CA2780155A1 - Ethynyl derivatives - Google Patents

Ethynyl derivatives Download PDF

Info

Publication number
CA2780155A1
CA2780155A1 CA2780155A CA2780155A CA2780155A1 CA 2780155 A1 CA2780155 A1 CA 2780155A1 CA 2780155 A CA2780155 A CA 2780155A CA 2780155 A CA2780155 A CA 2780155A CA 2780155 A1 CA2780155 A1 CA 2780155A1
Authority
CA
Canada
Prior art keywords
pyrimidine
pyrazolo
phenylethynyl
tert
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2780155A
Other languages
English (en)
French (fr)
Inventor
Luke Green
Wolfgang Guba
Georg Jaeschke
Synese Jolidon
Lothar Lindemann
Heinz Stadler
Eric Vieira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43446449&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2780155(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2780155A1 publication Critical patent/CA2780155A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2780155A 2009-12-17 2010-12-14 Ethynyl derivatives Abandoned CA2780155A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09179719.1 2009-12-17
EP09179719 2009-12-17
PCT/EP2010/069593 WO2011073172A1 (en) 2009-12-17 2010-12-14 Ethynyl derivatives

Publications (1)

Publication Number Publication Date
CA2780155A1 true CA2780155A1 (en) 2011-06-23

Family

ID=43446449

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2780155A Abandoned CA2780155A1 (en) 2009-12-17 2010-12-14 Ethynyl derivatives

Country Status (27)

Country Link
US (2) US8586581B2 (ja)
EP (1) EP2513102B1 (ja)
JP (1) JP5763094B2 (ja)
KR (1) KR101407856B1 (ja)
CN (1) CN102686589B (ja)
AR (1) AR079467A1 (ja)
AU (1) AU2010332987B2 (ja)
BR (1) BR112012014770A2 (ja)
CA (1) CA2780155A1 (ja)
CL (1) CL2012001596A1 (ja)
CO (1) CO6531478A2 (ja)
CR (1) CR20120269A (ja)
EC (1) ECSP12011977A (ja)
ES (1) ES2551582T3 (ja)
HK (1) HK1171225A1 (ja)
IL (1) IL219371A (ja)
MA (1) MA33802B1 (ja)
MX (1) MX2012006789A (ja)
MY (1) MY162998A (ja)
NZ (1) NZ599553A (ja)
PE (1) PE20121443A1 (ja)
RU (1) RU2553461C2 (ja)
SG (1) SG181779A1 (ja)
TW (1) TWI448465B (ja)
UA (1) UA107002C2 (ja)
WO (1) WO2011073172A1 (ja)
ZA (1) ZA201204429B (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2689956T3 (es) * 2010-11-05 2018-11-16 Oat Agrio Co., Ltd. Compuesto de etinilfenilamidina o sal del mismo, procedimiento para producir el mismo y fungicida para una utilización agrícola y hortícola
US8957213B2 (en) 2011-04-26 2015-02-17 Hoffman-La Roche Inc. Ethynyl compounds
US20130123254A1 (en) 2011-09-30 2013-05-16 Barbara Biemans Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification
UA110862C2 (uk) * 2011-10-07 2016-02-25 Ф. Хоффманн-Ля Рош Аг Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5
DK2900659T3 (en) * 2012-09-27 2016-10-03 Hoffmann La Roche ARYLETHYNYL DERIVATIVES
PE20150733A1 (es) * 2012-10-18 2015-05-17 Hoffmann La Roche Derivados de etinilo como moduladores de la actividad del receptor mglur5
CA2888324A1 (en) * 2012-11-07 2014-05-15 Alexander Flohr Triazolo compounds
KR102035048B1 (ko) 2015-06-03 2019-10-22 에프. 호프만-라 로슈 아게 에틴일 유도체
LT3322701T (lt) 2015-07-15 2019-07-10 F. Hoffmann-La Roche Ag Etinilo dariniai kaip metabotropinių glutamato receptorių moduliatoriai
DK3484889T3 (da) 2016-07-18 2020-10-26 Hoffmann La Roche Ethynylderivater

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1117403E (pt) * 1998-10-02 2004-04-30 Sibia Neurosciences Inc Antagonistas de mglurs para o tratamento da dor e ansiedade
AR029803A1 (es) 2000-02-21 2003-07-16 Smithkline Beecham Plc Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden
GB0027987D0 (en) 2000-11-16 2001-01-03 Smithkline Beecham Plc Compounds
US6910976B2 (en) 2001-06-26 2005-06-28 Stx, Llc Multi-component lacrosse stick head
GB0127433D0 (en) * 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
GB0127430D0 (en) * 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
TWI292318B (en) * 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
GB0413605D0 (en) 2004-06-17 2004-07-21 Addex Pharmaceuticals Sa Novel compounds
EP1809620B1 (en) 2004-11-04 2010-12-29 Addex Pharma SA Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
JP2008542322A (ja) * 2005-06-01 2008-11-27 ユセベ ファルマ ソシエテ アノニム ２−オキソ−１−ピロリジン誘導体
CN102887891B (zh) 2005-11-15 2016-03-09 阿雷生物药品公司 N4-苯基-喹唑啉-4-胺衍生物和相关化合物
MX2008016523A (es) 2006-06-30 2009-01-19 Astrazeneca Ab Derivados de pirimidina utiles en el tratamiento de cancer.
EP1972628A1 (en) 2007-03-21 2008-09-24 Schwarz Pharma Ag Indolizines and aza-analog derivatives thereof as CNS active compounds
MX2009011753A (es) * 2007-04-30 2009-12-01 Abbott Lab Inhibidores de enzima de diacilglicerol o-aciltransferasa tipo 1.
SG185285A1 (en) 2007-06-03 2012-11-29 Univ Vanderbilt Benzamide mglur5 positive allosteric modulators and methods of making and using same
TW201116532A (en) * 2009-08-05 2011-05-16 Merz Pharma Gmbh & Co Kgaa Metabotropic glutamate receptor modulators

Also Published As

Publication number Publication date
US20140073638A1 (en) 2014-03-13
WO2011073172A1 (en) 2011-06-23
ECSP12011977A (es) 2012-07-31
EP2513102A1 (en) 2012-10-24
PE20121443A1 (es) 2012-10-26
BR112012014770A2 (pt) 2016-03-29
AR079467A1 (es) 2012-01-25
RU2012128551A (ru) 2014-01-27
JP2013514305A (ja) 2013-04-25
TW201144314A (en) 2011-12-16
KR101407856B1 (ko) 2014-06-16
CR20120269A (es) 2012-07-04
MA33802B1 (fr) 2012-12-03
US8933094B2 (en) 2015-01-13
AU2010332987A1 (en) 2012-06-07
CL2012001596A1 (es) 2013-01-04
ES2551582T3 (es) 2015-11-20
CO6531478A2 (es) 2012-09-28
US20110152257A1 (en) 2011-06-23
CN102686589A (zh) 2012-09-19
MY162998A (en) 2017-07-31
CN102686589B (zh) 2014-12-10
EP2513102B1 (en) 2015-08-19
SG181779A1 (en) 2012-07-30
MX2012006789A (es) 2012-07-10
ZA201204429B (en) 2013-02-27
RU2553461C2 (ru) 2015-06-20
IL219371A (en) 2015-02-26
UA107002C2 (uk) 2014-11-10
US8586581B2 (en) 2013-11-19
IL219371A0 (en) 2012-06-28
KR20120095472A (ko) 2012-08-28
AU2010332987B2 (en) 2015-08-13
HK1171225A1 (en) 2013-03-22
NZ599553A (en) 2014-05-30
JP5763094B2 (ja) 2015-08-12
TWI448465B (zh) 2014-08-11

Similar Documents

Publication Publication Date Title
AU2010332987B2 (en) Ethynyl derivatives
AU2012266941B2 (en) Substituted pyridopyrazines as novel Syk inhibitors
EP2699547B1 (en) 5-(phenyl/pyridinyl-ethinyl)-2-pyridine/2-pyrimidine-carborxamides as mglur5 modulators
EP2909180B1 (en) Ethynyl derivatives as modulators of mglur5 receptor activity
JP6134441B2 (ja) エチニル誘導体
CA2829171C (en) Pyrazolidin-3-one derivatives
EP2909179B1 (en) Ethynyl derivatives as modulators of mglur5 receptor activity
DK2763969T3 (en) ETHYNYLDER DERIVATIVES AS METABOTROPLE GLUTAMATRECEPTOR MODULATORS
AU2012247654B2 (en) Pyrazolidin-3-one derivatives
AU2012320509B8 (en) Ethynyl derivatives as metabotropic glutamate receptor modulators
NZ614883B2 (en) Pyrazolidin-3-one derivatives

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20151210

FZDE Discontinued

Effective date: 20190205