CA2712621A1 - Inhaler - Google Patents
Inhaler Download PDFInfo
- Publication number
- CA2712621A1 CA2712621A1 CA2712621A CA2712621A CA2712621A1 CA 2712621 A1 CA2712621 A1 CA 2712621A1 CA 2712621 A CA2712621 A CA 2712621A CA 2712621 A CA2712621 A CA 2712621A CA 2712621 A1 CA2712621 A1 CA 2712621A1
- Authority
- CA
- Canada
- Prior art keywords
- cap
- actuator
- inhaler according
- blister
- mouthpiece
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003814 drug Substances 0.000 claims abstract description 61
- 230000004044 response Effects 0.000 claims abstract description 20
- 230000007246 mechanism Effects 0.000 claims description 38
- 238000010168 coupling process Methods 0.000 claims description 30
- 238000005859 coupling reaction Methods 0.000 claims description 30
- 230000008878 coupling Effects 0.000 claims description 27
- -1 methpentermine Chemical compound 0.000 description 82
- 150000001875 compounds Chemical class 0.000 description 41
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 38
- 229910052739 hydrogen Inorganic materials 0.000 description 37
- 239000001257 hydrogen Substances 0.000 description 33
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 31
- 229940079593 drug Drugs 0.000 description 25
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 24
- 239000011737 fluorine Chemical group 0.000 description 24
- 229910052731 fluorine Chemical group 0.000 description 24
- 239000000546 pharmaceutical excipient Substances 0.000 description 24
- 238000000034 method Methods 0.000 description 22
- 150000003839 salts Chemical class 0.000 description 21
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 20
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 19
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 18
- 108091006146 Channels Proteins 0.000 description 17
- 150000002431 hydrogen Chemical class 0.000 description 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 16
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 16
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 description 16
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 description 16
- 229960004017 salmeterol Drugs 0.000 description 16
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 15
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 15
- 229960002848 formoterol Drugs 0.000 description 15
- 239000000203 mixture Substances 0.000 description 15
- 229910052736 halogen Chemical group 0.000 description 14
- 239000013543 active substance Substances 0.000 description 13
- 239000000843 powder Substances 0.000 description 12
- FIMXSEMBHGTNKT-UHFFFAOYSA-N Scopine Natural products CN1C2CC(O)CC1C1C2O1 FIMXSEMBHGTNKT-UHFFFAOYSA-N 0.000 description 11
- 150000002367 halogens Chemical group 0.000 description 11
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 10
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 10
- 229910052794 bromium Inorganic materials 0.000 description 10
- 150000004677 hydrates Chemical class 0.000 description 10
- 239000008194 pharmaceutical composition Substances 0.000 description 10
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 9
- 239000002253 acid Substances 0.000 description 9
- 230000008901 benefit Effects 0.000 description 9
- 239000000460 chlorine Substances 0.000 description 9
- 229910052801 chlorine Inorganic materials 0.000 description 9
- 150000003431 steroids Chemical class 0.000 description 9
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 8
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 239000000808 adrenergic beta-agonist Substances 0.000 description 8
- 230000003454 betamimetic effect Effects 0.000 description 8
- 125000004432 carbon atom Chemical group C* 0.000 description 8
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 description 6
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 6
- LUKZNWIVRBCLON-GXOBDPJESA-N Ciclesonide Chemical compound C1([C@H]2O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(C[C@H](O)[C@@H]3[C@@]4(C)C=CC(=O)C=C4CC[C@H]32)C)C(=O)COC(=O)C(C)C)CCCCC1 LUKZNWIVRBCLON-GXOBDPJESA-N 0.000 description 6
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 6
- AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 6
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 6
- 125000003545 alkoxy group Chemical group 0.000 description 6
- 229960004436 budesonide Drugs 0.000 description 6
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 229960003728 ciclesonide Drugs 0.000 description 6
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 6
- 229960002714 fluticasone Drugs 0.000 description 6
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 description 6
- 239000003112 inhibitor Substances 0.000 description 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 229960001664 mometasone Drugs 0.000 description 6
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 6
- FIMXSEMBHGTNKT-RZVDLVGDSA-N scopine Chemical compound C([C@@H]1N2C)[C@H](O)C[C@@H]2[C@@H]2[C@H]1O2 FIMXSEMBHGTNKT-RZVDLVGDSA-N 0.000 description 6
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 5
- DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 description 5
- LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 description 5
- QZZUEBNBZAPZLX-UHFFFAOYSA-N 5-[2-[(5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-1h-quinolin-2-one Chemical compound N1C(=O)C=CC2=C1C(O)=CC=C2C(O)CNC1CC(C=C(C(=C2)CC)CC)=C2C1 QZZUEBNBZAPZLX-UHFFFAOYSA-N 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 5
- 229940092705 beclomethasone Drugs 0.000 description 5
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
- HUPFGZXOMWLGNK-UHFFFAOYSA-N diflunisal Chemical compound C1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 HUPFGZXOMWLGNK-UHFFFAOYSA-N 0.000 description 5
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- 230000003287 optical effect Effects 0.000 description 5
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- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 5
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- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 4
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Classifications
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
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- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
- A61M15/0036—Piercing means hollow piercing means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/0081—Locking means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08100906A EP2082772A1 (en) | 2008-01-24 | 2008-01-24 | Inhaler |
| EP08100906.0 | 2008-01-24 | ||
| PCT/EP2009/050733 WO2009092770A1 (en) | 2008-01-24 | 2009-01-22 | Inhaler |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2712621A1 true CA2712621A1 (en) | 2009-07-30 |
Family
ID=39587041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2712621A Abandoned CA2712621A1 (en) | 2008-01-24 | 2009-01-22 | Inhaler |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20110094510A1 (enExample) |
| EP (2) | EP2082772A1 (enExample) |
| JP (1) | JP2011523861A (enExample) |
| KR (1) | KR20100129727A (enExample) |
| CN (1) | CN101980742A (enExample) |
| AR (1) | AR070244A1 (enExample) |
| AU (1) | AU2009207609B2 (enExample) |
| BR (1) | BRPI0906779A2 (enExample) |
| CA (1) | CA2712621A1 (enExample) |
| IL (1) | IL207160A0 (enExample) |
| NZ (1) | NZ586973A (enExample) |
| RU (1) | RU2481129C2 (enExample) |
| SG (1) | SG187449A1 (enExample) |
| TW (1) | TW200946153A (enExample) |
| WO (1) | WO2009092770A1 (enExample) |
| ZA (1) | ZA201005622B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201020130D0 (en) * | 2010-11-26 | 2011-01-12 | Vectura Delivery Devices Ltd | Inhaler |
| US8763608B2 (en) | 2008-10-09 | 2014-07-01 | Vectura Delivery Devices Limited | Inhaler |
| FR2962422B1 (fr) * | 2010-07-07 | 2012-08-03 | Valois Sas | Dispositif de distribution de produit fluide. |
| AU2014253494B2 (en) * | 2010-11-26 | 2016-01-21 | Vectura Delivery Devices Limited | Inhaler |
| GB2502348A (en) * | 2012-05-25 | 2013-11-27 | Vectura Delivery Devices Ltd | Inhaler with blister piercing mechanism |
| GB2502350A (en) * | 2012-05-25 | 2013-11-27 | Vectura Delivery Devices Ltd | Inhaler having means to control the force applied to an actuating lever |
| CA2924772A1 (en) | 2013-10-01 | 2015-04-09 | Novartis Ag | Blister track inhaler device having a separate end path and methods of use thereof |
| EP3268364A1 (en) | 2015-03-10 | 2018-01-17 | Vectura Limited | Crystalline form of a jak3 kinase inhibitor |
| RU2717638C2 (ru) * | 2015-07-20 | 2020-03-24 | Медикал Дивелопментс Интернэшнл Лимитед | Ингаляторное устройство для ингаляционных жидкостей |
| US10967139B2 (en) * | 2016-01-19 | 2021-04-06 | Novartis Ag | Multidose inhaler |
| EP3852849B1 (en) * | 2018-09-17 | 2022-06-29 | Vectura Delivery Devices Limited | Dry powder inhaler |
| WO2020135920A1 (en) * | 2018-12-28 | 2020-07-02 | Université Libre de Bruxelles | Kit for inhaled chemotherapy, and treatment of lung cancer with said kit |
| DE102020100551A1 (de) * | 2019-01-14 | 2020-07-16 | Alfred Von Schuckmann | Vorrichtung zum Inhalieren pulverförmiger Substanzen |
| AU2023406464A1 (en) | 2022-12-02 | 2025-07-17 | Kinaset Therapeutics, Inc. | Formulation of a pan-jak inhibitor |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB324358A (en) | 1928-10-24 | 1930-01-24 | John Leathart Hankey | Improvements in the treatment of vegetable and silk material with chrome mordants |
| GB8909891D0 (en) * | 1989-04-28 | 1989-06-14 | Riker Laboratories Inc | Device |
| YU48707B (sh) * | 1990-03-02 | 1999-07-28 | Glaxo Group Limited | Aparat za inhaliranje - inhalator |
| GB9016789D0 (en) * | 1990-07-31 | 1990-09-12 | Lilly Industries Ltd | Medicament administering devices |
| CA2166799A1 (en) | 1993-07-29 | 1995-02-09 | Paul D. Ries | Composite membranes and their preparation from polymer particles on a porous substrate |
| US5921237A (en) * | 1995-04-24 | 1999-07-13 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
| DE19523516C1 (de) * | 1995-06-30 | 1996-10-31 | Asta Medica Ag | Inhalator zum Verabreichen von Medikamenten aus Blisterpackungen |
| GB2340758A (en) * | 1998-08-21 | 2000-03-01 | Bespak Plc | Drug dispensing system |
| HU225917B1 (en) | 1999-09-16 | 2007-12-28 | Tanabe Seiyaku Co | Pyrimidine and pyrazine derivatives, pharmaceutical compositions containing them and their use |
| ES2225246T3 (es) * | 1999-10-12 | 2005-03-16 | Shl Medical Ab | Inhalador. |
| US7171965B2 (en) * | 2000-02-01 | 2007-02-06 | Valois S.A.S. | Breath actuated dry powder inhaler and tape dose strip |
| UA75375C2 (en) | 2000-10-12 | 2006-04-17 | Boehringer Ingelheim Pharma | Method for producing powdery preparations for inhaling |
| DE10050994A1 (de) | 2000-10-14 | 2002-04-18 | Boehringer Ingelheim Pharma | Neue als Arneimittel einsetzbare Anticholinergika sowie Verfahren zu deren Herstellung |
| DE10050995A1 (de) | 2000-10-14 | 2002-04-18 | Boehringer Ingelheim Pharma | Neue Anticholinergika, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| DE10141376A1 (de) | 2001-08-23 | 2003-03-13 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Inhalationspulvern |
| DE10141377A1 (de) | 2001-08-23 | 2003-03-13 | Boehringer Ingelheim Pharma | Aufstreuverfahren zur Herstellung von Pulverformulierungen |
| GB0125134D0 (en) * | 2001-10-19 | 2001-12-12 | Glaxo Group Ltd | Medicament dispenser |
| DE10203741A1 (de) | 2002-01-31 | 2003-08-14 | Boehringer Ingelheim Pharma | Neue Fluorencarbonsäureester, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| DE10203753A1 (de) | 2002-01-31 | 2003-08-14 | Boehringer Ingelheim Pharma | Neue Xanthencarbonsäureester, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| DE10203749A1 (de) | 2002-01-31 | 2003-08-14 | Boehringer Ingelheim Pharma | Neue Anticholinergika, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| GB2407042B (en) * | 2003-10-17 | 2007-10-24 | Vectura Ltd | Inhaler |
| GB0428169D0 (en) * | 2004-12-23 | 2005-01-26 | 3M Innovative Properties Co | Pressurized inhalation devices |
| GB0515584D0 (en) * | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Medicament dispenser |
-
2008
- 2008-01-24 EP EP08100906A patent/EP2082772A1/en not_active Withdrawn
-
2009
- 2009-01-22 AU AU2009207609A patent/AU2009207609B2/en not_active Expired - Fee Related
- 2009-01-22 JP JP2010543499A patent/JP2011523861A/ja active Pending
- 2009-01-22 SG SG2013001987A patent/SG187449A1/en unknown
- 2009-01-22 WO PCT/EP2009/050733 patent/WO2009092770A1/en not_active Ceased
- 2009-01-22 KR KR1020107018489A patent/KR20100129727A/ko not_active Withdrawn
- 2009-01-22 CN CN2009801105008A patent/CN101980742A/zh active Pending
- 2009-01-22 US US12/863,944 patent/US20110094510A1/en not_active Abandoned
- 2009-01-22 EP EP09704436A patent/EP2244770A1/en not_active Withdrawn
- 2009-01-22 RU RU2010135348/14A patent/RU2481129C2/ru not_active IP Right Cessation
- 2009-01-22 CA CA2712621A patent/CA2712621A1/en not_active Abandoned
- 2009-01-22 BR BRPI0906779-5A patent/BRPI0906779A2/pt not_active IP Right Cessation
- 2009-01-22 NZ NZ586973A patent/NZ586973A/xx not_active IP Right Cessation
- 2009-01-23 AR ARP090100214A patent/AR070244A1/es unknown
- 2009-01-23 TW TW098102955A patent/TW200946153A/zh unknown
-
2010
- 2010-07-22 IL IL207160A patent/IL207160A0/en unknown
- 2010-08-05 ZA ZA2010/05622A patent/ZA201005622B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009207609B2 (en) | 2013-11-07 |
| RU2481129C2 (ru) | 2013-05-10 |
| TW200946153A (en) | 2009-11-16 |
| KR20100129727A (ko) | 2010-12-09 |
| WO2009092770A1 (en) | 2009-07-30 |
| ZA201005622B (en) | 2011-06-29 |
| IL207160A0 (en) | 2010-12-30 |
| EP2082772A1 (en) | 2009-07-29 |
| US20110094510A1 (en) | 2011-04-28 |
| JP2011523861A (ja) | 2011-08-25 |
| RU2010135348A (ru) | 2012-02-27 |
| NZ586973A (en) | 2013-01-25 |
| AR070244A1 (es) | 2010-03-25 |
| BRPI0906779A2 (pt) | 2015-07-14 |
| EP2244770A1 (en) | 2010-11-03 |
| AU2009207609A1 (en) | 2009-07-30 |
| SG187449A1 (en) | 2013-02-28 |
| CN101980742A (zh) | 2011-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20150122 |
|
| FZDE | Discontinued |
Effective date: 20150122 |