CA2774612C - Umbilical cord lining stem cells and methods and material for isolating and culturing same - Google Patents

Umbilical cord lining stem cells and methods and material for isolating and culturing same Download PDF

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Publication number
CA2774612C
CA2774612C CA2774612A CA2774612A CA2774612C CA 2774612 C CA2774612 C CA 2774612C CA 2774612 A CA2774612 A CA 2774612A CA 2774612 A CA2774612 A CA 2774612A CA 2774612 C CA2774612 C CA 2774612C
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CA
Canada
Prior art keywords
ulscs
cells
composition
growth factor
umbilical cord
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Active
Application number
CA2774612A
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English (en)
French (fr)
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CA2774612A1 (en
Inventor
Francisco J. Silva
Rafael Gonzalez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Restem LLC
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Restem LLC
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Publication date
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Priority to CA3049393A priority Critical patent/CA3049393C/en
Publication of CA2774612A1 publication Critical patent/CA2774612A1/en
Application granted granted Critical
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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0605Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0607Non-embryonic pluripotent stem cells, e.g. MASC
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/52Fibronectin; Laminin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pregnancy & Childbirth (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2774612A 2009-09-23 2010-09-23 Umbilical cord lining stem cells and methods and material for isolating and culturing same Active CA2774612C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3049393A CA3049393C (en) 2009-09-23 2010-09-23 Umbilical cord lining stem cells and methods and material for isolating and culturing same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24512309P 2009-09-23 2009-09-23
US61/245,123 2009-09-23
PCT/US2010/050025 WO2011038133A2 (en) 2009-09-23 2010-09-23 Umbilical cord lining stem cells and methods and material for isolating and culturing same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3049393A Division CA3049393C (en) 2009-09-23 2010-09-23 Umbilical cord lining stem cells and methods and material for isolating and culturing same

Publications (2)

Publication Number Publication Date
CA2774612A1 CA2774612A1 (en) 2011-03-31
CA2774612C true CA2774612C (en) 2019-09-03

Family

ID=43796487

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2774612A Active CA2774612C (en) 2009-09-23 2010-09-23 Umbilical cord lining stem cells and methods and material for isolating and culturing same
CA3049393A Active CA3049393C (en) 2009-09-23 2010-09-23 Umbilical cord lining stem cells and methods and material for isolating and culturing same

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3049393A Active CA3049393C (en) 2009-09-23 2010-09-23 Umbilical cord lining stem cells and methods and material for isolating and culturing same

Country Status (9)

Country Link
US (1) US8778679B2 (enExample)
EP (1) EP2483392B1 (enExample)
CN (1) CN102686722B (enExample)
CA (2) CA2774612C (enExample)
CR (1) CR20120132A (enExample)
ES (1) ES2559937T3 (enExample)
IN (1) IN2012DN02532A (enExample)
MX (1) MX337480B (enExample)
WO (1) WO2011038133A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2890126T3 (es) 2011-12-30 2022-01-17 Amit Patel Métodos y composiciones para la obtención clínica de una célula alogénica y usos terapéuticos
US9913466B2 (en) 2014-09-10 2018-03-13 Healthbanks Biotech Co. Ltd. Cryopreservation of umbilical cord tissue strips for cord tissue-derived stem cells
US20210355437A1 (en) * 2015-09-02 2021-11-18 Restem Llc Factor rich product from umbilical cord mesenchymal stem cells
US20170233697A1 (en) * 2015-09-02 2017-08-17 Rafael Gonzalez Composition and Methods of Using Umbilical Cord Lining Stem Cells
US10456423B2 (en) 2016-06-13 2019-10-29 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US10426796B2 (en) 2016-06-13 2019-10-01 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
EP3405204B1 (en) * 2016-08-26 2025-06-25 Restem Llc Composition and methods of using umbilical cord lining stem cells
EP3909593A1 (en) 2020-05-15 2021-11-17 Rigshospitalet Stem cells for treating skin lesions
US20230218572A1 (en) * 2021-12-08 2023-07-13 Versitech Limited Compositions and methods for improved mesenchymal stem cell therapy
WO2023151475A1 (en) * 2022-02-10 2023-08-17 The University Of Hong Kong A method of derivation of mesenchymal stem cells from mammalian pluripotent stem cells
US20230320346A1 (en) * 2022-04-12 2023-10-12 Avenge Bio, Inc. Encapsulated cells and methods of preserving thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2646438B1 (fr) 1989-03-20 2007-11-02 Pasteur Institut Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration
DE69033493D1 (de) 1989-07-25 2004-08-12 Cell Genesys Inc Homologe rekombination für universelle donorzellen und chimerische säugetierzellen
WO1993004169A1 (en) 1991-08-20 1993-03-04 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US20030082152A1 (en) 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
CN1847393A (zh) * 2000-06-09 2006-10-18 维特罗莱夫公司 添加剂,制剂和培养基
CA2530421C (en) * 2003-06-27 2015-04-21 Ethicon, Incorporated Repair and regeneration of ocular tissue using postpartum-derived cells
US20070196918A1 (en) * 2004-07-15 2007-08-23 Sayre Chauncey B Reprogramming of adult human testicular stem cells to pluripotent germ-line stem cells
NZ553695A (en) * 2004-08-16 2009-10-30 Cellres Corp Pte Ltd Isolation of stem/progenitor cells from amniotic membrane of umbilical cord
US20060182724A1 (en) * 2005-02-15 2006-08-17 Riordan Neil H Method for expansion of stem cells
US8287854B2 (en) 2005-10-21 2012-10-16 Cellresearch Corporation Pte Ltd Skin equivalents derived from umbilical cord mesenchymal stem/progenitor cells and umbilical cord epithelial stem/progenitor cells
CN101835479A (zh) * 2007-07-25 2010-09-15 佰欧益有限公司 多系祖细胞分化为软骨细胞

Also Published As

Publication number Publication date
US8778679B2 (en) 2014-07-15
EP2483392A2 (en) 2012-08-08
WO2011038133A2 (en) 2011-03-31
WO2011038133A3 (en) 2011-07-28
CR20120132A (es) 2012-10-30
MX2012003475A (es) 2012-07-20
IN2012DN02532A (enExample) 2015-08-28
CN102686722A (zh) 2012-09-19
CA3049393A1 (en) 2011-03-31
EP2483392A4 (en) 2013-07-31
ES2559937T3 (es) 2016-02-16
CA3049393C (en) 2020-12-29
EP2483392B1 (en) 2015-11-11
US20130065302A1 (en) 2013-03-14
CA2774612A1 (en) 2011-03-31
CN102686722B (zh) 2014-11-05
MX337480B (es) 2016-03-08

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Effective date: 20150804