CA2773592C - Method and composition for treating alzheimer-type dementia - Google Patents
Method and composition for treating alzheimer-type dementia Download PDFInfo
- Publication number
- CA2773592C CA2773592C CA2773592A CA2773592A CA2773592C CA 2773592 C CA2773592 C CA 2773592C CA 2773592 A CA2773592 A CA 2773592A CA 2773592 A CA2773592 A CA 2773592A CA 2773592 C CA2773592 C CA 2773592C
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- Prior art keywords
- type dementia
- achei
- patient
- alzheimer type
- antiemetic agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27238209P | 2009-09-18 | 2009-09-18 | |
| US61/272,382 | 2009-09-18 | ||
| PCT/US2010/002475 WO2011034568A1 (en) | 2009-09-18 | 2010-09-13 | Method and composition for treating alzheimer-type dementia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2773592A1 CA2773592A1 (en) | 2011-03-24 |
| CA2773592C true CA2773592C (en) | 2018-10-23 |
Family
ID=43757155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2773592A Active CA2773592C (en) | 2009-09-18 | 2010-09-13 | Method and composition for treating alzheimer-type dementia |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US8877768B2 (enExample) |
| EP (1) | EP2478099B1 (enExample) |
| JP (2) | JP6050115B2 (enExample) |
| AU (1) | AU2010296044B2 (enExample) |
| CA (1) | CA2773592C (enExample) |
| ES (1) | ES2746480T3 (enExample) |
| IN (1) | IN2012DN02122A (enExample) |
| MX (2) | MX345236B (enExample) |
| WO (1) | WO2011034568A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8969402B2 (en) | 2006-11-15 | 2015-03-03 | Steven A. Rich | Combined acetylcholinesterase inhibitor and quaternary ammonium antimuscarinic therapy to alter progression of cognitive diseases |
| US20110201597A1 (en) | 2008-03-27 | 2011-08-18 | Chase Thomas N | Method and composition for treating alzheimer-type dementia |
| EP4088717A1 (en) | 2008-03-27 | 2022-11-16 | Chase Pharmaceuticals Corporation | Use and composition for treating dementia |
| ES2746480T3 (es) | 2009-09-18 | 2020-03-06 | Chase Pharmaceuticals Corp | Combinación para tratar demencia de tipo Alzheimer |
| KR20200065113A (ko) | 2012-09-05 | 2020-06-08 | 체이스 파마슈티칼스 코포레이션 | 항콜린 신경보호 조성물 및 그 방법 |
| BR112015032161A2 (pt) | 2013-07-02 | 2017-07-25 | Eustralis Pharmaceuticals Ltd Trading As Pressura Neuro | método para prevenir e/ou tratar encefalopatia traumática crônica, composição farmacêutica e uso de antagonista do receptor da substância p |
| CA2845443A1 (en) * | 2014-03-04 | 2015-09-04 | Pharmascience Inc. | Orally disintegrating tablet of nabilone and method of manufacturing |
| AU2014385084B2 (en) * | 2014-03-07 | 2017-08-03 | Mitsubishi Electric Corporation | Air-conditioning apparatus |
| US10149828B2 (en) | 2015-01-09 | 2018-12-11 | Chase Pharmaceuticals Corporation | Oxybutynin transdermal therapeutic system combination |
| US10307409B2 (en) * | 2015-03-06 | 2019-06-04 | Chase Pharmaceuticals Corporation | Muscarinic combinations and their use for combating hypocholinergic disorders of the central nervous system |
| US10596139B2 (en) | 2015-03-06 | 2020-03-24 | Chase Pharmaceuticals Corporation | Oxybutynin transdermal therapeutic system muscarinic agonist combination |
| WO2016204998A1 (en) | 2015-06-15 | 2016-12-22 | Qaam Pharmaceuticals, Llc | Glycopyrronium fatty acid salts and methods of making same |
| US20170143664A1 (en) * | 2015-08-06 | 2017-05-25 | Charles E. Ankner | Cannabinoid formulation for the sedation and/or anaesthetizing of a human or animal |
| WO2017044693A1 (en) | 2015-09-11 | 2017-03-16 | Chase Pharmaceuticals Corporation | Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system |
| WO2018039159A1 (en) * | 2016-08-22 | 2018-03-01 | Chase Pharmaceuticals Corporation | Muscarinic m2-antagonist combination |
| EP3589369A4 (en) | 2017-01-09 | 2020-03-18 | DAS-MG, Inc. | USE AND COMPOSITION FOR TREATING MYASTHENIA GRAVIS AND OTHER MYASTHENIC SYNDROME |
| US20200000756A1 (en) * | 2017-01-24 | 2020-01-02 | Gt Biopharma, Inc. | Neostigmine combination and compositions |
| EP3600291A4 (en) * | 2017-03-27 | 2020-12-23 | Chase Therapeutics Corporation | COMPOSITIONS AND METHODS OF TREATMENT OF SYNUCLEINOPATHIES |
| ES3065670T3 (en) | 2017-04-24 | 2026-05-07 | Alto Neuroscience Inc | Compositions and method for treating depression |
| US11439630B2 (en) * | 2017-06-19 | 2022-09-13 | Kathleen E. Clarence-Smith | Use and composition for protection against organophosphorus poisoning |
| IL271464B2 (en) | 2017-06-30 | 2024-08-01 | Chase Therapeutics Corp | NK-1 antagonist compositions and methods for use in the treatment of depression |
| WO2019023175A1 (en) | 2017-07-25 | 2019-01-31 | Gt Biopharma, Inc. | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE AND NEOSTIGMINE AND AN ANTAGONIST NK-1 FOR THE TREATMENT OF SEVERE MYASTHENIA |
| US20210052544A1 (en) * | 2018-01-29 | 2021-02-25 | Solantech Inc. | Methods of treating and/or preventing bedsores using nabilone |
| WO2019204764A1 (en) * | 2018-04-19 | 2019-10-24 | Washington University | Compositions and methods of use thereof for treatment of proteinopathies |
| US11065265B2 (en) | 2018-05-18 | 2021-07-20 | Spes Pharmaceuticals Inc. | Compositions of fosaprepitant and methods of preparation |
| EP3937749A1 (en) | 2019-03-11 | 2022-01-19 | Integrated Endoscopy, Inc. | Cordless disposable endoscope |
| US11744833B2 (en) | 2019-04-12 | 2023-09-05 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of insomnia |
| US10898493B2 (en) | 2019-04-12 | 2021-01-26 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for psychiatric symptoms of patients with Alzheimer's disease |
| US10639315B1 (en) | 2019-05-21 | 2020-05-05 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treating Alzheimer's disease |
| US10966989B2 (en) | 2019-04-12 | 2021-04-06 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treating mental, behavioral, cognitive disorders |
| US10639314B1 (en) | 2019-04-30 | 2020-05-05 | LA PharmaTech Inc. | Method of treating Alzheimer's disease |
| US11690849B2 (en) | 2019-04-12 | 2023-07-04 | LA PharmaTech Inc. | Method of treating dementia |
| US11389458B2 (en) | 2019-04-12 | 2022-07-19 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treating parkinson's and huntington's disease |
| US11938139B2 (en) | 2019-04-12 | 2024-03-26 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for anxiety, depression and other psychiatric disorders |
| US11318144B2 (en) | 2019-04-12 | 2022-05-03 | LA PharmaTech Inc. | Compositions and methods for treating Alzheimer's disease and Parkinson's disease |
| CN116669715A (zh) * | 2020-11-18 | 2023-08-29 | Fb-Hrs有限责任公司 | 含有多非利特和美西律的组合物及其应用 |
| US12109202B2 (en) | 2021-01-29 | 2024-10-08 | Qaam Pharmaceuticals, Llc | Fixed dose combination of cholinesterase inhibitor and a quaternary ammonium antimuscarinic agent to treat neurodegenerative cognitive disorders |
| WO2022182658A1 (en) * | 2021-02-23 | 2022-09-01 | Hoth Therapeutics, Inc. | Use of aprepitant for treating alzheimer's disease |
| US11351179B1 (en) | 2021-08-05 | 2022-06-07 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of psychiatric disorders |
Family Cites Families (19)
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|---|---|---|---|---|
| GB1204580A (en) | 1968-10-05 | 1970-09-09 | Aspro Nicholas Ltd | Pharmaceutical dosage forms |
| US4663318A (en) | 1986-01-15 | 1987-05-05 | Bonnie Davis | Method of treating Alzheimer's disease |
| GB9423588D0 (en) * | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
| US5576317A (en) * | 1994-12-09 | 1996-11-19 | Pfizer Inc. | NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis |
| EP0976404A3 (en) | 1998-07-30 | 2001-06-27 | Pfizer Products Inc. | A pharmaceutical composition for the prevention and treatment of diseases of cognitive dysfunction in a mammal |
| CN1406126A (zh) * | 1998-10-01 | 2003-03-26 | 诺瓦提斯公司 | 新型缓释口服制剂 |
| US7427280B2 (en) | 2002-09-06 | 2008-09-23 | Medtronic, Inc. | Method, system and device for treating disorders of the pelvic floor by delivering drugs to various nerves or tissues |
| CN1520818A (zh) | 2003-02-09 | 2004-08-18 | ɽ����Ҷ��Ȼҩ���о���������˾ | 治疗老年性痴呆的胆碱酯酶抑制剂药物组合物 |
| GB0322140D0 (en) | 2003-09-22 | 2003-10-22 | Pfizer Ltd | Combinations |
| CA2552558A1 (en) | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
| US7390816B2 (en) | 2005-06-21 | 2008-06-24 | Bridge Pharma, Inc. | Methods for treating urinary incontinence in patients suffering from memory disorders |
| US20070224259A1 (en) | 2005-09-21 | 2007-09-27 | Gupta Anil K | Anti-inflammatory pharmaceutical composition |
| CA2649396A1 (en) | 2006-04-21 | 2007-11-08 | Wyeth | Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof |
| US20070259933A1 (en) * | 2006-05-04 | 2007-11-08 | Xenoport, Inc. | Compositions, dosage forms and methods of treating emesis |
| EP2399577A1 (en) | 2006-09-12 | 2011-12-28 | Adolor Corporation | Use of N-containing spirocompounds for the enhancement of cognitive function |
| US8097633B2 (en) | 2006-11-15 | 2012-01-17 | Rich Steven A | Uses for quaternary ammonium anticholinergic muscarinic receptor antagonists in patients being treated for cognitive impairment or acute delirium |
| EP4088717A1 (en) | 2008-03-27 | 2022-11-16 | Chase Pharmaceuticals Corporation | Use and composition for treating dementia |
| US20110201597A1 (en) | 2008-03-27 | 2011-08-18 | Chase Thomas N | Method and composition for treating alzheimer-type dementia |
| ES2746480T3 (es) | 2009-09-18 | 2020-03-06 | Chase Pharmaceuticals Corp | Combinación para tratar demencia de tipo Alzheimer |
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| EP2478099A1 (en) | 2012-07-25 |
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