CA2757744C - Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer - Google Patents
Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer Download PDFInfo
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- CA2757744C CA2757744C CA2757744A CA2757744A CA2757744C CA 2757744 C CA2757744 C CA 2757744C CA 2757744 A CA2757744 A CA 2757744A CA 2757744 A CA2757744 A CA 2757744A CA 2757744 C CA2757744 C CA 2757744C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16711909P | 2009-04-06 | 2009-04-06 | |
| US61/167,119 | 2009-04-06 | ||
| PCT/US2010/030078 WO2010118010A1 (en) | 2009-04-06 | 2010-04-06 | Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2757744A1 CA2757744A1 (en) | 2010-10-14 |
| CA2757744C true CA2757744C (en) | 2018-02-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2757744A Active CA2757744C (en) | 2009-04-06 | 2010-04-06 | Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8329666B2 (OSRAM) |
| EP (1) | EP2416780B1 (OSRAM) |
| JP (1) | JP5730854B2 (OSRAM) |
| AR (1) | AR076263A1 (OSRAM) |
| AU (1) | AU2010234641B2 (OSRAM) |
| CA (1) | CA2757744C (OSRAM) |
| ES (1) | ES2628580T3 (OSRAM) |
| JO (1) | JO3262B1 (OSRAM) |
| TW (1) | TWI503121B (OSRAM) |
| UY (1) | UY32546A (OSRAM) |
| WO (1) | WO2010118010A1 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2870937B2 (ja) | 1990-02-26 | 1999-03-17 | 凸版印刷株式会社 | 金属蒸着フィルムの製造方法 |
| JO2778B1 (en) | 2007-10-16 | 2014-03-15 | ايساي انك | Certain Compounds, Compositions and Methods |
| ES2593088T3 (es) * | 2009-04-06 | 2016-12-05 | Otsuka Pharmaceutical Co., Ltd. | Derivados de (2'-Desoxi-Ribofuranosil)-1,3,4,7-Tetrahidro-(1,3)Diazepin-2-ona para Tratamiento de Cáncer |
| US8609631B2 (en) | 2009-04-06 | 2013-12-17 | Eisai Inc. | Compositions and methods for treating cancer |
| CA2757745C (en) * | 2009-04-06 | 2018-02-13 | Eisai Inc. | Combination of cytidine-based antineoplastic drugs with cytidine deaminase inhibitor and use thereof in the treatment of cancer |
| DK3960182T3 (da) | 2015-12-03 | 2025-04-07 | Epidestiny Inc | Sammensætninger indeholdende decitabin, 5-azacytidin og tetrahydrouridin samt anvendelser deraf |
| DK3562946T3 (da) | 2016-12-28 | 2022-01-31 | Transgene Sa | Oncolytiske virusser og terapeutiske molekyler |
| US11224610B2 (en) | 2018-09-19 | 2022-01-18 | Otsuka Pharmaceutical Co., Ltd. | Low dose combination CDA substrate drug/cedazuridine with extended administration |
| DK3946322T3 (da) * | 2019-03-29 | 2023-11-27 | Novocure Gmbh | Fremgangsmåder til genoprettelse af sensitivitet over for ttfields i ttfields-resistente kræftceller med ptger3-inhibitorer |
| AU2022370354A1 (en) | 2021-10-19 | 2024-05-30 | Akirabio, Inc. | Compositions comprising 2'-deoxycytidine analogs and use thereof for the treatment of sickle cell disease, thalassemia, and cancers |
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| US4017606A (en) * | 1973-10-04 | 1977-04-12 | The Upjohn Company | Organic compounds and process |
| US4275057A (en) * | 1980-01-28 | 1981-06-23 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Seven-membered ring compounds as inhibitors of cytidine deaminase |
| US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| EP0160079B1 (en) | 1983-10-26 | 1990-01-31 | GREER, Sheldon B. | Method and materials for sensitizing neoplastic tissue to radiation |
| DE3587500T2 (de) * | 1984-12-04 | 1993-12-16 | Lilly Co Eli | Tumorbehandlung bei Säugetieren. |
| US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
| US5223608A (en) * | 1987-08-28 | 1993-06-29 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
| US5968914A (en) * | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
| WO1992018517A1 (en) | 1991-04-17 | 1992-10-29 | Yale University | Method of treating or preventing hepatitis b virus |
| FR2682112B1 (fr) * | 1991-10-08 | 1993-12-10 | Commissariat A Energie Atomique | Procede de synthese d'acide ribonucleique (arn) utilisant un nouveau reactif de deprotection. |
| US5594124A (en) * | 1992-06-22 | 1997-01-14 | Eli Lilly And Company | Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof |
| US5821357A (en) * | 1992-06-22 | 1998-10-13 | Eli Lilly And Company | Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides |
| US5606048A (en) * | 1992-06-22 | 1997-02-25 | Eli Lilly And Company | Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
| US5426183A (en) * | 1992-06-22 | 1995-06-20 | Eli Lilly And Company | Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
| US5371210A (en) * | 1992-06-22 | 1994-12-06 | Eli Lilly And Company | Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
| DE69403588T2 (de) * | 1993-02-23 | 1998-01-22 | Hope City | 4-ethoxy-5-fluor-2'-deoxyuridine |
| AU6081294A (en) | 1993-05-14 | 1994-12-12 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
| GB9311252D0 (en) | 1993-06-01 | 1993-07-21 | Hafslund Nycomed As | Cell growth regualtors |
| US5637688A (en) * | 1994-12-13 | 1997-06-10 | Eli Lilly And Company | Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride |
| US5521294A (en) * | 1995-01-18 | 1996-05-28 | Eli Lilly And Company | 2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides |
| US6001994A (en) * | 1995-12-13 | 1999-12-14 | Eli Lilly And Company | Process for making gemcitabine hydrochloride |
| US5760208A (en) * | 1996-08-14 | 1998-06-02 | The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Process to prepare pyrimidine nucleosides |
| WO2000051639A2 (en) | 1999-03-01 | 2000-09-08 | Halogenetics, Inc. | Treatment of neoplastic diseases by radiation |
| US6933287B1 (en) * | 1999-03-01 | 2005-08-23 | Sheldon B. Greer | Dramatic simplification of a method to treat neoplastic disease by radiation |
| US6462191B1 (en) | 2000-07-13 | 2002-10-08 | Air Products And Chemicals, Inc. | Synthesis of 2-deoxy-2-fluoro-arabinose derivatives |
| CN100368422C (zh) | 2000-11-29 | 2008-02-13 | 三井化学株式会社 | L-核酸衍生物及其合成方法 |
| DE60203260T2 (de) * | 2001-01-16 | 2006-02-02 | Glaxo Group Ltd., Greenford | Pharmazeutische kombination, die ein 4-chinazolinamin und paclitaxel, carboplatin oder vinorelbin enthält, zur behandlung von krebs |
| US7589077B2 (en) | 2001-05-18 | 2009-09-15 | Rakesh Kumar | Antiviral nucleosides |
| US7772197B2 (en) | 2002-09-24 | 2010-08-10 | 1,3,5-Triazines for Treatment of Viral Diseases | 1,3,5-triazines for treatment of viral diseases |
| WO2005115410A2 (en) | 2004-05-06 | 2005-12-08 | University Of Rochester | Context dependent inhibitors of cytidine deaminases and uses thereof |
| EP1812457A1 (en) | 2004-07-30 | 2007-08-01 | Pharmaessentia Corp. | STEREOSELECTIVE SYNTHESIS OF ß-NUCLEOSIDES |
| MX2007006837A (es) | 2004-12-08 | 2007-10-23 | Sicor Inc | Difluoronucleosidos y proceso de preparacion de los mismos. |
| WO2008085611A2 (en) * | 2006-11-27 | 2008-07-17 | University Of Miami | Designer theraphy of pancreatic tumors |
| WO2009021551A1 (en) | 2007-08-13 | 2009-02-19 | Universite De La Mediterranee | A method for assessing the risk of toxicity in a chemotherapy |
| JO2778B1 (en) | 2007-10-16 | 2014-03-15 | ايساي انك | Certain Compounds, Compositions and Methods |
| WO2010047698A1 (en) | 2008-10-22 | 2010-04-29 | University Of Alabama At Birmingham | Activation-induced cytidine deaminase inhibitor suppression of autoimmune diseases |
| CA2757745C (en) * | 2009-04-06 | 2018-02-13 | Eisai Inc. | Combination of cytidine-based antineoplastic drugs with cytidine deaminase inhibitor and use thereof in the treatment of cancer |
| ES2593088T3 (es) * | 2009-04-06 | 2016-12-05 | Otsuka Pharmaceutical Co., Ltd. | Derivados de (2'-Desoxi-Ribofuranosil)-1,3,4,7-Tetrahidro-(1,3)Diazepin-2-ona para Tratamiento de Cáncer |
-
2010
- 2010-04-06 US US12/755,122 patent/US8329666B2/en active Active
- 2010-04-06 JO JOP/2010/0108A patent/JO3262B1/ar active
- 2010-04-06 UY UY0001032546A patent/UY32546A/es active IP Right Grant
- 2010-04-06 AU AU2010234641A patent/AU2010234641B2/en active Active
- 2010-04-06 EP EP10713755.6A patent/EP2416780B1/en active Active
- 2010-04-06 CA CA2757744A patent/CA2757744C/en active Active
- 2010-04-06 JP JP2012504773A patent/JP5730854B2/ja active Active
- 2010-04-06 WO PCT/US2010/030078 patent/WO2010118010A1/en not_active Ceased
- 2010-04-06 AR ARP100101143A patent/AR076263A1/es not_active Application Discontinuation
- 2010-04-06 ES ES10713755.6T patent/ES2628580T3/es active Active
- 2010-04-06 TW TW099110582A patent/TWI503121B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| JO3262B1 (ar) | 2018-09-16 |
| EP2416780B1 (en) | 2017-03-08 |
| UY32546A (es) | 2010-10-29 |
| TWI503121B (zh) | 2015-10-11 |
| CA2757744A1 (en) | 2010-10-14 |
| JP2012522841A (ja) | 2012-09-27 |
| WO2010118010A1 (en) | 2010-10-14 |
| AU2010234641B2 (en) | 2016-04-21 |
| AU2010234641A1 (en) | 2011-11-10 |
| JP5730854B2 (ja) | 2015-06-10 |
| ES2628580T3 (es) | 2017-08-03 |
| EP2416780A1 (en) | 2012-02-15 |
| US8329666B2 (en) | 2012-12-11 |
| TW201102072A (en) | 2011-01-16 |
| US20100279967A1 (en) | 2010-11-04 |
| AR076263A1 (es) | 2011-06-01 |
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