CA2687124A1 - Low dose doxepin formulations, including buccal, sublingual and fastmelt formulations, and uses of the same to treat insomnia - Google Patents

Low dose doxepin formulations, including buccal, sublingual and fastmelt formulations, and uses of the same to treat insomnia Download PDF

Info

Publication number
CA2687124A1
CA2687124A1 CA002687124A CA2687124A CA2687124A1 CA 2687124 A1 CA2687124 A1 CA 2687124A1 CA 002687124 A CA002687124 A CA 002687124A CA 2687124 A CA2687124 A CA 2687124A CA 2687124 A1 CA2687124 A1 CA 2687124A1
Authority
CA
Canada
Prior art keywords
doxepin
composition
amount
orally disintegrating
dosage form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002687124A
Other languages
English (en)
French (fr)
Inventor
Luigi Schioppi
Brian Dorsey
Michael Skinner
John Carter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Currax Pharmaceuticals LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2687124A1 publication Critical patent/CA2687124A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA002687124A 2006-05-19 2007-05-18 Low dose doxepin formulations, including buccal, sublingual and fastmelt formulations, and uses of the same to treat insomnia Abandoned CA2687124A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US80182406P 2006-05-19 2006-05-19
US80182306P 2006-05-19 2006-05-19
US60/801,823 2006-05-19
US60/801,824 2006-05-19
US83331906P 2006-07-25 2006-07-25
US60/833,319 2006-07-25
PCT/US2007/012107 WO2007142811A2 (en) 2006-05-19 2007-05-18 Low dose doxepin formulations, including buccal, sublingual and fastmelt formulations, and uses of the same to treat insomnia

Publications (1)

Publication Number Publication Date
CA2687124A1 true CA2687124A1 (en) 2007-12-13

Family

ID=38801963

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002687124A Abandoned CA2687124A1 (en) 2006-05-19 2007-05-18 Low dose doxepin formulations, including buccal, sublingual and fastmelt formulations, and uses of the same to treat insomnia

Country Status (5)

Country Link
US (2) US20110318412A1 (enExample)
EP (1) EP2026792A2 (enExample)
JP (1) JP2009537554A (enExample)
CA (1) CA2687124A1 (enExample)
WO (1) WO2007142811A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8513299B2 (en) 2006-05-19 2013-08-20 Pernix Sleep, Inc. Methods of using low-dose doxepin for the improvement of sleep
US20080058408A1 (en) 2006-05-19 2008-03-06 Rogowski Roberta L Low-dose doxepin for treatment of sleep disorders in elderly patients
US20100179214A1 (en) 2006-05-19 2010-07-15 Somaxon Pharmaceuticals, Inc. Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders
US20100227916A1 (en) * 2006-05-19 2010-09-09 Somaxon Pharmaceuticals, Inc N-desmethyl-doxepin and methods of using the same to treat sleep disorders
US20100179215A1 (en) 2006-05-19 2010-07-15 Somaxon Pharmaceuticals, Inc. Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
CA2693992C (en) 2006-07-20 2017-01-31 Somaxon Pharmaceuticals, Inc. Methods of improving the pharmacokinetics of doxepin
WO2008085567A1 (en) * 2006-10-04 2008-07-17 Somaxon Pharmaceuticals, Inc. Methods of using low-dose doxepin for the improvement of sleep
US20100105614A1 (en) 2006-10-25 2010-04-29 Somaxon Pharmaceuticals, Inc. Ultra low dose doxepin and methods of using the same to treat sleep disorders
WO2008070795A2 (en) 2006-12-06 2008-06-12 Somaxon Pharmaceuticals, Inc. Combination therapy using low-dose doxepin for the improvement of sleep
CA2721133C (en) 2007-04-13 2018-11-06 Somaxon Pharmaceuticals, Inc. Low-dose doxepin formulations and methods of making and using the same
CA2888219C (en) * 2014-02-07 2018-07-10 Scilabs Pharmaceuticals, Inc. All natural, non-toxic sublingual drug delivery systems
US11096896B2 (en) 2018-05-17 2021-08-24 Fertin Pharma A/S Tablet dosage form for buccal absorption of active ingredients
CN111728958B (zh) 2019-12-23 2022-02-08 力品药业(厦门)股份有限公司 一种多塞平口腔贴膜及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4517179A (en) * 1983-04-29 1985-05-14 Pennwalt Corporation Rapid dissolving, uniform drug compositions and their preparation
US5502047A (en) * 1993-03-22 1996-03-26 Kavey; Neil B. Treatment for insomnia
US6403597B1 (en) * 1997-10-28 2002-06-11 Vivus, Inc. Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
WO1999040898A2 (en) * 1998-02-12 1999-08-19 Centrapharm Inc. Sublingual drug formulations having combined rapid onset of action and long lasting therapeutic effect
US7122198B1 (en) * 1999-11-30 2006-10-17 Panacea Biotec Limited Fast dissolving composition with prolonged sweet taste
US6211229B1 (en) * 2000-02-17 2001-04-03 Neil B. Kavey Treatment of transient and short term insomnia
EP1429736A2 (en) * 2001-09-26 2004-06-23 Pharmacia Corporation Organoleptically acceptable intraorally disintegrating compositions
US6863901B2 (en) * 2001-11-30 2005-03-08 Collegium Pharmaceutical, Inc. Pharmaceutical composition for compressed annular tablet with molded triturate tablet for both intraoral and oral administration
CA2474190A1 (en) * 2002-02-07 2003-08-14 Pharmacia Corporation Pharmaceutical dosage form for mucosal delivery
US6941948B2 (en) * 2002-03-07 2005-09-13 Vectura Drug Delivery Medicament storage and delivery devices
JP2007510733A (ja) * 2003-11-05 2007-04-26 サンタラス インコーポレイティッド プロトンポンプ阻害剤および睡眠剤の併用
KR20070030178A (ko) * 2004-02-17 2007-03-15 트랜스오랄 파마슈티칼스, 인코포레이티드 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의사용 방법
CN1562013A (zh) * 2004-03-31 2005-01-12 江西天施康中药股份有限公司 用于治疗高血压病的尼索地平口腔崩解片及制备方法
WO2005102335A2 (en) * 2004-04-23 2005-11-03 Hypnion, Inc. Methods of treating sleep disorders

Also Published As

Publication number Publication date
JP2009537554A (ja) 2009-10-29
WO2007142811A3 (en) 2008-03-13
US20110318412A1 (en) 2011-12-29
US20200078295A1 (en) 2020-03-12
EP2026792A2 (en) 2009-02-25
WO2007142811A2 (en) 2007-12-13

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Legal Events

Date Code Title Description
EEER Examination request
EEER Examination request

Effective date: 20120507

FZDE Discontinued

Effective date: 20230728