CA2731432A1 - Tri-cyclic pyrazolopyridine kinase inhibitors - Google Patents
Tri-cyclic pyrazolopyridine kinase inhibitors Download PDFInfo
- Publication number
- CA2731432A1 CA2731432A1 CA2731432A CA2731432A CA2731432A1 CA 2731432 A1 CA2731432 A1 CA 2731432A1 CA 2731432 A CA2731432 A CA 2731432A CA 2731432 A CA2731432 A CA 2731432A CA 2731432 A1 CA2731432 A1 CA 2731432A1
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- Prior art keywords
- independently
- optionally
- substituted
- ring
- compound
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- 229940043355 kinase inhibitor Drugs 0.000 title description 6
- 239000003757 phosphotransferase inhibitor Substances 0.000 title description 4
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
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- Physical Education & Sports Medicine (AREA)
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- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8291908P | 2008-07-23 | 2008-07-23 | |
| US61/082,919 | 2008-07-23 | ||
| US11603208P | 2008-11-19 | 2008-11-19 | |
| US61/116,032 | 2008-11-19 | ||
| US14010008P | 2008-12-23 | 2008-12-23 | |
| US61/140,100 | 2008-12-23 | ||
| US16315209P | 2009-03-25 | 2009-03-25 | |
| US61/163,152 | 2009-03-25 | ||
| PCT/US2009/051437 WO2010011772A2 (en) | 2008-07-23 | 2009-07-22 | Tri-cyclic pyrazolopyridine kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2731432A1 true CA2731432A1 (en) | 2010-01-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2731432A Abandoned CA2731432A1 (en) | 2008-07-23 | 2009-07-22 | Tri-cyclic pyrazolopyridine kinase inhibitors |
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| Country | Link |
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| EP (1) | EP2318408B1 (enExample) |
| JP (2) | JP2011529066A (enExample) |
| KR (1) | KR20110033299A (enExample) |
| CN (1) | CN102159574A (enExample) |
| AR (1) | AR074171A1 (enExample) |
| AU (1) | AU2009274027A1 (enExample) |
| BR (1) | BRPI0916295A2 (enExample) |
| CA (1) | CA2731432A1 (enExample) |
| IL (1) | IL210822A0 (enExample) |
| MX (1) | MX2011000843A (enExample) |
| TW (1) | TW201018680A (enExample) |
| WO (1) | WO2010011772A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP3140759B2 (ja) | 1990-04-02 | 2001-03-05 | キンセキ株式会社 | 弾性表面波素子の製造方法 |
| JP3362860B2 (ja) | 1991-01-09 | 2003-01-07 | 大日本印刷株式会社 | 表面弾性波素子の製造方法 |
| MX2012008642A (es) * | 2010-01-27 | 2012-11-23 | Vertex Pharma | Inhibidores de cinasas de pirazolopiridinas. |
| EP2528917B1 (en) * | 2010-01-27 | 2016-10-19 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridines useful for the treatment of autoimmune, inflammatory or (hyper)proliferative diseases |
| EP2582702A1 (en) | 2010-01-27 | 2013-04-24 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrimidine kinase inhibitors |
| AU2011209649A1 (en) | 2010-01-27 | 2012-08-09 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrazine kinase inhibitors |
| US20130096160A1 (en) * | 2010-04-14 | 2013-04-18 | Secretary, Department Of Health And Human Services | Arylthiazolyl piperidines and related compounds as modulators of survival motor neuron (smn) protein production |
| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| JP2013545817A (ja) | 2010-12-16 | 2013-12-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | インフルエンザウイルス複製阻害物質 |
| AU2011343647A1 (en) | 2010-12-16 | 2013-05-02 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| US8846712B2 (en) | 2011-09-12 | 2014-09-30 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2567959B1 (en) * | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013037390A1 (en) * | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) * | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2771340B1 (en) * | 2011-10-25 | 2016-04-13 | Sanofi | 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2847191B1 (en) | 2012-05-09 | 2016-06-15 | Sanofi | Substituted 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors |
| WO2013184985A1 (en) | 2012-06-08 | 2013-12-12 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| WO2014181813A1 (ja) * | 2013-05-10 | 2014-11-13 | 武田薬品工業株式会社 | 複素環化合物 |
| ES2824576T3 (es) * | 2015-06-19 | 2021-05-12 | Novartis Ag | Compuestos y composiciones para inhibir la actividad de SHP2 |
| JP6828271B2 (ja) | 2016-05-18 | 2021-02-10 | ソニー株式会社 | 通信装置、通信方法、プログラム、および、通信システム |
| EP3600328A4 (en) * | 2017-03-24 | 2021-01-06 | 3100 Central Expressway LLC | MERGED TRIAZOLO-PYRIMIDINE COMPOUNDS WITH USEFUL PHARMACEUTICAL APPLICATION |
| EP3668513B1 (en) * | 2017-08-15 | 2021-11-10 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use in treating blood disorders |
| CN111620866A (zh) * | 2019-02-27 | 2020-09-04 | 南京药石科技股份有限公司 | 一种顺式-7,7-二氟-六氢-1H 吡咯并[3,4-c]吡啶衍生物及其制备方法 |
| TW202337433A (zh) * | 2022-02-08 | 2023-10-01 | 美商德洛斯股份有限公司 | 用於治療癌症及其他適應症之組成物及方法 |
| CN118834206A (zh) * | 2023-04-24 | 2024-10-25 | 北京宇繁科技有限责任公司 | 一种map4k4抑制剂及其制备方法和应用 |
| WO2026076002A1 (en) * | 2024-10-01 | 2026-04-09 | Theras, Inc. | Compositions and methods for use in the treatment of cancer and other indications |
| WO2026080382A1 (en) * | 2024-10-07 | 2026-04-16 | Theras, Inc. | Compositions and methods for use in the treatment of cancer and other indications |
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| DE10222550A1 (de) * | 2002-05-17 | 2003-11-27 | Bayer Ag | Substituierte Benzyl-pyrazolopyridine |
| US7186716B2 (en) * | 2002-08-12 | 2007-03-06 | Sugen, Inc. | 3-Pyrrol-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors |
| ES2364340T3 (es) * | 2004-03-30 | 2011-08-31 | Vertex Pharmaceuticals Incorporated | Azaindoles útiles como inhibidores de jak y otras proteína quinasas. |
| US7514448B2 (en) * | 2004-04-02 | 2009-04-07 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of rock and other protein kinases |
| AU2006247322A1 (en) * | 2005-05-16 | 2006-11-23 | Irm Llc | Pyrrolopyridine derivatives as protein kinase inhibitors |
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2009
- 2009-07-22 CA CA2731432A patent/CA2731432A1/en not_active Abandoned
- 2009-07-22 CN CN2009801367212A patent/CN102159574A/zh active Pending
- 2009-07-22 KR KR1020117004087A patent/KR20110033299A/ko not_active Withdrawn
- 2009-07-22 BR BRPI0916295A patent/BRPI0916295A2/pt not_active IP Right Cessation
- 2009-07-22 JP JP2011520175A patent/JP2011529066A/ja not_active Withdrawn
- 2009-07-22 AU AU2009274027A patent/AU2009274027A1/en not_active Abandoned
- 2009-07-22 EP EP09790736.4A patent/EP2318408B1/en active Active
- 2009-07-22 MX MX2011000843A patent/MX2011000843A/es not_active Application Discontinuation
- 2009-07-22 WO PCT/US2009/051437 patent/WO2010011772A2/en not_active Ceased
- 2009-07-23 TW TW098124909A patent/TW201018680A/zh unknown
- 2009-07-23 AR ARP090102815A patent/AR074171A1/es unknown
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2011
- 2011-01-23 IL IL210822A patent/IL210822A0/en unknown
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2014
- 2014-08-11 JP JP2014163360A patent/JP5931976B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010011772A3 (en) | 2010-04-29 |
| WO2010011772A2 (en) | 2010-01-28 |
| AU2009274027A1 (en) | 2010-01-28 |
| MX2011000843A (es) | 2011-04-11 |
| JP5931976B2 (ja) | 2016-06-08 |
| BRPI0916295A2 (pt) | 2019-09-24 |
| EP2318408B1 (en) | 2016-02-17 |
| KR20110033299A (ko) | 2011-03-30 |
| JP2011529066A (ja) | 2011-12-01 |
| IL210822A0 (en) | 2011-04-28 |
| AR074171A1 (es) | 2010-12-29 |
| TW201018680A (en) | 2010-05-16 |
| CN102159574A (zh) | 2011-08-17 |
| JP2014208710A (ja) | 2014-11-06 |
| EP2318408A2 (en) | 2011-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20140722 |