CA2768169C - Aminopyridine derivatives for the treatment of tumors and inflammatory diseases - Google Patents

Aminopyridine derivatives for the treatment of tumors and inflammatory diseases Download PDF

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Publication number
CA2768169C
CA2768169C CA2768169A CA2768169A CA2768169C CA 2768169 C CA2768169 C CA 2768169C CA 2768169 A CA2768169 A CA 2768169A CA 2768169 A CA2768169 A CA 2768169A CA 2768169 C CA2768169 C CA 2768169C
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Canada
Prior art keywords
pyrazol
benzimidazol
hplc
diseases
pyridin
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Expired - Fee Related
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CA2768169A
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English (en)
French (fr)
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CA2768169A1 (en
Inventor
Michel Calderini
Margarita Wucherer-Plietker
Ulrich Graedler
Christina Esdar
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • AIDS & HIV (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
CA2768169A 2009-07-15 2010-06-17 Aminopyridine derivatives for the treatment of tumors and inflammatory diseases Expired - Fee Related CA2768169C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102009033208.1 2009-07-15
DE102009033208A DE102009033208A1 (de) 2009-07-15 2009-07-15 Aminopyridinderivate
PCT/EP2010/003659 WO2011006567A1 (de) 2009-07-15 2010-06-17 Aminopyridinderivate zur behandlung von tumoren und entzündungskrankheiten

Publications (2)

Publication Number Publication Date
CA2768169A1 CA2768169A1 (en) 2011-01-20
CA2768169C true CA2768169C (en) 2017-06-13

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2768169A Expired - Fee Related CA2768169C (en) 2009-07-15 2010-06-17 Aminopyridine derivatives for the treatment of tumors and inflammatory diseases

Country Status (11)

Country Link
US (1) US8648201B2 (OSRAM)
EP (1) EP2454253B1 (OSRAM)
JP (1) JP5681182B2 (OSRAM)
CN (1) CN102471317B (OSRAM)
AR (1) AR077567A1 (OSRAM)
AU (1) AU2010272920B2 (OSRAM)
CA (1) CA2768169C (OSRAM)
DE (1) DE102009033208A1 (OSRAM)
ES (1) ES2534095T3 (OSRAM)
IL (1) IL217467A (OSRAM)
WO (1) WO2011006567A1 (OSRAM)

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JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
TWI842978B (zh) 2018-07-13 2024-05-21 美商基利科學股份有限公司 衍生物
CN112457308B (zh) * 2019-09-09 2024-01-02 上海长森药业有限公司 新型三环芳香杂环化合物，及其制备方法、药物组合物和应用
AU2021358123A1 (en) 2020-10-05 2023-06-08 Enliven Inc. 5- and 6-azaindole compounds for inhibition of bcr-abl tyrosine kinases
US20250179040A1 (en) * 2022-03-02 2025-06-05 Hangzhou Bio-Sincerity Pharma-Tech Co., Ltd. Histamine h3 receptor antagonists and their pharmaceutical uses

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AU2010272920A1 (en) 2012-03-08
US20120115861A1 (en) 2012-05-10
EP2454253A1 (de) 2012-05-23
IL217467A (en) 2015-09-24
WO2011006567A1 (de) 2011-01-20
EP2454253B1 (de) 2015-01-21
DE102009033208A1 (de) 2011-01-20
AU2010272920B2 (en) 2016-05-05
JP2012532899A (ja) 2012-12-20
CN102471317A (zh) 2012-05-23
US8648201B2 (en) 2014-02-11
AR077567A1 (es) 2011-09-07
CN102471317B (zh) 2014-02-26
CA2768169A1 (en) 2011-01-20

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