CA2692079C - Spectrometre de masse - Google Patents
Spectrometre de masse Download PDFInfo
- Publication number
- CA2692079C CA2692079C CA2692079A CA2692079A CA2692079C CA 2692079 C CA2692079 C CA 2692079C CA 2692079 A CA2692079 A CA 2692079A CA 2692079 A CA2692079 A CA 2692079A CA 2692079 C CA2692079 C CA 2692079C
- Authority
- CA
- Canada
- Prior art keywords
- ions
- ion trap
- electrodes
- electrode set
- ion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000002500 ions Chemical class 0.000 claims abstract description 422
- 238000005040 ion trap Methods 0.000 claims abstract description 308
- 230000007423 decrease Effects 0.000 claims abstract description 28
- 238000006073 displacement reaction Methods 0.000 claims description 61
- 230000004888 barrier function Effects 0.000 claims description 55
- 238000005036 potential barrier Methods 0.000 claims description 54
- 238000000605 extraction Methods 0.000 claims description 43
- 230000005405 multipole Effects 0.000 claims description 21
- 230000005284 excitation Effects 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 14
- 230000005540 biological transmission Effects 0.000 claims description 6
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 238000004949 mass spectrometry Methods 0.000 claims description 3
- 238000012790 confirmation Methods 0.000 description 52
- 238000013467 fragmentation Methods 0.000 description 34
- 238000006062 fragmentation reaction Methods 0.000 description 34
- 238000011144 upstream manufacturing Methods 0.000 description 31
- 238000010494 dissociation reaction Methods 0.000 description 28
- 230000005593 dissociations Effects 0.000 description 28
- 230000001419 dependent effect Effects 0.000 description 25
- 238000006243 chemical reaction Methods 0.000 description 19
- 230000005684 electric field Effects 0.000 description 17
- 238000004088 simulation Methods 0.000 description 13
- 230000004323 axial length Effects 0.000 description 10
- 230000001052 transient effect Effects 0.000 description 10
- 238000000576 coating method Methods 0.000 description 8
- 238000001211 electron capture detection Methods 0.000 description 8
- 238000001077 electron transfer detection Methods 0.000 description 8
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 7
- 239000011248 coating agent Substances 0.000 description 6
- 230000009977 dual effect Effects 0.000 description 6
- 239000012634 fragment Substances 0.000 description 6
- 230000001133 acceleration Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000001360 collision-induced dissociation Methods 0.000 description 4
- 238000003795 desorption Methods 0.000 description 4
- 238000000688 desorption electrospray ionisation Methods 0.000 description 4
- 238000010265 fast atom bombardment Methods 0.000 description 4
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 238000001698 laser desorption ionisation Methods 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 238000005513 bias potential Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000132 electrospray ionisation Methods 0.000 description 3
- 239000001307 helium Substances 0.000 description 3
- 229910052734 helium Inorganic materials 0.000 description 3
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 3
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 description 2
- 208000035699 Distal ileal obstruction syndrome Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- -1 anions) Chemical class 0.000 description 2
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000000451 chemical ionisation Methods 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000001976 enzyme digestion Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000010884 ion-beam technique Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 238000005381 potential energy Methods 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 101001011741 Bos taurus Insulin Proteins 0.000 description 1
- 238000004252 FT/ICR mass spectrometry Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- IXIBAKNTJSCKJM-BUBXBXGNSA-N bovine insulin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 IXIBAKNTJSCKJM-BUBXBXGNSA-N 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- PXHVJJICTQNCMI-RNFDNDRNSA-N nickel-63 Chemical compound [63Ni] PXHVJJICTQNCMI-RNFDNDRNSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000004150 penning trap Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000012495 reaction gas Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000004885 tandem mass spectrometry Methods 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/426—Methods for controlling ions
- H01J49/427—Ejection and selection methods
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0713590.8A GB0713590D0 (en) | 2007-07-12 | 2007-07-12 | Mass spectrometer |
| GB0713590.8 | 2007-07-12 | ||
| US95197407P | 2007-07-26 | 2007-07-26 | |
| US60/951,974 | 2007-07-26 | ||
| PCT/GB2008/002402 WO2009007739A2 (fr) | 2007-07-12 | 2008-07-14 | Spectromètre de masse |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2692079A1 CA2692079A1 (fr) | 2009-01-15 |
| CA2692079C true CA2692079C (fr) | 2016-07-05 |
Family
ID=38461504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2692079A Expired - Fee Related CA2692079C (fr) | 2007-07-12 | 2008-07-14 | Spectrometre de masse |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8426803B2 (fr) |
| EP (3) | EP2581928B1 (fr) |
| JP (1) | JP5301537B2 (fr) |
| CN (1) | CN101802966B (fr) |
| CA (1) | CA2692079C (fr) |
| GB (2) | GB0713590D0 (fr) |
| HK (1) | HK1145566A1 (fr) |
| WO (1) | WO2009007739A2 (fr) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0514964D0 (en) | 2005-07-21 | 2005-08-24 | Ms Horizons Ltd | Mass spectrometer devices & methods of performing mass spectrometry |
| JP5341753B2 (ja) | 2006-07-10 | 2013-11-13 | マイクロマス ユーケー リミテッド | 質量分析計 |
| GB0624740D0 (en) * | 2006-12-12 | 2007-01-17 | Micromass Ltd | Mass spectrometer |
| GB0713590D0 (en) * | 2007-07-12 | 2007-08-22 | Micromass Ltd | Mass spectrometer |
| GB0810125D0 (en) * | 2008-06-03 | 2008-07-09 | Thermo Fisher Scient Bremen | Collosion cell |
| GB0900917D0 (en) | 2009-01-20 | 2009-03-04 | Micromass Ltd | Mass spectrometer |
| GB0900973D0 (en) | 2009-01-21 | 2009-03-04 | Micromass Ltd | Method and apparatus for performing MS^N |
| US8541737B2 (en) * | 2009-11-30 | 2013-09-24 | Battelle Memorial Institute | System and method for collisional activation of charged particles |
| DE102010001349B9 (de) * | 2010-01-28 | 2014-08-28 | Carl Zeiss Microscopy Gmbh | Vorrichtung zum Fokussieren sowie zum Speichern von Ionen |
| CN103119689B (zh) * | 2010-08-04 | 2016-10-05 | Dh科技发展私人贸易有限公司 | 用于径向幅值辅助转移的线性离子阱 |
| CA2809207C (fr) * | 2010-08-25 | 2018-01-16 | Dh Technologies Development Pte. Ltd. | Procedes et systemes donnant un champ sensiblement quadripolaire avec des composantes hexapolaires et octapolaires |
| GB201018184D0 (en) * | 2010-10-27 | 2010-12-08 | Micromass Ltd | Asymmetric field ion mobility in a linear geometry ion trap |
| WO2012067195A1 (fr) * | 2010-11-19 | 2012-05-24 | 株式会社日立ハイテクノロジーズ | Spectromètre de masse et procédé de spectrométrie de masse |
| US8581177B2 (en) * | 2011-04-11 | 2013-11-12 | Thermo Finnigan Llc | High duty cycle ion storage/ion mobility separation mass spectrometer |
| GB201114734D0 (en) * | 2011-08-25 | 2011-10-12 | Micromass Ltd | Mass spectrometer |
| GB201116026D0 (en) | 2011-09-16 | 2011-10-26 | Micromass Ltd | Performance improvements for rf-only quadrupole mass filters and linear quadrupole ion traps with axial ejection |
| EP2798663A4 (fr) * | 2011-12-27 | 2015-09-02 | Dh Technologies Dev Pte Ltd | Procédé d'extraction d'ions avec un rapport m/z faible au moyen d'un piège ionique |
| US9368336B2 (en) | 2013-01-31 | 2016-06-14 | Beijing Institute Of Technology | Ion trap-based apparatus and method for analyzing and detecting bipolar ions |
| CA2901378C (fr) * | 2013-02-18 | 2019-07-02 | Micromass Uk Limited | Efficacite amelioree et commande precise des reactions en phase gazeuse dans des spectrometres de masse a l'aide d'un piege a ions a ejection automatique |
| CN104576288B (zh) * | 2013-10-28 | 2017-02-08 | 北京理工大学 | 一种离子连续收集装置和方法、以及离子富集系统和方法 |
| CN106373854B (zh) * | 2015-07-23 | 2018-12-21 | 株式会社岛津制作所 | 一种离子导引装置 |
| CN105632878B (zh) * | 2016-01-01 | 2017-11-17 | 杭州谱育科技发展有限公司 | 四极杆质量分析器的工作方法 |
| CN105869986B (zh) * | 2016-05-04 | 2017-07-25 | 苏州大学 | 一种可提高离子探测效率的质谱分析系统 |
| GB2558221B (en) | 2016-12-22 | 2022-07-20 | Micromass Ltd | Ion mobility separation exit transmission control |
| US10242857B2 (en) * | 2017-08-31 | 2019-03-26 | The University Of North Carolina At Chapel Hill | Ion traps with Y-directional ion manipulation for mass spectrometry and related mass spectrometry systems and methods |
| GB2573485B (en) | 2017-11-20 | 2022-01-12 | Thermo Fisher Scient Bremen Gmbh | Mass spectrometer |
| US11251029B2 (en) * | 2018-08-29 | 2022-02-15 | Dh Technologies Development Pte. Ltd. | Method for top down proteomics using ExD and PTR |
| US11087968B2 (en) | 2018-12-14 | 2021-08-10 | Thermo Finnigan Llc. | Traveling wave multipole |
| US11201044B2 (en) | 2020-03-03 | 2021-12-14 | Thermo Finnigan Llc | Multipole assembly configurations for reduced capacitive coupling |
| US20240087868A1 (en) * | 2022-09-09 | 2024-03-14 | The Trustees Of Indiana University | Method of controlling a multi-pole device to reduce omission of exiting charged particles from downstream analysis |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5783824A (en) | 1995-04-03 | 1998-07-21 | Hitachi, Ltd. | Ion trapping mass spectrometry apparatus |
| JP3495512B2 (ja) * | 1996-07-02 | 2004-02-09 | 株式会社日立製作所 | イオントラップ質量分析装置 |
| EP0843887A1 (fr) * | 1995-08-11 | 1998-05-27 | Mds Health Group Limited | Spectrometre a champ axial |
| US6177668B1 (en) * | 1996-06-06 | 2001-01-23 | Mds Inc. | Axial ejection in a multipole mass spectrometer |
| WO1998052209A1 (fr) * | 1997-05-12 | 1998-11-19 | Mds Inc. | Spectrometre de masse uniquement rf a excitation auxiliaire |
| US6504148B1 (en) * | 1999-05-27 | 2003-01-07 | Mds Inc. | Quadrupole mass spectrometer with ION traps to enhance sensitivity |
| US6630662B1 (en) * | 2002-04-24 | 2003-10-07 | Mds Inc. | Setup for mobility separation of ions implementing an ion guide with an axial field and counterflow of gas |
| AU2003229212A1 (en) * | 2002-05-30 | 2003-12-19 | Mds Inc., Doing Business As Mds Sciex | Methods and apparatus for reducing artifacts in mass spectrometers |
| DE10236346A1 (de) * | 2002-08-08 | 2004-02-19 | Bruker Daltonik Gmbh | Nichtlinearer Resonanzauswurf aus linearen Ionenfallen |
| EP1609167A4 (fr) * | 2003-03-21 | 2007-07-25 | Dana Farber Cancer Inst Inc | Systeme de spectroscopie de masse |
| JP4223937B2 (ja) * | 2003-12-16 | 2009-02-12 | 株式会社日立ハイテクノロジーズ | 質量分析装置 |
| DE602005027656D1 (de) | 2004-01-09 | 2011-06-09 | Micromass Ltd | Ionenextraktionseinrichtungen und verfahren zur selektiven extraktion von ionen |
| CA2608972A1 (fr) | 2005-05-18 | 2006-11-23 | Mds Inc. Doing Business As Mds Sciex | Procede et appareil de transport axial selectif de masse utilisant un cc quadripolaire |
| US7675033B2 (en) * | 2005-10-31 | 2010-03-09 | Hitachi, Ltd. | Method of mass spectrometry and mass spectrometer |
| EP1955359B1 (fr) * | 2005-11-30 | 2015-04-01 | DH Technologies Development Pte. Ltd. | Procede et dispositif pour transport axial par selection de masse au moyen d'un champ axial pulse |
| JP5341753B2 (ja) | 2006-07-10 | 2013-11-13 | マイクロマス ユーケー リミテッド | 質量分析計 |
| JP5081436B2 (ja) * | 2006-11-24 | 2012-11-28 | 株式会社日立ハイテクノロジーズ | 質量分析装置及び質量分析方法 |
| US7633060B2 (en) | 2007-04-24 | 2009-12-15 | Thermo Finnigan Llc | Separation and axial ejection of ions based on m/z ratio |
| GB0713590D0 (en) * | 2007-07-12 | 2007-08-22 | Micromass Ltd | Mass spectrometer |
| KR101484297B1 (ko) | 2007-08-31 | 2015-01-19 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 표시장치 및 표시장치의 제작방법 |
-
2007
- 2007-07-12 GB GBGB0713590.8A patent/GB0713590D0/en not_active Ceased
-
2008
- 2008-07-14 CN CN2008801066691A patent/CN101802966B/zh active Active
- 2008-07-14 JP JP2010515599A patent/JP5301537B2/ja not_active Expired - Fee Related
- 2008-07-14 CA CA2692079A patent/CA2692079C/fr not_active Expired - Fee Related
- 2008-07-14 WO PCT/GB2008/002402 patent/WO2009007739A2/fr active Application Filing
- 2008-07-14 GB GB0812827A patent/GB2455377B/en active Active
- 2008-07-14 EP EP12194500.0A patent/EP2581928B1/fr active Active
- 2008-07-14 EP EP08775941.1A patent/EP2168141B1/fr active Active
- 2008-07-14 US US12/668,813 patent/US8426803B2/en active Active
- 2008-07-14 EP EP12194499.5A patent/EP2581927B1/fr active Active
-
2010
- 2010-12-23 HK HK10112045.8A patent/HK1145566A1/xx not_active IP Right Cessation
-
2013
- 2013-03-21 US US13/848,504 patent/US8796615B2/en active Active
-
2014
- 2014-01-17 US US14/158,111 patent/US8987661B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2581928A2 (fr) | 2013-04-17 |
| EP2168141A2 (fr) | 2010-03-31 |
| EP2581927A3 (fr) | 2013-12-25 |
| CN101802966A (zh) | 2010-08-11 |
| WO2009007739A2 (fr) | 2009-01-15 |
| CN101802966B (zh) | 2013-02-27 |
| GB2455377B (en) | 2010-04-28 |
| EP2581928B1 (fr) | 2018-09-19 |
| US20100252730A1 (en) | 2010-10-07 |
| US20140131568A1 (en) | 2014-05-15 |
| US8426803B2 (en) | 2013-04-23 |
| GB0713590D0 (en) | 2007-08-22 |
| JP2010533353A (ja) | 2010-10-21 |
| CA2692079A1 (fr) | 2009-01-15 |
| US8987661B2 (en) | 2015-03-24 |
| EP2168141B1 (fr) | 2014-06-25 |
| JP5301537B2 (ja) | 2013-09-25 |
| US8796615B2 (en) | 2014-08-05 |
| WO2009007739A3 (fr) | 2009-10-29 |
| US20130221242A1 (en) | 2013-08-29 |
| EP2581927A2 (fr) | 2013-04-17 |
| EP2581928A3 (fr) | 2013-12-25 |
| GB0812827D0 (en) | 2008-08-20 |
| EP2581927B1 (fr) | 2020-09-02 |
| HK1145566A1 (en) | 2011-04-21 |
| GB2455377A (en) | 2009-06-10 |
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