CA2697057A1 - Therapy for complications of diabetes - Google Patents
Therapy for complications of diabetes Download PDFInfo
- Publication number
- CA2697057A1 CA2697057A1 CA2697057A CA2697057A CA2697057A1 CA 2697057 A1 CA2697057 A1 CA 2697057A1 CA 2697057 A CA2697057 A CA 2697057A CA 2697057 A CA2697057 A CA 2697057A CA 2697057 A1 CA2697057 A1 CA 2697057A1
- Authority
- CA
- Canada
- Prior art keywords
- selective
- receptor antagonist
- group
- darusentan
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000002560 therapeutic procedure Methods 0.000 title claims description 56
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- 239000002464 receptor antagonist Substances 0.000 claims abstract description 208
- 238000000034 method Methods 0.000 claims abstract description 83
- 238000011282 treatment Methods 0.000 claims abstract description 71
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims abstract description 53
- 208000033679 diabetic kidney disease Diseases 0.000 claims abstract description 50
- 230000003276 anti-hypertensive effect Effects 0.000 claims abstract description 43
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 40
- 206010020772 Hypertension Diseases 0.000 claims abstract description 39
- 206010022489 Insulin Resistance Diseases 0.000 claims abstract description 38
- 230000001708 anti-dyslipidemic effect Effects 0.000 claims abstract description 38
- 208000001145 Metabolic Syndrome Diseases 0.000 claims abstract description 35
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims abstract description 35
- 230000003178 anti-diabetic effect Effects 0.000 claims abstract description 35
- 238000011360 adjunctive therapy Methods 0.000 claims abstract description 29
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- 230000002641 glycemic effect Effects 0.000 claims abstract description 26
- 230000002708 enhancing effect Effects 0.000 claims abstract description 15
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 13
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Public Health (AREA)
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- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
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- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2904447A CA2904447C (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95730007P | 2007-08-22 | 2007-08-22 | |
| US60/957,300 | 2007-08-22 | ||
| PCT/US2008/074013 WO2009026517A2 (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2904447A Division CA2904447C (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2697057A1 true CA2697057A1 (en) | 2009-02-26 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2697057A Abandoned CA2697057A1 (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
| CA2904447A Expired - Fee Related CA2904447C (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2904447A Expired - Fee Related CA2904447C (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
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| US (5) | US20090054473A1 (enExample) |
| EP (2) | EP2545920A1 (enExample) |
| JP (5) | JP2010536880A (enExample) |
| CA (2) | CA2697057A1 (enExample) |
| WO (1) | WO2009026517A2 (enExample) |
Families Citing this family (24)
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| US20070196510A1 (en) * | 2006-02-17 | 2007-08-23 | Gerber Michael J | Method for treating resistant hypertension |
| JP2010535210A (ja) * | 2007-07-31 | 2010-11-18 | ギリード・コロラド・インコーポレーテッド | アンブリセンタンの代謝産物および誘導体 |
| EP2545920A1 (en) * | 2007-08-22 | 2013-01-16 | Abbott GmbH & Co. KG | Therapy for complications of diabetes |
| CN101632672B (zh) * | 2008-07-24 | 2011-01-12 | 鲁南制药集团股份有限公司 | 一种用于治疗高血压的复方药物组合物 |
| BRPI1013904A2 (pt) * | 2009-04-30 | 2016-07-19 | Univ Midwestern | método e composição para tratar cetoacidose diabética |
| US9255931B2 (en) * | 2010-06-24 | 2016-02-09 | Morehouse School Of Medicine | Method and compositions for the treatment and detection of endothelin-1 related kidney diseases |
| EP2727587A1 (en) * | 2012-10-30 | 2014-05-07 | Pharnext | Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level |
| KR20160003128A (ko) | 2013-04-30 | 2016-01-08 | 애브비 인코포레이티드 | 아트라센탄을 사용하는 지질 프로파일을 개선시키기 위한 방법 |
| JO3624B1 (ar) * | 2014-05-08 | 2020-08-27 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
| CN107106522A (zh) * | 2014-11-07 | 2017-08-29 | 艾伯维公司 | 使用液体潴留的预测因子治疗ckd的方法 |
| JO3749B1 (ar) * | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
| US10369156B2 (en) * | 2016-11-15 | 2019-08-06 | The George Institute for Global Health | Compositions for the treatment of hypertension |
| DK4101454T3 (da) | 2017-01-25 | 2024-06-17 | The George Inst For Global Health | Sammensætninger til behandling af hypertension |
| US12521380B2 (en) | 2017-01-25 | 2026-01-13 | The George Institute for Global Health | Compositions for the treatment of hypertension |
| EP3658140B1 (en) * | 2017-02-27 | 2025-05-21 | Idorsia Pharmaceuticals Ltd | Combinations of aprocitentan with further active ingredients for the treatment of resistant hypertension |
| US20190260657A1 (en) * | 2018-02-21 | 2019-08-22 | Cisco Technology, Inc. | In-band performance loss measurement in ipv6/srv6 software defined networks |
| JP7458032B2 (ja) * | 2018-05-03 | 2024-03-29 | ミッドウェスタン ユニバーシティ | 出血およびセンタキンによる蘇生後のエンドセリン受容体の変化 |
| US20210186930A1 (en) * | 2018-05-23 | 2021-06-24 | University Of Miami | Methods of Treating Renal Disease Associated With Chronic Kidney Disease Such as Alport Syndrome |
| KR20210038931A (ko) * | 2018-07-26 | 2021-04-08 | 더 조지 인스티튜트 포 글로벌 헬스 | 고혈압 치료용 조성물 |
| MX2022005063A (es) | 2019-10-30 | 2022-08-04 | Perfuse Therapeutics Inc | Tratamiento de enfermedades oculares con antagonistas de receptor de endotelina. |
| KR20230015874A (ko) | 2019-12-17 | 2023-01-31 | 치누크 세라퓨틱스, 인크. | 아트라센탄에 의해 iga 신장병증을 치료하는 방법 |
| CR20230083A (es) | 2020-07-10 | 2023-05-16 | Astrazeneca Ab | Combinación de zibotentan y dapagliflozina para el tratamiento de la enfermedad renal crónica |
| MX2023012723A (es) | 2021-04-30 | 2024-02-08 | Perfuse Therapeutics Inc | Composiciones farmacéuticas y sistemas de administración de medicamentos intravítreos para el tratamiento de enfermedades oculares. |
| CN116804048B (zh) * | 2023-02-24 | 2024-11-15 | 中国农业大学 | 豌豆白蛋白分离肽、组合物及其用途 |
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2008
- 2008-08-22 EP EP12182366A patent/EP2545920A1/en not_active Withdrawn
- 2008-08-22 CA CA2697057A patent/CA2697057A1/en not_active Abandoned
- 2008-08-22 CA CA2904447A patent/CA2904447C/en not_active Expired - Fee Related
- 2008-08-22 EP EP08798489A patent/EP2190433A2/en not_active Withdrawn
- 2008-08-22 JP JP2010522066A patent/JP2010536880A/ja active Pending
- 2008-08-22 US US12/196,635 patent/US20090054473A1/en not_active Abandoned
- 2008-08-22 WO PCT/US2008/074013 patent/WO2009026517A2/en not_active Ceased
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2013
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- 2013-09-05 JP JP2013183975A patent/JP2014001234A/ja active Pending
- 2013-11-13 US US14/079,464 patent/US8865650B2/en active Active
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2014
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2015
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2016
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2017
- 2017-02-28 JP JP2017035751A patent/JP2017145251A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20130178424A1 (en) | 2013-07-11 |
| CA2904447A1 (en) | 2009-02-26 |
| JP2015028062A (ja) | 2015-02-12 |
| US20140073574A1 (en) | 2014-03-13 |
| WO2009026517A2 (en) | 2009-02-26 |
| US20170079978A1 (en) | 2017-03-23 |
| US9592231B2 (en) | 2017-03-14 |
| WO2009026517A3 (en) | 2009-05-28 |
| JP2014001234A (ja) | 2014-01-09 |
| JP2017145251A (ja) | 2017-08-24 |
| US20090054473A1 (en) | 2009-02-26 |
| US20150051234A1 (en) | 2015-02-19 |
| JP2010536880A (ja) | 2010-12-02 |
| JP2016053057A (ja) | 2016-04-14 |
| US8865650B2 (en) | 2014-10-21 |
| EP2190433A2 (en) | 2010-06-02 |
| EP2545920A1 (en) | 2013-01-16 |
| US8623819B2 (en) | 2014-01-07 |
| CA2904447C (en) | 2017-01-03 |
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