CA2694516A1 - Direct compressible dextrose - Google Patents
Direct compressible dextrose Download PDFInfo
- Publication number
- CA2694516A1 CA2694516A1 CA2694516A CA2694516A CA2694516A1 CA 2694516 A1 CA2694516 A1 CA 2694516A1 CA 2694516 A CA2694516 A CA 2694516A CA 2694516 A CA2694516 A CA 2694516A CA 2694516 A1 CA2694516 A1 CA 2694516A1
- Authority
- CA
- Canada
- Prior art keywords
- dextrose
- dextrose composition
- direct
- direct compressible
- tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 193
- 239000008121 dextrose Substances 0.000 title claims abstract description 189
- 239000000203 mixture Substances 0.000 claims abstract description 168
- 238000000034 method Methods 0.000 claims abstract description 59
- 238000007906 compression Methods 0.000 claims abstract description 31
- 230000006835 compression Effects 0.000 claims abstract description 30
- 238000009472 formulation Methods 0.000 claims abstract description 24
- 235000013305 food Nutrition 0.000 claims abstract description 23
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 17
- 238000004519 manufacturing process Methods 0.000 claims abstract description 16
- 239000003826 tablet Substances 0.000 claims description 114
- 238000009490 roller compaction Methods 0.000 claims description 59
- 239000008187 granular material Substances 0.000 claims description 45
- 239000004480 active ingredient Substances 0.000 claims description 25
- 239000002245 particle Substances 0.000 claims description 24
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 24
- 239000000843 powder Substances 0.000 claims description 23
- 238000007907 direct compression Methods 0.000 claims description 17
- 238000007908 dry granulation Methods 0.000 claims description 16
- 238000009826 distribution Methods 0.000 claims description 13
- 241000237858 Gastropoda Species 0.000 claims description 11
- 238000012216 screening Methods 0.000 claims description 10
- 235000012041 food component Nutrition 0.000 claims description 9
- 239000005417 food ingredient Substances 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 8
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- 235000011475 lollipops Nutrition 0.000 claims description 2
- 239000007909 solid dosage form Substances 0.000 claims description 2
- 238000005469 granulation Methods 0.000 abstract description 26
- 230000003179 granulation Effects 0.000 abstract description 26
- 238000002360 preparation method Methods 0.000 abstract description 8
- 229960001031 glucose Drugs 0.000 description 160
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 18
- SPFMQWBKVUQXJV-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;hydrate Chemical compound O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O SPFMQWBKVUQXJV-BTVCFUMJSA-N 0.000 description 17
- 229960000673 dextrose monohydrate Drugs 0.000 description 17
- 239000002775 capsule Substances 0.000 description 15
- 239000007891 compressed tablet Substances 0.000 description 14
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 9
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 7
- 239000007910 chewable tablet Substances 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- 238000007873 sieving Methods 0.000 description 7
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- 235000019698 starch Nutrition 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 229940068682 chewable tablet Drugs 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
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- 238000010998 test method Methods 0.000 description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
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- 239000008103 glucose Substances 0.000 description 4
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 229930195725 Mannitol Natural products 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
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- 239000008101 lactose Substances 0.000 description 3
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- 229920000881 Modified starch Polymers 0.000 description 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
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- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical class [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 230000001055 chewing effect Effects 0.000 description 2
- 235000019219 chocolate Nutrition 0.000 description 2
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- 238000010586 diagram Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
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- 239000007788 liquid Substances 0.000 description 2
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- 238000003801 milling Methods 0.000 description 2
- 235000019426 modified starch Nutrition 0.000 description 2
- 150000004682 monohydrates Chemical group 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
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- XZKUCJJNNDINKX-HGLHLWFZSA-N (2r,3s,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4s)-3,4,5-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]methoxy]oxane-3,4,5-triol;hydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)C(O)(CO)O1 XZKUCJJNNDINKX-HGLHLWFZSA-N 0.000 description 1
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 1
- DBTMGCOVALSLOR-UHFFFAOYSA-N 32-alpha-galactosyl-3-alpha-galactosyl-galactose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(OC2C(C(CO)OC(O)C2O)O)OC(CO)C1O DBTMGCOVALSLOR-UHFFFAOYSA-N 0.000 description 1
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- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
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- 241001465754 Metazoa Species 0.000 description 1
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- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
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- 150000004781 alginic acids Chemical class 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 229940089206 anhydrous dextrose Drugs 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
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- 229940124584 antitussives Drugs 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- QXJJQWWVWRCVQT-UHFFFAOYSA-K calcium;sodium;phosphate Chemical compound [Na+].[Ca+2].[O-]P([O-])([O-])=O QXJJQWWVWRCVQT-UHFFFAOYSA-K 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
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- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 1
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- 229940125722 laxative agent Drugs 0.000 description 1
- FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 description 1
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- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/0002—Processes of manufacture not relating to composition and compounding ingredients
- A23G3/0004—Processes specially adapted for manufacture or treatment of sweetmeats or confectionery
- A23G3/0019—Shaping of liquid, paste, powder; Manufacture of moulded articles, e.g. modelling, moulding, calendering
- A23G3/0025—Processes in which the material is shaped at least partially in a mould in the hollows of a surface, a drum, an endless band, or by a drop-by-drop casting or dispensing of the material on a surface, e.g. injection moulding, transfer moulding
- A23G3/004—Compression moulding of paste, e.g. in the form of a ball or rope or other preforms, or of a powder or granules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/346—Finished or semi-finished products in the form of powders, paste or liquids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/25—Agglomeration or granulation by extrusion or by pressing, e.g. through small holes, through sieves or between surfaces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
- A23G2200/06—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing beet sugar or cane sugar if specifically mentioned or containing other carbohydrates, e.g. starches, gums, alcohol sugar, polysaccharides, dextrin or containing high or low amount of carbohydrate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07015044.6 | 2007-07-31 | ||
| EP07015044 | 2007-07-31 | ||
| PCT/EP2008/006283 WO2009015880A1 (en) | 2007-07-31 | 2008-07-30 | Direct compressible dextrose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2694516A1 true CA2694516A1 (en) | 2009-02-05 |
Family
ID=39227032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2694516A Abandoned CA2694516A1 (en) | 2007-07-31 | 2008-07-30 | Direct compressible dextrose |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20100273873A1 (enExample) |
| EP (1) | EP2175740B1 (enExample) |
| JP (1) | JP5623275B2 (enExample) |
| CN (1) | CN101772304B (enExample) |
| BR (1) | BRPI0815376A2 (enExample) |
| CA (1) | CA2694516A1 (enExample) |
| ES (1) | ES2686081T3 (enExample) |
| RU (1) | RU2471356C2 (enExample) |
| WO (1) | WO2009015880A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103501817B (zh) | 2011-04-06 | 2015-07-15 | 陶氏环球技术有限责任公司 | 新型多糖衍生物和剂型 |
| KR101923723B1 (ko) | 2012-09-17 | 2018-11-29 | 한국전자통신연구원 | 사용자 간 상호작용이 가능한 메타버스 공간을 제공하기 위한 메타버스 클라이언트 단말 및 방법 |
| EP3116325B1 (en) * | 2014-03-11 | 2020-12-16 | Mars, Incorporated | Heat resistant chocolate composition and method of making it |
| SG11201700451QA (en) | 2014-07-21 | 2017-02-27 | Roquette Freres | Sugar compositions for tableting by direct compression |
| GEAP201914562A (en) * | 2015-02-09 | 2019-04-10 | Rivopharm Sa | Pharmaceutical formulation of racecadotril |
| CN105148280A (zh) * | 2015-07-07 | 2015-12-16 | 深圳国源国药有限公司 | 一种创新药用辅料可压性蔗糖及其制备方法 |
| CN108553645A (zh) * | 2018-03-27 | 2018-09-21 | 天津信诚康达药业有限公司 | 一种创新型辅料蔗糖及其制备方法 |
| WO2020252284A1 (en) * | 2019-06-13 | 2020-12-17 | Imbucanna, Inc | Compressible cannabinoid pharmaceutical composition |
| WO2020254940A1 (en) * | 2019-06-15 | 2020-12-24 | Shrinivasan Shesha Iyengar | Glucose sustained release compositions and it's process |
| AU2021268062B2 (en) * | 2020-05-08 | 2024-08-15 | Fertin Pharma A/S | Flowpack for oral delivery of active ingredients |
| US20230123099A1 (en) * | 2021-10-15 | 2023-04-20 | Fertin Pharma A/S | Dextrose tablets with improved mouthfeel |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3619292A (en) * | 1968-07-15 | 1971-11-09 | Penick & Ford Ltd | Tablets and method of forming |
| US4072535A (en) * | 1970-12-28 | 1978-02-07 | A. E. Staley Manufacturing Company | Precompacted-starch binder-disintegrant-filler material for direct compression tablets and dry dosage capsules |
| US4684534A (en) * | 1985-02-19 | 1987-08-04 | Dynagram Corporation Of America | Quick-liquifying, chewable tablet |
| DE19615422A1 (de) * | 1996-04-19 | 1997-11-20 | Boehringer Ingelheim Kg | Zweikammer-Kartusche für treibgasfreie Dosieraerosole |
| GB9613470D0 (en) * | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
| RU2189227C2 (ru) * | 1996-07-12 | 2002-09-20 | Дайити Фармасьютикал Ко., Лтд. | Быстро распадающиеся прессованные в формах материалы и способ их получения |
| FR2787811B1 (fr) * | 1998-12-24 | 2001-03-02 | Roquette Freres | Dextrose pulverulent et son procede de preparation |
| US6527868B2 (en) * | 1999-12-15 | 2003-03-04 | Roquette Freres | Dextrose in powder form and a process for the preparation thereof |
| FR2802551B1 (fr) * | 1999-12-17 | 2006-08-04 | Roquette Freres | Dextrose hydrate pulverulent et son procede de preparation |
| HUP0304078A2 (hu) * | 2001-05-15 | 2004-04-28 | Warner-Lambert Co. Llc | Tömörítési eljárás nátrium-fenitoin gyógyszerkészítmény előállítására |
| NZ532707A (en) * | 2001-12-21 | 2006-07-28 | Pfizer Prod Inc | Directly compressible formulations of azithromycin |
| BR0307666A (pt) * | 2002-02-14 | 2005-01-11 | Glaxo Group Ltd | Composição farmacêutica compreendendo n-[(1-n-butil-4-piperidinil)metil]-3,4-diidro-2h[1-3]oxazi no(3,2-a) indol-10-carboxamida ou sal e processo para esta compreendendo granulação seca |
| US20070178150A1 (en) * | 2003-07-10 | 2007-08-02 | Prasad Adusumilli | Pharmaceutical compositions |
| DK2792363T3 (da) * | 2003-08-26 | 2016-09-26 | Shire Biopharmaceuticals Holdings Ireland Ltd | Farmaceutisk formulering, der omfatter lanthanforbindelser |
| TWI415635B (zh) * | 2004-05-28 | 2013-11-21 | 必治妥施貴寶公司 | 加衣錠片調製物及製備彼之方法 |
-
2008
- 2008-07-30 JP JP2010518562A patent/JP5623275B2/ja active Active
- 2008-07-30 CA CA2694516A patent/CA2694516A1/en not_active Abandoned
- 2008-07-30 US US12/671,455 patent/US20100273873A1/en not_active Abandoned
- 2008-07-30 EP EP08785228.1A patent/EP2175740B1/en active Active
- 2008-07-30 ES ES08785228.1T patent/ES2686081T3/es active Active
- 2008-07-30 CN CN200880101215.5A patent/CN101772304B/zh not_active Expired - Fee Related
- 2008-07-30 WO PCT/EP2008/006283 patent/WO2009015880A1/en not_active Ceased
- 2008-07-30 BR BRPI0815376-0A2A patent/BRPI0815376A2/pt active Search and Examination
- 2008-07-30 RU RU2010107185/13A patent/RU2471356C2/ru not_active IP Right Cessation
-
2012
- 2012-11-21 US US13/682,883 patent/US20130075948A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2686081T3 (es) | 2018-10-16 |
| RU2010107185A (ru) | 2011-09-10 |
| BRPI0815376A2 (pt) | 2014-10-07 |
| JP5623275B2 (ja) | 2014-11-12 |
| CN101772304A (zh) | 2010-07-07 |
| EP2175740B1 (en) | 2018-06-06 |
| RU2471356C2 (ru) | 2013-01-10 |
| US20130075948A1 (en) | 2013-03-28 |
| CN101772304B (zh) | 2014-07-09 |
| US20100273873A1 (en) | 2010-10-28 |
| EP2175740A1 (en) | 2010-04-21 |
| WO2009015880A1 (en) | 2009-02-05 |
| JP2010534698A (ja) | 2010-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20130723 |
|
| FZDE | Discontinued |
Effective date: 20160725 |