CA2782085A1 - Dp2 antagonist and uses thereof - Google Patents
Dp2 antagonist and uses thereof Download PDFInfo
- Publication number
- CA2782085A1 CA2782085A1 CA2782085A CA2782085A CA2782085A1 CA 2782085 A1 CA2782085 A1 CA 2782085A1 CA 2782085 A CA2782085 A CA 2782085A CA 2782085 A CA2782085 A CA 2782085A CA 2782085 A1 CA2782085 A1 CA 2782085A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- theta
- pharmaceutically acceptable
- acceptable salt
- pattern
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
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| US29280710P | 2010-01-06 | 2010-01-06 | |
| US61/292,807 | 2010-01-06 | ||
| PCT/US2011/020264 WO2011085033A2 (en) | 2010-01-06 | 2011-01-05 | Dp2 antagonist and uses thereof |
Publications (1)
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| CA2782085A1 true CA2782085A1 (en) | 2011-07-14 |
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| Country | Link |
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| US (1) | US9688624B2 (https=) |
| EP (1) | EP2521713A4 (https=) |
| JP (1) | JP2013516475A (https=) |
| KR (1) | KR20120115989A (https=) |
| CN (1) | CN102812000A (https=) |
| AU (1) | AU2011203649A1 (https=) |
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| EA (1) | EA201270653A1 (https=) |
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| MX (1) | MX2012007927A (https=) |
| PH (1) | PH12012501349A1 (https=) |
| SG (1) | SG182398A1 (https=) |
| WO (1) | WO2011085033A2 (https=) |
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| EP2307362A4 (en) * | 2008-07-03 | 2012-05-09 | Panmira Pharmaceuticals Llc | ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS |
| KR20120038544A (ko) | 2009-07-31 | 2012-04-23 | 판미라 파마슈티칼스, 엘엘씨 | Ｄｐ2 수용체 길항제의 안과용 약학 조성물 |
| EP2790696A1 (en) | 2011-12-16 | 2014-10-22 | Atopix Therapeutics Limited | Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis |
| CA2867901A1 (en) * | 2012-03-21 | 2013-09-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods for regulating hair growth |
| CN103830194A (zh) * | 2014-03-11 | 2014-06-04 | 熊妲妮 | 茚达特罗固体分散体及含有其的药物组合物 |
| US12059695B2 (en) * | 2021-09-16 | 2024-08-13 | Caterpillar Paving Products Inc. | Fluid spray system timing control |
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| US5239084A (en) | 1990-06-29 | 1993-08-24 | Hoffmann-La Roche Inc. | Substituted aminoalkyl biphenyl compounds |
| US5827868A (en) | 1991-10-07 | 1998-10-27 | E. R. Squibb & Sons, Inc. | Prostaglandin analogs |
| US5565485A (en) | 1993-03-19 | 1996-10-15 | Merck & Co., Inc. | Biphenyl compounds useful or endothelin antagonists |
| US5334598A (en) | 1993-03-19 | 1994-08-02 | Merck & Co., Inc. | Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives |
| US5391566A (en) | 1993-07-20 | 1995-02-21 | Merck & Co., Inc. | Benzimidazolinones substituted with phenoxyphenylacetic acid derivatives |
| DE19601782A1 (de) | 1996-01-19 | 1997-07-24 | Merck Patent Gmbh | Chinolin-2-(1H)one |
| CO4960662A1 (es) * | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
| AU4692399A (en) | 1998-06-17 | 2000-01-05 | Du Pont Pharmaceuticals Company | Cyclic hydroxamic acids as metalloproteinase inhibitors |
| US6617351B1 (en) | 1998-07-31 | 2003-09-09 | Eli Lilly And Company | Amide, carbamate, and urea derivatives |
| EP1177176B1 (en) | 1999-04-28 | 2006-04-19 | Aventis Pharma Deutschland GmbH | Tri-aryl acid derivatives as ppar receptor ligands |
| DE19937537A1 (de) | 1999-08-09 | 2001-03-08 | Gruenenthal Gmbh | Substituierte 2-Dialkylaminoalkylbiphenyl-Derivate |
| JP3486408B2 (ja) | 1999-08-23 | 2004-01-13 | 株式会社ビー・エム・エル | 物質のヒトプロスタグランジンｄ２受容体に対する性質の同定方法 |
| US20010047027A1 (en) | 2000-04-12 | 2001-11-29 | Marc Labelle | Prostaglandin D2 receptor antagonists |
| US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
| JP4279561B2 (ja) | 2001-05-23 | 2009-06-17 | メルク フロスト カナダ リミテツド | プロスタグランジンＤ２受容体拮抗薬としてのジヒドロピロロ［１，２−ａ］インドールおよびテトラヒドロピリド［１，２−ａ］−インドール誘導体 |
| US20030114457A1 (en) | 2001-07-09 | 2003-06-19 | Axys Pharmaceuticals, Inc. | 2- [5- (5-carbamimidoyl-1H-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinic acid derivatives as factor viia inhibitors |
| EP1435946B8 (en) * | 2001-09-14 | 2013-12-18 | Amgen Inc. | Linked biaryl compounds |
| EP1558614B1 (en) | 2002-10-30 | 2010-09-01 | Merck Frosst Canada Ltd. | Pyridopyrrolizine and pyridoindolizine derivatives |
| JP2004182657A (ja) | 2002-12-04 | 2004-07-02 | Eisai Co Ltd | Ｈｄｌレベル上昇促進剤 |
| ZA200505523B (en) | 2002-12-20 | 2006-09-27 | Amgen Inc | Asthma and allergic inflammation modulators |
| DE60303238T2 (de) | 2003-04-25 | 2006-09-14 | Actimis Pharmaceuticals, Inc., La Jolla | Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten |
| AU2004283139A1 (en) | 2003-10-14 | 2005-05-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| CA2547430A1 (en) | 2003-11-26 | 2005-06-09 | Takeda Pharmaceutical Company Limited | Receptor function regulating agent |
| US7019022B2 (en) | 2003-12-15 | 2006-03-28 | Merck Frosst Canada & Co. | Substituted tetrahydrocarbazole and cyclopentanoindole derivatives |
| CN1942428A (zh) | 2004-04-13 | 2007-04-04 | 默克公司 | Cetp抑制剂 |
| GB0409921D0 (en) | 2004-05-04 | 2004-06-09 | Novartis Ag | Organic compounds |
| GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| MX2007001943A (es) | 2004-08-17 | 2007-05-09 | Galderma Res & Dev | Nuevos compuestos biaromaticos activadores de los receptores del tipo receptor activado del proliferador de peroxisoma (ppar) y su uso en composiciones cosmeticas o farmaceuticas. |
| AU2005286717A1 (en) | 2004-09-21 | 2006-03-30 | Wyeth | Benzimidazole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof |
| MX2007003336A (es) | 2004-09-21 | 2007-06-05 | Athersys Inc | Acidos aceticos de indol que muestran antagonismo de receptor crth2 y usos de los mismos. |
| US20070299122A1 (en) | 2004-11-08 | 2007-12-27 | Tobert Jonathan A | Method of Treating Pathological Blushing |
| PE20061124A1 (es) | 2004-11-23 | 2006-10-13 | Pfizer Prod Inc | Compuestos y derivados de dibencil amina |
| GB0510584D0 (en) | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
| GB0518783D0 (en) | 2005-09-14 | 2005-10-26 | Argenta Discovery Ltd | Indolizine compounds |
| AU2006296004B2 (en) | 2005-09-27 | 2011-11-17 | Shionogi & Co., Ltd. | Sulfonamide derivative having PGD2 receptor antagonistic activity |
| US8148572B2 (en) | 2005-10-06 | 2012-04-03 | Astrazeneca Ab | Compounds |
| ATE545637T1 (de) * | 2005-12-15 | 2012-03-15 | Astrazeneca Ab | Substituierte diphenylether, -amine, -sulfide und methane zur behandlung von atemwegserkrankungen |
| WO2007079078A1 (en) | 2005-12-29 | 2007-07-12 | Bayer Schering Pharma Aktiengesellschaft | Diamine derivatives as inhibitors of leukotriene a4 hydrolase |
| BRPI0712332A2 (pt) * | 2006-06-09 | 2012-12-18 | Icos Corp | composto e derivados farmaceuticamente aceitáveis dos mesmos, composição farmacêutica, método de antagonização de um receptor dp-2, e, uso de um composto |
| MY149934A (en) * | 2006-08-21 | 2013-10-31 | Array Biopharma Inc | 4-substituted phenoxyphenylacetic acid derivatives |
| JP5539864B2 (ja) | 2007-06-12 | 2014-07-02 | アカオゲン，インコーポレーテッド | 抗菌剤 |
| CN101687844B (zh) | 2007-07-02 | 2013-11-13 | 弗·哈夫曼-拉罗切有限公司 | 用作ccr2受体拮抗剂的咪唑衍生物 |
| CN101801952A (zh) | 2007-10-01 | 2010-08-11 | 弗·哈夫曼-拉罗切有限公司 | 用作ccr受体拮抗剂的n-杂环联芳基甲酰胺类化合物 |
| GB0719521D0 (en) | 2007-10-05 | 2007-11-14 | Argenta Discovery Ltd | Compounds |
| GB0722203D0 (en) | 2007-11-13 | 2007-12-19 | Oxagen Ltd | Use of CRTH2 antagonist compounds |
| GB0722216D0 (en) | 2007-11-13 | 2007-12-27 | Oxagen Ltd | Use of crth2 antagonist compounds |
| AU2009204700B2 (en) | 2008-01-18 | 2013-07-04 | Atopix Therapeutics Limited | Compounds having CRTH2 antagonist activity |
| CN101952244B (zh) | 2008-02-01 | 2014-11-05 | 潘米拉制药公司 | 前列腺素d2受体的n，n-二取代氨基烷基联苯拮抗剂 |
| UA98839C2 (en) | 2008-02-01 | 2012-06-25 | Панмира Фармасьютикалз, Ллк. | N,n-disubstituted aminoalkylbiphenyl antagonists of prostaglandin d2 receptors |
| EP2257536A4 (en) | 2008-02-14 | 2011-03-23 | Amira Pharmaceuticals Inc | CYCLIC DIARYL ETHERS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS |
| WO2009145989A2 (en) * | 2008-04-02 | 2009-12-03 | Amira Pharmaceuticals, Inc. | Aminoalkylphenyl antagonists of prostaglandin d2 receptors |
| EP2307362A4 (en) | 2008-07-03 | 2012-05-09 | Panmira Pharmaceuticals Llc | ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS |
| WO2010039977A2 (en) | 2008-10-01 | 2010-04-08 | Amira Pharmaceuticals, Inc. | Heteroaryl antagonists of prostaglandin d2 receptors |
| US8524748B2 (en) | 2008-10-08 | 2013-09-03 | Panmira Pharmaceuticals, Llc | Heteroalkyl biphenyl antagonists of prostaglandin D2 receptors |
| US8383654B2 (en) | 2008-11-17 | 2013-02-26 | Panmira Pharmaceuticals, Llc | Heterocyclic antagonists of prostaglandin D2 receptors |
| US20100173313A1 (en) | 2009-01-08 | 2010-07-08 | Amira Pharmaceuticals, Inc. | Biomarkers of inflammation |
| CN102596193A (zh) | 2009-07-31 | 2012-07-18 | 潘米拉制药公司 | Dp2受体拮抗的皮肤调配物 |
| KR20120038544A (ko) * | 2009-07-31 | 2012-04-23 | 판미라 파마슈티칼스, 엘엘씨 | Ｄｐ2 수용체 길항제의 안과용 약학 조성물 |
-
2011
- 2011-01-05 CA CA2782085A patent/CA2782085A1/en not_active Abandoned
- 2011-01-05 SG SG2012050043A patent/SG182398A1/en unknown
- 2011-01-05 AU AU2011203649A patent/AU2011203649A1/en not_active Abandoned
- 2011-01-05 JP JP2012548102A patent/JP2013516475A/ja active Pending
- 2011-01-05 CN CN2011800054059A patent/CN102812000A/zh active Pending
- 2011-01-05 EP EP11732103.4A patent/EP2521713A4/en not_active Withdrawn
- 2011-01-05 US US13/519,292 patent/US9688624B2/en not_active Expired - Fee Related
- 2011-01-05 WO PCT/US2011/020264 patent/WO2011085033A2/en not_active Ceased
- 2011-01-05 MX MX2012007927A patent/MX2012007927A/es not_active Application Discontinuation
- 2011-01-05 PH PH1/2012/501349A patent/PH12012501349A1/en unknown
- 2011-01-05 KR KR1020127019754A patent/KR20120115989A/ko not_active Withdrawn
- 2011-01-05 EA EA201270653A patent/EA201270653A1/ru unknown
-
2012
- 2012-05-24 IL IL219987A patent/IL219987A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2521713A2 (en) | 2012-11-14 |
| PH12012501349A1 (en) | 2013-01-14 |
| WO2011085033A3 (en) | 2011-11-17 |
| IL219987A0 (en) | 2012-07-31 |
| US9688624B2 (en) | 2017-06-27 |
| SG182398A1 (en) | 2012-08-30 |
| EP2521713A4 (en) | 2013-10-02 |
| KR20120115989A (ko) | 2012-10-19 |
| US20130053444A1 (en) | 2013-02-28 |
| WO2011085033A2 (en) | 2011-07-14 |
| MX2012007927A (es) | 2012-08-15 |
| JP2013516475A (ja) | 2013-05-13 |
| EA201270653A1 (ru) | 2012-11-30 |
| AU2011203649A1 (en) | 2012-06-14 |
| CN102812000A (zh) | 2012-12-05 |
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| EEER | Examination request |
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| FZDE | Discontinued |
Effective date: 20190107 |