CA2687557A1 - Derives d'acides amines polyfonctionnels du fullerene c60 - Google Patents

Derives d'acides amines polyfonctionnels du fullerene c60 Download PDF

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Publication number
CA2687557A1
CA2687557A1 CA002687557A CA2687557A CA2687557A1 CA 2687557 A1 CA2687557 A1 CA 2687557A1 CA 002687557 A CA002687557 A CA 002687557A CA 2687557 A CA2687557 A CA 2687557A CA 2687557 A1 CA2687557 A1 CA 2687557A1
Authority
CA
Canada
Prior art keywords
amino acid
fullerene
nitroxyalkyl
fullerenyl
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002687557A
Other languages
English (en)
Inventor
Alexandr Ivanovich Kotelnikov
Valentina Semenovna Romanova
Gennady Nikolaevich Bogdanov
Nina Petrovna Konovalova
Oleg Ivanovich Pisarenko
Raisa Alekseevna Kotelnikova
Irina Igorevna Faingold
Elena Sergeevna Frog
Yury Nikolaevich Bubnov
Sergei Mikhailovich Aldoshin
Mikhail Ivanovich Davydov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Federalnoe Gosudarstvennoe Uchrezhdenie Rossysky Kardiologichesky Nauchno-Proizvodstvenny Kompleks Federalnogo Agenstva Pozdravookhraneniyu I Sotsialnomu Razvitiyu Roszdrava
Institute of Problems of Chemcial Physics RAS (IPCP RAS)
Original Assignee
Institute Of Problems Of Chemical Physics Ras (Ipcp Ras)
Federalnoe Gosudarstvennoe Uchrezhdenie Rossysky Kardiologichesky Nauchno-Proizvodstvenny Kompleks Federalnogo Agenstva Pozdravookhraneniyu I Sotsialnomu Razvitiyu Roszdrava
Alexandr Ivanovich Kotelnikov
Valentina Semenovna Romanova
Gennady Nikolaevich Bogdanov
Nina Petrovna Konovalova
Oleg Ivanovich Pisarenko
Raisa Alekseevna Kotelnikova
Irina Igorevna Faingold
Elena Sergeevna Frog
Yury Nikolaevich Bubnov
Sergei Mikhailovich Aldoshin
Mikhail Ivanovich Davydov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute Of Problems Of Chemical Physics Ras (Ipcp Ras), Federalnoe Gosudarstvennoe Uchrezhdenie Rossysky Kardiologichesky Nauchno-Proizvodstvenny Kompleks Federalnogo Agenstva Pozdravookhraneniyu I Sotsialnomu Razvitiyu Roszdrava, Alexandr Ivanovich Kotelnikov, Valentina Semenovna Romanova, Gennady Nikolaevich Bogdanov, Nina Petrovna Konovalova, Oleg Ivanovich Pisarenko, Raisa Alekseevna Kotelnikova, Irina Igorevna Faingold, Elena Sergeevna Frog, Yury Nikolaevich Bubnov, Sergei Mikhailovich Aldoshin, Mikhail Ivanovich Davydov filed Critical Institute Of Problems Of Chemical Physics Ras (Ipcp Ras)
Publication of CA2687557A1 publication Critical patent/CA2687557A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002687557A 2007-06-19 2007-06-19 Derives d'acides amines polyfonctionnels du fullerene c60 Abandoned CA2687557A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU2007/000337 WO2009002203A1 (fr) 2007-06-19 2007-06-19 Dérivés d'acides aminés polyfonctionnels du fullerène c60

Publications (1)

Publication Number Publication Date
CA2687557A1 true CA2687557A1 (fr) 2008-12-31

Family

ID=40185849

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002687557A Abandoned CA2687557A1 (fr) 2007-06-19 2007-06-19 Derives d'acides amines polyfonctionnels du fullerene c60

Country Status (2)

Country Link
CA (1) CA2687557A1 (fr)
WO (1) WO2009002203A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015138819A1 (fr) * 2014-03-14 2015-09-17 Livepet, Llc. Améliorations cellulaires par l'intermédiaire de combinaisons de groupes lipofullerènes et peptidiques
US9246104B2 (en) 2013-09-25 2016-01-26 Showa Denko K.K. Fullerene derivative, method of manufacturing fullerene derivative and solar cell

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2458914C1 (ru) 2011-02-01 2012-08-20 Лев Давидович Раснецов Гомо- и гетеро-полиаминокислотные производные фуллерена c60, способ их получения и фармацевтические композиции на их основе

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4293735B2 (ja) * 2001-01-19 2009-07-08 三栄源エフ・エフ・アイ株式会社 フラーレン誘導体およびそれからなる組成物
RU2213049C1 (ru) * 2002-07-08 2003-09-27 Закрытое акционерное общество "ДЕСКО" Способ получения водорастворимых аминокислотных производных фуллерена
RU2236852C1 (ru) * 2003-06-23 2004-09-27 Закрытое акционерное общество "ДЕСКО" Средство для ингибирования репродукции оболоченных вирусов, способ его получения, фармацевтическая композиция и способ ингибирования вирусных инфекций
WO2005070827A2 (fr) * 2004-01-14 2005-08-04 William Marsh Rice University Acides amines a base de fullerenes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9246104B2 (en) 2013-09-25 2016-01-26 Showa Denko K.K. Fullerene derivative, method of manufacturing fullerene derivative and solar cell
WO2015138819A1 (fr) * 2014-03-14 2015-09-17 Livepet, Llc. Améliorations cellulaires par l'intermédiaire de combinaisons de groupes lipofullerènes et peptidiques

Also Published As

Publication number Publication date
WO2009002203A8 (fr) 2009-04-02
WO2009002203A1 (fr) 2008-12-31

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Date Code Title Description
EEER Examination request
FZDE Dead

Effective date: 20170620