CA2732440C - Cystamine analogues for the treatment of parkinson`s disease - Google Patents
Cystamine analogues for the treatment of parkinson`s disease Download PDFInfo
- Publication number
- CA2732440C CA2732440C CA2732440A CA2732440A CA2732440C CA 2732440 C CA2732440 C CA 2732440C CA 2732440 A CA2732440 A CA 2732440A CA 2732440 A CA2732440 A CA 2732440A CA 2732440 C CA2732440 C CA 2732440C
- Authority
- CA
- Canada
- Prior art keywords
- cystamine
- pharmaceutically acceptable
- cysteine
- acceptable salt
- analogue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
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- Neurology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2732440A CA2732440C (en) | 2011-02-23 | 2011-02-23 | Cystamine analogues for the treatment of parkinson`s disease |
| BR112013021616-6A BR112013021616A2 (pt) | 2011-02-23 | 2012-02-23 | análogos de cistamina para o tratamento de doença de parkinson |
| US14/000,234 US20140073694A1 (en) | 2011-02-23 | 2012-02-23 | Cystamine analogues for the treatment of parkinson's disease |
| AU2012220314A AU2012220314B2 (en) | 2011-02-23 | 2012-02-23 | Cystamine analogues for the treatment of Parkinson's disease |
| JP2013554768A JP6000985B2 (ja) | 2011-02-23 | 2012-02-23 | パーキンソン病を治療するためのシスタミン類似体 |
| KR1020137024680A KR20140115239A (ko) | 2011-02-23 | 2012-02-23 | 파킨슨병 치료용 시스타민 유사체 |
| CN2012800099995A CN103442704A (zh) | 2011-02-23 | 2012-02-23 | 用于治疗帕金森病的胱胺类似物 |
| PCT/CA2012/050106 WO2012113079A1 (en) | 2011-02-23 | 2012-02-23 | Cystamine analogues for the treatment of parkinson's disease |
| MX2013009608A MX350195B (es) | 2011-02-23 | 2012-02-23 | Analogos de cistamina para el tratamiento de la enfermedad de parkinson. |
| EP12750124.5A EP2678009B1 (en) | 2011-02-23 | 2012-02-23 | Cystamine analogues for the treatment of parkinson's disease |
| RU2013137645A RU2630583C2 (ru) | 2011-02-23 | 2012-02-23 | Аналоги цистамина, применяемые для лечения болезни паркинсона |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2732440A CA2732440C (en) | 2011-02-23 | 2011-02-23 | Cystamine analogues for the treatment of parkinson`s disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2732440A1 CA2732440A1 (en) | 2012-08-23 |
| CA2732440C true CA2732440C (en) | 2017-10-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2732440A Expired - Fee Related CA2732440C (en) | 2011-02-23 | 2011-02-23 | Cystamine analogues for the treatment of parkinson`s disease |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20140073694A1 (enExample) |
| EP (1) | EP2678009B1 (enExample) |
| JP (1) | JP6000985B2 (enExample) |
| KR (1) | KR20140115239A (enExample) |
| CN (1) | CN103442704A (enExample) |
| AU (1) | AU2012220314B2 (enExample) |
| BR (1) | BR112013021616A2 (enExample) |
| CA (1) | CA2732440C (enExample) |
| MX (1) | MX350195B (enExample) |
| RU (1) | RU2630583C2 (enExample) |
| WO (1) | WO2012113079A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR096629A1 (es) * | 2013-06-17 | 2016-01-20 | Raptor Pharmaceuticals Inc | Métodos para analizar composiciones de cisteamina |
| TW201618760A (zh) * | 2014-11-05 | 2016-06-01 | 雷普特製藥有限公司 | 使用半胱胺組合物治療亨廷頓氏病之方法 |
| KR20180004756A (ko) | 2015-05-06 | 2018-01-12 | 신애질 코포레이션 | 약물 입자를 함유하는 제약 현탁액, 그의 투여를 위한 장치, 및 그의 사용 방법 |
| RU2766579C2 (ru) | 2015-07-02 | 2022-03-15 | ХОРАЙЗОН ОРФАН ЭлЭлСи | Цистеаминдиоксигеназа-резистентные аналоги цистеамина и их применение |
| US10764961B2 (en) | 2016-03-30 | 2020-09-01 | Guangdong Oppo Mobile Telecommunications Corp., Ltd. | Relay transmission method and device |
| WO2020198529A1 (en) * | 2019-03-26 | 2020-10-01 | The Regents Of The University Ofcalifornia | Substituted amino-thiol and amino-disulfide compounds, and uses thereof |
| US20220265583A1 (en) * | 2019-07-30 | 2022-08-25 | The Regents Of The University Of California | Methods and composition for treating respiratory obstructive diseases |
| CN119909064B (zh) * | 2025-04-07 | 2025-08-15 | 北京大学深圳研究生院 | 胱胺衍生物或其盐以及其在制备具有抗氧化功效的药物中的应用 |
| CN120437102B (zh) * | 2025-07-09 | 2025-09-16 | 中南大学湘雅医院 | 胱胺在制备治疗脓毒症脑病药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060211624A1 (en) * | 2003-02-02 | 2006-09-21 | Goverment of the US, as Represented by | Methods and compositions for the treatment of parkinson's disease and other alpha-synucleinopathies |
| RU2255775C1 (ru) * | 2003-12-25 | 2005-07-10 | Государственное учреждение научно-исследовательский институт неврологии Российской академии медицинских наук | Способ лечения болезни паркинсона |
| CA2640531C (en) * | 2006-01-27 | 2017-01-03 | The Regents Of The University Of California | Enterically coated cysteamine, cystamine and derivatives thereof |
| WO2008143876A2 (en) * | 2007-05-14 | 2008-11-27 | The Trustees Of Columia University In The City Of New York | Agents and assays for modulating neurodegeneration |
| CN102065687A (zh) * | 2008-06-13 | 2011-05-18 | 泰华制药工业有限公司 | 雷沙吉兰用于改善帕金森氏症 |
-
2011
- 2011-02-23 CA CA2732440A patent/CA2732440C/en not_active Expired - Fee Related
-
2012
- 2012-02-23 US US14/000,234 patent/US20140073694A1/en not_active Abandoned
- 2012-02-23 KR KR1020137024680A patent/KR20140115239A/ko not_active Ceased
- 2012-02-23 JP JP2013554768A patent/JP6000985B2/ja not_active Expired - Fee Related
- 2012-02-23 MX MX2013009608A patent/MX350195B/es active IP Right Grant
- 2012-02-23 AU AU2012220314A patent/AU2012220314B2/en not_active Ceased
- 2012-02-23 BR BR112013021616-6A patent/BR112013021616A2/pt not_active IP Right Cessation
- 2012-02-23 CN CN2012800099995A patent/CN103442704A/zh active Pending
- 2012-02-23 EP EP12750124.5A patent/EP2678009B1/en not_active Not-in-force
- 2012-02-23 RU RU2013137645A patent/RU2630583C2/ru not_active IP Right Cessation
- 2012-02-23 WO PCT/CA2012/050106 patent/WO2012113079A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140115239A (ko) | 2014-09-30 |
| AU2012220314B2 (en) | 2017-04-06 |
| US20140073694A1 (en) | 2014-03-13 |
| AU2012220314A1 (en) | 2013-08-22 |
| BR112013021616A2 (pt) | 2020-09-29 |
| EP2678009B1 (en) | 2017-11-01 |
| CA2732440A1 (en) | 2012-08-23 |
| JP2014508758A (ja) | 2014-04-10 |
| CN103442704A (zh) | 2013-12-11 |
| JP6000985B2 (ja) | 2016-10-05 |
| RU2013137645A (ru) | 2015-02-20 |
| RU2630583C2 (ru) | 2017-09-11 |
| WO2012113079A1 (en) | 2012-08-30 |
| EP2678009A1 (en) | 2014-01-01 |
| MX350195B (es) | 2017-08-30 |
| MX2013009608A (es) | 2013-09-16 |
| EP2678009A4 (en) | 2014-08-06 |
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