CA2766627C - Variants fc optimises et leurs procedes de generation - Google Patents

Variants fc optimises et leurs procedes de generation Download PDF

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Publication number
CA2766627C
CA2766627C CA2766627A CA2766627A CA2766627C CA 2766627 C CA2766627 C CA 2766627C CA 2766627 A CA2766627 A CA 2766627A CA 2766627 A CA2766627 A CA 2766627A CA 2766627 C CA2766627 C CA 2766627C
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CA
Canada
Prior art keywords
antibody
variants
protein
polypeptide
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CA2766627A
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English (en)
Other versions
CA2766627A1 (fr
Inventor
Gregory Alan Lazar
Arthur J. Chirino
Wei Dang
John Rudolph Desjarlais
Stephen Kohl Doberstein
Robert J. Hayes
Sher Bahadur Karki
Omid Vafa
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Xencor Inc
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Xencor Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38312218&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2766627(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US10/672,280 external-priority patent/US20040132101A1/en
Application filed by Xencor Inc filed Critical Xencor Inc
Priority to CA2916863A priority Critical patent/CA2916863C/fr
Publication of CA2766627A1 publication Critical patent/CA2766627A1/fr
Application granted granted Critical
Publication of CA2766627C publication Critical patent/CA2766627C/fr
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne les variantes Fc optimisés, leurs méthodes de production et les anticorps et fusions Fc comprenant des variantes Fc optimisées.
CA2766627A 2003-05-02 2004-03-26 Variants fc optimises et leurs procedes de generation Expired - Lifetime CA2766627C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2916863A CA2916863C (fr) 2003-05-02 2004-03-26 Variants fc optimises et leurs procedes de generation

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US46760603P 2003-05-02 2003-05-02
US60/467,606 2003-05-02
US47783903P 2003-06-12 2003-06-12
US60/477,839 2003-06-12
US10/672,280 2003-09-26
US10/672,280 US20040132101A1 (en) 2002-09-27 2003-09-26 Optimized Fc variants and methods for their generation
CA2524399A CA2524399C (fr) 2003-05-02 2004-03-26 Variants fc optimises et leurs procedes de generation

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2524399A Division CA2524399C (fr) 2003-05-02 2004-03-26 Variants fc optimises et leurs procedes de generation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2916863A Division CA2916863C (fr) 2003-05-02 2004-03-26 Variants fc optimises et leurs procedes de generation

Publications (2)

Publication Number Publication Date
CA2766627A1 CA2766627A1 (fr) 2004-11-18
CA2766627C true CA2766627C (fr) 2019-12-03

Family

ID=38312218

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2766627A Expired - Lifetime CA2766627C (fr) 2003-05-02 2004-03-26 Variants fc optimises et leurs procedes de generation

Country Status (5)

Country Link
JP (1) JP5226613B2 (fr)
KR (1) KR100973564B1 (fr)
CA (1) CA2766627C (fr)
IL (1) IL213648A (fr)
RU (1) RU2337107C2 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
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WO2006106905A1 (fr) 2005-03-31 2006-10-12 Chugai Seiyaku Kabushiki Kaisha Procede pour la production de polypeptide au moyen de la regulation d’un ensemble
EP2576616A4 (fr) 2010-05-27 2014-05-21 Merck Sharp & Dohme Méthode de synthèse d'anticorps présentant des propriétés améliorées
AU2011337704B2 (en) 2010-11-30 2017-06-15 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
KR20200103845A (ko) 2011-02-25 2020-09-02 추가이 세이야쿠 가부시키가이샤 ＦｃγＲＩＩｂ 특이적 Ｆｃ 항체
TWI687441B (zh) 2011-06-30 2020-03-11 中外製藥股份有限公司 異源二聚化多胜肽
TW201817744A (zh) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子
EP3939996A1 (fr) 2011-09-30 2022-01-19 Chugai Seiyaku Kabushiki Kaisha Molécule se liant à l'antigène favorisant la disparition des antigènes ayant une pluralité d'activités biologiques
CN104080909A (zh) 2011-11-30 2014-10-01 中外制药株式会社 包含进入细胞内以形成免疫复合体的搬运体(载体)的药物
NZ702241A (en) * 2012-08-07 2018-04-27 Roche Glycart Ag Composition comprising two antibodies engineered to have reduced and increased effector function
KR102273985B1 (ko) * 2012-08-24 2021-07-06 추가이 세이야쿠 가부시키가이샤 ＦｃγＲＩＩｂ 특이적 Ｆｃ영역 개변체
JP6433297B2 (ja) 2012-12-27 2018-12-05 中外製薬株式会社 ヘテロ二量化ポリペプチド
BR112015023084A2 (pt) * 2013-03-15 2017-11-21 Abbvie Biotechnology Ltd anticorpo anti-cd25 monoclonal ou um fragmento ligante anti-cd25 de um anticorpo monoclonal, conjugado de anticorpo-droga, composição farmacêutica, ácido nucleico, vetor, célula hospedeira procariota e eucariota, método para a produção de um anticorpo anti-cd25 ou fragmento ligante anti-cd25, e, uso de um anticorpo anti-cd25 monoclonal de um conjugado anticorpo-droga ou de uma composição farmacêutica
EP4039281A1 (fr) * 2013-03-15 2022-08-10 Biomolecular Holdings LLC Immunoglobuline hybride contenant une liaison non peptidyle
KR102426481B1 (ko) 2013-03-15 2022-07-27 제넨테크, 인크. IL-22 폴리펩티드 및 IL-22 Fc 융합 단백질 및 사용 방법
KR102318483B1 (ko) 2013-04-02 2021-10-27 추가이 세이야쿠 가부시키가이샤 Ｆｃ영역 개변체
MY184628A (en) * 2013-08-01 2021-04-10 Five Prime Therapeutics Inc Afucosylated anti-fgfr2iiib antibodies
SG11201607434WA (en) * 2014-04-07 2016-10-28 Chugai Pharmaceutical Co Ltd Immunoactivating antigen-binding molecule
WO2015174439A1 (fr) 2014-05-13 2015-11-19 中外製薬株式会社 Molécule de liaison à un antigène redirigé vers un lymphocyte t pour cellules présentant une fonction d'immunosuppression
BR112016025393A2 (pt) * 2014-06-12 2017-12-12 Hoffmann La Roche método para selecionar um anticorpo inteiro, pluralidade de anticorpos, uso de uma ou mais mutações de aminoácidos e anticorpo inteiro variante
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
CA2963760A1 (fr) 2014-12-19 2016-06-23 Yoshinao Ruike Anticorps anti-myostatine, polypeptides contenant des variants de regions fc, et procedes d'utilisation
SG10201907215QA (en) 2015-02-05 2019-09-27 Chugai Pharmaceutical Co Ltd Antibodies Comprising An Ion Concentration Dependent Antigen-Binding Domain, Fc Region Variants, Il-8-Binding Antibodies, And Uses Therof
EP3378487B1 (fr) 2015-11-18 2022-03-16 Chugai Seiyaku Kabushiki Kaisha Polythérapie utilisant une molécule de liaison à l'antigène à rôle de redirection des cellules t, ciblant des cellules immunosupressives
JP6925278B2 (ja) 2015-11-18 2021-08-25 中外製薬株式会社 液性免疫応答の増強方法
WO2017110981A1 (fr) 2015-12-25 2017-06-29 Chugai Seiyaku Kabushiki Kaisha Anticorps anti-myostatine et procédés d'utilisation
CA3026050A1 (fr) 2016-08-05 2018-02-08 Chugai Seiyaku Kabushiki Kaisha Composition pour la prophylaxie ou le traitement de maladies liees a il-8
CN106872713A (zh) * 2016-12-27 2017-06-20 许洋 一种微量蛋白质原位检测的免疫质谱试剂盒及制备方法
JP2021502967A (ja) 2017-11-14 2021-02-04 中外製薬株式会社 抗Ｃ１ｓ抗体および使用方法
KR20200099807A (ko) * 2019-02-15 2020-08-25 아주대학교산학협력단 항체의 불변부위로만 구성된 항체 단편 및 이의 용도
CN112397159B (zh) * 2019-08-19 2024-03-22 金色熊猫有限公司 临床试验报告自动录入方法及装置、电子设备、存储介质
KR20240054902A (ko) * 2022-10-18 2024-04-26 고려대학교 산학협력단 인간 항체 Fc 도메인 변이체 및 그 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1141024B1 (fr) * 1999-01-15 2018-08-08 Genentech, Inc. POLYPEPTIDE COMPRENANT UNE VARIANTE DE LA REGION Fc DE L'IgG1 HUMAIN
EP3502133A1 (fr) * 2002-09-27 2019-06-26 Xencor, Inc. Variantes fc optimisées et leurs procédés de génération

Also Published As

Publication number Publication date
KR20090059170A (ko) 2009-06-10
IL213648A0 (en) 2011-07-31
JP2009209150A (ja) 2009-09-17
JP5226613B2 (ja) 2013-07-03
KR100973564B1 (ko) 2010-08-03
CA2766627A1 (fr) 2004-11-18
RU2337107C2 (ru) 2008-10-27
IL213648A (en) 2017-01-31
RU2005137578A (ru) 2007-06-10

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