CA2752868C - Treatment of energy utilization disease - Google Patents
Treatment of energy utilization disease Download PDFInfo
- Publication number
- CA2752868C CA2752868C CA2752868A CA2752868A CA2752868C CA 2752868 C CA2752868 C CA 2752868C CA 2752868 A CA2752868 A CA 2752868A CA 2752868 A CA2752868 A CA 2752868A CA 2752868 C CA2752868 C CA 2752868C
- Authority
- CA
- Canada
- Prior art keywords
- sugar acid
- imino sugar
- compound
- acid
- spp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract 7
- 201000010099 disease Diseases 0.000 title abstract 3
- 239000002253 acid Substances 0.000 claims abstract 38
- 125000001841 imino group Chemical group [H]N=* 0.000 claims abstract 31
- 150000001875 compounds Chemical class 0.000 claims abstract 15
- 238000000034 method Methods 0.000 claims abstract 12
- 239000000203 mixture Substances 0.000 claims abstract 10
- 208000001145 Metabolic Syndrome Diseases 0.000 claims abstract 5
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims abstract 5
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract 4
- 208000035475 disorder Diseases 0.000 claims abstract 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract 4
- 206010022489 Insulin Resistance Diseases 0.000 claims abstract 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims abstract 2
- 241000196324 Embryophyta Species 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 4
- 208000008589 Obesity Diseases 0.000 claims 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 241001093501 Rutaceae Species 0.000 claims 3
- 244000228451 Stevia rebaudiana Species 0.000 claims 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 235000020824 obesity Nutrition 0.000 claims 3
- 241000746375 Andrographis Species 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 241000219104 Cucurbitaceae Species 0.000 claims 2
- 244000068988 Glycine max Species 0.000 claims 2
- 235000010469 Glycine max Nutrition 0.000 claims 2
- 241000208251 Gymnema Species 0.000 claims 2
- 241000208292 Solanaceae Species 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- DGGKXQQCVPAUEA-UHFFFAOYSA-N 8-azabicyclo[3.2.1]octane Chemical compound C1CCC2CCC1N2 DGGKXQQCVPAUEA-UHFFFAOYSA-N 0.000 claims 1
- 208000010444 Acidosis Diseases 0.000 claims 1
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 1
- 244000036975 Ambrosia artemisiifolia Species 0.000 claims 1
- 244000286893 Aspalathus contaminatus Species 0.000 claims 1
- 235000000832 Ayote Nutrition 0.000 claims 1
- 241000212973 Baphia Species 0.000 claims 1
- 206010065687 Bone loss Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 241001107116 Castanospermum australe Species 0.000 claims 1
- 208000002177 Cataract Diseases 0.000 claims 1
- 241000207199 Citrus Species 0.000 claims 1
- 244000183685 Citrus aurantium Species 0.000 claims 1
- 244000259764 Cucurbita melanosperma Species 0.000 claims 1
- 235000000861 Cucurbita melanosperma Nutrition 0.000 claims 1
- 235000009854 Cucurbita moschata Nutrition 0.000 claims 1
- 240000001980 Cucurbita pepo Species 0.000 claims 1
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 208000032781 Diabetic cardiomyopathy Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 108010001394 Disaccharidases Proteins 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 1
- 206010018473 Glycosuria Diseases 0.000 claims 1
- 241000208253 Gymnema sylvestre Species 0.000 claims 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- HXEACLLIILLPRG-YFKPBYRVSA-N L-pipecolic acid Chemical compound [O-]C(=O)[C@@H]1CCCC[NH2+]1 HXEACLLIILLPRG-YFKPBYRVSA-N 0.000 claims 1
- 244000241838 Lycium barbarum Species 0.000 claims 1
- 235000015459 Lycium barbarum Nutrition 0.000 claims 1
- 206010027417 Metabolic acidosis Diseases 0.000 claims 1
- 208000029725 Metabolic bone disease Diseases 0.000 claims 1
- 244000302512 Momordica charantia Species 0.000 claims 1
- 235000009811 Momordica charantia Nutrition 0.000 claims 1
- SEWARTPIJFHCRP-UHFFFAOYSA-N N-hydroxypipecolic acid Chemical compound ON1CCCCC1C(O)=O SEWARTPIJFHCRP-UHFFFAOYSA-N 0.000 claims 1
- 240000002853 Nelumbo nucifera Species 0.000 claims 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims 1
- 206010049088 Osteopenia Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010049416 Short-bowel syndrome Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 235000020971 citrus fruits Nutrition 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 206010016256 fatigue Diseases 0.000 claims 1
- 206010061989 glomerulosclerosis Diseases 0.000 claims 1
- 230000004153 glucose metabolism Effects 0.000 claims 1
- 230000035780 glucosuria Effects 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 230000035879 hyperinsulinaemia Effects 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- HAJKHJOABGFIGP-UHFFFAOYSA-N indolizidine Chemical compound C1CCCN2CCCC21 HAJKHJOABGFIGP-UHFFFAOYSA-N 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 230000008991 intestinal motility Effects 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000002417 nutraceutical Substances 0.000 claims 1
- 235000021436 nutraceutical agent Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 235000015136 pumpkin Nutrition 0.000 claims 1
- ADRDEXBBJTUCND-UHFFFAOYSA-N pyrrolizidine Chemical compound C1CCN2CCCC21 ADRDEXBBJTUCND-UHFFFAOYSA-N 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 208000004611 Abdominal Obesity Diseases 0.000 abstract 1
- 206010065941 Central obesity Diseases 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000003626 triacylglycerols Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/12—Ophthalmic agents for cataracts
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Neurology (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0802903.5 | 2008-02-18 | ||
| GB0802907.6 | 2008-02-18 | ||
| GB0802904A GB0802904D0 (en) | 2008-02-18 | 2008-02-18 | Treatment of metabolic syndrome |
| GB0802903A GB0802903D0 (en) | 2008-02-18 | 2008-02-18 | Treatment of diabetes |
| GB0802907A GB0802907D0 (en) | 2008-02-18 | 2008-02-18 | Method for monitoring the quality of a herbal food additive |
| GB0802904.3 | 2008-02-18 | ||
| PCT/GB2009/000417 WO2009103953A1 (en) | 2008-02-18 | 2009-02-17 | Treatment of energy utilization disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2752868A1 CA2752868A1 (en) | 2009-08-27 |
| CA2752868C true CA2752868C (en) | 2018-11-27 |
Family
ID=40589554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2752868A Active CA2752868C (en) | 2008-02-18 | 2009-02-17 | Treatment of energy utilization disease |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20110015226A1 (enExample) |
| EP (1) | EP2257286B1 (enExample) |
| JP (1) | JP5722632B2 (enExample) |
| CN (1) | CN102006869B (enExample) |
| CA (1) | CA2752868C (enExample) |
| ES (1) | ES2620743T3 (enExample) |
| WO (1) | WO2009103953A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10273598B2 (en) | 2009-12-22 | 2019-04-30 | Element Six Technologies Limited | Synthetic CVD diamond |
| KR101598935B1 (ko) * | 2010-04-16 | 2016-03-03 | 씨제이제일제당(주) | 레바우디오사이드 ａ의 생산 공정에서 발생하는 부산물을 재활용하여 고수득율의 레바우디오사이드 ａ를 제조하는 방법 |
| GB201117490D0 (en) * | 2011-10-11 | 2011-11-23 | Phytoquest Ltd | Anti-inflammatory compounds |
| GB2496388B (en) * | 2011-11-08 | 2014-10-08 | Phynova Ltd | Morus extracts rich in n-acids of imino sugars and or pipecolic acids |
| GB201313440D0 (en) | 2013-07-29 | 2013-09-11 | Phytoquest Ltd | Characterization of rice |
| JP6283569B2 (ja) * | 2014-05-26 | 2018-02-21 | 株式会社シャローム | 脂肪蓄積抑制物質の製造方法 |
| CN105624181B (zh) * | 2014-11-03 | 2019-06-11 | 中国科学院微生物研究所 | 一种高通量鉴定产生1-脱氧野尻霉素菌株的方法 |
| KR102408480B1 (ko) * | 2018-05-30 | 2022-06-10 | 이삼구 | 당뇨질환의 치료용 조성물 |
| CN119950503A (zh) * | 2019-07-26 | 2025-05-09 | 植物探索有限公司 | 生物活性植物化学物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO154918C (no) | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| WO1992021657A1 (en) | 1991-05-30 | 1992-12-10 | The Scripps Research Institute | Omega-deoxy-azasugars |
| US5863903A (en) | 1994-03-09 | 1999-01-26 | Novo Nordisk A/S | Use of hydroxy alkyl piperidine and pyrrolidine compounds to treat diabetes |
| WO2000056334A1 (en) * | 1999-03-19 | 2000-09-28 | The Trustees Of Boston College | Use of imino sugars for anti-tumor therapy |
| WO2000066105A2 (en) * | 1999-04-30 | 2000-11-09 | The Trustees Of Boston College | Treatment of epilepsy with imino sugars |
| US20040019082A1 (en) * | 2002-03-13 | 2004-01-29 | United Therapeutics Corporation | Reversible infertility in male mice following oral administration of alkylated imino sugars: a non-hormonal approach to male contraception |
| US20060025449A1 (en) | 2004-03-25 | 2006-02-02 | United Therapeutics | Use of N-substituted imino sugars for appetite suppression |
| JP2007262017A (ja) | 2006-03-29 | 2007-10-11 | Ajinomoto Co Inc | ピペコリン酸含有抗糖尿病組成物 |
-
2009
- 2009-02-17 JP JP2010546398A patent/JP5722632B2/ja active Active
- 2009-02-17 CA CA2752868A patent/CA2752868C/en active Active
- 2009-02-17 US US12/918,037 patent/US20110015226A1/en not_active Abandoned
- 2009-02-17 WO PCT/GB2009/000417 patent/WO2009103953A1/en not_active Ceased
- 2009-02-17 CN CN2009801136557A patent/CN102006869B/zh active Active
- 2009-02-17 ES ES09712052.1T patent/ES2620743T3/es active Active
- 2009-02-17 EP EP09712052.1A patent/EP2257286B1/en active Active
-
2013
- 2013-02-05 US US13/759,173 patent/US20140011841A1/en not_active Abandoned
-
2015
- 2015-12-18 US US14/974,536 patent/US10842784B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009103953A1 (en) | 2009-08-27 |
| EP2257286A1 (en) | 2010-12-08 |
| US20160151341A1 (en) | 2016-06-02 |
| CN102006869B (zh) | 2013-11-06 |
| US10842784B2 (en) | 2020-11-24 |
| CA2752868A1 (en) | 2009-08-27 |
| ES2620743T3 (es) | 2017-06-29 |
| US20110015226A1 (en) | 2011-01-20 |
| JP5722632B2 (ja) | 2015-05-27 |
| EP2257286B1 (en) | 2016-12-28 |
| JP2011512347A (ja) | 2011-04-21 |
| CN102006869A (zh) | 2011-04-06 |
| US20140011841A1 (en) | 2014-01-09 |
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