CA2704361C - Mitochondrial dna deletion between about residues 12317-16254 for use in the detection of cancer - Google Patents

Mitochondrial dna deletion between about residues 12317-16254 for use in the detection of cancer Download PDF

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Publication number
CA2704361C
CA2704361C CA2704361A CA2704361A CA2704361C CA 2704361 C CA2704361 C CA 2704361C CA 2704361 A CA2704361 A CA 2704361A CA 2704361 A CA2704361 A CA 2704361A CA 2704361 C CA2704361 C CA 2704361C
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Prior art keywords
mtdna
deletion
seq
cancer
amount
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CA2704361A
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English (en)
French (fr)
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CA2704361A1 (en
Inventor
Andrew Harbottle
Gabriel Dakubo
Kerry Robinson
Andrea Maggrah
Brian Reguly
Jude Alexander
Jennifer Creed
Katrina Maki
Ryan Parr
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MDNA LIFE SCIENCES Inc
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MDNA LIFE SCIENCES Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2704361A 2007-11-09 2008-11-10 Mitochondrial dna deletion between about residues 12317-16254 for use in the detection of cancer Active CA2704361C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US263707P 2007-11-09 2007-11-09
US61/002,637 2007-11-09
PCT/CA2008/001956 WO2009059414A1 (en) 2007-11-09 2008-11-10 Mitochondrial dna deletion between about residues 12317-16254 for use in the detection of cancer

Publications (2)

Publication Number Publication Date
CA2704361A1 CA2704361A1 (en) 2009-05-14
CA2704361C true CA2704361C (en) 2023-04-04

Family

ID=40625325

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2704361A Active CA2704361C (en) 2007-11-09 2008-11-10 Mitochondrial dna deletion between about residues 12317-16254 for use in the detection of cancer

Country Status (9)

Country Link
US (5) US20100311057A1 (https=)
EP (2) EP2220252B1 (https=)
JP (1) JP5481383B2 (https=)
KR (1) KR101644661B1 (https=)
CN (1) CN101883864B (https=)
AU (1) AU2008324675B2 (https=)
CA (1) CA2704361C (https=)
NZ (1) NZ584656A (https=)
WO (1) WO2009059414A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9410188B2 (en) * 2010-05-28 2016-08-09 Biomerieux Method and kit for discriminating between breast cancer and benign breast disease
CN107604061B (zh) * 2017-08-31 2021-02-02 中国科学院北京基因组研究所 线粒体-细胞核dna甲基化联合位点的筛选方法和应用
WO2024130647A1 (zh) * 2022-12-22 2024-06-27 中国科学院广州生物医药与健康研究院 分离的环状rna及其在预防和治疗肺癌中的用途
WO2026012452A1 (en) * 2024-07-12 2026-01-15 Hong Kong Baptist University Nad-capped rnas in human mitochondria and their applications in cancer diagnosis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6582908B2 (en) * 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
DE19653439A1 (de) * 1996-12-20 1998-07-02 Svante Dr Paeaebo Verfahren zur direkten, exponentiellen Amplifikation und Sequenzierung von DNA Molekülen und dessen Anwendung
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
JP2005506057A (ja) * 2001-06-11 2005-03-03 １３０４８５４ オンタリオ・リミテッド 健康科学のための診断ツールとしての全ミトコンドリアゲノム配列
US20050026167A1 (en) * 2001-06-11 2005-02-03 Mark Birch-Machin Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
EP1694695A4 (en) * 2003-12-11 2007-10-31 1304854 Ontario Ltd COMPLETE MITOCHONDRIAL GENOME SEQUENCES AS A DIAGNOSTIC TOOL FOR MEDICAL SCIENCES
EP1877559B1 (en) * 2005-04-18 2010-10-13 Mitomics Inc. Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers
CA2700941A1 (en) * 2007-09-26 2009-04-02 Genesis Genomics Inc. 3.4 kb mitochondrial dna deletion for use in the detection of cancer

Also Published As

Publication number Publication date
EP3409793A1 (en) 2018-12-05
CN101883864B (zh) 2014-02-12
US20100311057A1 (en) 2010-12-09
KR101644661B1 (ko) 2016-08-01
US20180230549A1 (en) 2018-08-16
AU2008324675B2 (en) 2015-04-23
CN101883864A (zh) 2010-11-10
JP5481383B2 (ja) 2014-04-23
CA2704361A1 (en) 2009-05-14
JP2011502487A (ja) 2011-01-27
NZ584656A (en) 2012-08-31
US20130288243A1 (en) 2013-10-31
EP2220252B1 (en) 2018-03-14
EP2220252A4 (en) 2012-08-22
US20150004619A1 (en) 2015-01-01
AU2008324675A1 (en) 2009-05-14
KR20100090702A (ko) 2010-08-16
US20160289772A1 (en) 2016-10-06
WO2009059414A1 (en) 2009-05-14
US10400290B2 (en) 2019-09-03
EP2220252A1 (en) 2010-08-25

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