CA2769251C - 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives - Google Patents

5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives Download PDF

Info

Publication number
CA2769251C
CA2769251C CA2769251A CA2769251A CA2769251C CA 2769251 C CA2769251 C CA 2769251C CA 2769251 A CA2769251 A CA 2769251A CA 2769251 A CA2769251 A CA 2769251A CA 2769251 C CA2769251 C CA 2769251C
Authority
CA
Canada
Prior art keywords
optionally substituted
compound
ring system
benzyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2769251A
Other languages
English (en)
French (fr)
Other versions
CA2769251A1 (en
Inventor
Timothy A. Boebel
Kristy Bryan
Beth Lorsbach
Timothy P. Martin
W. John Owen
Mark A. Pobanz
Scott Thornburgh
Jeffery D. Webster
Chenglin Yao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adama Makhteshim Ltd
Original Assignee
Adama Makhteshim Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43535293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2769251(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Adama Makhteshim Ltd filed Critical Adama Makhteshim Ltd
Publication of CA2769251A1 publication Critical patent/CA2769251A1/en
Application granted granted Critical
Publication of CA2769251C publication Critical patent/CA2769251C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/541,3-Diazines; Hydrogenated 1,3-diazines
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/16Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2769251A 2009-08-07 2010-08-05 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives Expired - Fee Related CA2769251C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23223209P 2009-08-07 2009-08-07
US61/232,232 2009-08-07
PCT/US2010/044585 WO2011017544A1 (en) 2009-08-07 2010-08-05 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives

Publications (2)

Publication Number Publication Date
CA2769251A1 CA2769251A1 (en) 2011-02-10
CA2769251C true CA2769251C (en) 2018-05-15

Family

ID=43535293

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2769251A Expired - Fee Related CA2769251C (en) 2009-08-07 2010-08-05 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives

Country Status (28)

Country Link
US (1) US8318758B2 (instruction)
EP (1) EP2462133B1 (instruction)
JP (1) JP5818791B2 (instruction)
KR (1) KR101792286B1 (instruction)
CN (1) CN102548979B (instruction)
AU (1) AU2010279408B2 (instruction)
BR (1) BR112012002807B1 (instruction)
CA (1) CA2769251C (instruction)
CL (1) CL2012000314A1 (instruction)
CO (1) CO6491089A2 (instruction)
CR (1) CR20120033A (instruction)
DK (1) DK2462133T3 (instruction)
EA (1) EA022930B1 (instruction)
EC (1) ECSP12011651A (instruction)
ES (1) ES2506169T3 (instruction)
HN (1) HN2012000261A (instruction)
IL (1) IL217954A (instruction)
IN (1) IN2012DN00695A (instruction)
MX (1) MX2012001623A (instruction)
NI (1) NI201200019A (instruction)
NZ (1) NZ597638A (instruction)
PE (1) PE20120689A1 (instruction)
PL (1) PL2462133T3 (instruction)
PT (1) PT2462133E (instruction)
RS (1) RS53658B1 (instruction)
UA (1) UA106086C2 (instruction)
WO (1) WO2011017544A1 (instruction)
ZA (1) ZA201305992B (instruction)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2012DN00692A (instruction) * 2009-08-07 2015-06-19 Dow Agroscience Llc
HUE047711T2 (hu) * 2012-12-28 2020-05-28 Adama Makhteshim Ltd N-(szubsztituált)-5-fluor-4-imino-3-metil-2-oxo-3,4-dihidropirimidin-1(2H)-karboxilát származékok
EP2945635A4 (en) 2012-12-28 2016-05-25 Dow Agrosciences Llc 1- (BENZOYL-SUBSTITUTED) -5-FLUORO-4-IMINO-3-METHYL-3,4-DIHYDROPYRIMIDIN-2 (1H) -ONE DERIVATIVES
KR20150100869A (ko) 2012-12-28 2015-09-02 다우 아그로사이언시즈 엘엘씨 N-(치환된)-5-플루오로-4-이미노-3-메틸-2-옥소-3,4-디히드로피리미딘-1(2h)-카르복스아미드 유도체
AU2013370494B2 (en) 2012-12-31 2017-08-17 Adama Makhteshim Ltd. 3-alkyl-5-fluoro-4-substituted-imino-3,4-dihydropyrimidin-2(1H)-one derivatives as fungicides
AU2014373850A1 (en) 2013-12-31 2016-08-11 Adama Makhteshim Ltd. Synergistic fungicidal mixtures and compositions for fungal control
MX375727B (es) 2013-12-31 2025-03-06 Adama Makhteshim Ltd 5-fluor-4-imino-3-(alquil/alquilo sustituido)-1-(arilsulfonil)-3,4-dihidropirimidin-2(1h)-ona y los procesos para su preparacion.
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
AU2016348639B2 (en) 2015-11-06 2022-09-08 Samumed, Llc Treatment of osteoarthritis
SG10201912248RA (en) 2016-06-01 2020-02-27 Samumed Llc Process for preparing n-(5-(3-(7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide
IL309708A (en) 2017-07-17 2024-02-01 Adama Makhteshim Ltd Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-4,3-dihydropyrimidin-2-one
US12414559B2 (en) 2018-11-05 2025-09-16 Adama Makhteshim Ltd. Mixtures and compositions comprising 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2-one, and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3368938A (en) * 1966-01-13 1968-02-13 Hoffmann La Roche Controlling fungi with 5-fluorocytosine
KR100482919B1 (ko) * 1996-03-11 2005-10-12 신젠타 파티서페이션즈 아게 살충제로서의피리미딘-4-온유도체
AU2003274652A1 (en) * 2002-10-23 2004-05-13 Obetherapy Biotechnology Compounds, compositions and methods for modulating fat metabolism
KR101456316B1 (ko) * 2007-04-27 2014-11-03 다이이찌 산쿄 가부시키가이샤 함질소 방향족 6 원자 고리 유도체 그리고 그것들을 포함하는 의약
CN102215691B (zh) 2008-08-01 2015-02-04 陶氏益农公司 5-氟胞嘧啶作为杀真菌剂的用途

Also Published As

Publication number Publication date
CR20120033A (es) 2012-03-22
PE20120689A1 (es) 2012-06-06
BR112012002807B1 (pt) 2018-07-10
MX2012001623A (es) 2012-04-11
AU2010279408A1 (en) 2012-02-09
JP2013501726A (ja) 2013-01-17
DK2462133T3 (en) 2015-01-05
ECSP12011651A (es) 2012-03-30
US20110034491A1 (en) 2011-02-10
EP2462133A4 (en) 2013-01-16
IN2012DN00695A (instruction) 2015-06-19
CL2012000314A1 (es) 2012-10-05
AU2010279408B2 (en) 2015-09-10
KR20120043069A (ko) 2012-05-03
BR112012002807A8 (pt) 2017-07-11
CN102548979A (zh) 2012-07-04
CN102548979B (zh) 2015-05-13
NZ597638A (en) 2014-06-27
RS53658B1 (en) 2015-04-30
CA2769251A1 (en) 2011-02-10
ES2506169T3 (es) 2014-10-13
WO2011017544A1 (en) 2011-02-10
PT2462133E (pt) 2014-12-26
BR112012002807A2 (pt) 2015-10-13
UA106086C2 (uk) 2014-07-25
HK1172892A1 (en) 2013-05-03
KR101792286B1 (ko) 2017-10-31
EP2462133A1 (en) 2012-06-13
NI201200019A (es) 2012-05-22
CO6491089A2 (es) 2012-07-31
PL2462133T3 (pl) 2015-03-31
IL217954A0 (en) 2012-03-29
EP2462133B1 (en) 2014-09-24
EA022930B1 (ru) 2016-03-31
US8318758B2 (en) 2012-11-27
ZA201305992B (en) 2014-10-29
IL217954A (en) 2016-02-29
HN2012000261A (es) 2015-01-05
JP5818791B2 (ja) 2015-11-18
EA201270255A1 (ru) 2012-07-30

Similar Documents

Publication Publication Date Title
US9862686B2 (en) N1-sulfonyl-5-fluoropyrimidinone derivatives
CA2769251C (en) 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives
EP2519512B1 (en) N1-acyl- 5-fluoropyrimidinone derivatives
CA2769656C (en) N1-substituted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives
EP2462132A1 (en) 5-fluoropyrimidinone derivatives
US8912207B2 (en) 2-aldoximino-5-fluoropyrimidine derivatives
AU2010279409B2 (en) N1-substituted-5-fluoro-2-oxopyrimidinone-1(2H)-carboxamide derivatives

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150731

MKLA Lapsed

Effective date: 20190806