CA2702344C - Analogues of glycolipids useful as immunoadjuvants - Google Patents

Analogues of glycolipids useful as immunoadjuvants Download PDF

Info

Publication number
CA2702344C
CA2702344C CA2702344A CA2702344A CA2702344C CA 2702344 C CA2702344 C CA 2702344C CA 2702344 A CA2702344 A CA 2702344A CA 2702344 A CA2702344 A CA 2702344A CA 2702344 C CA2702344 C CA 2702344C
Authority
CA
Canada
Prior art keywords
alkyl
group
groups
compound
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2702344A
Other languages
English (en)
French (fr)
Other versions
CA2702344A1 (en
Inventor
Luigi Panza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2702344A1 publication Critical patent/CA2702344A1/en
Application granted granted Critical
Publication of CA2702344C publication Critical patent/CA2702344C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
CA2702344A 2007-10-12 2008-10-10 Analogues of glycolipids useful as immunoadjuvants Active CA2702344C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97978507P 2007-10-12 2007-10-12
US60/979,785 2007-10-12
PCT/IB2008/003263 WO2009060305A2 (en) 2007-10-12 2008-10-10 Analogues of glycolipids useful as immunoadjuvants

Publications (2)

Publication Number Publication Date
CA2702344A1 CA2702344A1 (en) 2009-05-14
CA2702344C true CA2702344C (en) 2016-09-27

Family

ID=40626266

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2702344A Active CA2702344C (en) 2007-10-12 2008-10-10 Analogues of glycolipids useful as immunoadjuvants

Country Status (8)

Country Link
US (1) US8697659B2 (https=)
EP (1) EP2483287B1 (https=)
JP (1) JP5416125B2 (https=)
CN (1) CN102066394B (https=)
AU (1) AU2008326138B2 (https=)
CA (1) CA2702344C (https=)
ES (1) ES2574825T3 (https=)
WO (1) WO2009060305A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2530049T3 (es) 2009-05-18 2015-02-26 Sigmoid Pharma Limited Composición que comprende gotas de aceite
CN102573802A (zh) * 2009-08-12 2012-07-11 希格默伊德药业有限公司 包含聚合物基质和油相的免疫调节组合物
TWI633112B (zh) * 2012-03-19 2018-08-21 馬克斯普朗克科學發展組織 醣類－醣脂類結合性疫苗
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
JP6716582B2 (ja) 2014-11-07 2020-07-01 サブリミティ・セラピューティクス・リミテッドＳｕｂｌｉｍｉｔｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ シクロスポリンを含む組成物
US12257214B2 (en) * 2021-06-02 2025-03-25 The Charlotte Mecklenburg Hospital Authority Compositions and methods comprising deoxy-pentitols

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW261533B (https=) * 1992-07-16 1995-11-01 Kirin Brewery
EP1437358B1 (en) * 2001-08-16 2006-10-18 Daiichi Asubio Pharma Co., Ltd. Novel glycolipid and remedial agent for autoimmune disease containing the same as active ingredient
GB0314682D0 (en) * 2003-06-24 2003-07-30 Isis Innovation Materials and methods relating to the modulation of T cell response to soluble antigen
EP1784196B1 (en) 2004-08-27 2016-12-21 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity
US7923013B2 (en) 2004-12-28 2011-04-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NKT cells
EP1776963A1 (en) 2005-10-19 2007-04-25 Gbf-Gesellschaft Für Biotechnologische Forschung Mbh Hexosylceramides as adjuvants and their uses in pharmaceutical compositions

Also Published As

Publication number Publication date
US20110033485A1 (en) 2011-02-10
WO2009060305A3 (en) 2013-05-23
CA2702344A1 (en) 2009-05-14
ES2574825T3 (es) 2016-06-22
JP2011510910A (ja) 2011-04-07
AU2008326138A1 (en) 2009-05-14
US8697659B2 (en) 2014-04-15
CN102066394B (zh) 2015-04-01
AU2008326138B2 (en) 2013-10-17
EP2483287B1 (en) 2016-03-16
EP2483287A2 (en) 2012-08-08
JP5416125B2 (ja) 2014-02-12
WO2009060305A2 (en) 2009-05-14
CN102066394A (zh) 2011-05-18

Similar Documents

Publication Publication Date Title
AU740663B2 (en) Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
US6764840B2 (en) Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
US6303347B1 (en) Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
CA2702344C (en) Analogues of glycolipids useful as immunoadjuvants
CN107531736A (zh) 脂质a模拟物、其制备方法和用途
JP2011510910A5 (https=)
JP2005516980A (ja) 新規な免疫エフェクター化合物
EP3331556B1 (en) Synthetic vaccines against streptococcus pneumoniae serotype 2
Thomann et al. Novel glycolipid TLR2 ligands of the type Pam2Cys-α-Gal: Synthesis and biological properties
EP1940464B1 (en) Hexosylceramides as adjuvants and their uses in pharmaceutical compositions
CN114126419A (zh) 基于皂苷的疫苗佐剂
US20140105932A1 (en) Multivalent [beta] - 1 - 2 - linked mannose oligosaccharides as immunostimulatory compounds and uses thereof
Turánek et al. Application of liposomes for construction of vaccines
RU2289585C2 (ru) Новые аминоалкилглюкозаминидфосфатные соединения, иммуностимулирующая фармацевтическая композиция, их содержащая, и способ индуцирования иммунного ответа
Li Towards fully synthetic anticancer vaccines: synthesis of tumor associated carbohydrate antigens and development of carbohydrate-based anticancer vaccines
EP3181148A1 (en) Synthetic vaccines against streptococcus pneumoniae serotype 2
HK1120436B (en) Hexosylceramides as adjuvants and their uses in pharmaceutical compositions
HK1029120B (en) Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130930

H11 Ip right ceased following rejected request for revival

Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED

Effective date: 20250410