JP5963443B2 - がん幹細胞を可視化・排除するための組成物および方法 - Google Patents
がん幹細胞を可視化・排除するための組成物および方法 Download PDFInfo
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- JP5963443B2 JP5963443B2 JP2011552066A JP2011552066A JP5963443B2 JP 5963443 B2 JP5963443 B2 JP 5963443B2 JP 2011552066 A JP2011552066 A JP 2011552066A JP 2011552066 A JP2011552066 A JP 2011552066A JP 5963443 B2 JP5963443 B2 JP 5963443B2
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2257—Prolactin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- C07K14/4703—Inhibitors; Suppressors
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/5756—Prolactin
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
Landscapes
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- General Chemical & Material Sciences (AREA)
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- Biophysics (AREA)
- Toxicology (AREA)
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| US15562409P | 2009-02-26 | 2009-02-26 | |
| US61/155,624 | 2009-02-26 | ||
| PCT/US2010/024340 WO2010099003A2 (en) | 2009-02-26 | 2010-02-16 | Compositions and methods for visualizing and eliminating cancer stem cells |
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| JP2014108085A Division JP2014156484A (ja) | 2009-02-26 | 2014-05-26 | がん幹細胞を可視化・排除するための組成物および方法 |
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| JP2012519168A JP2012519168A (ja) | 2012-08-23 |
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| JP2011552066A Expired - Fee Related JP5963443B2 (ja) | 2009-02-26 | 2010-02-16 | がん幹細胞を可視化・排除するための組成物および方法 |
| JP2014108085A Pending JP2014156484A (ja) | 2009-02-26 | 2014-05-26 | がん幹細胞を可視化・排除するための組成物および方法 |
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| US8648046B2 (en) * | 2009-02-26 | 2014-02-11 | Oncolix, Inc. | Compositions and methods for visualizing and eliminating cancer stem cells |
| EP2576823A1 (en) * | 2010-06-04 | 2013-04-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Constitutively active prolactin receptor variants as prognostic markers and therapeutic targets to prevent progression of hormone-dependent cancers towards hormone-independence |
| TW201920283A (zh) | 2012-12-24 | 2019-06-01 | 美商艾伯維有限公司 | 催乳激素受體結合蛋白質及其用途 |
| WO2015193417A1 (en) * | 2014-06-18 | 2015-12-23 | Prorec Bio Ab | Prolactin receptor antagonists for treatment of glioblastoma |
| CN107198779A (zh) * | 2016-11-29 | 2017-09-26 | 南京东纳生物科技有限公司 | 一种干细胞标记示踪及靶向导航的纳米偶联复合物及其制备方法和应用 |
| TW201836647A (zh) | 2017-04-06 | 2018-10-16 | 美商艾伯維有限公司 | 抗－ｐｒｌｒ抗體藥物軛合物（ａｄｃ）及其用途 |
| WO2020011998A1 (en) * | 2018-07-13 | 2020-01-16 | Hifibio Sas | Use of droplet single cell epigenome profiling for patient stratification |
| AR124681A1 (es) | 2021-01-20 | 2023-04-26 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
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| CA1055932A (en) | 1975-10-22 | 1979-06-05 | Hematech Inc. | Blood substitute based on hemoglobin |
| DE2616086C2 (de) | 1976-04-13 | 1986-04-03 | Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg | Substanz zur Verwendung in einem kolloidalen Blutvolumenersatzmittel aus Hydroxyethylstärke und Hämoglobin |
| ATE366114T1 (de) * | 1998-05-12 | 2007-07-15 | Greenville Hospital System | Verwendung von anti-prolaktin agentien zur behandlung von krebs |
| CA2921260A1 (en) | 1999-12-24 | 2001-06-28 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| WO2001085777A2 (en) | 2000-05-09 | 2001-11-15 | Greenville Hospital System | Therapeutic pore-forming peptides |
| KR100567718B1 (ko) * | 2001-07-31 | 2006-04-05 | 화이자 프로덕츠 인크. | 에스트로겐 작용제/길항제와 에스트로겐과 프로게스틴의조합을 포함하는 약학 조성물, 키트 및 방법 |
| AU2003230750A1 (en) | 2002-03-29 | 2003-10-13 | Threshold Pharmaceuticals, Inc. | Compositions and methods for treating cancer |
| RU2329274C2 (ru) | 2002-09-11 | 2008-07-20 | Фрезениус Каби Дойчланд Гмбх | Способ получения производных гидроксиалкилкрахмала |
| MXPA05006945A (es) | 2002-12-26 | 2005-12-14 | Mountain View Pharmaceuticals | Conjugados polimericos de citoquinas, quimiocinas, factores de crecimiento, hormonas polipeptidicas y sus antagonistas con actividad conservada de union al receptor. |
| US8754031B2 (en) * | 2004-03-08 | 2014-06-17 | Oncolix, Inc. | Use of prolactin receptor antagonists in combination with an agent that inactivates the HER2/neu signaling pathway |
| US20050238628A1 (en) | 2004-04-08 | 2005-10-27 | Blau Carl A | Methods for treating cancer |
| US7422899B2 (en) * | 2005-10-05 | 2008-09-09 | Biogen Idec Ma Inc. | Antibodies to the human prolactin receptor |
| US8420665B2 (en) | 2008-01-11 | 2013-04-16 | Northwestern University | Anti-cancer compounds |
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| Publication number | Publication date |
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| JP2014156484A (ja) | 2014-08-28 |
| EP2400979A2 (en) | 2012-01-04 |
| CA2753804A1 (en) | 2010-09-02 |
| CA2753804C (en) | 2018-03-13 |
| AU2010218261B2 (en) | 2015-08-20 |
| WO2010099003A2 (en) | 2010-09-02 |
| AU2010218261A1 (en) | 2011-09-01 |
| US20100215577A1 (en) | 2010-08-26 |
| CN106177954A (zh) | 2016-12-07 |
| KR101672401B1 (ko) | 2016-11-16 |
| WO2010099003A3 (en) | 2011-02-17 |
| IL214545A (en) | 2016-07-31 |
| KR20110139703A (ko) | 2011-12-29 |
| IL214545A0 (en) | 2011-09-27 |
| US8754035B2 (en) | 2014-06-17 |
| JP2012519168A (ja) | 2012-08-23 |
| EP2400979B1 (en) | 2015-05-20 |
| CN102341118A (zh) | 2012-02-01 |
| IL246247A0 (en) | 2016-07-31 |
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