CA2719718C - Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor - Google Patents

Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor Download PDF

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Publication number
CA2719718C
CA2719718C CA2719718A CA2719718A CA2719718C CA 2719718 C CA2719718 C CA 2719718C CA 2719718 A CA2719718 A CA 2719718A CA 2719718 A CA2719718 A CA 2719718A CA 2719718 C CA2719718 C CA 2719718C
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Canada
Prior art keywords
cancer
transcript
mtdna
seq
mitochondrial
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Expired - Fee Related
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CA2719718A
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English (en)
French (fr)
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CA2719718A1 (en
Inventor
Ryan Parr
Gabriel Dakubo
Jennifer Creed
Kerry Robinson
Brian Reguly
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MDNA LIFE SCIENCES Inc
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Priority to CA3044262A priority Critical patent/CA3044262C/en
Publication of CA2719718A1 publication Critical patent/CA2719718A1/en
Application granted granted Critical
Publication of CA2719718C publication Critical patent/CA2719718C/en
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
CA2719718A 2008-03-28 2009-03-27 Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor Expired - Fee Related CA2719718C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3044262A CA3044262C (en) 2008-03-28 2009-03-27 Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4061608P 2008-03-28 2008-03-28
US61/040,616 2008-03-28
PCT/CA2009/000351 WO2009117811A1 (en) 2008-03-28 2009-03-27 Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3044262A Division CA3044262C (en) 2008-03-28 2009-03-27 Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor

Publications (2)

Publication Number Publication Date
CA2719718A1 CA2719718A1 (en) 2009-10-01
CA2719718C true CA2719718C (en) 2019-07-02

Family

ID=41112880

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2719718A Expired - Fee Related CA2719718C (en) 2008-03-28 2009-03-27 Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor
CA3044262A Active CA3044262C (en) 2008-03-28 2009-03-27 Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3044262A Active CA3044262C (en) 2008-03-28 2009-03-27 Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor

Country Status (10)

Country Link
US (4) US20110172113A1 (enExample)
EP (1) EP2274426B1 (enExample)
JP (1) JP5938690B2 (enExample)
KR (2) KR101693387B1 (enExample)
CN (3) CN107011428B (enExample)
AU (1) AU2009227935B2 (enExample)
CA (2) CA2719718C (enExample)
NZ (2) NZ588658A (enExample)
SG (3) SG192453A1 (enExample)
WO (1) WO2009117811A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107011428B (zh) * 2008-03-28 2022-02-25 Mdna生命科学有限公司 异常线粒体dna、相关的融合转录物及其杂交探针
EP2411522B1 (en) * 2009-03-27 2017-09-06 MDNA Life Sciences Inc. Aberrant mitochondrial dna, associated fusion transcripts and translation products and hybridization probes therefor
AU2011223463B2 (en) * 2010-03-01 2015-07-30 Mdna Life Sciences Inc. UV associated mtDNA fusion transcripts and methods and uses thereof
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
CA2807942C (en) 2010-08-10 2021-07-27 Ecole Polytechnique Federale De Lausanne Erythrocyte-binding therapeutics
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
CA2946064C (en) 2014-02-21 2023-09-26 Ecole Polytechnique Federale De Lausanne (Epfl) Glycotargeting therapeutics
EP3475448B1 (en) * 2016-06-22 2022-03-30 Degen Zhuo Method and kit for detecting fusion transcripts
US11978535B2 (en) * 2017-02-01 2024-05-07 The Translational Genomics Research Institute Methods of detecting somatic and germline variants in impure tumors
US11253579B2 (en) 2017-06-16 2022-02-22 The University Of Chicago Compositions and methods for inducing immune tolerance
WO2019191079A1 (en) * 2018-03-26 2019-10-03 The University Of Chicago Methods and compositions for targeting liver and lymph node sinusoidal endothelial cell c-type lectin (lsectin)
AU2019265734B2 (en) 2018-05-09 2026-03-19 Anokion Sa Compositions and methods concerning immune tolerance
CA3124497A1 (en) * 2018-12-22 2020-06-25 Mdna Life Sciences Inc. Mitochondrial dna deletions associated with endometriosis
CN117384269B (zh) * 2023-09-21 2024-06-18 南方医科大学南方医院 短肽mfrlp及其在制备动脉重塑相关疾病药物中的应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) * 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4275149A (en) * 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) * 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US6605433B1 (en) * 1998-08-20 2003-08-12 The Johns Hopkins University Mitochondrial dosimeter
US6203990B1 (en) * 1998-11-06 2001-03-20 Mitokor Method and system for pattern analysis, such as for analyzing oligonucleotide primer extension assay products
US6933120B2 (en) * 2000-06-20 2005-08-23 Michael D. Seidman Method of determining biological/molecular age
JP2005506057A (ja) * 2001-06-11 2005-03-03 １３０４８５４ オンタリオ・リミテッド 健康科学のための診断ツールとしての全ミトコンドリアゲノム配列
US20030162174A1 (en) * 2001-06-11 2003-08-28 Sutherland John W. Detecting nucleic acid deletion sequences
US20050026167A1 (en) * 2001-06-11 2005-02-03 Mark Birch-Machin Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
GB2380194B (en) * 2001-10-01 2005-06-22 Roger Michael Marchbanks A mitochondrial mutation associated with schizophrenia and increased oxidative stress
US20060051796A1 (en) * 2004-09-09 2006-03-09 Inga Boell Real time PCR with the addition of pyrophosphatase
SG2014011837A (en) * 2005-04-18 2014-04-28 Mitomics Inc Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers
US20070134678A1 (en) * 2005-12-12 2007-06-14 Rees Dianne M Comparative genome hybridization of organelle genomes
ES2484044T3 (es) 2007-09-26 2014-08-08 Mitomics Inc. Deleción de 3,4 kb en el ADN mitocondrial para uso en la detección de cáncer
CN107011428B (zh) * 2008-03-28 2022-02-25 Mdna生命科学有限公司 异常线粒体dna、相关的融合转录物及其杂交探针
EP2411522B1 (en) 2009-03-27 2017-09-06 MDNA Life Sciences Inc. Aberrant mitochondrial dna, associated fusion transcripts and translation products and hybridization probes therefor
AU2011223463B2 (en) * 2010-03-01 2015-07-30 Mdna Life Sciences Inc. UV associated mtDNA fusion transcripts and methods and uses thereof

Also Published As

Publication number Publication date
KR101819852B1 (ko) 2018-02-28
US20110172113A1 (en) 2011-07-14
CN102016039B (zh) 2017-06-09
SG10201400985RA (en) 2014-05-29
US10266899B2 (en) 2019-04-23
JP2011515091A (ja) 2011-05-19
NZ602175A (en) 2014-03-28
AU2009227935A1 (en) 2009-10-01
EP2274426A4 (en) 2011-11-16
SG174514A1 (en) 2011-10-28
KR20110004860A (ko) 2011-01-14
US20190382846A1 (en) 2019-12-19
SG192453A1 (en) 2013-08-30
EP2274426A1 (en) 2011-01-19
US20130059299A1 (en) 2013-03-07
US20170152567A1 (en) 2017-06-01
CN102016039A (zh) 2011-04-13
CN107011428A (zh) 2017-08-04
CN102388140B (zh) 2015-07-08
AU2009227935B2 (en) 2015-07-09
WO2009117811A1 (en) 2009-10-01
JP5938690B2 (ja) 2016-06-22
KR20170004033A (ko) 2017-01-10
CN107011428B (zh) 2022-02-25
EP2274426B1 (en) 2016-11-16
KR101693387B1 (ko) 2017-01-05
CA3044262A1 (en) 2009-10-01
CA2719718A1 (en) 2009-10-01
CN102388140A (zh) 2012-03-21
NZ588658A (en) 2012-10-26
CA3044262C (en) 2023-02-28
US8715960B2 (en) 2014-05-06

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Effective date: 20140304

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