CA2745446A1 - Novel semi-synthetic glycopeptides as antibacterial agents - Google Patents

Novel semi-synthetic glycopeptides as antibacterial agents Download PDF

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Publication number
CA2745446A1
CA2745446A1 CA2745446A CA2745446A CA2745446A1 CA 2745446 A1 CA2745446 A1 CA 2745446A1 CA 2745446 A CA2745446 A CA 2745446A CA 2745446 A CA2745446 A CA 2745446A CA 2745446 A1 CA2745446 A1 CA 2745446A1
Authority
CA
Canada
Prior art keywords
alkoxy
compound
substituted
bacteria
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2745446A
Other languages
English (en)
French (fr)
Inventor
Daniel Chu
Tao Ye
Bing Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomarin Pharmaceutical Inc
Original Assignee
Biomarin Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2008/085716 external-priority patent/WO2009085562A1/en
Application filed by Biomarin Pharmaceutical Inc filed Critical Biomarin Pharmaceutical Inc
Publication of CA2745446A1 publication Critical patent/CA2745446A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2745446A 2008-12-05 2009-09-01 Novel semi-synthetic glycopeptides as antibacterial agents Abandoned CA2745446A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/US2008/085716 WO2009085562A1 (en) 2007-12-26 2008-12-05 Novel semi-synthetic glycopeptides as antibacterial agents
USPCT/US2008/085716 2008-12-05
US22016709P 2009-06-24 2009-06-24
US61/220,167 2009-06-24
PCT/US2009/055633 WO2010065174A1 (en) 2008-12-05 2009-09-01 Novel semi-synthetic glycopeptides as antibacterial agents

Publications (1)

Publication Number Publication Date
CA2745446A1 true CA2745446A1 (en) 2010-06-10

Family

ID=41203726

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2745446A Abandoned CA2745446A1 (en) 2008-12-05 2009-09-01 Novel semi-synthetic glycopeptides as antibacterial agents

Country Status (12)

Country Link
US (1) US20110015119A1 (enExample)
EP (1) EP2373694A1 (enExample)
JP (1) JP2012510999A (enExample)
KR (1) KR20110099028A (enExample)
CN (1) CN102307903A (enExample)
AR (1) AR075354A1 (enExample)
AU (1) AU2009322925A1 (enExample)
CA (1) CA2745446A1 (enExample)
GB (1) GB2465863A (enExample)
IL (1) IL213390A0 (enExample)
TW (1) TW201021805A (enExample)
WO (1) WO2010065174A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011140009A1 (en) * 2010-05-04 2011-11-10 Biomarin Pharmaceutical Inc. Methods of using semi-synthetic glycopeptides as antibacterial agents
CN107325159A (zh) * 2016-04-29 2017-11-07 中国科学院上海药物研究所 一类万古霉素衍生物、其制备方法、药物组合物和用途
IL270685B (en) * 2017-05-22 2022-09-01 Insmed Inc Cleavable derivatives of lipoglycopeptide and their uses
CN109422800A (zh) * 2017-08-22 2019-03-05 复旦大学 抗革兰氏阳性菌季铵盐糖肽类化合物及其药用用途
CN111793076B (zh) * 2020-06-05 2021-10-12 华北制药河北华民药业有限责任公司 一种注射用硫酸头孢匹罗的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0662674B2 (ja) * 1985-01-11 1994-08-17 三共株式会社 抗生物質クロロポリスポリンｂまたはｃ
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
CA2337103A1 (en) * 1998-07-14 2000-01-27 Robert Kerns Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
PT1140993E (pt) * 1998-12-23 2003-10-31 Theravance Inc Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos
US6518243B1 (en) * 1999-04-02 2003-02-11 Trustees Of Princeton University Desleucyl glycopeptide antibiotics and methods of making same
CN1425025A (zh) * 1999-12-15 2003-06-18 卡比斯特制药公司 作为抗菌剂的新颖的脂肽
US6397405B1 (en) * 2000-04-11 2002-06-04 Thetford Corporation Flush toilet for RV's and boats
AU2001259298A1 (en) * 2000-05-02 2001-11-12 Advanced Medicine, Inc. Polyacid glycopeptide derivatives
UA75083C2 (uk) * 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
ES2302733T3 (es) * 2000-06-22 2008-08-01 Theravance, Inc. Derivados carboxi-sacaridos de glucopeptido.
US20030008812A1 (en) * 2001-02-02 2003-01-09 Christensen Burton G. Glycopeptide derivatives
TWI233932B (en) * 2001-08-24 2005-06-11 Theravance Inc Process for purifying glycopeptide phosphonate derivatives
JP2006528704A (ja) * 2003-05-27 2006-12-21 セラヴァンス インコーポレーテッド グリコペプチド抗細菌剤と組み合わせたポリエンマクロライド抗真菌剤の使用
US8778874B2 (en) * 2004-11-29 2014-07-15 National University Corporation Nagoya University Glycopeptide antibiotic monomer derivatives
US7632918B2 (en) * 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US8236926B2 (en) * 2006-09-06 2012-08-07 Wisconsin Alumni Research Foundation Rapid glycopeptide optimization via neoglycosylation
WO2008075684A1 (ja) * 2006-12-19 2008-06-26 Shionogi & Co., Ltd. グリコペプチド抗生物質誘導体
GB2449156B8 (en) * 2007-05-08 2010-06-02 Lead Therapeutics Inc Semi-synthetic glycopeptides with antibacterial activity.
US20090062268A1 (en) * 2007-08-27 2009-03-05 Lead Therapeutics, Inc. Novel inhibitors of poly(adp-ribose)polymerase (parp)
CA2710602A1 (en) * 2007-12-26 2009-07-09 Lead Therapeutics, Inc. Novel semi-synthetic glycopeptides as antibacterial agents
WO2010048340A2 (en) * 2008-10-24 2010-04-29 Lead Therapeutics, Inc. Novel semi-synthetic glycopeptides as antibacterial agents
US20100216699A1 (en) * 2009-02-09 2010-08-26 Lead Therapeutics, Inc. Semi-synthetic glycopeptides having antibacterial activity

Also Published As

Publication number Publication date
AU2009322925A1 (en) 2011-06-30
US20110015119A1 (en) 2011-01-20
WO2010065174A1 (en) 2010-06-10
EP2373694A1 (en) 2011-10-12
KR20110099028A (ko) 2011-09-05
GB2465863A (en) 2010-06-09
CN102307903A (zh) 2012-01-04
IL213390A0 (en) 2011-07-31
GB0915258D0 (en) 2009-10-07
TW201021805A (en) 2010-06-16
AR075354A1 (es) 2011-03-30
JP2012510999A (ja) 2012-05-17

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CA2710602A1 (en) Novel semi-synthetic glycopeptides as antibacterial agents
US20080214444A1 (en) Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
WO2011140009A1 (en) Methods of using semi-synthetic glycopeptides as antibacterial agents
US20090131304A1 (en) Semi-Synthetic Desmethyl-Vancomycin-Based Glycopeptides With Antibiotic Activity
US7632918B2 (en) Semi-synthetic glycopeptides with antibiotic activity
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US20120252741A1 (en) Novel semi-synthetic glycopeptides as antibacterial agents

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20140903