CA2753871A1 - Immunomodulatory therapeutic agents - Google Patents
Immunomodulatory therapeutic agents Download PDFInfo
- Publication number
- CA2753871A1 CA2753871A1 CA2753871A CA2753871A CA2753871A1 CA 2753871 A1 CA2753871 A1 CA 2753871A1 CA 2753871 A CA2753871 A CA 2753871A CA 2753871 A CA2753871 A CA 2753871A CA 2753871 A1 CA2753871 A1 CA 2753871A1
- Authority
- CA
- Canada
- Prior art keywords
- fibrinopeptide
- patient
- peptides
- fibrin
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000002519 immonomodulatory effect Effects 0.000 title abstract description 20
- 239000003814 drug Substances 0.000 title description 43
- 229940124597 therapeutic agent Drugs 0.000 title description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 243
- 101800000974 Fibrinopeptide A Proteins 0.000 claims abstract description 170
- JWICNZAGYSIBAR-LEEGLKINSA-N (4s)-4-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-2-aminopropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-5-[[2-[[(2s)-3-carboxy-1-[[(2s)-1-[[1-[[(2s)-1-[[(2s)-4-carboxy-1-[[2-[[2-[[2-[[(2s)-1-[[(1s)-1-carboxy-4-(diaminomethylideneamino Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)C(CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)N)CC1=CC=CC=C1 JWICNZAGYSIBAR-LEEGLKINSA-N 0.000 claims abstract description 160
- 102400000525 Fibrinopeptide A Human genes 0.000 claims abstract description 155
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims abstract description 149
- 108010073385 Fibrin Proteins 0.000 claims abstract description 147
- 102000009123 Fibrin Human genes 0.000 claims abstract description 147
- 229950003499 fibrin Drugs 0.000 claims abstract description 147
- 230000000694 effects Effects 0.000 claims abstract description 132
- 210000002966 serum Anatomy 0.000 claims abstract description 116
- 230000008021 deposition Effects 0.000 claims abstract description 83
- 239000012634 fragment Substances 0.000 claims abstract description 79
- 101800003778 Fibrinopeptide B Proteins 0.000 claims abstract description 65
- MYRIFIVQGRMHRF-OECXYHNASA-N fibrinopeptide b Chemical compound N([C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(=O)CNC(=O)[C@@H]1CCC(=O)N1 MYRIFIVQGRMHRF-OECXYHNASA-N 0.000 claims abstract description 51
- 102400001063 Fibrinopeptide B Human genes 0.000 claims abstract description 50
- 241000124008 Mammalia Species 0.000 claims abstract description 40
- 238000000034 method Methods 0.000 claims description 109
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 102
- 210000000987 immune system Anatomy 0.000 claims description 75
- 241000282414 Homo sapiens Species 0.000 claims description 72
- 239000003795 chemical substances by application Substances 0.000 claims description 55
- 239000000203 mixture Substances 0.000 claims description 40
- 241000894007 species Species 0.000 claims description 27
- 241000283073 Equus caballus Species 0.000 claims description 23
- 210000004204 blood vessel Anatomy 0.000 claims description 23
- 208000035475 disorder Diseases 0.000 claims description 22
- 208000023275 Autoimmune disease Diseases 0.000 claims description 21
- 241000283690 Bos taurus Species 0.000 claims description 21
- 239000003937 drug carrier Substances 0.000 claims description 20
- 239000008194 pharmaceutical composition Substances 0.000 claims description 16
- 102000000589 Interleukin-1 Human genes 0.000 claims description 15
- 108010002352 Interleukin-1 Proteins 0.000 claims description 15
- 150000001413 amino acids Chemical group 0.000 claims description 15
- 150000002632 lipids Chemical class 0.000 claims description 15
- 210000004324 lymphatic system Anatomy 0.000 claims description 14
- 208000029078 coronary artery disease Diseases 0.000 claims description 13
- 235000015872 dietary supplement Nutrition 0.000 claims description 13
- 238000006467 substitution reaction Methods 0.000 claims description 13
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 239000008157 edible vegetable oil Substances 0.000 claims description 12
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 11
- 239000000194 fatty acid Substances 0.000 claims description 11
- 229930195729 fatty acid Natural products 0.000 claims description 11
- 150000004665 fatty acids Chemical class 0.000 claims description 11
- 230000001926 lymphatic effect Effects 0.000 claims description 11
- 241000282324 Felis Species 0.000 claims description 10
- 239000003921 oil Substances 0.000 claims description 10
- 235000019198 oils Nutrition 0.000 claims description 10
- 241000282465 Canis Species 0.000 claims description 9
- 241001529936 Murinae Species 0.000 claims description 9
- 150000004676 glycans Chemical class 0.000 claims description 9
- 229920001282 polysaccharide Polymers 0.000 claims description 9
- 239000005017 polysaccharide Substances 0.000 claims description 9
- 239000004480 active ingredient Substances 0.000 claims description 8
- 235000019501 Lemon oil Nutrition 0.000 claims description 6
- 239000011230 binding agent Substances 0.000 claims description 6
- 229920002678 cellulose Polymers 0.000 claims description 6
- 239000001913 cellulose Substances 0.000 claims description 6
- 206010012601 diabetes mellitus Diseases 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 6
- 239000008169 grapeseed oil Substances 0.000 claims description 6
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 6
- 238000001990 intravenous administration Methods 0.000 claims description 6
- 239000010501 lemon oil Substances 0.000 claims description 6
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 6
- 231100000252 nontoxic Toxicity 0.000 claims description 6
- 230000003000 nontoxic effect Effects 0.000 claims description 6
- 235000019477 peppermint oil Nutrition 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 4
- 201000004681 Psoriasis Diseases 0.000 claims description 4
- 206010039710 Scleroderma Diseases 0.000 claims description 4
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 4
- 230000004957 immunoregulator effect Effects 0.000 claims description 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 4
- 208000015943 Coeliac disease Diseases 0.000 claims description 3
- 208000011231 Crohn disease Diseases 0.000 claims description 3
- 208000003807 Graves Disease Diseases 0.000 claims description 3
- 208000015023 Graves' disease Diseases 0.000 claims description 3
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims description 3
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims description 3
- 208000035868 Vascular inflammations Diseases 0.000 claims description 3
- 206010003246 arthritis Diseases 0.000 claims description 3
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims description 3
- 102000003814 Interleukin-10 Human genes 0.000 claims description 2
- 108090000174 Interleukin-10 Proteins 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 178
- 230000001684 chronic effect Effects 0.000 abstract description 36
- 208000024891 symptom Diseases 0.000 abstract description 34
- 230000003247 decreasing effect Effects 0.000 abstract description 31
- 230000007423 decrease Effects 0.000 abstract description 30
- 108010049003 Fibrinogen Proteins 0.000 abstract description 26
- 102000008946 Fibrinogen Human genes 0.000 abstract description 26
- 229940012952 fibrinogen Drugs 0.000 abstract description 26
- 239000000126 substance Substances 0.000 abstract description 24
- 239000004475 Arginine Substances 0.000 abstract description 20
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract description 20
- 230000004913 activation Effects 0.000 abstract description 16
- 230000028709 inflammatory response Effects 0.000 abstract description 16
- 108010028780 Complement C3 Proteins 0.000 abstract description 13
- 102000016918 Complement C3 Human genes 0.000 abstract description 13
- 230000002708 enhancing effect Effects 0.000 abstract description 13
- 230000004936 stimulating effect Effects 0.000 abstract description 13
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract description 12
- 230000024203 complement activation Effects 0.000 abstract description 8
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 7
- 230000015572 biosynthetic process Effects 0.000 abstract description 7
- 208000012902 Nervous system disease Diseases 0.000 abstract description 5
- 206010002198 Anaphylactic reaction Diseases 0.000 abstract description 4
- 208000003455 anaphylaxis Diseases 0.000 abstract description 4
- 239000006227 byproduct Substances 0.000 abstract description 4
- 238000004949 mass spectrometry Methods 0.000 abstract description 4
- 230000036783 anaphylactic response Effects 0.000 abstract description 2
- 239000012678 infectious agent Substances 0.000 abstract description 2
- 210000005170 neoplastic cell Anatomy 0.000 abstract description 2
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 208000030961 allergic reaction Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 229960003121 arginine Drugs 0.000 abstract 1
- 235000009697 arginine Nutrition 0.000 abstract 1
- 208000022371 chronic pain syndrome Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 80
- 238000000151 deposition Methods 0.000 description 79
- 210000004027 cell Anatomy 0.000 description 75
- 102000004127 Cytokines Human genes 0.000 description 67
- 108090000695 Cytokines Proteins 0.000 description 67
- 238000011282 treatment Methods 0.000 description 67
- 230000004044 response Effects 0.000 description 63
- 230000008901 benefit Effects 0.000 description 55
- 230000008569 process Effects 0.000 description 54
- 235000018102 proteins Nutrition 0.000 description 48
- 108090000623 proteins and genes Proteins 0.000 description 48
- 102000004169 proteins and genes Human genes 0.000 description 48
- 230000001225 therapeutic effect Effects 0.000 description 48
- 241001465754 Metazoa Species 0.000 description 45
- 208000015181 infectious disease Diseases 0.000 description 39
- 206010028980 Neoplasm Diseases 0.000 description 37
- 230000003110 anti-inflammatory effect Effects 0.000 description 37
- 238000004519 manufacturing process Methods 0.000 description 37
- 230000000638 stimulation Effects 0.000 description 36
- 208000027418 Wounds and injury Diseases 0.000 description 33
- 230000006378 damage Effects 0.000 description 33
- 201000011510 cancer Diseases 0.000 description 31
- 229940079593 drug Drugs 0.000 description 27
- 230000004054 inflammatory process Effects 0.000 description 27
- 206010061218 Inflammation Diseases 0.000 description 26
- 210000004369 blood Anatomy 0.000 description 26
- 239000008280 blood Substances 0.000 description 26
- 241000700605 Viruses Species 0.000 description 25
- 238000012360 testing method Methods 0.000 description 25
- 241000283707 Capra Species 0.000 description 24
- 210000001519 tissue Anatomy 0.000 description 24
- 230000035876 healing Effects 0.000 description 23
- 201000006417 multiple sclerosis Diseases 0.000 description 23
- 230000001965 increasing effect Effects 0.000 description 21
- 208000014674 injury Diseases 0.000 description 21
- 230000007246 mechanism Effects 0.000 description 20
- 238000002360 preparation method Methods 0.000 description 20
- 230000000770 proinflammatory effect Effects 0.000 description 20
- 208000002193 Pain Diseases 0.000 description 19
- 206010052428 Wound Diseases 0.000 description 19
- 208000017667 Chronic Disease Diseases 0.000 description 18
- 208000024827 Alzheimer disease Diseases 0.000 description 17
- 241000699670 Mus sp. Species 0.000 description 17
- 230000002159 abnormal effect Effects 0.000 description 17
- 238000003776 cleavage reaction Methods 0.000 description 17
- 230000006872 improvement Effects 0.000 description 17
- 239000000825 pharmaceutical preparation Substances 0.000 description 17
- 230000007017 scission Effects 0.000 description 17
- 230000001154 acute effect Effects 0.000 description 16
- 230000005012 migration Effects 0.000 description 16
- 238000013508 migration Methods 0.000 description 16
- 238000011160 research Methods 0.000 description 16
- 241000725303 Human immunodeficiency virus Species 0.000 description 15
- 238000002347 injection Methods 0.000 description 15
- 239000007924 injection Substances 0.000 description 15
- 244000052769 pathogen Species 0.000 description 15
- 108090000176 Interleukin-13 Proteins 0.000 description 14
- 102000003816 Interleukin-13 Human genes 0.000 description 14
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 14
- 230000009931 harmful effect Effects 0.000 description 14
- 230000028993 immune response Effects 0.000 description 14
- 210000004698 lymphocyte Anatomy 0.000 description 14
- 235000001014 amino acid Nutrition 0.000 description 13
- 230000010534 mechanism of action Effects 0.000 description 13
- 230000001717 pathogenic effect Effects 0.000 description 13
- 206010053567 Coagulopathies Diseases 0.000 description 12
- 210000003719 b-lymphocyte Anatomy 0.000 description 12
- 230000035602 clotting Effects 0.000 description 12
- 230000006870 function Effects 0.000 description 12
- 230000036039 immunity Effects 0.000 description 12
- 108010001779 Ancrod Proteins 0.000 description 11
- 208000013586 Complex regional pain syndrome type 1 Diseases 0.000 description 11
- 201000001947 Reflex Sympathetic Dystrophy Diseases 0.000 description 11
- 229960004233 ancrod Drugs 0.000 description 11
- 230000008859 change Effects 0.000 description 11
- 230000002757 inflammatory effect Effects 0.000 description 11
- 230000001575 pathological effect Effects 0.000 description 11
- 230000002792 vascular Effects 0.000 description 11
- 238000010521 absorption reaction Methods 0.000 description 10
- 210000005007 innate immune system Anatomy 0.000 description 10
- 108090000790 Enzymes Proteins 0.000 description 9
- 102000004190 Enzymes Human genes 0.000 description 9
- 102000004889 Interleukin-6 Human genes 0.000 description 9
- 108090001005 Interleukin-6 Proteins 0.000 description 9
- 230000009286 beneficial effect Effects 0.000 description 9
- 238000011161 development Methods 0.000 description 9
- 230000018109 developmental process Effects 0.000 description 9
- 230000008030 elimination Effects 0.000 description 9
- 238000003379 elimination reaction Methods 0.000 description 9
- 229940088598 enzyme Drugs 0.000 description 9
- 210000002540 macrophage Anatomy 0.000 description 9
- 210000001616 monocyte Anatomy 0.000 description 9
- 108010091748 peptide A Proteins 0.000 description 9
- 108010002350 Interleukin-2 Proteins 0.000 description 8
- 102000000588 Interleukin-2 Human genes 0.000 description 8
- 108090000190 Thrombin Proteins 0.000 description 8
- 102100040247 Tumor necrosis factor Human genes 0.000 description 8
- 230000000903 blocking effect Effects 0.000 description 8
- 230000017531 blood circulation Effects 0.000 description 8
- 210000004899 c-terminal region Anatomy 0.000 description 8
- 230000001413 cellular effect Effects 0.000 description 8
- 230000022811 deglycosylation Effects 0.000 description 8
- 201000002491 encephalomyelitis Diseases 0.000 description 8
- 230000003993 interaction Effects 0.000 description 8
- 230000004048 modification Effects 0.000 description 8
- 238000012986 modification Methods 0.000 description 8
- 229960004072 thrombin Drugs 0.000 description 8
- 230000003612 virological effect Effects 0.000 description 8
- 208000035473 Communicable disease Diseases 0.000 description 7
- 108090000978 Interleukin-4 Proteins 0.000 description 7
- 102000004388 Interleukin-4 Human genes 0.000 description 7
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 7
- 230000033115 angiogenesis Effects 0.000 description 7
- 238000004128 high performance liquid chromatography Methods 0.000 description 7
- 230000001900 immune effect Effects 0.000 description 7
- 229910052742 iron Inorganic materials 0.000 description 7
- 230000003902 lesion Effects 0.000 description 7
- 230000031990 negative regulation of inflammatory response Effects 0.000 description 7
- 230000002085 persistent effect Effects 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 230000001681 protective effect Effects 0.000 description 7
- 239000000523 sample Substances 0.000 description 7
- 230000008961 swelling Effects 0.000 description 7
- 210000004881 tumor cell Anatomy 0.000 description 7
- 208000035143 Bacterial infection Diseases 0.000 description 6
- 208000000094 Chronic Pain Diseases 0.000 description 6
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 6
- 241000282412 Homo Species 0.000 description 6
- 208000037273 Pathologic Processes Diseases 0.000 description 6
- 210000001744 T-lymphocyte Anatomy 0.000 description 6
- 208000036142 Viral infection Diseases 0.000 description 6
- 230000032683 aging Effects 0.000 description 6
- 150000001412 amines Chemical class 0.000 description 6
- 239000000427 antigen Substances 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 238000013459 approach Methods 0.000 description 6
- 208000022362 bacterial infectious disease Diseases 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 6
- 238000002512 chemotherapy Methods 0.000 description 6
- 230000006735 deficit Effects 0.000 description 6
- 239000007857 degradation product Substances 0.000 description 6
- 230000004069 differentiation Effects 0.000 description 6
- 210000002950 fibroblast Anatomy 0.000 description 6
- 210000002865 immune cell Anatomy 0.000 description 6
- 230000002458 infectious effect Effects 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 238000002483 medication Methods 0.000 description 6
- 230000003472 neutralizing effect Effects 0.000 description 6
- 230000009054 pathological process Effects 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 230000035755 proliferation Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- -1 superoxide anions Chemical class 0.000 description 6
- 230000004083 survival effect Effects 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 6
- 230000003827 upregulation Effects 0.000 description 6
- 230000008728 vascular permeability Effects 0.000 description 6
- 208000030507 AIDS Diseases 0.000 description 5
- 201000001320 Atherosclerosis Diseases 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 5
- 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 description 5
- 206010051125 Hypofibrinogenaemia Diseases 0.000 description 5
- 102100039065 Interleukin-1 beta Human genes 0.000 description 5
- 108010002616 Interleukin-5 Proteins 0.000 description 5
- 108090001007 Interleukin-8 Proteins 0.000 description 5
- 102000015696 Interleukins Human genes 0.000 description 5
- 108010063738 Interleukins Proteins 0.000 description 5
- 210000005006 adaptive immune system Anatomy 0.000 description 5
- 230000004071 biological effect Effects 0.000 description 5
- 230000033228 biological regulation Effects 0.000 description 5
- 230000015556 catabolic process Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000003111 delayed effect Effects 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 230000000521 hyperimmunizing effect Effects 0.000 description 5
- 230000001976 improved effect Effects 0.000 description 5
- 108040006849 interleukin-2 receptor activity proteins Proteins 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 210000000440 neutrophil Anatomy 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 206010039073 rheumatoid arthritis Diseases 0.000 description 5
- 238000003786 synthesis reaction Methods 0.000 description 5
- 230000009885 systemic effect Effects 0.000 description 5
- 230000008733 trauma Effects 0.000 description 5
- 208000019553 vascular disease Diseases 0.000 description 5
- 230000009385 viral infection Effects 0.000 description 5
- 230000029663 wound healing Effects 0.000 description 5
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 4
- 108010082126 Alanine transaminase Proteins 0.000 description 4
- 102000004506 Blood Proteins Human genes 0.000 description 4
- 108010017384 Blood Proteins Proteins 0.000 description 4
- 102400000524 Fibrinogen alpha chain Human genes 0.000 description 4
- 101710137044 Fibrinogen alpha chain Proteins 0.000 description 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 4
- 208000030852 Parasitic disease Diseases 0.000 description 4
- 208000018737 Parkinson disease Diseases 0.000 description 4
- 208000037581 Persistent Infection Diseases 0.000 description 4
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 238000010171 animal model Methods 0.000 description 4
- 230000000840 anti-viral effect Effects 0.000 description 4
- 230000006907 apoptotic process Effects 0.000 description 4
- 230000001363 autoimmune Effects 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 230000008499 blood brain barrier function Effects 0.000 description 4
- 210000001218 blood-brain barrier Anatomy 0.000 description 4
- 238000000502 dialysis Methods 0.000 description 4
- 230000006806 disease prevention Effects 0.000 description 4
- 230000000977 initiatory effect Effects 0.000 description 4
- 230000015788 innate immune response Effects 0.000 description 4
- 229940047122 interleukins Drugs 0.000 description 4
- 239000006166 lysate Substances 0.000 description 4
- 208000002780 macular degeneration Diseases 0.000 description 4
- 210000002569 neuron Anatomy 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 239000000902 placebo Substances 0.000 description 4
- 229940068196 placebo Drugs 0.000 description 4
- 230000010076 replication Effects 0.000 description 4
- 229960000329 ribavirin Drugs 0.000 description 4
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 4
- 238000012163 sequencing technique Methods 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 239000003981 vehicle Substances 0.000 description 4
- 101710131943 40S ribosomal protein S3a Proteins 0.000 description 3
- 208000030090 Acute Disease Diseases 0.000 description 3
- 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 3
- 102000003670 Carboxypeptidase B Human genes 0.000 description 3
- 108090000087 Carboxypeptidase B Proteins 0.000 description 3
- 108010088842 Fibrinolysin Proteins 0.000 description 3
- 101500025440 Homo sapiens Fibrinopeptide A Proteins 0.000 description 3
- 101500026911 Homo sapiens Fibrinopeptide B Proteins 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000008649 adaptation response Effects 0.000 description 3
- 230000004075 alteration Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000002491 angiogenic effect Effects 0.000 description 3
- 230000003466 anti-cipated effect Effects 0.000 description 3
- 230000000118 anti-neoplastic effect Effects 0.000 description 3
- 150000001483 arginine derivatives Chemical class 0.000 description 3
- 230000006470 autoimmune attack Effects 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 230000024245 cell differentiation Effects 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 230000004154 complement system Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 230000001066 destructive effect Effects 0.000 description 3
- 230000005750 disease progression Effects 0.000 description 3
- 239000002158 endotoxin Substances 0.000 description 3
- 210000000416 exudates and transudate Anatomy 0.000 description 3
- 239000002350 fibrinopeptide Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 229960001340 histamine Drugs 0.000 description 3
- 210000003630 histaminocyte Anatomy 0.000 description 3
- 230000013632 homeostatic process Effects 0.000 description 3
- 239000002955 immunomodulating agent Substances 0.000 description 3
- 229940121354 immunomodulator Drugs 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 230000003960 inflammatory cascade Effects 0.000 description 3
- 230000004968 inflammatory condition Effects 0.000 description 3
- 208000037797 influenza A Diseases 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 206010025135 lupus erythematosus Diseases 0.000 description 3
- 230000002132 lysosomal effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000000116 mitigating effect Effects 0.000 description 3
- 210000000822 natural killer cell Anatomy 0.000 description 3
- 230000001613 neoplastic effect Effects 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 210000002682 neurofibrillary tangle Anatomy 0.000 description 3
- 150000007523 nucleic acids Chemical group 0.000 description 3
- 230000007170 pathology Effects 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 229940012957 plasmin Drugs 0.000 description 3
- 230000003389 potentiating effect Effects 0.000 description 3
- 230000000750 progressive effect Effects 0.000 description 3
- 238000011321 prophylaxis Methods 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 238000012552 review Methods 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 229960005486 vaccine Drugs 0.000 description 3
- 201000002282 venous insufficiency Diseases 0.000 description 3
- 208000009043 Chemical Burns Diseases 0.000 description 2
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 208000025962 Crush injury Diseases 0.000 description 2
- 208000016192 Demyelinating disease Diseases 0.000 description 2
- 208000008960 Diabetic foot Diseases 0.000 description 2
- 206010056340 Diabetic ulcer Diseases 0.000 description 2
- 206010061818 Disease progression Diseases 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 206010015866 Extravasation Diseases 0.000 description 2
- 102400001064 Fibrinogen beta chain Human genes 0.000 description 2
- 101710170765 Fibrinogen beta chain Proteins 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 208000031886 HIV Infections Diseases 0.000 description 2
- 101000901154 Homo sapiens Complement C3 Proteins 0.000 description 2
- 241001662043 Icterus Species 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 108010083674 Myelin Proteins Proteins 0.000 description 2
- 102000006386 Myelin Proteins Human genes 0.000 description 2
- 208000008457 Neurologic Manifestations Diseases 0.000 description 2
- 206010060860 Neurological symptom Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 101800005149 Peptide B Proteins 0.000 description 2
- 208000004210 Pressure Ulcer Diseases 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 206010053615 Thermal burn Diseases 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 2
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 2
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 2
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 2
- 108020000999 Viral RNA Proteins 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000009692 acute damage Effects 0.000 description 2
- 230000003044 adaptive effect Effects 0.000 description 2
- 230000033289 adaptive immune response Effects 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- 230000001668 ameliorated effect Effects 0.000 description 2
- 230000002052 anaphylactic effect Effects 0.000 description 2
- 239000012805 animal sample Substances 0.000 description 2
- 229940037642 autologous vaccine Drugs 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000012888 bovine serum Substances 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 239000013592 cell lysate Substances 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 230000009134 cell regulation Effects 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 238000009295 crossflow filtration Methods 0.000 description 2
- 231100000433 cytotoxic Toxicity 0.000 description 2
- 230000001472 cytotoxic effect Effects 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 230000007123 defense Effects 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 230000001627 detrimental effect Effects 0.000 description 2
- 235000021434 dietary agent Nutrition 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 210000002889 endothelial cell Anatomy 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 230000036251 extravasation Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 230000020764 fibrinolysis Effects 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 230000003118 histopathologic effect Effects 0.000 description 2
- 102000057770 human C3 Human genes 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 230000016784 immunoglobulin production Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 210000001613 integumentary system Anatomy 0.000 description 2
- 229940100601 interleukin-6 Drugs 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 230000001483 mobilizing effect Effects 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 208000004296 neuralgia Diseases 0.000 description 2
- 208000015122 neurodegenerative disease Diseases 0.000 description 2
- 230000003959 neuroinflammation Effects 0.000 description 2
- 230000000926 neurological effect Effects 0.000 description 2
- 201000008482 osteoarthritis Diseases 0.000 description 2
- 230000008533 pain sensitivity Effects 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 210000000578 peripheral nerve Anatomy 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 108010005636 polypeptide C Proteins 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 208000023504 respiratory system disease Diseases 0.000 description 2
- 230000008458 response to injury Effects 0.000 description 2
- 230000003938 response to stress Effects 0.000 description 2
- 201000000980 schizophrenia Diseases 0.000 description 2
- 210000004116 schwann cell Anatomy 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 230000008093 supporting effect Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 229960000187 tissue plasminogen activator Drugs 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 210000005167 vascular cell Anatomy 0.000 description 2
- 210000005166 vasculature Anatomy 0.000 description 2
- DSVOSLJAGTUKFB-SPAGYVKCSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]pentanedioic acid Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)CN DSVOSLJAGTUKFB-SPAGYVKCSA-N 0.000 description 1
- 102000011767 Acute-Phase Proteins Human genes 0.000 description 1
- 108010062271 Acute-Phase Proteins Proteins 0.000 description 1
- 208000037259 Amyloid Plaque Diseases 0.000 description 1
- 102000009091 Amyloidogenic Proteins Human genes 0.000 description 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 description 1
- 208000033399 Anaphylactic responses Diseases 0.000 description 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 1
- 101100152731 Arabidopsis thaliana TH2 gene Proteins 0.000 description 1
- 206010062542 Arterial insufficiency Diseases 0.000 description 1
- 206010003267 Arthritis reactive Diseases 0.000 description 1
- 208000027496 Behcet disease Diseases 0.000 description 1
- 208000009137 Behcet syndrome Diseases 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 102000019034 Chemokines Human genes 0.000 description 1
- 108010012236 Chemokines Proteins 0.000 description 1
- 208000030939 Chronic inflammatory demyelinating polyneuropathy Diseases 0.000 description 1
- 102400000636 Complement C3c alpha' chain fragment 2 Human genes 0.000 description 1
- 101800001197 Complement C3c alpha' chain fragment 2 Proteins 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 206010012305 Demyelination Diseases 0.000 description 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 1
- 241000605721 Dichelobacter nodosus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000009025 Endorphins Human genes 0.000 description 1
- 108010049140 Endorphins Proteins 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 101150036151 FIBIN gene Proteins 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 208000003098 Ganglion Cysts Diseases 0.000 description 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
- 206010018364 Glomerulonephritis Diseases 0.000 description 1
- 206010018366 Glomerulonephritis acute Diseases 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 206010018985 Haemorrhage intracranial Diseases 0.000 description 1
- 108010033040 Histones Proteins 0.000 description 1
- 101000739160 Homo sapiens Secretoglobin family 3A member 1 Proteins 0.000 description 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
- 241000713340 Human immunodeficiency virus 2 Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010020974 Hypocomplementaemia Diseases 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 206010022004 Influenza like illness Diseases 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102000010789 Interleukin-2 Receptors Human genes 0.000 description 1
- 108010038453 Interleukin-2 Receptors Proteins 0.000 description 1
- 206010022562 Intermittent claudication Diseases 0.000 description 1
- 208000008574 Intracranial Hemorrhages Diseases 0.000 description 1
- 208000032382 Ischaemic stroke Diseases 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 235000019687 Lamb Nutrition 0.000 description 1
- 241000594011 Leuciscus leuciscus Species 0.000 description 1
- 208000005777 Lupus Nephritis Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 102000019149 MAP kinase activity proteins Human genes 0.000 description 1
- 108040008097 MAP kinase activity proteins Proteins 0.000 description 1
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 1
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 description 1
- 208000003250 Mixed connective tissue disease Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 208000008636 Neoplastic Processes Diseases 0.000 description 1
- 208000028389 Nerve injury Diseases 0.000 description 1
- 208000036110 Neuroinflammatory disease Diseases 0.000 description 1
- 235000010676 Ocimum basilicum Nutrition 0.000 description 1
- 240000007926 Ocimum gratissimum Species 0.000 description 1
- 208000001388 Opportunistic Infections Diseases 0.000 description 1
- 241000283903 Ovis aries Species 0.000 description 1
- 208000007542 Paresis Diseases 0.000 description 1
- 241000606856 Pasteurella multocida Species 0.000 description 1
- 108010033276 Peptide Fragments Proteins 0.000 description 1
- 102000007079 Peptide Fragments Human genes 0.000 description 1
- 206010067633 Peripheral nerve lesion Diseases 0.000 description 1
- 229940122791 Plasmin inhibitor Drugs 0.000 description 1
- 102000013566 Plasminogen Human genes 0.000 description 1
- 108010051456 Plasminogen Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010036141 Polyserositis Diseases 0.000 description 1
- 241000282405 Pongo abelii Species 0.000 description 1
- 101800004937 Protein C Proteins 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- 102400000827 Saposin-D Human genes 0.000 description 1
- 101800001700 Saposin-D Proteins 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 206010048908 Seasonal allergy Diseases 0.000 description 1
- 102100037268 Secretoglobin family 3A member 1 Human genes 0.000 description 1
- 208000021386 Sjogren Syndrome Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000589970 Spirochaetales Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 208000005400 Synovial Cyst Diseases 0.000 description 1
- 241000711517 Torovirus Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000024248 Vascular System injury Diseases 0.000 description 1
- 208000012339 Vascular injury Diseases 0.000 description 1
- 206010047115 Vasculitis Diseases 0.000 description 1
- 206010058874 Viraemia Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 231100000851 acute glomerulonephritis Toxicity 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000010398 acute inflammatory response Effects 0.000 description 1
- 230000008578 acute process Effects 0.000 description 1
- 230000004721 adaptive immunity Effects 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000012870 ammonium sulfate precipitation Methods 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 206010002022 amyloidosis Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001772 anti-angiogenic effect Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 210000002565 arteriole Anatomy 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 208000015294 blood coagulation disease Diseases 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 210000004970 cd4 cell Anatomy 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000031902 chemoattractant activity Effects 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 230000009693 chronic damage Effects 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 description 1
- 230000008576 chronic process Effects 0.000 description 1
- 210000003040 circulating cell Anatomy 0.000 description 1
- 208000024980 claudication Diseases 0.000 description 1
- 230000009852 coagulant defect Effects 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 108010041513 complement C3f Proteins 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000016396 cytokine production Effects 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000779 depleting effect Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 230000003828 downregulation Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000773 effect on pain Effects 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 239000003532 endogenous pyrogen Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 230000003090 exacerbative effect Effects 0.000 description 1
- 208000012997 experimental autoimmune encephalomyelitis Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000573 exposure to toxins Toxicity 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 108010073651 fibrinmonomer Proteins 0.000 description 1
- 229940126864 fibroblast growth factor Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 208000010801 foot rot Diseases 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 108010074605 gamma-Globulins Proteins 0.000 description 1
- 229940044627 gamma-interferon Drugs 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 102000054766 genetic haplotypes Human genes 0.000 description 1
- 230000001434 glomerular Effects 0.000 description 1
- 206010061989 glomerulosclerosis Diseases 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 108010053364 glycyl-prolyl-arginyl-valyl-valyl-glutamic acid Proteins 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000009442 healing mechanism Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000003284 homeostatic effect Effects 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 230000000899 immune system response Effects 0.000 description 1
- 230000006058 immune tolerance Effects 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 239000000367 immunologic factor Substances 0.000 description 1
- 230000002584 immunomodulator Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000030214 innervation Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000035992 intercellular communication Effects 0.000 description 1
- 229940076144 interleukin-10 Drugs 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 108010052620 leukocyte endogenous mediator Proteins 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000008752 local inflammatory process Effects 0.000 description 1
- 230000008376 long-term health Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 208000037819 metastatic cancer Diseases 0.000 description 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 210000002643 mouth floor Anatomy 0.000 description 1
- 208000013465 muscle pain Diseases 0.000 description 1
- 210000002346 musculoskeletal system Anatomy 0.000 description 1
- 210000005012 myelin Anatomy 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- 230000037420 neurological improvement Effects 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 208000012318 pareses Diseases 0.000 description 1
- 229940051027 pasteurella multocida Drugs 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000008529 pathological progression Effects 0.000 description 1
- 230000006320 pegylation Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000010773 plant oil Substances 0.000 description 1
- 239000002806 plasmin inhibitor Substances 0.000 description 1
- 239000002797 plasminogen activator inhibitor Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000009290 primary effect Effects 0.000 description 1
- 230000007112 pro inflammatory response Effects 0.000 description 1
- 230000002947 procoagulating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 229960000856 protein c Drugs 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
- 208000036273 reactive airway disease Diseases 0.000 description 1
- 208000002574 reactive arthritis Diseases 0.000 description 1
- 210000003289 regulatory T cell Anatomy 0.000 description 1
- 230000012423 response to bacterium Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 201000000306 sarcoidosis Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000001044 sensory neuron Anatomy 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 210000002437 synoviocyte Anatomy 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 230000005747 tumor angiogenesis Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
- 230000009723 vascular congestion Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/363—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15852609P | 2009-03-09 | 2009-03-09 | |
| US61/158,526 | 2009-03-09 | ||
| PCT/US2010/026665 WO2010104854A2 (en) | 2009-03-09 | 2010-03-09 | Immunomodulatory therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2753871A1 true CA2753871A1 (en) | 2010-09-16 |
Family
ID=42729052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2753871A Abandoned CA2753871A1 (en) | 2009-03-09 | 2010-03-09 | Immunomodulatory therapeutic agents |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20110318375A1 (https=) |
| EP (1) | EP2405935A2 (https=) |
| JP (1) | JP2012520306A (https=) |
| KR (1) | KR20120008029A (https=) |
| CN (1) | CN102439175A (https=) |
| AU (1) | AU2010222851A1 (https=) |
| BR (1) | BRPI1009569A2 (https=) |
| CA (1) | CA2753871A1 (https=) |
| EC (1) | ECSP11011373A (https=) |
| MX (1) | MX2011009475A (https=) |
| RU (1) | RU2011137856A (https=) |
| SG (1) | SG174290A1 (https=) |
| WO (1) | WO2010104854A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104837358B (zh) | 2012-12-14 | 2019-03-29 | 希尔氏宠物营养品公司 | 用于陪伴动物的抗衰老食物 |
| EP3439683A4 (en) * | 2016-04-04 | 2020-07-29 | Marpe Holdings, LLC | MODULATION OF THE IMMUNE SYSTEM FOR THE PROPHYLAXIS AND TREATMENT OF DISEASES AND DISORDERS |
| JP2018163071A (ja) * | 2017-03-27 | 2018-10-18 | 京都府公立大学法人 | 関節リウマチに関するペプチドマーカー |
| CN110045130B (zh) * | 2019-04-17 | 2022-03-29 | 中山大学附属第一医院 | 一种与IgA肾病相关的多肽的免疫分析检测试剂盒 |
| WO2025017038A2 (en) * | 2023-07-17 | 2025-01-23 | Angus Dalgleish | Serum-derived peptides |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6673561B1 (en) * | 1999-06-30 | 2004-01-06 | Regents Of The University Of California | Diagnostic test for thrombotic or thromboembolic disease |
| WO2003065997A2 (en) * | 2002-02-06 | 2003-08-14 | Vicor Technologies, Inc. | Anti-infarction molecules |
| US20080294261A1 (en) * | 2007-05-24 | 2008-11-27 | Kevin Pauza | Method for treating herniated discs |
-
2010
- 2010-03-09 WO PCT/US2010/026665 patent/WO2010104854A2/en not_active Ceased
- 2010-03-09 AU AU2010222851A patent/AU2010222851A1/en not_active Abandoned
- 2010-03-09 CA CA2753871A patent/CA2753871A1/en not_active Abandoned
- 2010-03-09 KR KR1020117023511A patent/KR20120008029A/ko not_active Ceased
- 2010-03-09 JP JP2011554122A patent/JP2012520306A/ja not_active Withdrawn
- 2010-03-09 BR BRPI1009569A patent/BRPI1009569A2/pt not_active Application Discontinuation
- 2010-03-09 SG SG2011064581A patent/SG174290A1/en unknown
- 2010-03-09 CN CN2010800203608A patent/CN102439175A/zh active Pending
- 2010-03-09 RU RU2011137856/15A patent/RU2011137856A/ru not_active Application Discontinuation
- 2010-03-09 EP EP10751287A patent/EP2405935A2/en not_active Withdrawn
- 2010-03-09 MX MX2011009475A patent/MX2011009475A/es not_active Application Discontinuation
- 2010-03-09 US US13/203,045 patent/US20110318375A1/en not_active Abandoned
-
2011
- 2011-10-04 EC EC2011011373A patent/ECSP11011373A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2011137856A (ru) | 2013-04-20 |
| KR20120008029A (ko) | 2012-01-25 |
| ECSP11011373A (es) | 2011-11-30 |
| SG174290A1 (en) | 2011-10-28 |
| WO2010104854A3 (en) | 2010-11-04 |
| BRPI1009569A2 (https=) | 2016-03-22 |
| AU2010222851A1 (en) | 2011-09-15 |
| US20110318375A1 (en) | 2011-12-29 |
| EP2405935A2 (en) | 2012-01-18 |
| CN102439175A (zh) | 2012-05-02 |
| JP2012520306A (ja) | 2012-09-06 |
| MX2011009475A (es) | 2011-12-08 |
| WO2010104854A2 (en) | 2010-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8637034B2 (en) | Pharmaceutical compositions comprising activated-potentiated antibodies to interferon-gamma and S100 protein | |
| US20110318375A1 (en) | Immunomodulatory Therapeutic Agents | |
| HU214905B (hu) | Eljárás VIII. faktor izolálására | |
| AU2019364271B2 (en) | Use of plasma and plasma fractions for improvement of pain, wound healing, and postoperative recovery | |
| AU2011286486B9 (en) | Drug and method for the prophylaxis of HIV infection and for the prophylaxis and treatment of diseases caused by or associated with HIV, including aids | |
| CN102458478A (zh) | 白蛋白-淀粉样肽缀合物及其用途 | |
| US20240239841A1 (en) | Peptide and method for treating pain using the same | |
| RU2192882C1 (ru) | Лекарственное средство и способ лечения патологического синдрома, обусловленного нарушением кроветворения | |
| Czajka et al. | Mechanism of Vipera berus venom activity and the principles of antivenom administration in treatment | |
| WO2019115745A1 (en) | RECOMBINANT igG Fc MULTIMERS FOR THE TREATMENT OF NEUROMYELITIS OPTICA | |
| CN1300172C (zh) | 一种抗SARS－CoV免疫球蛋白抗体 | |
| RU2205026C1 (ru) | Лекарственное средство и способ лечения патологического синдрома, обусловленного нарушением кроветворения | |
| Ichiki et al. | Cleavage of bacterial flagellin with proteolytic enzymes: II. Induction of enhanced delayed-type hypersensitivity to flagellin by peptic fragments of the protein | |
| CN103087194B (zh) | 一种抗血循型蛇毒鸡卵黄抗体及其应用 | |
| RU2405560C1 (ru) | Средство для защиты клеток мозга | |
| RU2141341C1 (ru) | Способ получения иммуноглобулина человека антистафилококкового для внутривенного введения | |
| CN1128810C (zh) | 防治肝病的鲨鱼肝多肽结构及纯化 | |
| RU2264826C1 (ru) | Способ получения антитимоцитарного глобулина для внутривенного введения | |
| RU2024129731A (ru) | Альфа-1-антитрипсин для использования при лечении заболеваний или расстройств нервной системы, таких как хроническая воспалительная демиелинизирующая полинейропатия | |
| CN119638834A (zh) | 一种缓解鼻炎的蛋黄球蛋白及其应用 | |
| CN120966834A (zh) | 一种靶向FcRn和FcγRs的双特异性纳米抗体及其制备方法和用途 | |
| JPH10504310A (ja) | 生物学的に活性な化合物で患者を治療する方法 | |
| JPH03153632A (ja) | 第８因子阻害剤産生の抑制のための医薬組成物および方法 | |
| Fauve | explained mainly by an increased influx of the cellular effec | |
| JPH02264728A (ja) | 高脂血症治療剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20140311 |