CA2713199C - Topical formulation - Google Patents
Topical formulation Download PDFInfo
- Publication number
- CA2713199C CA2713199C CA2713199A CA2713199A CA2713199C CA 2713199 C CA2713199 C CA 2713199C CA 2713199 A CA2713199 A CA 2713199A CA 2713199 A CA2713199 A CA 2713199A CA 2713199 C CA2713199 C CA 2713199C
- Authority
- CA
- Canada
- Prior art keywords
- composition
- combinations
- formulation
- transdermal
- methimazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000012049 topical pharmaceutical composition Substances 0.000 title description 3
- 239000000203 mixture Substances 0.000 claims abstract description 103
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- 229940079593 drug Drugs 0.000 claims abstract description 50
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 48
- 241000282326 Felis catus Species 0.000 claims description 36
- PMRYVIKBURPHAH-UHFFFAOYSA-N methimazole Chemical compound CN1C=CNC1=S PMRYVIKBURPHAH-UHFFFAOYSA-N 0.000 claims description 36
- 229960002178 thiamazole Drugs 0.000 claims description 36
- 206010020850 Hyperthyroidism Diseases 0.000 claims description 34
- CFOYWRHIYXMDOT-UHFFFAOYSA-N carbimazole Chemical compound CCOC(=O)N1C=CN(C)C1=S CFOYWRHIYXMDOT-UHFFFAOYSA-N 0.000 claims description 32
- 238000011282 treatment Methods 0.000 claims description 32
- 229960001704 carbimazole Drugs 0.000 claims description 31
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 20
- 239000003961 penetration enhancing agent Substances 0.000 claims description 20
- 238000002156 mixing Methods 0.000 claims description 18
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- 235000021314 Palmitic acid Nutrition 0.000 claims description 2
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- JCGNDDUYTRNOFT-UHFFFAOYSA-N oxolane-2,4-dione Chemical compound O=C1COC(=O)C1 JCGNDDUYTRNOFT-UHFFFAOYSA-N 0.000 description 2
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- 238000002360 preparation method Methods 0.000 description 2
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 2
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- 210000001685 thyroid gland Anatomy 0.000 description 2
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
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- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ552816A NZ552816A (en) | 2007-01-24 | 2007-01-24 | Formulation for transdermal administration of antihyperthyroid drug comprising a penetration enhancer selected from oleic acid, d-limonene, pyrrolidones, a C2-C8 alcohol, glycol ethers, triacetin and combinations thereof |
| NZ552816 | 2007-01-24 | ||
| PCT/NZ2008/000011 WO2008091167A1 (en) | 2007-01-24 | 2008-01-22 | Topical formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2713199A1 CA2713199A1 (en) | 2008-07-31 |
| CA2713199C true CA2713199C (en) | 2015-05-19 |
Family
ID=39644688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2713199A Expired - Fee Related CA2713199C (en) | 2007-01-24 | 2008-01-22 | Topical formulation |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8748467B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2124938A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010516761A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008208151B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2713199C (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ552816A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008091167A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ552816A (en) | 2007-01-24 | 2009-05-31 | Bomac Research Ltd | Formulation for transdermal administration of antihyperthyroid drug comprising a penetration enhancer selected from oleic acid, d-limonene, pyrrolidones, a C2-C8 alcohol, glycol ethers, triacetin and combinations thereof |
| RU2576612C2 (ru) * | 2010-09-30 | 2016-03-10 | Тояма Кемикал Ко., Лтд. | Трансдермальный абсорбируемый препарат |
| CA2902282C (en) * | 2013-02-27 | 2023-03-14 | Laurie Robert BATT | Transdermal formulations |
| DE112015002229A5 (de) | 2014-05-13 | 2017-06-29 | Dendropharm Gmbh | Formulierungen zur Behandlung von Hyperthyreose |
| WO2016198472A1 (en) | 2015-06-09 | 2016-12-15 | Hpf Ip Holding S.A. | Topical delivery system |
| AU2018254556B2 (en) * | 2017-04-21 | 2024-05-02 | Steven Hoffman | Compositions and methods for treating retinopathy |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5296222A (en) * | 1989-02-23 | 1994-03-22 | University Of Utah | Percutaneous drug delivery system |
| US5091182A (en) | 1990-07-23 | 1992-02-25 | Syntex (U.S.A.) Inc. | Dispensing units for ketorolac topical gel formlations |
| AU695120B2 (en) | 1993-06-07 | 1998-08-06 | Baylor College Of Medicine | Use of an MHC class I suppressor drug for the treatment of autoimmune diseases and transplantation rejection |
| CN1046089C (zh) * | 1993-07-24 | 1999-11-03 | 陈凌 | 外敷用抗甲状腺乳膏 |
| US5601839A (en) * | 1995-04-26 | 1997-02-11 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
| JP2000513336A (ja) | 1996-05-22 | 2000-10-10 | ディバーシファイド ファーマシューティカルズ，インコーポレーテッド | 薬物の経皮送達のための組成物、方法及びデバイス |
| EP0958355A1 (en) * | 1996-07-23 | 1999-11-24 | Wilson Trafton Crandall | Transdermal transport of molecules |
| US5919436A (en) * | 1997-09-25 | 1999-07-06 | The Board Of Regents Of The University Of Oklahoma | Method of lightening skin |
| US20030170195A1 (en) | 2000-01-10 | 2003-09-11 | Noven Pharmaceuticals, Inc. | Compositions and methods for drug delivery |
| ES2237415T5 (es) | 1999-01-14 | 2008-12-16 | Noven Pharmaceuticals, Inc. | Composiciones dermicas. |
| ATE290856T1 (de) * | 1999-12-16 | 2005-04-15 | Dermatrends Inc | Hydroxide freisetzende verbindungen zum verbessern der hautdurchlässigkeit |
| US7691404B2 (en) * | 2000-11-06 | 2010-04-06 | Samyang Corporation | Transdermal delivery system of diclofenac with improved water absorbability and adhesion properties |
| JP2007516230A (ja) * | 2003-05-19 | 2007-06-21 | トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | 心臓組織の変性を治療及び予防するための組成物及び方法並びにその用途 |
| WO2005009510A2 (en) * | 2003-07-23 | 2005-02-03 | The Regents Of The University Of California | Penetration enhancer combinations for transdermal delivery |
| US20050209295A1 (en) | 2004-03-16 | 2005-09-22 | Kohn Leonard D | Methimazole derivatives and tautomeric cyclic thiones to inhibit cell adhesion |
| FR2873883B1 (fr) * | 2004-07-28 | 2006-09-29 | Sagem | Procede de tramage d'une image |
| CN100406063C (zh) * | 2005-05-18 | 2008-07-30 | 陈凌 | 外敷用抗甲状腺软膏及其制备方法 |
| CN102225046A (zh) | 2005-08-05 | 2011-10-26 | 努沃研究公司 | 透皮释药剂型 |
| NZ552816A (en) | 2007-01-24 | 2009-05-31 | Bomac Research Ltd | Formulation for transdermal administration of antihyperthyroid drug comprising a penetration enhancer selected from oleic acid, d-limonene, pyrrolidones, a C2-C8 alcohol, glycol ethers, triacetin and combinations thereof |
-
2007
- 2007-01-24 NZ NZ552816A patent/NZ552816A/en unknown
-
2008
- 2008-01-22 EP EP08724001A patent/EP2124938A4/en not_active Withdrawn
- 2008-01-22 WO PCT/NZ2008/000011 patent/WO2008091167A1/en not_active Ceased
- 2008-01-22 AU AU2008208151A patent/AU2008208151B2/en active Active
- 2008-01-22 JP JP2009547189A patent/JP2010516761A/ja active Pending
- 2008-01-22 CA CA2713199A patent/CA2713199C/en not_active Expired - Fee Related
- 2008-01-22 US US12/524,421 patent/US8748467B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2124938A4 (en) | 2010-04-14 |
| AU2008208151B2 (en) | 2014-02-20 |
| WO2008091167A1 (en) | 2008-07-31 |
| NZ552816A (en) | 2009-05-31 |
| EP2124938A1 (en) | 2009-12-02 |
| CA2713199A1 (en) | 2008-07-31 |
| US8748467B2 (en) | 2014-06-10 |
| AU2008208151A1 (en) | 2008-07-31 |
| US20100137389A1 (en) | 2010-06-03 |
| JP2010516761A (ja) | 2010-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20130118 |
|
| MKLA | Lapsed |
Effective date: 20200122 |