CA2718262A1 - Formulations of vitamin k analogs for topical use - Google Patents

Formulations of vitamin k analogs for topical use Download PDF

Info

Publication number
CA2718262A1
CA2718262A1 CA2718262A CA2718262A CA2718262A1 CA 2718262 A1 CA2718262 A1 CA 2718262A1 CA 2718262 A CA2718262 A CA 2718262A CA 2718262 A CA2718262 A CA 2718262A CA 2718262 A1 CA2718262 A1 CA 2718262A1
Authority
CA
Canada
Prior art keywords
formulation
menadione
pharmaceutical formulation
lotion
conforms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2718262A
Other languages
English (en)
French (fr)
Inventor
Christopher G. Salentine
Kieran O'donoghue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Talon Therapeutics Inc
Original Assignee
Hana Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hana Biosciences Inc filed Critical Hana Biosciences Inc
Publication of CA2718262A1 publication Critical patent/CA2718262A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2718262A 2008-03-13 2009-03-13 Formulations of vitamin k analogs for topical use Abandoned CA2718262A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6921808P 2008-03-13 2008-03-13
US61/069,218 2008-03-13
US20493909P 2009-01-13 2009-01-13
US61/204,939 2009-01-13
PCT/US2009/037041 WO2009114745A1 (en) 2008-03-13 2009-03-13 Formulations of vitamin k analogs for topical use

Publications (1)

Publication Number Publication Date
CA2718262A1 true CA2718262A1 (en) 2009-09-17

Family

ID=40677542

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2718262A Abandoned CA2718262A1 (en) 2008-03-13 2009-03-13 Formulations of vitamin k analogs for topical use

Country Status (7)

Country Link
US (2) US8815953B2 (cg-RX-API-DMAC7.html)
EP (1) EP2265255A1 (cg-RX-API-DMAC7.html)
JP (2) JP2011513501A (cg-RX-API-DMAC7.html)
KR (1) KR20110004382A (cg-RX-API-DMAC7.html)
AU (1) AU2009223158B2 (cg-RX-API-DMAC7.html)
CA (1) CA2718262A1 (cg-RX-API-DMAC7.html)
WO (1) WO2009114745A1 (cg-RX-API-DMAC7.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100010100A1 (en) * 2008-07-09 2010-01-14 Hinman Andrew W Dermatological compositions with anti-aging and skin even-toning properties
WO2010014361A1 (en) * 2008-07-30 2010-02-04 Edison Pharmaceuticals, Inc. Naphthoquinone compositions with anti-aging, anti- inflammatory and skin even-toning properties
IN2012DN02184A (cg-RX-API-DMAC7.html) * 2009-09-14 2015-05-22 Nestec Sa
ITPD20100090A1 (it) * 2010-03-22 2011-09-23 Sanitas Farmaceutici S R L Formulazione topica per il trattamento di eruzioni cutanee, in particolare conseguenti a trattamenti con farmaci anti egfr
JP2013538799A (ja) * 2010-08-06 2013-10-17 アンペア ライフ サイエンシーズ,インコーポレイテッド ビタミンkを用いたミトコンドリア病の処置
BR112012027864A2 (pt) 2011-02-14 2016-08-09 J Oil Mills Inc agente de elevação do teor de colágeno na pele
US9421297B2 (en) 2014-04-02 2016-08-23 Adhezion Biomedical, Llc Sterilized compositions of cyanoacrylate monomers and naphthoquinone 2,3-oxides
WO2019072877A1 (en) 2017-10-10 2019-04-18 Capsugel Belgium Nv GETTING MULTIPARTICULAR COMPOSITIONS
CA3085013A1 (en) 2017-12-13 2019-06-20 Onquality Pharmaceuticals China Ltd. A method for preventing or treating egfr-inhibition associated diseases
TW201943428A (zh) 2018-04-16 2019-11-16 大陸商上海岸闊醫藥科技有限公司 預防或治療腫瘤療法副作用的方法
WO2020067663A1 (ko) * 2018-09-28 2020-04-02 주식회사 엘지생활건강 피부 턴오버 촉진 및 멜라닌 배출 촉진용 조성물
KR20220022115A (ko) * 2019-04-17 2022-02-24 아조라 테라퓨틱스 인코포레이티드 염증성 피부 질환을 치료하기 위한 국소 조성물 및 방법
WO2023119230A1 (en) 2021-12-22 2023-06-29 L'oreal Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294852A (en) * 1973-11-01 1981-10-13 Johnson & Johnson Skin treating compositions
EP0015436B1 (de) * 1979-03-08 1982-02-03 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur stereospezifischen Herstellung von Verbindungen der Vitamin K1- und K2-Reihe sowie neue Ausgangsprodukte in diesem Verfahren
JPS6025918A (ja) * 1983-07-25 1985-02-08 Ajinomoto Co Inc 脂溶性薬物含有水性液
DE3406497A1 (de) * 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
DE3514724A1 (de) 1985-04-24 1986-10-30 Albin F. Dr. 4200 Oberhausen Jereb Salbe zur verbeugung und behandlung von augen- und hauterkrankungen
JPS62294636A (ja) * 1986-05-21 1987-12-22 Eisai Co Ltd 2−メチル−1,4−ナフトキノンの製造法
US5180747A (en) * 1989-02-28 1993-01-19 Nisshin Flour Milling Co., Ltd. Stabilized fat-soluble vitamin compositions
ZA902066B (en) 1989-04-14 1990-12-28 Minnesota Mining & Mfg Solid gel external drug delivery system
US4966779A (en) * 1989-12-21 1990-10-30 Basf Corporation Stable, water miscible emulsion comprising a fat-soluble vitamin
US5376645A (en) * 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) * 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5155031A (en) * 1990-06-07 1992-10-13 Posner Barry I Use of pervanadate as an inhibitor of phosphotyrosine phosphatase
FR2672288B1 (fr) * 1991-02-06 1993-04-23 Oreal Nouveaux amides dipeptidiques derivant de la glycyl-serine, utilisables, notamment dans des compositions cosmetiques, pharmaceutiques ou alimentaires.
DE4141351A1 (de) * 1991-12-14 1993-06-17 Basf Ag Stabile pulverfoermige vitamin- und/oder carotinoid-praeparate und verfahren zu deren herstellung
US5650156A (en) * 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
US6537579B1 (en) * 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US5885486A (en) * 1993-03-05 1999-03-23 Pharmaciaand Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
US5785976A (en) * 1993-03-05 1998-07-28 Pharmacia & Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
US5643765A (en) 1993-04-06 1997-07-01 University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5510391A (en) * 1993-10-22 1996-04-23 Mayapple Holdings, Llc Method of treating blood vessel disorders of the skin using vitamin K
FR2719219B1 (fr) * 1994-05-02 1996-06-21 Rocher Yves Biolog Vegetale Composition cosmétique ou pharmaceutique à usage topique comprenant des vésicules lipidiques.
US5637741A (en) * 1994-09-27 1997-06-10 Kuraray Co., Ltd. Process for producing 2-methyl-1,4-naphthoquinone
AU2804297A (en) 1996-04-22 1997-11-12 Advanced Polymer Systems Inc. Method of and composition for treating disorders of the skin using vitamin k
KR0178456B1 (ko) * 1996-04-25 1999-05-15 김흥기 2-메틸-1,4-나프토퀴논(비타민 k3)의 제조방법
SE9601665D0 (sv) * 1996-04-30 1996-04-30 Bioglan Ab Biologically active composition
US6110891A (en) * 1996-06-21 2000-08-29 Alizyme Therapeutics Ltd. Lectin compositions and uses thereof
DE19642359A1 (de) * 1996-10-14 1998-04-16 Basf Ag Stabile Emulsionen und Trockenpulver von Mischungen fettlöslicher Vitamine, deren Herstellung und Verwendung
US5916749A (en) * 1996-12-13 1999-06-29 Incyte Pharmaceuticals, Inc. Human phosphatase inhibitor protein
US6426078B1 (en) * 1997-03-17 2002-07-30 Roche Vitamins Inc. Oil in water microemulsion
US6599513B2 (en) * 1997-05-27 2003-07-29 Sembiosys Genetics Inc. Products for topical applications comprising oil bodies
US6372234B1 (en) * 1997-05-27 2002-04-16 Sembiosys Genetics Inc. Products for topical applications comprising oil bodies
US6696484B2 (en) * 1997-10-31 2004-02-24 University Of Chicago Office Of Technology And Intellectual Property Method and compositions for regulation of 5-alpha reductase activity
AU1289899A (en) * 1997-10-31 1999-05-24 Arch Development Corporation Methods and compositions for regulation of 5-alpha reductase activity
US6013665A (en) * 1997-12-16 2000-01-11 Abbott Laboratories Method for enhancing the absorption and transport of lipid soluble compounds using structured glycerides
AU4438399A (en) 1998-06-11 1999-12-30 University Of Medicine And Dentistry Of New Jersey Wound treatment through inhibition of adenosine diphosphate ribosyl transferase
US6207176B1 (en) * 1998-09-14 2001-03-27 National Starch And Chemical Investment Holding Corporation Starch based adhesives for skin cleaning tape
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6187822B1 (en) * 1999-06-11 2001-02-13 University Of Medicine & Dentistry Of Nj Wound treatment through inhibition of adenosine diphosphate ribosyl transferase
US6524594B1 (en) * 1999-06-23 2003-02-25 Johnson & Johnson Consumer Companies, Inc. Foaming oil gel compositions
US7927612B2 (en) * 2000-01-19 2011-04-19 Baofa Yu Combinations and methods for treating neoplasms
DE10003786A1 (de) 2000-01-28 2001-08-02 Merck Patent Gmbh Galenische Formulierung
EP2000136A3 (en) 2000-02-28 2008-12-31 The University of British Columbia Compositions and methods for the treatment of inflammatory diseases using topoisomerase inhibitors
EP1272059B1 (de) 2000-03-17 2005-12-07 Basf Aktiengesellschaft Verfahren zur herstellung öliger suspensionen wasserlöslicher vitamine
ATE297751T1 (de) * 2000-03-20 2005-07-15 Pfizer Prod Inc Kombinationstherapie mit keratinozyten- wachstumfaktor und ein epidermis-wachstumfaktor inhibitor
US20040047852A1 (en) * 2001-03-02 2004-03-11 Kennedy Thomas Preston Method of treating cancer
US20020040011A1 (en) 2000-06-01 2002-04-04 Brown Dennis M. Naphthoquinone compositions and uses thereof
PL342071A1 (en) 2000-08-18 2001-02-12 Szolomicka Orfinger Irena Cosmetic cream
GB0022079D0 (en) * 2000-09-08 2000-10-25 Inst Of Molecul & Cell Biology Novel protein tyrosine phosphatase inhibitor
US7094431B2 (en) * 2000-10-12 2006-08-22 Mickey L. Peshoff Method of healing skin wounds in mammals and a composition therefor
US6660306B2 (en) * 2000-10-12 2003-12-09 Mickey L. Peshoff Wound healing compound
US6774100B2 (en) * 2000-12-06 2004-08-10 Imaginative Research Associates, Inc. Anhydrous creams, lotions and gels
DK1214930T3 (da) 2000-12-15 2004-07-26 Patrick Dr Franke Hypoallergene og ikke-irriterende formuleringer til hudpleje
US7604812B2 (en) * 2000-12-15 2009-10-20 Patrick Franke Hypoallergenic and non-irritant skin care formulations
US6780439B2 (en) * 2001-03-06 2004-08-24 J. Ronald Wilk Wound treatment solution and method for using same
US6579994B2 (en) * 2001-03-29 2003-06-17 Council Of Scientific And Industrial Research Process for preparation of 2-Methyl-1,4-naphthoquinone
US20070238697A1 (en) * 2001-08-29 2007-10-11 University Of British Columbia Pharmaceutical compositions and methods relating to fucans
US6812220B2 (en) 2001-08-29 2004-11-02 University Of British Columbia Pharmaceutical compositions and methods relating to fucans
US8156471B2 (en) * 2001-11-09 2012-04-10 Oracle International Corporation Multi-language execution method
US7405188B2 (en) * 2001-12-12 2008-07-29 Wsp Chemicals & Technology, Llc Polymeric gel system and compositions for treating keratin substrates containing same
CA2472578A1 (en) 2002-01-24 2003-07-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Anti-cancer combination and use thereof
JP2003226639A (ja) * 2002-01-31 2003-08-12 Hisamitsu Pharmaceut Co Inc 神経成長因子活性増強剤としてのビタミンk類を含む医薬組成物およびその使用
US20030170187A1 (en) * 2002-03-01 2003-09-11 Alfred Marchal Skin treatments containing nano-sized vitamin K
AU2003228974A1 (en) 2002-05-07 2003-11-11 Memgen Corporation Method of and apparatus for forming three-dimensional structures
GB0212749D0 (en) 2002-06-01 2002-07-10 Boots Co Plc Personal care compositions
GB0220182D0 (en) 2002-08-30 2002-10-09 Cardiovascular Res Inst Maastr Organic compounds
US7326690B2 (en) * 2002-10-30 2008-02-05 Bach Pharma, Inc. Modulation of cell fates and activities by phthalazinediones
AU2003230980A1 (en) * 2003-04-18 2004-11-26 Northeastern University Micelle delivery system loaded with a pharmaceutical agent
US7320797B2 (en) * 2003-08-29 2008-01-22 Bioderm Research Antiaging cosmetic delivery systems
CN1856296A (zh) 2003-09-30 2006-11-01 阿库斯菲尔公司 可注射的、口服、或局部用缓释药物制剂
US20050092969A1 (en) * 2003-10-08 2005-05-05 Kaneka Corporation Method of stabilizing compound having quinone skeleton and stabilized composition
JP2005206521A (ja) 2004-01-22 2005-08-04 Nippon Menaade Keshohin Kk 抗菌剤
KR20060002239A (ko) * 2004-07-01 2006-01-09 삼성전자주식회사 레이저 출력 제어장치
US7691418B2 (en) 2004-09-17 2010-04-06 Oystershell Nv Composition for inhibiting or preventing the formation of a biofilm
US20090010887A1 (en) 2004-10-06 2009-01-08 Ben-Sasson Shmuel A Method and composition for enhancing anti-angiogenic therapy
WO2006107827A1 (en) 2005-04-05 2006-10-12 Creighton University Skin bonding process
KR101332869B1 (ko) 2005-04-15 2013-11-25 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 항-egfr 치료법에 속발된 피부 발진의 예방 및 치료를위한 비타민 k
US20060275504A1 (en) * 2005-06-07 2006-12-07 Tty Biopharm Company Limited Methods and compositions for augmenting cancer chemotherapeutic agents
WO2007016050A1 (en) * 2005-07-28 2007-02-08 Global Cosmeceutical Innovations, Llc Composition and method for treating cellulite
US7252816B1 (en) * 2006-03-29 2007-08-07 Dow Pharmaceutical Sciences Topical acne vulgairs medication with a sunscreen
WO2007147128A2 (en) 2006-06-16 2007-12-21 Summa Health System Non-toxic anti-cancer drug combining ascorbate, magnesium and a naphthoquinone
CA2656910C (en) 2006-07-07 2012-08-28 Tiltan Pharma Ltd. Anti-cancer therapy comprising an h2-blocker, at least one antiinflammatory agent and a cytotoxic agent

Also Published As

Publication number Publication date
US8815953B2 (en) 2014-08-26
JP2011513501A (ja) 2011-04-28
KR20110004382A (ko) 2011-01-13
US20140336268A1 (en) 2014-11-13
JP2015042658A (ja) 2015-03-05
AU2009223158A1 (en) 2009-09-17
US20090234022A1 (en) 2009-09-17
AU2009223158B2 (en) 2014-08-28
EP2265255A1 (en) 2010-12-29
WO2009114745A1 (en) 2009-09-17

Similar Documents

Publication Publication Date Title
AU2009223158B2 (en) Formulations of vitamin K analogs for topical use
CA3056395C (en) Topical therapy for the treatment of skin malignancies using nanoparticles of taxanes
AU2013289403B2 (en) Diclofenac formulations
US12447146B2 (en) Topical composition comprising tacrolimus
RU2703713C2 (ru) Композиции для местного нанесения, содержащие биматопрост, и способы стимуляции роста волос с их помощью
US20140107081A1 (en) Salicylic acid topical formulation
US20050137164A1 (en) Diclofenac compositions for the treatment of skin disorders
JP2008531693A (ja) 局所用ゲル組成物
JP5667052B2 (ja) ダナゾールを含む経真皮医薬組成物
US20230293543A1 (en) Fenoldopam topical formulations for treating skin disorders
US12458652B2 (en) Pharmaceutical compositions of spironolactone for deep dermal drug delivery
CN101541321A (zh) 局部用组合物
US20110319811A1 (en) Combination therapy with cryosurgery and low dosage strength imiquimod to treat actinic keratosis
AU2014386711B2 (en) Compositions that assist skin healing and/or maintain skin health
CA3211573A1 (en) Topical cannabinoid compositions and methods for treating skin diseases
HK1119058A (en) Topical gels compositions

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20140228

FZDE Discontinued

Effective date: 20170314