CA2684046A1 - Treatment of allergic disease with immunomodulator compounds - Google Patents
Treatment of allergic disease with immunomodulator compounds Download PDFInfo
- Publication number
- CA2684046A1 CA2684046A1 CA2684046A CA2684046A CA2684046A1 CA 2684046 A1 CA2684046 A1 CA 2684046A1 CA 2684046 A CA2684046 A CA 2684046A CA 2684046 A CA2684046 A CA 2684046A CA 2684046 A1 CA2684046 A1 CA 2684046A1
- Authority
- CA
- Canada
- Prior art keywords
- scv
- ova
- treatment
- animals
- lung
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 66
- 150000001875 compounds Chemical class 0.000 title claims abstract description 37
- 208000026935 allergic disease Diseases 0.000 title claims abstract description 30
- 239000002955 immunomodulating agent Substances 0.000 title claims abstract description 9
- 229940121354 immunomodulator Drugs 0.000 title claims abstract description 9
- 230000002584 immunomodulator Effects 0.000 title claims abstract description 8
- 230000000694 effects Effects 0.000 claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 29
- 125000003118 aryl group Chemical group 0.000 claims abstract description 5
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 5
- 125000002707 L-tryptophyl group Chemical group [H]C1=C([H])C([H])=C2C(C([C@](N([H])[H])(C(=O)[*])[H])([H])[H])=C([H])N([H])C2=C1[H] 0.000 claims abstract description 4
- 108010049353 golotimod Proteins 0.000 claims description 130
- CATMPQFFVNKDEY-YPMHNXCESA-N Golotimod Chemical compound C1=CC=C2C(C[C@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)=CNC2=C1 CATMPQFFVNKDEY-YPMHNXCESA-N 0.000 claims description 127
- 208000006673 asthma Diseases 0.000 claims description 48
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 201000010099 disease Diseases 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- -1 heterocyclic amino acid Chemical class 0.000 claims description 6
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims description 6
- 125000002252 acyl group Chemical group 0.000 claims description 5
- 206010003645 Atopy Diseases 0.000 claims description 4
- 230000037396 body weight Effects 0.000 claims description 4
- 229960004799 tryptophan Drugs 0.000 claims description 4
- 229930182827 D-tryptophan Chemical group 0.000 claims description 3
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical group C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims description 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-Tryptophan Natural products C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 3
- 108010033276 Peptide Fragments Chemical group 0.000 claims description 3
- 102000007079 Peptide Fragments Human genes 0.000 claims description 3
- 101710188315 Protein X Chemical group 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 239000000644 isotonic solution Substances 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract description 2
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 description 76
- 210000004072 lung Anatomy 0.000 description 53
- 210000004027 cell Anatomy 0.000 description 43
- 239000002953 phosphate buffered saline Substances 0.000 description 39
- 230000008595 infiltration Effects 0.000 description 32
- 238000001764 infiltration Methods 0.000 description 32
- 239000013566 allergen Substances 0.000 description 31
- 210000003979 eosinophil Anatomy 0.000 description 27
- 238000002360 preparation method Methods 0.000 description 26
- 239000000443 aerosol Substances 0.000 description 24
- 206010020751 Hypersensitivity Diseases 0.000 description 21
- 210000003743 erythrocyte Anatomy 0.000 description 19
- 238000002474 experimental method Methods 0.000 description 18
- 210000002966 serum Anatomy 0.000 description 17
- 206010013975 Dyspnoeas Diseases 0.000 description 16
- 210000000440 neutrophil Anatomy 0.000 description 16
- 206010011224 Cough Diseases 0.000 description 15
- 241000699670 Mus sp. Species 0.000 description 15
- 230000000172 allergic effect Effects 0.000 description 14
- 208000010668 atopic eczema Diseases 0.000 description 14
- 210000000621 bronchi Anatomy 0.000 description 14
- 230000004044 response Effects 0.000 description 14
- 241000700199 Cavia porcellus Species 0.000 description 13
- 241000700198 Cavia Species 0.000 description 12
- 208000000059 Dyspnea Diseases 0.000 description 12
- 108010092408 Eosinophil Peroxidase Proteins 0.000 description 12
- 102000044708 Eosinophil peroxidases Human genes 0.000 description 12
- 102000003896 Myeloperoxidases Human genes 0.000 description 12
- 108090000235 Myeloperoxidases Proteins 0.000 description 12
- 210000000265 leukocyte Anatomy 0.000 description 12
- 238000004458 analytical method Methods 0.000 description 11
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 238000005259 measurement Methods 0.000 description 11
- 230000009467 reduction Effects 0.000 description 11
- 230000002829 reductive effect Effects 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- 230000007815 allergy Effects 0.000 description 10
- 239000000739 antihistaminic agent Substances 0.000 description 10
- 230000001413 cellular effect Effects 0.000 description 10
- 230000008859 change Effects 0.000 description 10
- 238000011554 guinea pig model Methods 0.000 description 10
- 230000001965 increasing effect Effects 0.000 description 10
- 210000004969 inflammatory cell Anatomy 0.000 description 10
- 210000001519 tissue Anatomy 0.000 description 10
- 241000699666 Mus <mouse, genus> Species 0.000 description 9
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 9
- 208000030961 allergic reaction Diseases 0.000 description 9
- 230000001387 anti-histamine Effects 0.000 description 9
- 238000001802 infusion Methods 0.000 description 9
- 210000004698 lymphocyte Anatomy 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 102000004127 Cytokines Human genes 0.000 description 8
- 108090000695 Cytokines Proteins 0.000 description 8
- 108010058846 Ovalbumin Proteins 0.000 description 8
- 206010070834 Sensitisation Diseases 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 238000010790 dilution Methods 0.000 description 8
- 239000012895 dilution Substances 0.000 description 8
- 229940092253 ovalbumin Drugs 0.000 description 8
- 230000008313 sensitization Effects 0.000 description 8
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 7
- 206010006482 Bronchospasm Diseases 0.000 description 7
- 206010048908 Seasonal allergy Diseases 0.000 description 7
- 201000009961 allergic asthma Diseases 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 7
- 210000002175 goblet cell Anatomy 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 108090000765 processed proteins & peptides Proteins 0.000 description 7
- 102000003810 Interleukin-18 Human genes 0.000 description 6
- 108090000171 Interleukin-18 Proteins 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 230000005713 exacerbation Effects 0.000 description 6
- 244000144993 groups of animals Species 0.000 description 6
- 238000010172 mouse model Methods 0.000 description 6
- 230000035699 permeability Effects 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 6
- 206010014950 Eosinophilia Diseases 0.000 description 5
- 102000004388 Interleukin-4 Human genes 0.000 description 5
- 108090000978 Interleukin-4 Proteins 0.000 description 5
- 238000000540 analysis of variance Methods 0.000 description 5
- 230000007885 bronchoconstriction Effects 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 210000000981 epithelium Anatomy 0.000 description 5
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 5
- 231100000516 lung damage Toxicity 0.000 description 5
- 210000002540 macrophage Anatomy 0.000 description 5
- 230000001681 protective effect Effects 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 208000004852 Lung Injury Diseases 0.000 description 4
- 208000002200 Respiratory Hypersensitivity Diseases 0.000 description 4
- 206010069363 Traumatic lung injury Diseases 0.000 description 4
- 238000012387 aerosolization Methods 0.000 description 4
- 230000010085 airway hyperresponsiveness Effects 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 239000004044 bronchoconstricting agent Substances 0.000 description 4
- 230000003435 bronchoconstrictive effect Effects 0.000 description 4
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 4
- 239000000428 dust Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 230000003053 immunization Effects 0.000 description 4
- 238000002649 immunization Methods 0.000 description 4
- 231100000515 lung injury Toxicity 0.000 description 4
- 210000001616 monocyte Anatomy 0.000 description 4
- 239000006199 nebulizer Substances 0.000 description 4
- 229960005205 prednisolone Drugs 0.000 description 4
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 4
- 230000001932 seasonal effect Effects 0.000 description 4
- 238000007619 statistical method Methods 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 239000010267 Allergoid Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 108010062580 Concanavalin A Proteins 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 102000000588 Interleukin-2 Human genes 0.000 description 3
- 108010002350 Interleukin-2 Proteins 0.000 description 3
- 206010028735 Nasal congestion Diseases 0.000 description 3
- 206010035664 Pneumonia Diseases 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 210000002443 helper t lymphocyte Anatomy 0.000 description 3
- 210000003630 histaminocyte Anatomy 0.000 description 3
- 229960000890 hydrocortisone Drugs 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 238000010255 intramuscular injection Methods 0.000 description 3
- 239000007927 intramuscular injection Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 230000002085 persistent effect Effects 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000029058 respiratory gaseous exchange Effects 0.000 description 3
- 208000013220 shortness of breath Diseases 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- SRPWOOOHEPICQU-UHFFFAOYSA-N trimellitic anhydride Chemical compound OC(=O)C1=CC=C2C(=O)OC(=O)C2=C1 SRPWOOOHEPICQU-UHFFFAOYSA-N 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- 208000009079 Bronchial Spasm Diseases 0.000 description 2
- 208000014181 Bronchial disease Diseases 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 2
- 108010074328 Interferon-gamma Proteins 0.000 description 2
- 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 description 2
- 102000013462 Interleukin-12 Human genes 0.000 description 2
- 108010065805 Interleukin-12 Proteins 0.000 description 2
- 241001440840 Mikania micrantha Species 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 206010039085 Rhinitis allergic Diseases 0.000 description 2
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 201000010105 allergic rhinitis Diseases 0.000 description 2
- 210000002821 alveolar epithelial cell Anatomy 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000004159 blood analysis Methods 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 238000012754 cardiac puncture Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000004154 complement system Effects 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 229940109239 creatinine Drugs 0.000 description 2
- 229960000265 cromoglicic acid Drugs 0.000 description 2
- 230000002380 cytological effect Effects 0.000 description 2
- 230000003229 cytophilic effect Effects 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 description 2
- 230000009429 distress Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000003054 hormonal effect Effects 0.000 description 2
- 230000035874 hyperreactivity Effects 0.000 description 2
- 238000009169 immunotherapy Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- 230000003562 morphometric effect Effects 0.000 description 2
- 238000013425 morphometry Methods 0.000 description 2
- 210000003097 mucus Anatomy 0.000 description 2
- 235000019645 odor Nutrition 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- 230000009325 pulmonary function Effects 0.000 description 2
- 206010039083 rhinitis Diseases 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 210000004988 splenocyte Anatomy 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 210000003437 trachea Anatomy 0.000 description 2
- 229940070384 ventolin Drugs 0.000 description 2
- JXYWFNAQESKDNC-BTJKTKAUSA-N (z)-4-hydroxy-4-oxobut-2-enoate;2-[(4-methoxyphenyl)methyl-pyridin-2-ylamino]ethyl-dimethylazanium Chemical compound OC(=O)\C=C/C(O)=O.C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 JXYWFNAQESKDNC-BTJKTKAUSA-N 0.000 description 1
- QNVKOSLOVOTXKF-UHFFFAOYSA-N 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydron;chloride Chemical compound Cl.NC1=C(Br)C=C(Br)C=C1CNC1CCC(O)CC1 QNVKOSLOVOTXKF-UHFFFAOYSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 208000033399 Anaphylactic responses Diseases 0.000 description 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- 244000241235 Citrullus lanatus Species 0.000 description 1
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 240000009226 Corylus americana Species 0.000 description 1
- 235000001543 Corylus americana Nutrition 0.000 description 1
- 235000007466 Corylus avellana Nutrition 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010015548 Euthanasia Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 description 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010038453 Interleukin-2 Receptors Proteins 0.000 description 1
- 102000010789 Interleukin-2 Receptors Human genes 0.000 description 1
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 description 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229920005372 Plexiglas® Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 208000037883 airway inflammation Diseases 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229960004784 allergens Drugs 0.000 description 1
- 230000009285 allergic inflammation Effects 0.000 description 1
- 230000037446 allergic sensitization Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- FQPFAHBPWDRTLU-UHFFFAOYSA-N aminophylline Chemical compound NCCN.O=C1N(C)C(=O)N(C)C2=C1NC=N2.O=C1N(C)C(=O)N(C)C2=C1NC=N2 FQPFAHBPWDRTLU-UHFFFAOYSA-N 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 230000002052 anaphylactic effect Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000454 anti-cipatory effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 150000007860 aryl ester derivatives Chemical class 0.000 description 1
- 229940127225 asthma medication Drugs 0.000 description 1
- 238000002555 auscultation Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 1
- 229940124748 beta 2 agonist Drugs 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- 230000001813 broncholytic effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000000480 calcium channel blocker Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 230000035567 cellular accumulation Effects 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 208000023819 chronic asthma Diseases 0.000 description 1
- 231100000762 chronic effect Toxicity 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- QTCANKDTWWSCMR-UHFFFAOYSA-N costic aldehyde Natural products C1CCC(=C)C2CC(C(=C)C=O)CCC21C QTCANKDTWWSCMR-UHFFFAOYSA-N 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- KPHWPUGNDIVLNH-UHFFFAOYSA-M diclofenac sodium Chemical compound [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KPHWPUGNDIVLNH-UHFFFAOYSA-M 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 208000028659 discharge Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002497 edematous effect Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 description 1
- 229960000289 fluticasone propionate Drugs 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 239000010200 folin Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229940044627 gamma-interferon Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000011597 hartley guinea pig Methods 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
- 230000002962 histologic effect Effects 0.000 description 1
- 230000001632 homeopathic effect Effects 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 229940124622 immune-modulator drug Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 231100000824 inhalation exposure Toxicity 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229940117681 interleukin-12 Drugs 0.000 description 1
- 230000004073 interleukin-2 production Effects 0.000 description 1
- 229940028885 interleukin-4 Drugs 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- ISTFUJWTQAMRGA-UHFFFAOYSA-N iso-beta-costal Natural products C1C(C(=C)C=O)CCC2(C)CCCC(C)=C21 ISTFUJWTQAMRGA-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 230000010352 nasal breathing Effects 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 229940003691 nasonex Drugs 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- 238000009527 percussion Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000003075 phytoestrogen Substances 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 230000010152 pollination Effects 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000009862 primary prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 229940018203 pyrilamine maleate Drugs 0.000 description 1
- 238000011158 quantitative evaluation Methods 0.000 description 1
- 206010037833 rales Diseases 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229940127558 rescue medication Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000036387 respiratory rate Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000001020 rhythmical effect Effects 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 229940090585 serevent Drugs 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- RGHFKWPGWBFQLN-UHFFFAOYSA-M sodium;5,5-diethylpyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CCC1(CC)C([O-])=NC(=O)NC1=O RGHFKWPGWBFQLN-UHFFFAOYSA-M 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 229940046536 tree pollen allergenic extract Drugs 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229940063674 voltaren Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Ophthalmology & Optometry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2007118237/14A RU2007118237A (ru) | 2007-05-17 | 2007-05-17 | Способ лечения аллергических заболеваний |
| RU2007118237 | 2007-05-17 | ||
| US95720107P | 2007-08-22 | 2007-08-22 | |
| US60/957,201 | 2007-08-22 | ||
| PCT/US2008/006072 WO2008143824A1 (en) | 2007-05-17 | 2008-05-13 | Treatment of allergic disease with immunomodulator compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2684046A1 true CA2684046A1 (en) | 2008-11-27 |
Family
ID=40122024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2684046A Abandoned CA2684046A1 (en) | 2007-05-17 | 2008-05-13 | Treatment of allergic disease with immunomodulator compounds |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20100204295A1 (enExample) |
| EP (1) | EP2164507B1 (enExample) |
| JP (1) | JP2010527354A (enExample) |
| KR (1) | KR20100022044A (enExample) |
| CN (1) | CN101678069A (enExample) |
| AU (1) | AU2008253667A1 (enExample) |
| BR (1) | BRPI0811572A2 (enExample) |
| CA (1) | CA2684046A1 (enExample) |
| IL (1) | IL202114A0 (enExample) |
| MX (1) | MX2009012297A (enExample) |
| NZ (1) | NZ581748A (enExample) |
| RU (1) | RU2007118237A (enExample) |
| UA (1) | UA100018C2 (enExample) |
| WO (1) | WO2008143824A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7906486B2 (en) * | 2007-02-13 | 2011-03-15 | Sciclone Pharmaceuticals, Inc. | Method of treating or preventing tissue deterioration, injury or damage due to disease of mucosa |
| RU2635968C1 (ru) * | 2016-11-17 | 2017-11-17 | Аллан Герович Бениашвили | Способ лечения и профилактики состояний аллергического спектра |
| KR102633086B1 (ko) * | 2018-11-12 | 2024-02-05 | 씨제이제일제당 주식회사 | N-아세틸-l-트립토판을 유효성분으로 포함하는 젖소용 사료첨가제 |
| WO2020242133A1 (ko) * | 2019-05-24 | 2020-12-03 | 전북대학교 산학협력단 | N-아실-아미노산을 유효성분으로 포함하는 천식, 비염 또는 결막염의 예방 또는 치료용 조성물 |
| EP3977990A4 (en) * | 2019-05-24 | 2023-06-14 | Stemdr Inc. | COMPOSITION FOR THE PREVENTION OR TREATMENT OF ASTHMA, RHINITIS OR CONJUNCTIVITIS WITH N-ACYL AMINO ACID AS THE ACTIVE INGREDIENT |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5728680A (en) | 1987-12-30 | 1998-03-17 | Cytoven J.V. | Methods for normalizing numbers of lymphocytes |
| SU1544438A1 (ru) | 1988-04-04 | 1990-02-23 | Научно-исследовательский институт онкологии им.проф.Н.Н.Петрова | Способ плазмосорбции |
| US5032593A (en) * | 1988-07-01 | 1991-07-16 | Marion Merrell Dow Inc. | Method of treating bronchoconstriction with 1,3-unsymmetrical straight chain alkyl-substituted 8-phenylxanthines |
| US5811399A (en) * | 1988-12-14 | 1998-09-22 | Cytran, Inc. | Pharmaceutical dipeptide compositions and methods of use thereof: immunodepressants |
| US5916878A (en) * | 1995-11-28 | 1999-06-29 | Edward T. Wei | γ-glutamyl and β-aspartyl containing immunomodulator compounds and methods therewith |
| US5744452A (en) * | 1995-11-28 | 1998-04-28 | Edward T. Wei | γ-L-glutamyl containing immunomodulator compounds and methods therewith |
| US7173013B2 (en) * | 2001-06-08 | 2007-02-06 | Sciclone Pharmaceuticals, Inc. | Treatment of tuberculosis using immunomodulator compounds |
| CN1964731A (zh) * | 2004-05-14 | 2007-05-16 | 希克龙制药公司 | 用免疫调节剂化合物治疗或预防呼吸道病素性感染 |
-
2007
- 2007-05-17 RU RU2007118237/14A patent/RU2007118237A/ru unknown
-
2008
- 2008-05-13 JP JP2010508389A patent/JP2010527354A/ja not_active Ceased
- 2008-05-13 NZ NZ581748A patent/NZ581748A/en not_active IP Right Cessation
- 2008-05-13 US US12/600,584 patent/US20100204295A1/en not_active Abandoned
- 2008-05-13 CA CA2684046A patent/CA2684046A1/en not_active Abandoned
- 2008-05-13 CN CN200880016455A patent/CN101678069A/zh active Pending
- 2008-05-13 BR BRPI0811572-9A patent/BRPI0811572A2/pt not_active IP Right Cessation
- 2008-05-13 AU AU2008253667A patent/AU2008253667A1/en not_active Abandoned
- 2008-05-13 EP EP08825917A patent/EP2164507B1/en active Active
- 2008-05-13 WO PCT/US2008/006072 patent/WO2008143824A1/en not_active Ceased
- 2008-05-13 KR KR1020097026139A patent/KR20100022044A/ko not_active Withdrawn
- 2008-05-13 MX MX2009012297A patent/MX2009012297A/es not_active Application Discontinuation
- 2008-05-13 UA UAA200912624A patent/UA100018C2/ru unknown
-
2009
- 2009-11-12 IL IL202114A patent/IL202114A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2164507B1 (en) | 2012-07-11 |
| MX2009012297A (es) | 2010-02-17 |
| UA100018C2 (ru) | 2012-11-12 |
| RU2007118237A (ru) | 2008-11-27 |
| AU2008253667A1 (en) | 2008-11-27 |
| EP2164507A4 (en) | 2011-01-05 |
| US20100204295A1 (en) | 2010-08-12 |
| JP2010527354A (ja) | 2010-08-12 |
| IL202114A0 (en) | 2010-06-16 |
| KR20100022044A (ko) | 2010-02-26 |
| WO2008143824A1 (en) | 2008-11-27 |
| NZ581748A (en) | 2012-03-30 |
| BRPI0811572A2 (pt) | 2015-07-21 |
| CN101678069A (zh) | 2010-03-24 |
| EP2164507A1 (en) | 2010-03-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Molitorisova et al. | The anti-asthmatic potential of flavonol kaempferol in an experimental model of allergic airway inflammation | |
| US8603978B2 (en) | Use of muramyl dipeptide (MDP) for treating inflammation | |
| Borzutzky et al. | NOD2-associated diseases: Bridging innate immunity and autoinflammation | |
| EP2992881B1 (en) | Pharmaceutical composition for inhibiting immune response through inducing differentiation into regulator t cells and promoting proliferation of regulator t cells | |
| US8454967B2 (en) | Compositions and methods for modulating the immune system | |
| WO2017047769A1 (ja) | トール様受容体７またはトール様受容体９の活性化阻害剤 | |
| KR20030070092A (ko) | 죽상경화증을 예방 및 치료하기 위한 플라크 관련 분자를함유하는 조성물 및 이 분자를 이용하는 방법 | |
| EP2164507B1 (en) | Treatment of allergic disease with immunomodulator compounds | |
| KR101469167B1 (ko) | 봉독-ｐｌａ2를 포함하는 이상 조절 ｔ 세포 활성 저하 관련 질환의 치료 또는 예방용 약학적 조성물 | |
| JP2017061449A (ja) | ループスの処置のためのプロテアソーム阻害剤デランゾミブ | |
| JP2002503658A (ja) | ＣＯＰ−１及びＴｈ−２促進性サイトカインを使用した、多発性硬化症の治療 | |
| CN104411306A (zh) | 免疫耐受诱导剂 | |
| US9383348B2 (en) | Compositions and methods for treating lung disorders | |
| CN111821299A (zh) | 噻吩衍生物用于治疗免疫球蛋白E（IgE）介导的疾病的应用 | |
| CN109475549B (zh) | 药物组合物及其治疗自身免疫疾病的用途 | |
| US20230078511A1 (en) | Methods of using momelotinib to treat joint inflammation | |
| HK1142534A (en) | Treatment of allergic disease with immunomodulator compounds | |
| JP2009518387A (ja) | 免疫反応を調節する組成物および方法 | |
| Slavyanskaya | CANCER CHECKPOINT BLOCKADE | |
| WO2024185028A1 (ja) | 活性イオウ分子を含む医薬組成物 | |
| KR20070098916A (ko) | Ｔ 세포 기능화를 조절하는 방법 | |
| TW202402321A (zh) | 一種第i型甲醯胜肽受體拮抗劑及其用途 | |
| JP2015101585A (ja) | 中枢神経系自己免疫疾患治療用のアンジオテンシン変換酵素阻害剤 | |
| WO2021173476A1 (en) | Compounds, pharmaceutical formulations, and methods for treatment of cancer | |
| CN111821297A (zh) | 异吲哚啉衍生物用于治疗免疫球蛋白E（IgE）介导的疾病的应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20140513 |