CA2780963C - Disposable fluid path systems and methods for processing complex biological materials - Google Patents
Disposable fluid path systems and methods for processing complex biological materials Download PDFInfo
- Publication number
- CA2780963C CA2780963C CA2780963A CA2780963A CA2780963C CA 2780963 C CA2780963 C CA 2780963C CA 2780963 A CA2780963 A CA 2780963A CA 2780963 A CA2780963 A CA 2780963A CA 2780963 C CA2780963 C CA 2780963C
- Authority
- CA
- Canada
- Prior art keywords
- bag
- permeate
- assembly
- filter
- conduit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000012545 processing Methods 0.000 title claims abstract description 83
- 239000012530 fluid Substances 0.000 title claims abstract description 64
- 238000000034 method Methods 0.000 title claims abstract description 28
- 239000012620 biological material Substances 0.000 title claims description 34
- 239000000523 sample Substances 0.000 claims abstract description 43
- 238000000926 separation method Methods 0.000 claims abstract description 29
- 238000004062 sedimentation Methods 0.000 claims abstract description 23
- 239000012472 biological sample Substances 0.000 claims abstract description 16
- 230000005484 gravity Effects 0.000 claims abstract description 9
- 239000012466 permeate Substances 0.000 claims description 73
- 239000000463 material Substances 0.000 claims description 69
- 238000001914 filtration Methods 0.000 claims description 45
- 239000012465 retentate Substances 0.000 claims description 38
- 238000004891 communication Methods 0.000 claims description 25
- 238000003860 storage Methods 0.000 claims description 20
- 210000004027 cell Anatomy 0.000 claims description 11
- 239000012510 hollow fiber Substances 0.000 claims description 11
- 239000012528 membrane Substances 0.000 claims description 11
- 230000004931 aggregating effect Effects 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 210000004700 fetal blood Anatomy 0.000 claims description 7
- 230000003287 optical effect Effects 0.000 claims description 7
- 230000002572 peristaltic effect Effects 0.000 claims description 7
- 238000012546 transfer Methods 0.000 claims description 7
- 238000011010 flushing procedure Methods 0.000 claims description 5
- 238000005086 pumping Methods 0.000 claims description 5
- 238000010926 purge Methods 0.000 claims description 5
- 210000000601 blood cell Anatomy 0.000 claims description 3
- 210000001185 bone marrow Anatomy 0.000 claims description 3
- 230000036961 partial effect Effects 0.000 claims description 3
- 238000005192 partition Methods 0.000 claims description 3
- 210000000130 stem cell Anatomy 0.000 claims description 3
- 238000010586 diagram Methods 0.000 claims description 2
- 230000008014 freezing Effects 0.000 claims description 2
- 238000007710 freezing Methods 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 238000003908 quality control method Methods 0.000 claims description 2
- 239000002699 waste material Substances 0.000 claims description 2
- 238000003466 welding Methods 0.000 claims description 2
- 230000000712 assembly Effects 0.000 claims 1
- 238000000429 assembly Methods 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 239000011365 complex material Substances 0.000 abstract 1
- 230000008569 process Effects 0.000 description 7
- 238000004220 aggregation Methods 0.000 description 6
- 230000002776 aggregation Effects 0.000 description 6
- 238000011084 recovery Methods 0.000 description 6
- 238000013461 design Methods 0.000 description 5
- 230000002441 reversible effect Effects 0.000 description 5
- 230000036512 infertility Effects 0.000 description 4
- 239000000835 fiber Substances 0.000 description 3
- 239000013060 biological fluid Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- 230000035899 viability Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000000071 blow moulding Methods 0.000 description 1
- 238000013354 cell banking Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0429—Red blood cells; Erythrocytes
- A61M2202/0437—Blood stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0462—Placental blood, umbilical cord blood
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/30—Control equipment
- B01D21/34—Controlling the feed distribution; Controlling the liquid level ; Control of process parameters
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- External Artificial Organs (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Filtering Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/636,112 US8512566B2 (en) | 2009-12-11 | 2009-12-11 | Disposable fluid path systems and methods for processing complex biological materials |
| US12/636,112 | 2009-12-11 | ||
| PCT/EP2010/069134 WO2011070052A1 (en) | 2009-12-11 | 2010-12-08 | Disposable fluid path systems and methods for processing complex biological materials |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2780963A1 CA2780963A1 (en) | 2011-06-16 |
| CA2780963C true CA2780963C (en) | 2018-06-12 |
Family
ID=43532113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2780963A Active CA2780963C (en) | 2009-12-11 | 2010-12-08 | Disposable fluid path systems and methods for processing complex biological materials |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8512566B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2509652B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5865258B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101770846B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102639167B (cg-RX-API-DMAC7.html) |
| CA (1) | CA2780963C (cg-RX-API-DMAC7.html) |
| IN (1) | IN2012DN04847A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011070052A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9034280B2 (en) | 2009-12-16 | 2015-05-19 | General Electric Corporation | High-throughput methods and systems for processing biological materials |
| US10934519B2 (en) | 2011-07-29 | 2021-03-02 | Global Life Sciences Solutions Usa Llc | Systems, methods and control laws for cell harvesting |
| JP6227562B2 (ja) * | 2012-01-18 | 2017-11-08 | バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ | 灌流バイオリアクターシステムおよびその操作方法 |
| CN105112289A (zh) * | 2015-09-02 | 2015-12-02 | 广州广立生物科技有限公司 | 细胞分离装置及用于细胞分离装置的分液器 |
| JP2016512020A (ja) * | 2013-03-04 | 2016-04-25 | スイス・ステム・セル・ファンデーションＳｗｉｓｓ Ｓｔｅｍ Ｃｅｌｌ Ｆｏｕｎｄａｔｉｏｎ | 組織試料から細胞を抽出するためのシステム |
| US10113144B2 (en) * | 2013-07-23 | 2018-10-30 | Kaneka Corporation | Method for producing cell concentrate, and cell suspension treatment system |
| US10280390B2 (en) | 2014-12-22 | 2019-05-07 | Saint-Gobain Performance Plastics Corporation | System for culture of cells in a controlled environment |
| US9926524B2 (en) | 2014-12-22 | 2018-03-27 | Saint-Gobain Performance Plastics Corporation | Gas permeable material |
| US10655097B2 (en) | 2014-12-22 | 2020-05-19 | Saint-Gobain Performance Plastics Corporation | T-cell culture double bag assembly |
| ITUB20154668A1 (it) * | 2015-10-14 | 2017-04-14 | Mario Goisis | Dispositivo per la filtrazione del grasso estratto con procedure chirurgiche di liposuzione |
| US10711237B2 (en) | 2017-08-22 | 2020-07-14 | Idex Health & Science Llc | Apparatus and methods for bioprocesses and other processes |
| US10960393B2 (en) | 2017-08-22 | 2021-03-30 | Idex Health And Science Llc | Apparatus and methods for bioprocesses and other processes |
| US11027239B2 (en) * | 2017-10-05 | 2021-06-08 | Global Life Sciences Solutions Usa Llc | Systems and methods for utilizing crossflow filtration for cell enrichment |
| ES2985973T3 (es) * | 2017-12-28 | 2024-11-08 | I Sep | Sistema y procedimiento de tratamiento del líquido hemorrágico para autotransfusión |
| AU2019209458A1 (en) | 2018-01-16 | 2020-07-02 | Q.E.D. Environmental Systems, Inc. | Fluid level monitoring system and method incorporating pressure sensor system having inflatable/collapsible bag |
| EP3763807A1 (de) * | 2019-07-12 | 2021-01-13 | Eppendorf AG | Multi-connector-port |
| US11148083B2 (en) * | 2019-12-27 | 2021-10-19 | Pall Corporation | Method and system for recovering fluid |
| DK4106907T3 (en) | 2020-02-19 | 2025-08-18 | Emd Millipore Corp | Filtration system for cell removal systems and methods of using the same |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3576650A (en) * | 1968-01-18 | 1971-04-27 | Union Carbide Corp | Cryogenic plastic film package |
| US4276175A (en) * | 1979-07-19 | 1981-06-30 | Bower John D | Regeneratable peritoneal dialysis bag |
| GB2176715A (en) * | 1985-06-27 | 1987-01-07 | Apv Int Ltd | Beer filtration |
| JP2700170B2 (ja) * | 1987-07-11 | 1998-01-19 | 大日本インキ化学工業株式会社 | 膜型人工肺 |
| EP0381757B1 (en) | 1987-09-21 | 1993-03-10 | Terumo Kabushiki Kaisha | Medical instrument and production thereof |
| US5055198A (en) * | 1990-03-07 | 1991-10-08 | Shettigar U Ramakrishna | Autologous blood recovery membrane system and method |
| US5695653A (en) * | 1994-12-23 | 1997-12-09 | Pall Corporation | Device and method for separating components from a biological fluid |
| DE19530969A1 (de) * | 1995-08-23 | 1997-02-27 | Deutsches Rotes Kreuz Blutspen | Vorrichtung zum Fließtrennen von Vollblut als Gemisch von Flüssigkeiten in einzelne verschiedenfarbige Blutbestandteile, insbesondere zur Separation von Thrombozytenkonzentrat aus Buffycoat |
| US5876611A (en) * | 1997-06-16 | 1999-03-02 | Shettigar; U. Ramakrishna | Intraoperative blood salvaging system and method |
| US6251295B1 (en) * | 1998-01-08 | 2001-06-26 | Nexell Therapeutics Inc. | Method for recirculation washing of blood cells |
| US6695803B1 (en) * | 1998-10-16 | 2004-02-24 | Mission Medical, Inc. | Blood processing system |
| US6517508B1 (en) * | 1999-11-03 | 2003-02-11 | Dsu Medical Corporation | Set for blood processing |
| US7806845B2 (en) * | 2002-04-24 | 2010-10-05 | Biomet Biologics, Llc | Blood separation and concentration system |
| ES2755552T3 (es) | 2002-06-19 | 2020-04-22 | Northwest Biotherapeutics Inc | Dispositivos de filtración de flujo tangencial y métodos para el enriquecimiento de leucocitos |
| WO2004052270A1 (ja) | 2002-12-12 | 2004-06-24 | Asahi Kasei Kabushiki Kaisha | ウイルス除去バッグ及びそれを用いたウイルス除去方法 |
| US7189352B2 (en) * | 2003-01-14 | 2007-03-13 | Medtronic, Inc. | Extracorporeal blood circuit priming system and method |
| US20070175825A1 (en) * | 2004-05-18 | 2007-08-02 | Biomass Processing Technology, Inc. | System for the treating biomaterial waste streams |
| EP1893253B1 (en) * | 2005-03-23 | 2010-05-19 | Biosafe S.A. | Integrated system for collecting, processing and transplanting cell subsets, including adult stem cells, for regenerative medicine |
| EP1873171A1 (en) * | 2006-06-20 | 2008-01-02 | Daikin Industries, Ltd. | Method of concentrating fluoropolymer and fluorine-containing emulsifiers |
| EP2129764B1 (en) | 2007-03-05 | 2018-10-10 | Terumo BCT, Inc. | Cell expansion system and methods of use |
| EP2227270B1 (en) | 2007-12-21 | 2015-03-04 | Gambro Lundia AB | Disposable cassette assembly for an extracorporeal blood circuit and medical apparatus comprising the cassette |
| ITMI20080858A1 (it) * | 2008-05-13 | 2009-11-14 | Eurosets Srl | Dispositivo di autotrasfusione post-operatoria ad efficienza migliorata. |
-
2009
- 2009-12-11 US US12/636,112 patent/US8512566B2/en not_active Expired - Fee Related
-
2010
- 2010-12-08 EP EP10790754.5A patent/EP2509652B1/en not_active Not-in-force
- 2010-12-08 JP JP2012542533A patent/JP5865258B2/ja not_active Expired - Fee Related
- 2010-12-08 IN IN4847DEN2012 patent/IN2012DN04847A/en unknown
- 2010-12-08 KR KR1020127014901A patent/KR101770846B1/ko not_active Expired - Fee Related
- 2010-12-08 CA CA2780963A patent/CA2780963C/en active Active
- 2010-12-08 WO PCT/EP2010/069134 patent/WO2011070052A1/en not_active Ceased
- 2010-12-08 CN CN201080055881.7A patent/CN102639167B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120098771A (ko) | 2012-09-05 |
| JP5865258B2 (ja) | 2016-02-17 |
| CN102639167B (zh) | 2015-08-19 |
| EP2509652A1 (en) | 2012-10-17 |
| US8512566B2 (en) | 2013-08-20 |
| JP2013513406A (ja) | 2013-04-22 |
| EP2509652B1 (en) | 2017-05-17 |
| WO2011070052A1 (en) | 2011-06-16 |
| KR101770846B1 (ko) | 2017-08-23 |
| CN102639167A (zh) | 2012-08-15 |
| CA2780963A1 (en) | 2011-06-16 |
| US20110139723A1 (en) | 2011-06-16 |
| HK1174574A1 (zh) | 2013-06-14 |
| IN2012DN04847A (cg-RX-API-DMAC7.html) | 2015-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20151123 |