CA2702970A1 - Manufacture, compositions and uses of coagulation factor viia modulator - Google Patents
Manufacture, compositions and uses of coagulation factor viia modulator Download PDFInfo
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- CA2702970A1 CA2702970A1 CA2702970A CA2702970A CA2702970A1 CA 2702970 A1 CA2702970 A1 CA 2702970A1 CA 2702970 A CA2702970 A CA 2702970A CA 2702970 A CA2702970 A CA 2702970A CA 2702970 A1 CA2702970 A1 CA 2702970A1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98038607P | 2007-10-16 | 2007-10-16 | |
| US60/980,386 | 2007-10-16 | ||
| PCT/US2008/080221 WO2009052323A2 (en) | 2007-10-16 | 2008-10-16 | Manufacture, compositions and uses of coagulationfactor viia modulator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2702970A1 true CA2702970A1 (en) | 2009-04-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2702970A Abandoned CA2702970A1 (en) | 2007-10-16 | 2008-10-16 | Manufacture, compositions and uses of coagulation factor viia modulator |
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| Country | Link |
|---|---|
| US (3) | US8552046B2 (https=) |
| EP (2) | EP2586794A3 (https=) |
| JP (2) | JP5733744B2 (https=) |
| KR (1) | KR20100093046A (https=) |
| CN (2) | CN101861335B (https=) |
| CA (1) | CA2702970A1 (https=) |
| EA (2) | EA019258B1 (https=) |
| ES (1) | ES2403413T3 (https=) |
| WO (1) | WO2009052323A2 (https=) |
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| AU2003302238A1 (en) | 2002-12-03 | 2004-06-23 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
| KR100977903B1 (ko) | 2004-06-02 | 2010-08-24 | 파마시클릭스, 인코포레이티드 | Ⅶａ 인자 억제제 |
| US8729117B2 (en) | 2004-06-02 | 2014-05-20 | Pharmacyclics, Inc. | Factor VIIa inhibitor |
| US8552046B2 (en) | 2007-10-16 | 2013-10-08 | Pharmacyclics, Inc. | Manufacture, compositions and uses of coagulation factor VIIa modulator |
| US20140046277A1 (en) * | 2011-04-15 | 2014-02-13 | Gamma Therapeutics, Inc. | Fast-clotting wound dressings |
| US8980823B2 (en) | 2012-03-07 | 2015-03-17 | Shaker A. Mousa | Formulations of Factor VIIa inhibitors and utility |
| MY190257A (en) | 2012-04-16 | 2022-04-11 | Cantab Biopharmaceuticals Patents Ltd | Optimised subcutaneous therapeutic agents |
| CA2917298C (en) * | 2013-07-05 | 2021-06-22 | Shaker A. Mousa | Novel formulations of factor viia inhibitors and utility |
| IL312865B2 (en) | 2013-09-11 | 2025-06-01 | Eagle Biologics Inc | Liquid protein formulations containing viscosity-lowering agents |
| AU2015325055B2 (en) * | 2014-10-01 | 2021-02-25 | Eagle Biologics, Inc. | Polysaccharide and nucleic acid formulations containing viscosity-lowering agents |
| RU2641058C1 (ru) * | 2016-11-17 | 2018-01-15 | федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) | Способ профилактики венозной тромбоэмболии у больных раком шейки матки |
| CN109627218B (zh) * | 2018-11-27 | 2022-03-29 | 深圳市龙华区中心医院 | 一种抗凝小分子化合物及其应用和包含其的药物 |
| CN116283896B (zh) * | 2022-09-07 | 2024-10-29 | 广东晨康生物科技有限公司 | 一种具有pd-l1抑制活性的联苯类化合物及其用途 |
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| RU2093176C1 (ru) * | 1992-12-16 | 1997-10-20 | Левон Никитович Мкртчян | Способ лечения рака молочной железы и рака тела матки |
| HUP0104987A3 (en) | 1998-12-18 | 2002-09-30 | Axys Pharmaceuticals Inc South | Benzimidazole or indole derivatives protease inhibitors, and pharmaceutical compositions containing them |
| US20020037912A1 (en) | 2000-08-11 | 2002-03-28 | Leahy Ellen M. | Factor viia inhibitors |
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| EP1449555B1 (en) * | 2001-03-23 | 2006-06-21 | Novo Nordisk A/S | Needle cannula |
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| KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
| JP2005523279A (ja) | 2002-02-13 | 2005-08-04 | アクシス ファーマシューティカルズ インコーポレイティッド | 第ｖｉｉａ因子阻害剤としての２−［５−（５−カルバミミドイル−１ｈ−ヘテロアリール）］−６−ヒドロキシビフェニル−３−イル誘導体 |
| HUP0600241A2 (en) | 2002-04-08 | 2006-07-28 | Mgi Gp | Pharmaceutical compositions containing water-soluble prodrugs of propofol and methods of administering same |
| AU2003302238A1 (en) * | 2002-12-03 | 2004-06-23 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
| WO2004062661A1 (en) * | 2003-01-08 | 2004-07-29 | Axys Pharmaceuticals, Inc. | 2-‘5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl!- carboxylic acid derivatives as factor viia inhibitors |
| MXPA06014066A (es) * | 2004-06-02 | 2007-02-15 | Pharmacyclics Inc | Inhibicion de factor viia. |
| KR100977903B1 (ko) * | 2004-06-02 | 2010-08-24 | 파마시클릭스, 인코포레이티드 | Ⅶａ 인자 억제제 |
| US8552046B2 (en) | 2007-10-16 | 2013-10-08 | Pharmacyclics, Inc. | Manufacture, compositions and uses of coagulation factor VIIa modulator |
| US20110299806A1 (en) * | 2010-06-08 | 2011-12-08 | Leonid Kashchenevsky | Spindle, shaft supporting device and method of supporting a rotatable shaft |
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2008
- 2008-10-16 US US12/738,372 patent/US8552046B2/en active Active
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- 2008-10-16 EA EA201370191A patent/EA201370191A1/ru unknown
- 2008-10-16 EP EP12185553.0A patent/EP2586794A3/en not_active Withdrawn
- 2008-10-16 CN CN2008801165837A patent/CN101861335B/zh active Active
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- 2008-10-16 EP EP08839610A patent/EP2209801B1/en active Active
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- 2008-10-16 JP JP2010530121A patent/JP5733744B2/ja not_active Expired - Fee Related
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| EP2586794A3 (en) | 2013-07-17 |
| ES2403413T3 (es) | 2013-05-17 |
| EA019258B1 (ru) | 2014-02-28 |
| EP2586794A2 (en) | 2013-05-01 |
| CN101861335A (zh) | 2010-10-13 |
| JP2015157830A (ja) | 2015-09-03 |
| WO2009052323A3 (en) | 2009-09-11 |
| CN101861335B (zh) | 2013-09-04 |
| EA201000633A1 (ru) | 2011-04-29 |
| EP2209801A2 (en) | 2010-07-28 |
| EP2209801B1 (en) | 2013-01-16 |
| US20140039022A1 (en) | 2014-02-06 |
| JP2011500717A (ja) | 2011-01-06 |
| KR20100093046A (ko) | 2010-08-24 |
| US20130158089A1 (en) | 2013-06-20 |
| HK1147267A1 (en) | 2011-08-05 |
| EP2209801A4 (en) | 2011-04-06 |
| WO2009052323A2 (en) | 2009-04-23 |
| CN103705507A (zh) | 2014-04-09 |
| US20100298396A1 (en) | 2010-11-25 |
| US8552046B2 (en) | 2013-10-08 |
| US8748468B2 (en) | 2014-06-10 |
| JP5733744B2 (ja) | 2015-06-10 |
| EA201370191A1 (ru) | 2014-05-30 |
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