CA2698753A1 - Pyrazolo-pyridines as tyrosine kinase inhibitors - Google Patents

Info

Publication number

CA2698753A1

CA2698753A1 CA2698753A CA2698753A CA2698753A1 CA 2698753 A1 CA2698753 A1 CA 2698753A1 CA 2698753 A CA2698753 A CA 2698753A CA 2698753 A CA2698753 A CA 2698753A CA 2698753 A1 CA2698753 A1 CA 2698753A1

Authority

CA

Canada

Prior art keywords

alkyl

compound

nr10r11

heteroaryl

aryl

Prior art date

2007-09-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 150000005229 pyrazolopyridines Chemical class 0.000 title description 3
• 239000005483 tyrosine kinase inhibitor Substances 0.000 title description 3
• 229940121358 tyrosine kinase inhibitor Drugs 0.000 title description 3
• 150000001875 compounds Chemical class 0.000 claims abstract description 274
• 238000000034 method Methods 0.000 claims abstract description 124
• 150000003839 salts Chemical class 0.000 claims abstract description 39
• 238000011282 treatment Methods 0.000 claims abstract description 31
• 102000027426 receptor tyrosine kinases Human genes 0.000 claims abstract description 25
• 108091008598 receptor tyrosine kinases Proteins 0.000 claims abstract description 25
• 230000002401 inhibitory effect Effects 0.000 claims abstract description 11
• 230000001575 pathological effect Effects 0.000 claims abstract description 4
• -1 C3-C12 carbocyclyl Chemical group 0.000 claims description 147
• 239000000203 mixture Substances 0.000 claims description 133
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 91
• 125000000217 alkyl group Chemical group 0.000 claims description 73
• 125000000623 heterocyclic group Chemical group 0.000 claims description 72
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 69
• 125000001072 heteroaryl group Chemical group 0.000 claims description 63
• 125000003118 aryl group Chemical group 0.000 claims description 51
• 206010028980 Neoplasm Diseases 0.000 claims description 47
• 229910052731 fluorine Inorganic materials 0.000 claims description 44
• 229910052801 chlorine Inorganic materials 0.000 claims description 40
• 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims description 39
• 125000006736 (C6-C20) aryl group Chemical group 0.000 claims description 38
• 208000035475 disorder Diseases 0.000 claims description 38
• 201000011510 cancer Diseases 0.000 claims description 37
• 125000005842 heteroatom Chemical group 0.000 claims description 37
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 37
• 229910052794 bromium Inorganic materials 0.000 claims description 34
• 239000003795 chemical substances by application Substances 0.000 claims description 34
• 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 32
• 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims description 32
• 125000004429 atom Chemical group 0.000 claims description 32
• 229910052740 iodine Inorganic materials 0.000 claims description 32
• 229920006395 saturated elastomer Polymers 0.000 claims description 32
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• 229910052757 nitrogen Inorganic materials 0.000 claims description 30
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• 125000000304 alkynyl group Chemical group 0.000 claims description 20
• 125000005843 halogen group Chemical group 0.000 claims description 18
• 229910052736 halogen Inorganic materials 0.000 claims description 16
• 229910052717 sulfur Inorganic materials 0.000 claims description 16
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 15
• 125000006413 ring segment Chemical group 0.000 claims description 13
• 125000004452 carbocyclyl group Chemical group 0.000 claims description 12
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• 125000002619 bicyclic group Chemical group 0.000 claims description 11
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 11
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• 101000585507 Solanum tuberosum Cytochrome b-c1 complex subunit 7 Proteins 0.000 claims 1
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