CA2697057A1 - Therapy for complications of diabetes - Google Patents
Therapy for complications of diabetes Download PDFInfo
- Publication number
- CA2697057A1 CA2697057A1 CA2697057A CA2697057A CA2697057A1 CA 2697057 A1 CA2697057 A1 CA 2697057A1 CA 2697057 A CA2697057 A CA 2697057A CA 2697057 A CA2697057 A CA 2697057A CA 2697057 A1 CA2697057 A1 CA 2697057A1
- Authority
- CA
- Canada
- Prior art keywords
- selective
- receptor antagonist
- group
- darusentan
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000002560 therapeutic procedure Methods 0.000 title claims description 56
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- 239000002464 receptor antagonist Substances 0.000 claims abstract description 208
- 238000000034 method Methods 0.000 claims abstract description 83
- 238000011282 treatment Methods 0.000 claims abstract description 71
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims abstract description 53
- 208000033679 diabetic kidney disease Diseases 0.000 claims abstract description 50
- 230000003276 anti-hypertensive effect Effects 0.000 claims abstract description 43
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 40
- 206010020772 Hypertension Diseases 0.000 claims abstract description 39
- 206010022489 Insulin Resistance Diseases 0.000 claims abstract description 38
- 230000001708 anti-dyslipidemic effect Effects 0.000 claims abstract description 38
- 208000001145 Metabolic Syndrome Diseases 0.000 claims abstract description 35
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims abstract description 35
- 230000003178 anti-diabetic effect Effects 0.000 claims abstract description 35
- 238000011360 adjunctive therapy Methods 0.000 claims abstract description 29
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- 230000002641 glycemic effect Effects 0.000 claims abstract description 26
- 230000002708 enhancing effect Effects 0.000 claims abstract description 15
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 13
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2904447A CA2904447C (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95730007P | 2007-08-22 | 2007-08-22 | |
| US60/957,300 | 2007-08-22 | ||
| PCT/US2008/074013 WO2009026517A2 (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2904447A Division CA2904447C (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2697057A1 true CA2697057A1 (en) | 2009-02-26 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2697057A Abandoned CA2697057A1 (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
| CA2904447A Expired - Fee Related CA2904447C (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2904447A Expired - Fee Related CA2904447C (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
Country Status (5)
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| US (5) | US20090054473A1 (enExample) |
| EP (2) | EP2190433A2 (enExample) |
| JP (5) | JP2010536880A (enExample) |
| CA (2) | CA2697057A1 (enExample) |
| WO (1) | WO2009026517A2 (enExample) |
Families Citing this family (24)
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|---|---|---|---|---|
| US20070196510A1 (en) * | 2006-02-17 | 2007-08-23 | Gerber Michael J | Method for treating resistant hypertension |
| CN101801936B (zh) * | 2007-07-31 | 2012-10-03 | 吉利德科罗拉多公司 | 安立生坦的代谢物和衍生物 |
| CA2697057A1 (en) * | 2007-08-22 | 2009-02-26 | Gilead Colorado, Inc. | Therapy for complications of diabetes |
| CN101632672B (zh) * | 2008-07-24 | 2011-01-12 | 鲁南制药集团股份有限公司 | 一种用于治疗高血压的复方药物组合物 |
| PL2424530T3 (pl) * | 2009-04-30 | 2016-07-29 | Univ Midwestern | Sposób i kompozycja do leczenia cukrzycowej kwasicy ketonowej |
| US9255931B2 (en) | 2010-06-24 | 2016-02-09 | Morehouse School Of Medicine | Method and compositions for the treatment and detection of endothelin-1 related kidney diseases |
| EP2727587A1 (en) * | 2012-10-30 | 2014-05-07 | Pharnext | Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level |
| US9855245B2 (en) | 2013-04-30 | 2018-01-02 | Abbvie Inc. | Methods for improving lipid profiles using atrasentan |
| TWI685348B (zh) * | 2014-05-08 | 2020-02-21 | 美國禮來大藥廠 | 速效胰島素組合物 |
| WO2016073846A1 (en) * | 2014-11-07 | 2016-05-12 | Abbvie Inc. | Methods of treating ckd using predictors of fluid retention |
| JO3749B1 (ar) * | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
| US10369156B2 (en) * | 2016-11-15 | 2019-08-06 | The George Institute for Global Health | Compositions for the treatment of hypertension |
| US12521380B2 (en) | 2017-01-25 | 2026-01-13 | The George Institute for Global Health | Compositions for the treatment of hypertension |
| HRP20230267T1 (hr) | 2017-01-25 | 2023-06-09 | The George Institute for Global Health | Pripravci za liječenje hipertenzije |
| UA126122C2 (uk) * | 2017-02-27 | 2022-08-17 | Ідорсія Фармасьютікалз Лтд | Комбінації похідної 4-піримідинсульфаміду з активними інгредієнтами для лікування захворювань, пов'язаних з ендотеліном |
| US20190260657A1 (en) * | 2018-02-21 | 2019-08-22 | Cisco Technology, Inc. | In-band performance loss measurement in ipv6/srv6 software defined networks |
| CN112469474A (zh) * | 2018-05-03 | 2021-03-09 | 美国中西部大学 | 出血和centhaquin引起的复苏后内皮素受体的变化 |
| WO2019226417A1 (en) * | 2018-05-23 | 2019-11-28 | University Of Miami | Methods of treating renal disease associated with chronic kidney disease such as alport syndrome |
| JP7474738B2 (ja) * | 2018-07-26 | 2024-04-25 | ザ ジョージ インスティテュート フォー グローバル ヘルス | 高血圧症の処置のための組成物 |
| JP7664239B2 (ja) | 2019-10-30 | 2025-04-17 | パフューズ セラピューティクス， インコーポレイテッド | エンドセリンレセプターアンタゴニストを使用する眼疾患の処置 |
| HRP20260121T1 (hr) | 2019-12-17 | 2026-03-13 | Chinook Therapeutics, Inc. | Farmaceutski prihvatljiva sol atrasentana za uporabu u postupku za liječenje iga nefropatije |
| PH12023550025A1 (en) | 2020-07-10 | 2024-03-11 | Astrazeneca Ab | Combination of zibotentan and dapagliflozin for the treatment of chronic kidney disease |
| BR112023022705A2 (pt) | 2021-04-30 | 2024-01-16 | Perfuse Therapeutics Inc | Composições farmacêuticas e sistemas de entrega intravítrea de fármacos para o tratamento de doenças oculares |
| CN116804048B (zh) * | 2023-02-24 | 2024-11-15 | 中国农业大学 | 豌豆白蛋白分离肽、组合物及其用途 |
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| CA2126619A1 (en) * | 1993-06-24 | 1994-12-25 | Yasutaka Igari | Sustained-release preparation of anti-endothelin substance |
| ATE157869T1 (de) * | 1993-06-24 | 1997-09-15 | Lilly Co Eli | Antiöstrogene 2-phenyl-3-aroylbenzothiophene als hypoglykämische mittel |
| US7208517B1 (en) * | 1994-08-19 | 2007-04-24 | Abbott Labortories | Endothelin antagonists |
| US6946481B1 (en) * | 1994-08-19 | 2005-09-20 | Abbott Laboratories | Endothelin antagonists |
| US5767144A (en) * | 1994-08-19 | 1998-06-16 | Abbott Laboratories | Endothelin antagonists |
| AU711832B2 (en) | 1994-08-19 | 1999-10-21 | Abbvie Bahamas Ltd. | Endothelin antagonists |
| US6162927A (en) * | 1994-08-19 | 2000-12-19 | Abbott Laboratories | Endothelin antagonists |
| US7365093B2 (en) * | 1994-08-19 | 2008-04-29 | Abbott Laboratories | Endothelin antagonists |
| ES2259803T3 (es) | 1996-02-13 | 2006-10-16 | Abbott Laboratories | Nuevos derivados de pirrolidina sustituidos con benzo-1,3-dioxolilo y benzofuranilo como antagonistas de endostelina. |
| US6420412B2 (en) * | 1996-03-29 | 2002-07-16 | Smithkline Beecham Corporation | Eprosartan dihydate and a process for its production and formulation |
| US6121416A (en) * | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
| HUP0003484A3 (en) | 1997-08-04 | 2002-02-28 | Abbott Lab | Pyrrolidine-3-crboxylic acid derivatives and their use as endothelin antagonists |
| US7445792B2 (en) * | 2003-03-10 | 2008-11-04 | Abbott Laboratories | Medical device having a hydration inhibitor |
| US8257725B2 (en) * | 1997-09-26 | 2012-09-04 | Abbott Laboratories | Delivery of highly lipophilic agents via medical devices |
| JP4917707B2 (ja) | 1997-09-26 | 2012-04-18 | アボット ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | エンドセリン拮抗剤およびレニン−アンギオテンシン系阻害剤から成る組合せ剤 |
| DE19743140A1 (de) | 1997-09-30 | 1999-04-01 | Knoll Ag | Pharmazeutische Kombinationspräparate |
| DE19743142A1 (de) | 1997-09-30 | 1999-04-01 | Knoll Ag | Pharmazeutische Kombinationspräparate |
| DE19743143A1 (de) | 1997-09-30 | 1999-04-01 | Knoll Ag | Pharmazeutische Kombinationspräparate |
| DE19744799A1 (de) | 1997-10-10 | 1999-04-15 | Knoll Ag | Pharmazeutische Kombinationspräparate |
| DE19754082A1 (de) | 1997-12-05 | 1999-06-10 | Knoll Ag | Methode zur Bekämpfung der Fettleibigkeit |
| JP2002524546A (ja) | 1998-09-14 | 2002-08-06 | アボット・ラボラトリーズ | 立体選択性ニトロ化合物の製造方法 |
| US8257724B2 (en) * | 1998-09-24 | 2012-09-04 | Abbott Laboratories | Delivery of highly lipophilic agents via medical devices |
| US6238708B1 (en) * | 1999-02-23 | 2001-05-29 | The Iams Company | Composition and process for controlling glucose metabolism in companion animals by dietary starch |
| US6559188B1 (en) * | 1999-09-17 | 2003-05-06 | Novartis Ag | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes |
| US20020055457A1 (en) * | 2000-08-07 | 2002-05-09 | Janus Todd J. | Methods of treating cancer and the pain associated therewith using endothelin antagonists |
| TWI306760B (en) | 2000-08-07 | 2009-03-01 | Abbott Lab | Use of an endothelin et-a receptor antagonist and orally delivered pharmaceutical composition comprising the same |
| WO2002017912A1 (en) | 2000-08-31 | 2002-03-07 | Abbott Laboratories | Endothelin antagonists |
| IL158071A0 (en) | 2001-04-11 | 2004-03-28 | Abbott Lab | Favorable modulation of health-related quality of life and health-related quality-adjusted time-to-progression of disease in patients with prostate cancer |
| US20030092757A1 (en) * | 2001-04-11 | 2003-05-15 | Amitabh Singh | Favorable modulation of health-related quality of life and health-related quality-adjusted time-to-progression of disease in patients with prostate cancer |
| US20030022811A1 (en) * | 2001-04-11 | 2003-01-30 | Amitabh Singh | Favorable modulation of health-related quality of life and health-related quality-adjusted time-to-progression of disease in patients with prostate cancer |
| JP4263095B2 (ja) * | 2001-09-21 | 2009-05-13 | ノバルティス アクチエンゲゼルシャフト | Ａｃｅおよびｎｅｐの両阻害剤としてのピラン誘導体 |
| AU2003221042A1 (en) * | 2002-03-22 | 2003-10-08 | Kissei Pharmaceutical Co., Ltd. | Preventive or therapeutic agent for kidney disease |
| GB0212412D0 (en) * | 2002-05-29 | 2002-07-10 | Novartis Ag | Combination of organic compounds |
| CL2004000545A1 (es) | 2003-03-18 | 2005-01-28 | Pharmacia Corp Sa Organizada B | Uso de un antagonista de los receptores de aldosterona y un antagonista de receptores de endotelina para el tratamiento o profilaxis de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopatia y enfermedades cardiovascul |
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| RU2426532C2 (ru) * | 2004-03-17 | 2011-08-20 | Новартис Аг | Применение органических соединений |
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| WO2006034085A1 (en) | 2004-09-17 | 2006-03-30 | Abbott Laboratories | Crystalline form of atrasentan hydrochloride |
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| BRPI0609464A2 (pt) * | 2005-05-23 | 2010-04-13 | Japan Tobacco Inc | composto de pirazol e agente terapêutico para diabetes compreendendo o mesmo |
| US20080132710A1 (en) * | 2006-12-04 | 2008-06-05 | Abbott Laboratories | Atrasentan hydrochloride crystalline form 2 |
| CA2697057A1 (en) * | 2007-08-22 | 2009-02-26 | Gilead Colorado, Inc. | Therapy for complications of diabetes |
| US20100184026A1 (en) * | 2009-01-22 | 2010-07-22 | Abbott Laboratories | Companion Diagnostic Assays For Endothelin Receptor Antagonists |
-
2008
- 2008-08-22 CA CA2697057A patent/CA2697057A1/en not_active Abandoned
- 2008-08-22 EP EP08798489A patent/EP2190433A2/en not_active Withdrawn
- 2008-08-22 WO PCT/US2008/074013 patent/WO2009026517A2/en not_active Ceased
- 2008-08-22 US US12/196,635 patent/US20090054473A1/en not_active Abandoned
- 2008-08-22 JP JP2010522066A patent/JP2010536880A/ja active Pending
- 2008-08-22 EP EP12182366A patent/EP2545920A1/en not_active Withdrawn
- 2008-08-22 CA CA2904447A patent/CA2904447C/en not_active Expired - Fee Related
-
2013
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- 2013-09-05 JP JP2013183975A patent/JP2014001234A/ja active Pending
- 2013-11-13 US US14/079,464 patent/US8865650B2/en active Active
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2014
- 2014-09-19 US US14/491,479 patent/US9592231B2/en not_active Expired - Fee Related
- 2014-09-29 JP JP2014198604A patent/JP2015028062A/ja active Pending
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2015
- 2015-10-30 JP JP2015214045A patent/JP2016053057A/ja active Pending
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2016
- 2016-12-02 US US15/368,016 patent/US20170079978A1/en not_active Abandoned
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2017
- 2017-02-28 JP JP2017035751A patent/JP2017145251A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2904447A1 (en) | 2009-02-26 |
| US20130178424A1 (en) | 2013-07-11 |
| EP2190433A2 (en) | 2010-06-02 |
| US9592231B2 (en) | 2017-03-14 |
| US8623819B2 (en) | 2014-01-07 |
| US20150051234A1 (en) | 2015-02-19 |
| US8865650B2 (en) | 2014-10-21 |
| US20090054473A1 (en) | 2009-02-26 |
| JP2017145251A (ja) | 2017-08-24 |
| JP2015028062A (ja) | 2015-02-12 |
| JP2010536880A (ja) | 2010-12-02 |
| US20170079978A1 (en) | 2017-03-23 |
| JP2014001234A (ja) | 2014-01-09 |
| JP2016053057A (ja) | 2016-04-14 |
| WO2009026517A3 (en) | 2009-05-28 |
| WO2009026517A2 (en) | 2009-02-26 |
| US20140073574A1 (en) | 2014-03-13 |
| CA2904447C (en) | 2017-01-03 |
| EP2545920A1 (en) | 2013-01-16 |
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