CA2703738C - Monoclonal antibodies against activated and unactivated protein c - Google Patents
Monoclonal antibodies against activated and unactivated protein c Download PDFInfo
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- CA2703738C CA2703738C CA2703738A CA2703738A CA2703738C CA 2703738 C CA2703738 C CA 2703738C CA 2703738 A CA2703738 A CA 2703738A CA 2703738 A CA2703738 A CA 2703738A CA 2703738 C CA2703738 C CA 2703738C
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98309207P | 2007-10-26 | 2007-10-26 | |
| US60/983,092 | 2007-10-26 | ||
| PCT/US2008/081110 WO2009055669A2 (en) | 2007-10-26 | 2008-10-24 | Monoclonal antibodies against activated and unactivated protein c |
Publications (2)
| Publication Number | Publication Date |
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| CA2703738A1 CA2703738A1 (en) | 2009-04-30 |
| CA2703738C true CA2703738C (en) | 2018-02-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2703738A Active CA2703738C (en) | 2007-10-26 | 2008-10-24 | Monoclonal antibodies against activated and unactivated protein c |
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| EP (1) | EP2205638B1 (enExample) |
| JP (3) | JP2011500843A (enExample) |
| KR (2) | KR101856210B1 (enExample) |
| CN (3) | CN103232541A (enExample) |
| AU (1) | AU2008316661B2 (enExample) |
| BR (1) | BRPI0818865A2 (enExample) |
| CA (1) | CA2703738C (enExample) |
| IL (2) | IL205284A (enExample) |
| MX (1) | MX2010004615A (enExample) |
| RU (2) | RU2539729C2 (enExample) |
| WO (1) | WO2009055669A2 (enExample) |
| ZA (1) | ZA201105704B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2664473C2 (ru) * | 2012-03-16 | 2018-08-17 | Регенерон Фармасьютикалз, Инк. | ОТЛИЧНЫЕ ОТ ЧЕЛОВЕКА ЖИВОТНЫЕ, ЭКСПРЕССИРУЮЩИЕ ЧУВСТВИТЕЛЬНЫЕ К pН ПОСЛЕДОВАТЕЛЬНОСТИ ИММУНОГЛОБУЛИНОВ |
| EP2925351A4 (en) * | 2012-11-29 | 2016-08-24 | Bayer Healthcare Llc | MONOCLONAL ANTIBODIES DIRECTED AGAINST ACTIVATED PROTEIN C (APC) |
| KR20150088853A (ko) * | 2012-11-29 | 2015-08-03 | 바이엘 헬스케어 엘엘씨 | 활성화 단백질 c에 대한 인간화 모노클로날 항체 및 그의 용도 |
| EP3047857A4 (en) * | 2013-09-20 | 2017-08-09 | Chugai Seiyaku Kabushiki Kaisha | Treatment for hemorrhagic diseases by anti-protein-c antibody |
| GB201322091D0 (en) | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
| WO2015179435A1 (en) * | 2014-05-19 | 2015-11-26 | Bayer Healthcare Llc | Optimized humanized monoclonal antibodies against activated protein c and uses thereof |
| US11077187B2 (en) | 2015-11-17 | 2021-08-03 | Oklahoma Medical Research Foundation | Epitope of optimized humanized monoclonal antibodies against activated protein C and uses thereof |
| CN116284402A (zh) | 2016-12-21 | 2023-06-23 | 特尼奥生物股份有限公司 | 仅有重链的抗bcma抗体 |
| KR102742528B1 (ko) | 2017-06-20 | 2024-12-16 | 테네오바이오, 인코포레이티드 | 항-bcma 중쇄-단독 항체 |
| TW201906868A (zh) * | 2017-07-07 | 2019-02-16 | 日商第一三共股份有限公司 | 抗蛋白ｃ抗體 |
| US11447546B2 (en) | 2017-07-20 | 2022-09-20 | Nbe-Therapeutics Ag | Human antibodies binding to ROR2 |
| JP7346389B2 (ja) * | 2017-09-13 | 2023-09-19 | ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 異常な血小板レベルのマーカーとしてのプロアドレノメジュリン |
| US12319744B2 (en) | 2018-09-06 | 2025-06-03 | Board Of Regents, The University Of Texas System | Treatment and prevention of hemophilic arthropathy with an antibody against endothelial cell protein C receptor (EPCR) |
| AU2019360758B2 (en) * | 2018-10-18 | 2024-08-08 | Oklahoma Medical Research Foundation | Biomarkers for a Systemic Lupus Erythematosus (SLE) disease activity immune index that characterizes disease activity |
| CN109897108B (zh) * | 2019-03-11 | 2021-04-02 | 上海恒赛生物科技有限公司 | 抗人内皮蛋白c受体的羊驼单域抗体及应用 |
| CN115611986B (zh) * | 2021-07-13 | 2025-08-12 | 上海莱士血液制品股份有限公司 | 针对人活化蛋白c的单克隆抗体及其制备和应用 |
| CN118370814A (zh) * | 2023-01-20 | 2024-07-23 | 上海莱士血液制品股份有限公司 | 一种抗aPC单克隆抗体的制剂及其应用 |
| KR20250000042A (ko) | 2023-06-23 | 2025-01-02 | 충남대학교산학협력단 | 절단 반응성 펩타이드를 발현하는 키메라 t 세포 및 이를 포함하는 감염 질환 치료용 조성물 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7247453B1 (en) * | 1988-12-30 | 2007-07-24 | Oklahoma Medical Research Foundation | Calcium binding recombinant antibody against protein C |
| US5202253A (en) * | 1988-12-30 | 1993-04-13 | Oklahoma Medical Research Foundation | Monoclonal antibody specific for protein C and antibody purification method |
| US5279956A (en) * | 1991-06-24 | 1994-01-18 | The Scripps Research Institute | Activated protein C polypeptides and anti-peptide antibodies, diagnostic methods and systems for inhibiting activated protein C |
| US5695993A (en) | 1994-08-12 | 1997-12-09 | Oklahoma Medical Research Foundation | Cloning and regulation of an endothelial cell protein C/activated protein C receptor |
| US6953568B1 (en) | 1998-08-25 | 2005-10-11 | Oklahoma Medical Research Foundation | Targeting of molecules to large vessel endothelium using EPCR |
| AU2001296483B2 (en) * | 2000-10-02 | 2006-02-16 | Oklahoma Medical Research Foundation | Assay for rapid detection of human activated protein C and highly specific monoclonal antibody therefor |
| US7423128B2 (en) | 2004-11-03 | 2008-09-09 | Amgen Fremont Inc. | Anti-properdin antibodies, and methods for making and using same |
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2008
- 2008-10-24 MX MX2010004615A patent/MX2010004615A/es active IP Right Grant
- 2008-10-24 BR BRPI0818865 patent/BRPI0818865A2/pt active Search and Examination
- 2008-10-24 EP EP08841295.2A patent/EP2205638B1/en active Active
- 2008-10-24 KR KR1020107011548A patent/KR101856210B1/ko active Active
- 2008-10-24 KR KR1020157020430A patent/KR20150092358A/ko not_active Ceased
- 2008-10-24 US US12/257,706 patent/US8153766B2/en active Active
- 2008-10-24 WO PCT/US2008/081110 patent/WO2009055669A2/en not_active Ceased
- 2008-10-24 CN CN2013101082220A patent/CN103232541A/zh active Pending
- 2008-10-24 AU AU2008316661A patent/AU2008316661B2/en active Active
- 2008-10-24 CN CN201510462991.XA patent/CN105153308A/zh active Pending
- 2008-10-24 CA CA2703738A patent/CA2703738C/en active Active
- 2008-10-24 RU RU2010121148/10A patent/RU2539729C2/ru active
- 2008-10-24 JP JP2010531275A patent/JP2011500843A/ja not_active Withdrawn
- 2008-10-24 CN CN2008801210245A patent/CN101918453A/zh active Pending
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2010
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2011
- 2011-08-03 ZA ZA2011/05704A patent/ZA201105704B/en unknown
- 2011-11-29 US US13/306,301 patent/US9127072B2/en active Active
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2012
- 2012-06-24 IL IL220622A patent/IL220622A0/en unknown
- 2012-10-26 JP JP2012236531A patent/JP2013049694A/ja active Pending
- 2012-11-27 RU RU2012150953/10A patent/RU2012150953A/ru not_active Application Discontinuation
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2014
- 2014-07-02 JP JP2014136566A patent/JP6117741B2/ja active Active
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2015
- 2015-06-09 US US14/734,055 patent/US20150344588A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008316661A1 (en) | 2009-04-30 |
| KR20100116166A (ko) | 2010-10-29 |
| JP6117741B2 (ja) | 2017-04-19 |
| RU2539729C2 (ru) | 2015-01-27 |
| BRPI0818865A2 (pt) | 2015-05-05 |
| KR20150092358A (ko) | 2015-08-12 |
| ZA201105704B (en) | 2014-05-28 |
| KR101856210B1 (ko) | 2018-05-09 |
| MX2010004615A (es) | 2010-07-06 |
| US20120164150A1 (en) | 2012-06-28 |
| WO2009055669A3 (en) | 2009-09-03 |
| IL205284A0 (en) | 2010-12-30 |
| CA2703738A1 (en) | 2009-04-30 |
| IL205284A (en) | 2014-06-30 |
| CN105153308A (zh) | 2015-12-16 |
| EP2205638A2 (en) | 2010-07-14 |
| EP2205638B1 (en) | 2017-03-01 |
| IL220622A0 (en) | 2012-08-30 |
| US8153766B2 (en) | 2012-04-10 |
| US20090110683A1 (en) | 2009-04-30 |
| RU2010121148A (ru) | 2011-12-10 |
| JP2011500843A (ja) | 2011-01-06 |
| AU2008316661B2 (en) | 2013-05-23 |
| RU2012150953A (ru) | 2014-06-10 |
| WO2009055669A2 (en) | 2009-04-30 |
| JP2014237651A (ja) | 2014-12-18 |
| JP2013049694A (ja) | 2013-03-14 |
| CN101918453A (zh) | 2010-12-15 |
| US20150344588A1 (en) | 2015-12-03 |
| US9127072B2 (en) | 2015-09-08 |
| CN103232541A (zh) | 2013-08-07 |
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