CA2787331A1 - Aromatic-cationic peptides and uses of same - Google Patents
Aromatic-cationic peptides and uses of same Download PDFInfo
- Publication number
- CA2787331A1 CA2787331A1 CA2787331A CA2787331A CA2787331A1 CA 2787331 A1 CA2787331 A1 CA 2787331A1 CA 2787331 A CA2787331 A CA 2787331A CA 2787331 A CA2787331 A CA 2787331A CA 2787331 A1 CA2787331 A1 CA 2787331A1
- Authority
- CA
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- Prior art keywords
- lys
- dmt
- arg
- phe
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 229960004559 theobromine Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 230000034005 thiol-disulfide exchange Effects 0.000 description 1
- 150000003573 thiols Chemical group 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 238000013334 tissue model Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 150000003667 tyrosine derivatives Chemical group 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000009777 vacuum freeze-drying Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3008993A CA3008993A1 (en) | 2010-01-25 | 2011-01-24 | Aromatic-cationic peptides and uses of same |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29806210P | 2010-01-25 | 2010-01-25 | |
| US61/298,062 | 2010-01-25 | ||
| PCT/US2011/022247 WO2011091357A1 (en) | 2010-01-25 | 2011-01-24 | Aromatic-cationic peptides and uses of same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3008993A Division CA3008993A1 (en) | 2010-01-25 | 2011-01-24 | Aromatic-cationic peptides and uses of same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2787331A1 true CA2787331A1 (en) | 2011-07-28 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3008993A Abandoned CA3008993A1 (en) | 2010-01-25 | 2011-01-24 | Aromatic-cationic peptides and uses of same |
| CA2787331A Abandoned CA2787331A1 (en) | 2010-01-25 | 2011-01-24 | Aromatic-cationic peptides and uses of same |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3008993A Abandoned CA3008993A1 (en) | 2010-01-25 | 2011-01-24 | Aromatic-cationic peptides and uses of same |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US20120329730A1 (enExample) |
| EP (4) | EP2733150A1 (enExample) |
| JP (2) | JP2013518057A (enExample) |
| CN (2) | CN102834408A (enExample) |
| AU (2) | AU2011207432A1 (enExample) |
| CA (2) | CA3008993A1 (enExample) |
| HK (1) | HK1208686A1 (enExample) |
| WO (1) | WO2011091357A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102625709A (zh) * | 2009-08-24 | 2012-08-01 | 康肽德生物医药技术有限公司 | 用于预防或治疗眼科病症的方法和组合物 |
| WO2011106717A1 (en) * | 2010-02-26 | 2011-09-01 | University Of Florida Research Foundation, Inc. | Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy |
| WO2011116007A1 (en) | 2010-03-15 | 2011-09-22 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
| EP3290433A1 (en) * | 2010-05-03 | 2018-03-07 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| CN102327600A (zh) * | 2011-09-14 | 2012-01-25 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 用于预防和治疗辐射损伤的rx31肽 |
| EP2760460B1 (en) | 2011-09-29 | 2019-11-20 | Mayo Foundation For Medical Education And Research | Aromatic-cationic peptides and methods for using same |
| EP3466439A1 (en) * | 2011-12-09 | 2019-04-10 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| US9636378B2 (en) * | 2012-03-30 | 2017-05-02 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention and treatment neuropathy |
| US20150119552A1 (en) * | 2012-04-12 | 2015-04-30 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| SI2968443T1 (sl) | 2013-03-15 | 2022-01-31 | Protagonist Therapeutics, Inc. | Analogi hepcidina in njihova uporaba |
| US20140294902A1 (en) * | 2013-04-02 | 2014-10-02 | Protagonist Therapeutics, Inc. | Novel a4b7 peptide antagonists |
| WO2014210056A1 (en) * | 2013-06-27 | 2014-12-31 | Stealth Peptides International, Inc. | Peptide therapeutics and methods for using same |
| CA2920735A1 (en) * | 2013-08-12 | 2015-02-19 | Stealth Biotherapeutics Corp | Combination therapy for the treatment of ischemia-reperfusion injury |
| CN105939759B (zh) * | 2013-12-02 | 2020-01-17 | 康德生物医疗技术公司 | 用于治疗白癜风的组合物和方法 |
| KR102787208B1 (ko) | 2014-05-16 | 2025-03-27 | 프로타고니스트 테라퓨틱스, 인코포레이티드 | α4β7 인테그린 티오에테르 펩티드 길항제 |
| CN107206254B (zh) | 2014-07-17 | 2021-08-24 | 领导医疗有限公司 | 白细胞介素-23受体的口服肽抑制剂以及其治疗炎症性肠病的用途 |
| US9809623B2 (en) | 2014-10-01 | 2017-11-07 | Protagonist Therapeutics, Inc. | α4β7 peptide monomer and dimer antagonists |
| EP3800192A1 (en) * | 2015-03-06 | 2021-04-07 | Stealth Biotherapeutics Corp | Processes for preparing pharmaceutically relevant peptides |
| US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| JP6533723B2 (ja) * | 2015-09-11 | 2019-06-19 | キユーピー株式会社 | 抗酸化剤 |
| CA3006698A1 (en) * | 2015-11-30 | 2017-06-08 | Peter Schiller | Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome |
| US20190002503A1 (en) | 2015-12-30 | 2019-01-03 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
| WO2017117381A1 (en) * | 2015-12-31 | 2017-07-06 | Scott Duncan | Therapeutic compositions including peptides and uses thereof |
| WO2017156403A1 (en) | 2016-03-11 | 2017-09-14 | Stealth Biotherapeutics | Crystalline salt forms |
| CN109563131A (zh) | 2016-04-11 | 2019-04-02 | 卡诺有限责任公司 | 手性肽 |
| US11034724B2 (en) | 2017-04-05 | 2021-06-15 | Stealth Biotherapeutics Corp. | Crystalline salt forms of Boc-D-Arg-DMT-Lys-(Boc)-Phe-NH2 |
| EP3681900A4 (en) * | 2017-09-11 | 2021-09-08 | Protagonist Therapeutics, Inc. | OPIOID AGONIST PEPTIDES AND THEIR USES |
| EP4501952A3 (en) | 2018-02-08 | 2025-04-16 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| WO2020131283A1 (en) * | 2018-12-18 | 2020-06-25 | Stealth Biotherapeutics Corp. | Analogs that target mitochondrial diseases |
| AU2020311395A1 (en) | 2019-07-10 | 2022-02-03 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| CA3168135A1 (en) | 2020-01-15 | 2021-07-22 | Janssen Biotech, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| PL4090670T3 (pl) | 2020-01-15 | 2025-07-28 | Janssen Biotech, Inc | Peptydowe inhibitory receptora interleukiny-23 i ich zastosowanie w leczeniu chorób zapalnych |
| WO2022109328A1 (en) | 2020-11-20 | 2022-05-27 | Janssen Pharmaceutica Nv | Compositions of peptide inhibitors of interleukin-23 receptor |
| CN117881411A (zh) | 2021-06-01 | 2024-04-12 | 艾迪雅生物有限责任公司 | 用于眼部药物的延长释放药物递送系统和使用方法 |
| JP2024525732A (ja) | 2021-07-14 | 2024-07-12 | ヤンセン バイオテツク，インコーポレーテツド | インターロイキン－２３受容体の脂質化ペプチド阻害剤 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| EP0273696A2 (en) * | 1987-01-02 | 1988-07-06 | Merck & Co. Inc. | Renin inhibitors containing histidine replacements |
| KR920701242A (ko) * | 1989-11-06 | 1992-08-11 | 원본미기재 | 환원된 비가역성 봄베신 길항제 |
| CA2112566A1 (en) * | 1991-07-01 | 1993-02-18 | Graham J. Moore | Non-desensitizing analogs of gnrh and other biologically active ligands |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5716644A (en) | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5674534A (en) | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| US7576061B2 (en) * | 2003-02-04 | 2009-08-18 | Cornell Research Foundation, Inc. | Methods for preventing mitochondrial permeability transition |
| NZ549393A (en) * | 2004-01-23 | 2009-07-31 | Cornell Res Foundation Inc | Methods for reducing oxidative damage |
| JP5453320B2 (ja) * | 2008-02-07 | 2014-03-26 | コーネル ユニヴァーシティー | インスリン抵抗性を防止または処置するための方法 |
| EP3741381B1 (en) * | 2008-02-26 | 2024-04-24 | Cornell University | A peptide for use for prevention and treatment of acute renal injury |
-
2011
- 2011-01-24 EP EP14155476.6A patent/EP2733150A1/en not_active Withdrawn
- 2011-01-24 US US13/519,083 patent/US20120329730A1/en not_active Abandoned
- 2011-01-24 CN CN2011800071355A patent/CN102834408A/zh active Pending
- 2011-01-24 JP JP2012550189A patent/JP2013518057A/ja active Pending
- 2011-01-24 WO PCT/US2011/022247 patent/WO2011091357A1/en not_active Ceased
- 2011-01-24 CA CA3008993A patent/CA3008993A1/en not_active Abandoned
- 2011-01-24 AU AU2011207432A patent/AU2011207432A1/en not_active Abandoned
- 2011-01-24 EP EP11735303.7A patent/EP2528934A4/en not_active Withdrawn
- 2011-01-24 EP EP15185546.7A patent/EP3018138A1/en not_active Withdrawn
- 2011-01-24 CA CA2787331A patent/CA2787331A1/en not_active Abandoned
- 2011-01-24 EP EP14194189.8A patent/EP2848628A1/en not_active Withdrawn
- 2011-01-24 CN CN201510081030.4A patent/CN104725472A/zh active Pending
-
2013
- 2013-08-07 US US13/961,313 patent/US20130316964A1/en not_active Abandoned
-
2014
- 2014-09-16 US US14/488,007 patent/US20150005242A1/en not_active Abandoned
-
2015
- 2015-08-21 JP JP2015163826A patent/JP2016000750A/ja active Pending
- 2015-09-23 HK HK15109345.6A patent/HK1208686A1/xx unknown
-
2016
- 2016-02-05 AU AU2016200747A patent/AU2016200747A1/en not_active Abandoned
- 2016-02-11 US US15/041,235 patent/US20170008925A1/en not_active Abandoned
-
2017
- 2017-10-11 US US15/729,838 patent/US20180244721A1/en not_active Abandoned
-
2018
- 2018-11-30 US US16/206,777 patent/US20190330272A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013518057A (ja) | 2013-05-20 |
| AU2011207432A1 (en) | 2012-08-02 |
| CA3008993A1 (en) | 2011-07-28 |
| EP3018138A1 (en) | 2016-05-11 |
| EP2528934A4 (en) | 2013-08-21 |
| HK1208686A1 (en) | 2016-03-11 |
| JP2016000750A (ja) | 2016-01-07 |
| AU2016200747A1 (en) | 2016-02-25 |
| US20180244721A1 (en) | 2018-08-30 |
| CN104725472A (zh) | 2015-06-24 |
| EP2848628A1 (en) | 2015-03-18 |
| US20170008925A1 (en) | 2017-01-12 |
| US20150005242A1 (en) | 2015-01-01 |
| US20120329730A1 (en) | 2012-12-27 |
| WO2011091357A1 (en) | 2011-07-28 |
| CN102834408A (zh) | 2012-12-19 |
| US20190330272A1 (en) | 2019-10-31 |
| US20130316964A1 (en) | 2013-11-28 |
| EP2528934A1 (en) | 2012-12-05 |
| EP2733150A1 (en) | 2014-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160108 |
|
| FZDE | Discontinued |
Effective date: 20190625 |
|
| FZDE | Discontinued |
Effective date: 20190625 |