CA2772343A1 - Sprayable polymers as adhesion barriers - Google Patents

Sprayable polymers as adhesion barriers Download PDF

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Publication number
CA2772343A1
CA2772343A1 CA2772343A CA2772343A CA2772343A1 CA 2772343 A1 CA2772343 A1 CA 2772343A1 CA 2772343 A CA2772343 A CA 2772343A CA 2772343 A CA2772343 A CA 2772343A CA 2772343 A1 CA2772343 A1 CA 2772343A1
Authority
CA
Canada
Prior art keywords
particles
polymer
formulation
water soluble
film
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2772343A
Other languages
English (en)
French (fr)
Inventor
Donald J. Eaton
Bin Huang
Michael A. Savitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ARA MEDICAL LLC
Original Assignee
ARA MEDICAL LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ARA MEDICAL LLC filed Critical ARA MEDICAL LLC
Publication of CA2772343A1 publication Critical patent/CA2772343A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/765Polymers containing oxygen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061Use of materials characterised by their function or physical properties
    • A61L26/0076Sprayable compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04Homopolymers or copolymers of ethene
    • C08L23/08Copolymers of ethene
    • C08L23/0846Copolymers of ethene with unsaturated hydrocarbons containing atoms other than carbon or hydrogen
    • C08L23/0869Copolymers of ethene with unsaturated hydrocarbons containing atoms other than carbon or hydrogen with unsaturated acids, e.g. [meth]acrylic acid; with unsaturated esters, e.g. [meth]acrylic acid esters
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00Properties
    • C08L2201/06Biodegradable

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2772343A 2009-08-27 2010-08-24 Sprayable polymers as adhesion barriers Abandoned CA2772343A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23766909P 2009-08-27 2009-08-27
US61/237,669 2009-08-27
US12/705,436 2010-02-12
US12/705,436 US9649331B2 (en) 2009-08-27 2010-02-12 Sprayable polymers as adhesion barriers
PCT/US2010/046529 WO2011031457A2 (en) 2009-08-27 2010-08-24 Sprayable polymers as adhesion barriers

Publications (1)

Publication Number Publication Date
CA2772343A1 true CA2772343A1 (en) 2011-03-17

Family

ID=43625293

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2772343A Abandoned CA2772343A1 (en) 2009-08-27 2010-08-24 Sprayable polymers as adhesion barriers

Country Status (5)

Country Link
US (4) US9649331B2 (https=)
EP (1) EP2470223B1 (https=)
JP (1) JP5792724B2 (https=)
CA (1) CA2772343A1 (https=)
WO (1) WO2011031457A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9649331B2 (en) * 2009-08-27 2017-05-16 Ara Medical Llc Sprayable polymers as adhesion barriers
DE102011114986A1 (de) 2011-09-28 2013-03-28 Ethris Gmbh Sprühsystem
CN102433684B (zh) * 2011-11-04 2015-06-10 无锡中科光远生物材料有限公司 一种超细复合纤维膜、其制备方法及其用途
CA2856672A1 (en) * 2011-11-25 2013-05-30 Otsuka Pharmaceutical Factory, Inc. Pharmaceutical composition useful for prevention of adhesion or for hemostasis
DE102013211316A1 (de) 2013-06-17 2014-12-18 Aesculap Ag Hämostyptikum
WO2015089317A1 (en) * 2013-12-11 2015-06-18 Case Western Reserve University Spray on hemostatic system
US9962462B2 (en) * 2015-06-11 2018-05-08 Case Western Reserve University Dry spray on hemostatic system
US10980740B2 (en) * 2017-09-12 2021-04-20 Shilpa Medicare Limited Tranexamic acid spray for knee arthroplasty
US10624729B2 (en) 2017-10-12 2020-04-21 C.R. Bard, Inc. Repair prosthetic curl mitigation
US11013501B2 (en) 2017-12-08 2021-05-25 Davol, Inc. Method of protecting the peritoneum against tearing and other injury before an active surgical intervention at or near the peritoneum
US12263185B2 (en) * 2018-02-05 2025-04-01 Bc3 Technologies, Inc. Hemostatic material and spray

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GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US4895724A (en) * 1985-06-07 1990-01-23 Pfizer Inc. Chitosan compositions for controlled and prolonged release of macromolecules
US5725491A (en) * 1988-10-03 1998-03-10 Atrix Laboratories, Inc. Method of forming a biodegradable film dressing on tissue
DE3916020C2 (de) 1989-05-17 1994-06-01 Burkhard Dr Wichert Retardierende Mikropartikel aus bioabbaubaren Polyestern; Verfahren zu deren Herstellung unter Verzicht auf toxische Lösungsmittel und diese Mikropartikel enthaltende pharmazentische Zubereitungen
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
AU673160B2 (en) * 1992-02-28 1996-10-31 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US6696499B1 (en) * 1996-07-11 2004-02-24 Life Medical Sciences, Inc. Methods and compositions for reducing or eliminating post-surgical adhesion formation
US5711958A (en) * 1996-07-11 1998-01-27 Life Medical Sciences, Inc. Methods for reducing or eliminating post-surgical adhesion formation
US5836970A (en) * 1996-08-02 1998-11-17 The Kendall Company Hemostatic wound dressing
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
US5906997A (en) 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
GB9800957D0 (en) 1998-01-17 1998-03-11 Process Intelligence Limited Test probe interface unit and method for manufacturing the same
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
JP4159254B2 (ja) * 1998-08-14 2008-10-01 インセプト エルエルシー ヒドロゲルのインサイチュ形成のための方法および装置
US6153212A (en) 1998-10-02 2000-11-28 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same
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US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
ATE425776T1 (de) 2000-04-28 2009-04-15 Fziomed Inc Haemostatische zusammenstellung von polysauren und polyalkylenoxyden und deren verwendungsmethoden
US20040018238A1 (en) 2001-02-26 2004-01-29 Shukla Atul J Biodegradable vehicles and delivery systems of biolgically active substances
KR100523953B1 (ko) 2002-08-27 2005-10-25 주식회사 엘지생명과학 천연다당류와 히알루론산의 마이크로비드 및 이의 제조 방법
US20050048115A1 (en) 2003-08-27 2005-03-03 Murty Mangena Buprenorphine microspheres
WO2005023906A1 (ja) 2003-09-08 2005-03-17 Chugai Seiyaku Kabushiki Kaisha ヒアルロン酸修飾物、及びそれを用いた薬物担体
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US8071597B2 (en) * 2005-08-26 2011-12-06 Merck Serono Sa Pyrazine compounds and uses as PI3K inhibitors
KR100785378B1 (ko) 2005-09-05 2007-12-14 주식회사 바이오레인 다층구조의 유착방지제
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Also Published As

Publication number Publication date
US20190060219A9 (en) 2019-02-28
EP2470223A2 (en) 2012-07-04
US20220054403A1 (en) 2022-02-24
WO2011031457A3 (en) 2011-07-21
EP2470223B1 (en) 2017-01-04
US20170304191A1 (en) 2017-10-26
JP2013502993A (ja) 2013-01-31
JP5792724B2 (ja) 2015-10-14
WO2011031457A2 (en) 2011-03-17
US20190070102A1 (en) 2019-03-07
EP2470223A4 (en) 2013-04-03
US10543168B2 (en) 2020-01-28
US20110052712A1 (en) 2011-03-03
US9649331B2 (en) 2017-05-16

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20150825