하이드록시프로피온산의 생산 방법
CN112881463B (zh) * 2021-01-19 2022-02-22 西安交通大学 一种容器内液体温度变化可视化处理方法
CN112795525A (zh) * 2021-03-25 2021-05-14 辽宁大学 一种乙酸钙不动杆菌培养基及其在降解双酚a的中的应用
CN114369545B (zh) * 2021-12-24 2024-01-30 河北萌帮水溶肥料股份有限公司 一种具有固化重金属镉功能的台湾嗜铜菌菌株ky575及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US6566583B1 (en) * 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
CA2322105A1 (en) * 2000-10-23 2002-04-23 Plant Bioscience Limited Antibiotic production (ii)
AU1981802A (en) * 2000-11-20 2002-06-03 Cargill Inc 3-hydroxypropionic acid and other organic compounds
EP1706457B1 (en) * 2003-12-04 2012-02-01 Novozymes A/S Production of 3-hydroxypropionic acid using beta-alanine/pyruvate aminotransferase
WO2006125000A2 (en) * 2005-05-19 2006-11-23 E.I. Du Pont De Nemours And Company Method for the production of resveratrol in a recombinant oleaginous microorganism
MX2008011784A (es) * 2006-03-15 2008-11-27 Martek Biosciences Corp Produccion de ácido graso poli-insaturado en organismos heterologos usando sistemas de sintasa de policétido pufa.
CN101473038B (zh) * 2006-03-15 2014-05-28 Dsmip资产公司 含有多不饱和脂肪酸的植物种子油
US20090191599A1 (en) * 2007-09-10 2009-07-30 Joule Biotechnologies, Inc. Engineered light-harvesting organisms
US8518678B2 (en) * 2007-12-21 2013-08-27 Butamax(Tm) Advanced Biofuels Llc Strain comprising increased expression of a CFA coding region for butanol production
EP2285948B1 (en) * 2008-03-03 2014-01-08 Joule Unlimited Technologies, Inc. Engineered co2 fixing microorganisms producing carbon-based products of interest
US8153859B2 (en) * 2008-05-23 2012-04-10 E.I. Du Pont De Nemours And Company DGAT genes from oleaginous organisms for increased seed storage lipid production and altered fatty acid profiles in oilseed plants
DE102008002309A1 (de) * 2008-06-09 2009-12-10 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
NZ589632A (en) * 2008-06-09 2013-03-28 Lanzatech New Zealand Ltd Production of butanediol by anaerobic microbial fermentation
CN102317436B (zh) * 2008-07-23 2014-06-25 Opx生物工艺学公司 用于增加微生物对3-羟基丙酸(3-hp)的耐受性以及增加3-羟基丙酸产量的方法、系统和组合物
WO2010031083A2 (en) * 2008-09-15 2010-03-18 Opx Biotechnologies, Inc. Methods, systems and compositions related to reduction of conversions of microbially produced 3-hydroxypropionic acid (3-hp) to aldehyde metabolites
CA2807561C (en) * 2010-08-06 2022-04-12 Mascoma Corporation Production of malonyl-coa derived products via anaerobic pathways

Also Published As

Publication number Publication date
GB2492256A (en) 2012-12-26
US20150056651A1 (en) 2015-02-26
MX2012008700A (es) 2012-10-05
AU2011210852A1 (en) 2012-08-23
IN2012DN06617A (en:Method) 2015-10-23
US20130122541A1 (en) 2013-05-16
GB201213404D0 (en) 2012-09-12
EP2529023A1 (en) 2012-12-05
WO2011094457A8 (en) 2012-03-08
AU2011210852B2 (en) 2015-12-24
EP2529023A4 (en) 2015-06-10
KR20120136349A (ko) 2012-12-18
CN102822347A (zh) 2012-12-12
WO2011094457A1 (en) 2011-08-04

Similar Documents

Publication Publication Date Title
AU2011210852B2 (en) Microorganism production of high-value chemical products, and related compositions, methods and systems
US10100342B2 (en) Method for producing 3-hydroxypropionic acid and other products
EP2689020B1 (en) Microbial production of chemical products and related compositions, methods and systems
US20180312886A1 (en) Microbial production of chemical products and related compositions, methods and systems
US20150056684A1 (en) Methods, systems, and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-hp)
US20120264902A1 (en) Methods, Systems and Compositions for Increased Microorganism Tolerance to and Production of 3-Hydroxypropionic Acid (3-HP)
WO2013043758A2 (en) Compositions and methods regarding direct nadh utilization to produce 3-hydroxypropionic acid, derived chemicals and further derived products
HK1176963A (en) Method for producing 3-hydroxypropionic acid and other products

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160113

FZDE Discontinued

Effective date: 20180129