GB2573485B - Mass spectrometer - Google Patents

Mass spectrometer Download PDF

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Publication number
GB2573485B
GB2573485B GB1719226.1A GB201719226A GB2573485B GB 2573485 B GB2573485 B GB 2573485B GB 201719226 A GB201719226 A GB 201719226A GB 2573485 B GB2573485 B GB 2573485B
Authority
GB
United Kingdom
Prior art keywords
mass spectrometer
spectrometer
mass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1719226.1A
Other versions
GB2573485A (en
GB201719226D0 (en
Inventor
Ian Stewart Hamish
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermo Fisher Scientific Bremen GmbH
Original Assignee
Thermo Fisher Scientific Bremen GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermo Fisher Scientific Bremen GmbH filed Critical Thermo Fisher Scientific Bremen GmbH
Priority to GB1719226.1A priority Critical patent/GB2573485B/en
Priority to GB2117166.5A priority patent/GB2601063B/en
Publication of GB201719226D0 publication Critical patent/GB201719226D0/en
Priority to US16/168,707 priority patent/US10978289B2/en
Priority to CN201811374064.2A priority patent/CN109817507B/en
Priority to DE102018009119.9A priority patent/DE102018009119A1/en
Publication of GB2573485A publication Critical patent/GB2573485A/en
Priority to US17/206,083 priority patent/US11508567B2/en
Application granted granted Critical
Publication of GB2573485B publication Critical patent/GB2573485B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0072—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by ion/ion reaction, e.g. electron transfer dissociation, proton transfer dissociation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/067—Ion lenses, apertures, skimmers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/422—Two-dimensional RF ion traps
    • H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/4265—Controlling the number of trapped ions; preventing space charge effects
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/427—Ejection and selection methods
GB1719226.1A 2017-11-20 2017-11-20 Mass spectrometer Active GB2573485B (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB1719226.1A GB2573485B (en) 2017-11-20 2017-11-20 Mass spectrometer
GB2117166.5A GB2601063B (en) 2017-11-20 2017-11-20 Mass spectrometer
US16/168,707 US10978289B2 (en) 2017-11-20 2018-10-23 Methods and apparatus for ion fragmentation in a mass spectrometer
CN201811374064.2A CN109817507B (en) 2017-11-20 2018-11-19 Mass spectrometer
DE102018009119.9A DE102018009119A1 (en) 2017-11-20 2018-11-20 mass spectrometry
US17/206,083 US11508567B2 (en) 2017-11-20 2021-03-18 Methods and apparatus for ion fragmentation in a mass spectrometer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1719226.1A GB2573485B (en) 2017-11-20 2017-11-20 Mass spectrometer

Publications (3)

Publication Number Publication Date
GB201719226D0 GB201719226D0 (en) 2018-01-03
GB2573485A GB2573485A (en) 2019-11-13
GB2573485B true GB2573485B (en) 2022-01-12

Family

ID=60805736

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1719226.1A Active GB2573485B (en) 2017-11-20 2017-11-20 Mass spectrometer

Country Status (4)

Country Link
US (2) US10978289B2 (en)
CN (1) CN109817507B (en)
DE (1) DE102018009119A1 (en)
GB (1) GB2573485B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11728153B2 (en) * 2018-12-14 2023-08-15 Thermo Finnigan Llc Collision cell with enhanced ion beam focusing and transmission
US11087968B2 (en) 2018-12-14 2021-08-10 Thermo Finnigan Llc. Traveling wave multipole
CN111223740B (en) * 2020-01-19 2021-03-19 清华大学 Method and system for regulating and controlling ion quantity in mass spectrometer ion trap mass analyzer
GB2605395A (en) * 2021-03-30 2022-10-05 Thermo Fisher Scient Bremen Gmbh Ion trap

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009085794A2 (en) * 2007-12-20 2009-07-09 Purdue Research Foundation Method and apparatus for activation of cation transmission-mode ion/ion reactions
GB2460506A (en) * 2008-04-14 2009-12-09 Micromass Ltd Optimising electron transfer dissociation and/or charge reduction processes
WO2010002819A1 (en) * 2008-07-01 2010-01-07 Waters Technologies Corporation Stacked-electrode peptide-fragmentation device
WO2011095465A2 (en) * 2010-02-04 2011-08-11 Thermo Fisher Scientific (Bremen) Gmbh Dual ion trapping for ion/ion reactions in a linear rf multipole trap with an additional dc gradient

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002214196A (en) 2001-01-18 2002-07-31 Hitachi Ltd Dna analytic system
US6683301B2 (en) 2001-01-29 2004-01-27 Analytica Of Branford, Inc. Charged particle trapping in near-surface potential wells
US7265344B2 (en) 2001-03-23 2007-09-04 Thermo Finnigan Llc Mass spectrometry method and apparatus
US7026613B2 (en) 2004-01-23 2006-04-11 Thermo Finnigan Llc Confining positive and negative ions with fast oscillating electric potentials
US20060255261A1 (en) * 2005-04-04 2006-11-16 Craig Whitehouse Atmospheric pressure ion source for mass spectrometry
GB0511386D0 (en) 2005-06-03 2005-07-13 Shimadzu Res Lab Europe Ltd Method for introducing ions into an ion trap and an ion storage apparatus
US7351955B2 (en) 2005-09-09 2008-04-01 Thermo Finnigan Llc Reduction of chemical noise in a MALDI mass spectrometer by in-trap photodissociation of matrix cluster ions
CA2628922C (en) * 2005-11-10 2016-01-26 Micromass Uk Limited Mass spectrometer
US7385185B2 (en) * 2005-12-20 2008-06-10 Agilent Technologies, Inc. Molecular activation for tandem mass spectroscopy
US7829851B2 (en) * 2006-12-01 2010-11-09 Purdue Research Foundation Method and apparatus for collisional activation of polypeptide ions
GB0713590D0 (en) 2007-07-12 2007-08-22 Micromass Ltd Mass spectrometer
US8138472B2 (en) * 2009-04-29 2012-03-20 Academia Sinica Molecular ion accelerator
GB2490958B (en) 2011-05-20 2016-02-10 Thermo Fisher Scient Bremen Method and apparatus for mass analysis
GB201111560D0 (en) 2011-07-06 2011-08-24 Micromass Ltd Photo-dissociation of proteins and peptides in a mass spectrometer
EP2555225A1 (en) 2011-08-05 2013-02-06 Institut National De La Recherche Agronomique (Inra) Tandem mass spectrometer and tandem mass spectrometry method
US20140353491A1 (en) 2011-12-30 2014-12-04 DH Technologies Development Pte,Ltd. Creating an ion-ion reaction region within a low-pressure linear ion trap
US10840073B2 (en) 2012-05-18 2020-11-17 Thermo Fisher Scientific (Bremen) Gmbh Methods and apparatus for obtaining enhanced mass spectrometric data
GB201208812D0 (en) 2012-05-18 2012-07-04 Micromass Ltd Cryogenic collision cell
GB201409074D0 (en) 2014-05-21 2014-07-02 Thermo Fisher Scient Bremen Ion ejection from a quadrupole ion trap
US20160358766A1 (en) 2015-06-03 2016-12-08 Thermo Finnigan Llc Reducing overfragmentation in ultraviolet photodissociation
EP3343588A1 (en) 2016-12-29 2018-07-04 Thermo Finnigan LLC Methods of ultraviolet photodissociation for mass spectrometry

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009085794A2 (en) * 2007-12-20 2009-07-09 Purdue Research Foundation Method and apparatus for activation of cation transmission-mode ion/ion reactions
GB2460506A (en) * 2008-04-14 2009-12-09 Micromass Ltd Optimising electron transfer dissociation and/or charge reduction processes
WO2010002819A1 (en) * 2008-07-01 2010-01-07 Waters Technologies Corporation Stacked-electrode peptide-fragmentation device
WO2011095465A2 (en) * 2010-02-04 2011-08-11 Thermo Fisher Scientific (Bremen) Gmbh Dual ion trapping for ion/ion reactions in a linear rf multipole trap with an additional dc gradient

Also Published As

Publication number Publication date
CN109817507B (en) 2021-07-09
US11508567B2 (en) 2022-11-22
GB2573485A (en) 2019-11-13
GB201719226D0 (en) 2018-01-03
DE102018009119A1 (en) 2019-05-23
US10978289B2 (en) 2021-04-13
US20210210334A1 (en) 2021-07-08
US20190157065A1 (en) 2019-05-23
CN109817507A (en) 2019-05-28

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