CA2749930A1 - Composes antidiabetiques heterocycliques pontes et fusionnes - Google Patents

Composes antidiabetiques heterocycliques pontes et fusionnes Download PDF

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Publication number
CA2749930A1
CA2749930A1 CA2749930A CA2749930A CA2749930A1 CA 2749930 A1 CA2749930 A1 CA 2749930A1 CA 2749930 A CA2749930 A CA 2749930A CA 2749930 A CA2749930 A CA 2749930A CA 2749930 A1 CA2749930 A1 CA 2749930A1
Authority
CA
Canada
Prior art keywords
alkyl
group
cycloalkyl
cycloalkylalkyl
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2749930A
Other languages
English (en)
Inventor
Hubert B. Josien
John W. Clader
William J. Greenlee
Michael John Mayer
Robert Jason Herr
Jason L. Davis
Kai DENG
Ming Min Hsia
Shuangyi Wan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CA2749930A1 publication Critical patent/CA2749930A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2749930A 2009-01-23 2010-01-21 Composes antidiabetiques heterocycliques pontes et fusionnes Abandoned CA2749930A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14687909P 2009-01-23 2009-01-23
US61/146,879 2009-01-23
PCT/US2010/021583 WO2010085525A1 (fr) 2009-01-23 2010-01-21 Composés antidiabétiques hétérocycliques pontés et fusionnés

Publications (1)

Publication Number Publication Date
CA2749930A1 true CA2749930A1 (fr) 2010-07-29

Family

ID=42077587

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2749930A Abandoned CA2749930A1 (fr) 2009-01-23 2010-01-21 Composes antidiabetiques heterocycliques pontes et fusionnes

Country Status (8)

Country Link
US (1) US20110312995A1 (fr)
EP (1) EP2389226B1 (fr)
JP (1) JP2012515781A (fr)
AR (1) AR074965A1 (fr)
AU (1) AU2010206786A1 (fr)
CA (1) CA2749930A1 (fr)
TW (1) TW201040172A (fr)
WO (1) WO2010085525A1 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012515782A (ja) 2009-01-23 2012-07-12 シェーリング コーポレイション 抗糖尿病性架橋および縮合化合物
EP2393810A1 (fr) 2009-02-05 2011-12-14 Schering Corporation Composés antidiabétiques contenant de la phtalazine
JP5002077B2 (ja) 2009-12-25 2012-08-15 持田製薬株式会社 新規３−ヒドロキシ−５−アリールイソチアゾール誘導体
JP5809157B2 (ja) 2010-10-08 2015-11-10 持田製薬株式会社 環状アミド誘導体
JP5420796B2 (ja) 2011-04-27 2014-02-19 持田製薬株式会社 新規３−ヒドロキシイソチアゾール１−オキシド誘導体
AU2012248627A1 (en) 2011-04-28 2013-11-14 Mochida Pharmaceutical Co., Ltd. Cyclic amide derivative
CN102731390A (zh) * 2012-07-07 2012-10-17 盛世泰科生物医药技术(苏州)有限公司 一种6-溴-2,3-二氢-1h-喹啉-4酮的合成方法
EP2872127A1 (fr) 2012-07-11 2015-05-20 Elcelyx Therapeutics, Inc. Compositions comportant des statines, des biguanides et d'autres agents pour réduire un risque cardiométabolique
AU2013296470B2 (en) 2012-08-02 2016-03-17 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
MX2015010935A (es) 2013-02-22 2015-10-29 Merck Sharp & Dohme Compuestos biciclicos antidiabeticos.
WO2015051496A1 (fr) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Composés tricycliques antidiabétiques
AP2016009176A0 (en) 2013-11-14 2016-04-30 Cadila Healthcare Ltd Novel heterocyclic compounds
EP3068768B1 (fr) 2013-11-15 2019-07-31 Merck Sharp & Dohme Corp. Composés tricycliques antidiabétiques
WO2015084692A1 (fr) 2013-12-04 2015-06-11 Merck Sharp & Dohme Corp. Composés bicycliques antidiabétiques
WO2015089809A1 (fr) 2013-12-19 2015-06-25 Merck Sharp & Dohme Corp. Composés hétéroaryles substitués antidiabétiques
EP3102198B1 (fr) 2014-02-06 2020-08-26 Merck Sharp & Dohme Corp. Composés antidiabétiques
WO2015176267A1 (fr) 2014-05-22 2015-11-26 Merck Sharp & Dohme Corp. Composés tricycliques antidiabétiques
US10662171B2 (en) 2014-08-08 2020-05-26 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
WO2016019587A1 (fr) 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. Composés antidiabétiques bicycliques condensés [7, 6]
EP3177287B1 (fr) 2014-08-08 2022-02-23 Merck Sharp & Dohme Corp. Composés bicycliques antidiabétiques
US10100042B2 (en) 2014-08-08 2018-10-16 Merck Sharp & Dohme Corp. [5,6]—fused bicyclic antidiabetic compounds
US10676458B2 (en) 2016-03-29 2020-06-09 Merch Sharp & Dohne Corp. Rahway Antidiabetic bicyclic compounds
WO2018106518A1 (fr) 2016-12-06 2018-06-14 Merck Sharp & Dohme Corp. Composés hétérocycliques antidiabétiques
US10968232B2 (en) 2016-12-20 2021-04-06 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
WO2019099315A1 (fr) 2017-11-16 2019-05-23 Merck Sharp & Dohme Corp. Composés bicycliques antidiabétiques
MX2020008404A (es) 2018-02-13 2020-09-25 Gilead Sciences Inc Inhibidores de molecula de muerte programada 1 (pd-1)/ligando de molecula de muerte programada 1 (pd-l1).
WO2019170543A1 (fr) 2018-03-07 2019-09-12 Bayer Aktiengesellschaft Identification et utilisation d'inhibiteurs d'erk5
CA3093130C (fr) 2018-04-19 2023-10-17 Gilead Sciences, Inc. Inhibiteurs pd-1/pd-l1
AU2019301811B2 (en) 2018-07-13 2022-05-26 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
JP7158577B2 (ja) 2018-10-24 2022-10-21 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤
KR20220150270A (ko) 2019-10-07 2022-11-10 칼리오페, 인크. Gpr119 효능제
EP4153589A1 (fr) 2020-05-19 2023-03-29 Kallyope, Inc. Activateurs d'ampk
CA3183575A1 (fr) 2020-06-26 2021-12-30 Iyassu Sebhat Activateurs d'ampk

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997028149A1 (fr) 1996-02-02 1997-08-07 Merck & Co., Inc. Procede pour augmenter les niveaux de cholesterol hdl
AU2001277056B2 (en) 2000-07-25 2005-09-29 Merck & Co., Inc. N-substituted indoles useful in the treatment of diabetes
NZ538031A (en) 2002-08-29 2007-10-26 Merck & Co Inc Indoles having anti-diabetic activity
CA2510793A1 (fr) * 2002-12-20 2004-07-15 Bayer Pharmaceuticals Corporation Derives d'acide acetique d'indane et leur utilisation en tant qu'agents pharmaceutiques et intermediaires, et procede de preparation correspondant
CA2562082C (fr) 2004-04-13 2013-06-25 Merck & Co., Inc. Inhibiteurs de la cetp pour le traitement et la prevention de l'atherosclerose
US20050245529A1 (en) 2004-04-14 2005-11-03 Boehringer Ingelheim International Gmbh Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
DOP2005000123A (es) 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006083612A1 (fr) 2005-01-28 2006-08-10 Merck & Co., Inc. Composes bicycliques antidiabetiques
DE602006008576D1 (de) 2005-01-31 2009-10-01 Merck & Co Inc Antidiabetische bicyclische verbindungen
JP2009530281A (ja) * 2006-03-14 2009-08-27 アムジエン・インコーポレーテツド 代謝障害の治療に有用である二環式カルボン酸誘導体
EP2021327B1 (fr) 2006-05-15 2012-04-04 Merck Sharp & Dohme Corp. Composés bicycliques antidiabétiques
WO2008054674A2 (fr) 2006-10-31 2008-05-08 Merck & Co., Inc. Composés bicycliques antidiabétiques

Also Published As

Publication number Publication date
TW201040172A (en) 2010-11-16
EP2389226B1 (fr) 2013-11-20
WO2010085525A1 (fr) 2010-07-29
US20110312995A1 (en) 2011-12-22
AU2010206786A1 (en) 2011-07-28
EP2389226A1 (fr) 2011-11-30
AR074965A1 (es) 2011-02-23
JP2012515781A (ja) 2012-07-12

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20150121