CA2741034C - Lipoprotein insulin resistance indexes and related methods, systems and computer programs for generating same - Google Patents

Lipoprotein insulin resistance indexes and related methods, systems and computer programs for generating same Download PDF

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Publication number
CA2741034C
CA2741034C CA2741034A CA2741034A CA2741034C CA 2741034 C CA2741034 C CA 2741034C CA 2741034 A CA2741034 A CA 2741034A CA 2741034 A CA2741034 A CA 2741034A CA 2741034 C CA2741034 C CA 2741034C
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Prior art keywords
lipoprotein
insulin resistance
nmr
risk
index
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CA2741034A
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English (en)
French (fr)
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CA2741034A1 (en
Inventor
James D. Otvos
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Liposcience Inc
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Liposcience Inc
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Publication of CA2741034A1 publication Critical patent/CA2741034A1/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104165—Lipid, cholesterol, or triglyceride standard or control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2741034A 2008-10-20 2009-10-20 Lipoprotein insulin resistance indexes and related methods, systems and computer programs for generating same Active CA2741034C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10683308P 2008-10-20 2008-10-20
US61/106,833 2008-10-20
PCT/US2009/005689 WO2010047767A2 (en) 2008-10-20 2009-10-20 Lipoprotein insulin resistance indexes and related methods, systems and computer programs for generating same

Publications (2)

Publication Number Publication Date
CA2741034A1 CA2741034A1 (en) 2010-04-29
CA2741034C true CA2741034C (en) 2021-06-22

Family

ID=42109358

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2741034A Active CA2741034C (en) 2008-10-20 2009-10-20 Lipoprotein insulin resistance indexes and related methods, systems and computer programs for generating same

Country Status (7)

Country Link
US (1) US8386187B2 (https=)
EP (2) EP2344890B1 (https=)
JP (1) JP5393798B2 (https=)
KR (1) KR20110086074A (https=)
AU (1) AU2009308124B2 (https=)
CA (1) CA2741034C (https=)
WO (1) WO2010047767A2 (https=)

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KR20110086074A (ko) 2008-10-20 2011-07-27 리포사이언스, 인크. 지질단백질 인슐린 저항성 지표 및 이와 관련된 방법, 시스템 및 이를 생성하기 위한 컴퓨터 프로그램
SG10201608139VA (en) * 2011-06-30 2016-11-29 Liposcience Inc Quantitative nmr clinical analyzers with automatic nmr temperature sensitivity compensation that accommodate large ambient operational temperature ranges
TWI596494B (zh) 2012-03-05 2017-08-21 Ｏｐｋｏ診斷法有限責任公司 預測前列腺癌風險及前列腺腺體體積之方法及裝置
US9483612B2 (en) 2012-04-27 2016-11-01 Liposcience, Inc. CHD risk stratification evaluations for subjects with high levels of large HDL-P
US9361429B2 (en) * 2012-06-08 2016-06-07 Liposcience, Inc. Multi-parameter diabetes risk evaluations
US9928345B2 (en) 2012-06-08 2018-03-27 Liposciences, Inc. Multiple-marker risk parameters predictive of conversion to diabetes
US9470771B2 (en) 2012-06-08 2016-10-18 Liposcience, Inc. NMR measurements of NMR biomarker GlycA
US9551768B2 (en) 2013-03-15 2017-01-24 East Carolina University NMR method for monitoring changes in the core of lipoprotein particles in metabolism and disease
CA2931648C (en) * 2014-01-06 2022-11-29 Liposcience, Inc. Multiple-marker risk parameters predictive of conversion to diabetes
KR102505543B1 (ko) 2014-03-28 2023-03-02 옵코 다이어그노스틱스, 엘엘씨 전립선암 진단에 관한 조성물 및 방법
US12326453B2 (en) 2014-03-28 2025-06-10 Opko Diagnostics, Llc Compositions and methods for active surveillance of prostate cancer
US9952232B2 (en) 2014-09-11 2018-04-24 Liposcience, Inc. Cardiovascular risk evaluations using a risk parameter that includes an HDL and inflammatory biomarker interaction parameter
WO2016123163A2 (en) 2015-01-27 2016-08-04 Kardiatonos, Inc. Biomarkers of vascular disease
PT3253800T (pt) 2015-03-27 2021-04-28 Opko Diagnostics Llc Padrões de antigénio da próstata e suas utilizações
KR102539142B1 (ko) 2016-09-05 2023-06-01 삼성전자주식회사 스펙트럼 분석 장치와 방법, 및 혈당 측정 장치
US10775458B2 (en) 2018-03-05 2020-09-15 Texas Tech University System Method and system for non-invasive measurement of metabolic health
US12289368B2 (en) * 2020-10-29 2025-04-29 Telefonaktiebolaget Lm Ericsson (Publ) Checking state consistency in a log replication configuration
CN113117241B (zh) * 2021-04-15 2022-01-28 中国科学院合肥物质科学研究院 一种提高胰岛素水平和敏感性的磁场发生装置及其应用
CN115188493A (zh) * 2022-07-13 2022-10-14 天津市人民医院 一种胰岛素抵抗预测模型的构建系统、方法及应用
WO2024097429A1 (en) * 2022-11-05 2024-05-10 Texas Tech University System Methods and tools for assessing cardiometabolic health and hidden disease risk among apparently healthy individuals
CN120613144B (zh) * 2025-05-27 2026-02-03 中国科学院精密测量科学与技术创新研究院 一种基于血液nmr编辑谱的药物敏感度预测方法
CN120280166A (zh) * 2025-06-10 2025-07-08 南昌大学第二附属医院 术后胰岛素抵抗风险预测模型的构建方法及系统

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US4933844A (en) 1988-09-26 1990-06-12 Otvos James D Measurement of blood lipoprotein constituents by analysis of data acquired from an NMR spectrometer
WO1993003450A1 (en) 1991-07-30 1993-02-18 North Carolina State University Method and apparatus for measuring blood lipoprotein levels by nmr spectroscopy
US6653140B2 (en) * 1999-02-26 2003-11-25 Liposcience, Inc. Methods for providing personalized lipoprotein-based risk assessments
EP1171778B1 (en) * 1999-04-22 2006-03-01 Liposcience, Inc. Nmr-method for determining the risk of developing type 2 diabetes
US7395158B2 (en) * 2000-05-30 2008-07-01 Sensys Medical, Inc. Method of screening for disorders of glucose metabolism
US6890905B2 (en) * 2001-04-02 2005-05-10 Prosidion Limited Methods for improving islet signaling in diabetes mellitus and for its prevention
WO2003012416A1 (en) * 2001-08-01 2003-02-13 Liposcience, Inc. Method of determining presence and concentration of lipoprotein x in blood plasma and serum
CA2467420A1 (en) * 2001-11-13 2003-05-22 The Regents Of The University Of California Ion mobility analysis of biological particles
WO2004040407A2 (en) 2002-10-25 2004-05-13 Liposcience, Inc. Methods, systems and computer programs for deconvolving the spectral contribution of chemical constituents with overlapping signals
DE10315877B4 (de) * 2003-04-08 2005-11-17 Roche Diagnostics Gmbh Krankheitsverlaufkontrolle
FR2853911B1 (fr) * 2003-04-17 2005-07-08 Merck Sante Sas Gene induit par l'insuline, comme cible therapeutique dans le diabete
ES2556164T3 (es) * 2003-09-23 2016-01-13 The General Hospital Corporation Cribado de la preeclampsia
WO2005098463A2 (en) * 2004-04-01 2005-10-20 Liposcience, Inc. Nmr clinical analyzers and related methods, systems, modules and computer program products for clinical evaluation of biosamples
ES2571929T3 (es) * 2004-05-26 2016-05-27 Region Nordjylland Procedimiento para determinar la cantidad de CD36 circulante
DE102004026903B4 (de) * 2004-06-01 2006-05-18 Universität Regensburg Verfahren zur Bestimmung von Lipoproteinen in Körperflüssigkeiten und Messanordnung dafür
WO2006014678A2 (en) * 2004-07-20 2006-02-09 Genentech, Inc. Compositions and methods of using angiopoietin-like 4 protein
JP4210855B2 (ja) * 2004-09-28 2009-01-21 大塚製薬株式会社 インスリン抵抗性の評価方法
US7323296B2 (en) * 2004-10-01 2008-01-29 Yuanhong Ma Method and index for diagnosing insulin resistance
EP1645877A1 (en) * 2004-10-08 2006-04-12 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Method for providing a insulin resistance biomarker profile of one or more lipids
WO2006110082A1 (en) * 2005-04-11 2006-10-19 Astrazeneca Ab A method and a kit for diagnosing type 2 diabetes, metabolic syndrome, sub clinical atherosclerosis, myocardial infarct, stroke or clinical manifestations of diabetes.
WO2007133593A2 (en) * 2006-05-10 2007-11-22 Liposcience, Inc. Methods, systems and computer programs for assessing chd risk using weighted hdl particle number measurements
MX2010000414A (es) * 2007-07-17 2010-04-01 Metabolon Inc Biomarcadores para prediabetes, enfermedades cardiovasculares y otros trastornos relacionados con sindrome metabolico, y metodos de uso de los mismos.
US20090191576A1 (en) * 2008-01-28 2009-07-30 Yuanhong Ma Method and index for diagnosing insulin resistance
KR20110086074A (ko) 2008-10-20 2011-07-27 리포사이언스, 인크. 지질단백질 인슐린 저항성 지표 및 이와 관련된 방법, 시스템 및 이를 생성하기 위한 컴퓨터 프로그램

Also Published As

Publication number Publication date
WO2010047767A2 (en) 2010-04-29
US8386187B2 (en) 2013-02-26
WO2010047767A3 (en) 2010-08-26
CA2741034A1 (en) 2010-04-29
US20100100334A1 (en) 2010-04-22
EP2344890A2 (en) 2011-07-20
EP2344890A4 (en) 2012-12-26
EP2344890B1 (en) 2021-08-11
JP5393798B2 (ja) 2014-01-22
EP4016105A1 (en) 2022-06-22
KR20110086074A (ko) 2011-07-27
AU2009308124A1 (en) 2010-04-29
JP2012506051A (ja) 2012-03-08
AU2009308124B2 (en) 2014-12-11

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