CA2753804C - Compositions and methods for visualizing and eliminating cancer stem cells - Google Patents
Compositions and methods for visualizing and eliminating cancer stem cells Download PDFInfo
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- CA2753804C CA2753804C CA2753804A CA2753804A CA2753804C CA 2753804 C CA2753804 C CA 2753804C CA 2753804 A CA2753804 A CA 2753804A CA 2753804 A CA2753804 A CA 2753804A CA 2753804 C CA2753804 C CA 2753804C
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K38/2257—Prolactin
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/5756—Prolactin
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Molecular Biology (AREA)
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- Zoology (AREA)
- Biochemistry (AREA)
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- Physics & Mathematics (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15562409P | 2009-02-26 | 2009-02-26 | |
| US61/155,624 | 2009-02-26 | ||
| PCT/US2010/024340 WO2010099003A2 (en) | 2009-02-26 | 2010-02-16 | Compositions and methods for visualizing and eliminating cancer stem cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2753804A1 CA2753804A1 (en) | 2010-09-02 |
| CA2753804C true CA2753804C (en) | 2018-03-13 |
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| CA2753804A Expired - Fee Related CA2753804C (en) | 2009-02-26 | 2010-02-16 | Compositions and methods for visualizing and eliminating cancer stem cells |
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| Country | Link |
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| US (1) | US8754035B2 (enExample) |
| EP (1) | EP2400979B1 (enExample) |
| JP (2) | JP5963443B2 (enExample) |
| KR (1) | KR101672401B1 (enExample) |
| CN (2) | CN106177954A (enExample) |
| AU (1) | AU2010218261B2 (enExample) |
| CA (1) | CA2753804C (enExample) |
| IL (2) | IL214545A (enExample) |
| WO (1) | WO2010099003A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8648046B2 (en) * | 2009-02-26 | 2014-02-11 | Oncolix, Inc. | Compositions and methods for visualizing and eliminating cancer stem cells |
| EP2576823A1 (en) * | 2010-06-04 | 2013-04-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Constitutively active prolactin receptor variants as prognostic markers and therapeutic targets to prevent progression of hormone-dependent cancers towards hormone-independence |
| TW201920283A (zh) | 2012-12-24 | 2019-06-01 | 美商艾伯維有限公司 | 催乳激素受體結合蛋白質及其用途 |
| WO2015193417A1 (en) * | 2014-06-18 | 2015-12-23 | Prorec Bio Ab | Prolactin receptor antagonists for treatment of glioblastoma |
| CN107198779A (zh) * | 2016-11-29 | 2017-09-26 | 南京东纳生物科技有限公司 | 一种干细胞标记示踪及靶向导航的纳米偶联复合物及其制备方法和应用 |
| TW201836647A (zh) | 2017-04-06 | 2018-10-16 | 美商艾伯維有限公司 | 抗－ｐｒｌｒ抗體藥物軛合物（ａｄｃ）及其用途 |
| WO2020011998A1 (en) * | 2018-07-13 | 2020-01-16 | Hifibio Sas | Use of droplet single cell epigenome profiling for patient stratification |
| AR124681A1 (es) | 2021-01-20 | 2023-04-26 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA1055932A (en) | 1975-10-22 | 1979-06-05 | Hematech Inc. | Blood substitute based on hemoglobin |
| DE2616086C2 (de) | 1976-04-13 | 1986-04-03 | Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg | Substanz zur Verwendung in einem kolloidalen Blutvolumenersatzmittel aus Hydroxyethylstärke und Hämoglobin |
| ATE366114T1 (de) * | 1998-05-12 | 2007-07-15 | Greenville Hospital System | Verwendung von anti-prolaktin agentien zur behandlung von krebs |
| CA2921260A1 (en) | 1999-12-24 | 2001-06-28 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| WO2001085777A2 (en) | 2000-05-09 | 2001-11-15 | Greenville Hospital System | Therapeutic pore-forming peptides |
| KR100567718B1 (ko) * | 2001-07-31 | 2006-04-05 | 화이자 프로덕츠 인크. | 에스트로겐 작용제/길항제와 에스트로겐과 프로게스틴의조합을 포함하는 약학 조성물, 키트 및 방법 |
| AU2003230750A1 (en) | 2002-03-29 | 2003-10-13 | Threshold Pharmaceuticals, Inc. | Compositions and methods for treating cancer |
| RU2329274C2 (ru) | 2002-09-11 | 2008-07-20 | Фрезениус Каби Дойчланд Гмбх | Способ получения производных гидроксиалкилкрахмала |
| MXPA05006945A (es) | 2002-12-26 | 2005-12-14 | Mountain View Pharmaceuticals | Conjugados polimericos de citoquinas, quimiocinas, factores de crecimiento, hormonas polipeptidicas y sus antagonistas con actividad conservada de union al receptor. |
| US8754031B2 (en) * | 2004-03-08 | 2014-06-17 | Oncolix, Inc. | Use of prolactin receptor antagonists in combination with an agent that inactivates the HER2/neu signaling pathway |
| US20050238628A1 (en) | 2004-04-08 | 2005-10-27 | Blau Carl A | Methods for treating cancer |
| US7422899B2 (en) * | 2005-10-05 | 2008-09-09 | Biogen Idec Ma Inc. | Antibodies to the human prolactin receptor |
| US8420665B2 (en) | 2008-01-11 | 2013-04-16 | Northwestern University | Anti-cancer compounds |
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- 2010-02-16 KR KR1020117022422A patent/KR101672401B1/ko not_active Expired - Fee Related
- 2010-02-16 WO PCT/US2010/024340 patent/WO2010099003A2/en not_active Ceased
- 2010-02-16 EP EP20100705493 patent/EP2400979B1/en not_active Not-in-force
- 2010-02-16 CN CN201610657107.2A patent/CN106177954A/zh active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2014156484A (ja) | 2014-08-28 |
| EP2400979A2 (en) | 2012-01-04 |
| CA2753804A1 (en) | 2010-09-02 |
| AU2010218261B2 (en) | 2015-08-20 |
| WO2010099003A2 (en) | 2010-09-02 |
| AU2010218261A1 (en) | 2011-09-01 |
| US20100215577A1 (en) | 2010-08-26 |
| CN106177954A (zh) | 2016-12-07 |
| KR101672401B1 (ko) | 2016-11-16 |
| WO2010099003A3 (en) | 2011-02-17 |
| IL214545A (en) | 2016-07-31 |
| KR20110139703A (ko) | 2011-12-29 |
| IL214545A0 (en) | 2011-09-27 |
| JP5963443B2 (ja) | 2016-08-03 |
| US8754035B2 (en) | 2014-06-17 |
| JP2012519168A (ja) | 2012-08-23 |
| EP2400979B1 (en) | 2015-05-20 |
| CN102341118A (zh) | 2012-02-01 |
| IL246247A0 (en) | 2016-07-31 |
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