CA2738549A1

CA2738549A1 - Use of pituitary adenylate cyclase-activating polypeptide (pacap) and pacap analogs as adjunctive treatments with anticancer agents

Use of pituitary adenylate cyclase-activating polypeptide (pacap) and pacap analogs as adjunctive treatments with anticancer agents Download PDF

Info

Publication number: CA2738549A1
Authority: CA; Canada
Prior art keywords: pacap; compound; subject; administered; pacap38
Prior art date: 2008-09-25
Legal status : Abandoned

Application number

CA2738549A

Other languages

English (en)

French (fr)

Inventor

Min Li

Jerome L. Maderdrut

David H. Coy

Vecihi Batuman

Current Assignee

Tulane University

Original Assignee

Tulane University

Priority date

2008-09-25

Filing date

2009-09-25

Publication date

2010-04-01

2009-09-25 Application filed by Tulane University filed Critical Tulane University

2010-04-01 Publication of CA2738549A1 publication Critical patent/CA2738549A1/en

Status Abandoned legal-status Critical Current

Links

239000002246 antineoplastic agent Substances 0.000 title claims abstract description 109
238000011282 treatment Methods 0.000 title claims abstract description 71
UFTCZKMBJOPXDM-XXFCQBPRSA-N pituitary adenylate cyclase-activating polypeptide Chemical compound C([C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CN=CN1 UFTCZKMBJOPXDM-XXFCQBPRSA-N 0.000 title abstract description 120
108010004684 Pituitary adenylate cyclase-activating polypeptide Proteins 0.000 title description 309
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