CA2680842C - N-acetyl mannosamine ou derives de celui-ci pour le traitement d'une maladie renale chez un mammifere - Google Patents

N-acetyl mannosamine ou derives de celui-ci pour le traitement d'une maladie renale chez un mammifere Download PDF

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Publication number
CA2680842C
CA2680842C CA2680842A CA2680842A CA2680842C CA 2680842 C CA2680842 C CA 2680842C CA 2680842 A CA2680842 A CA 2680842A CA 2680842 A CA2680842 A CA 2680842A CA 2680842 C CA2680842 C CA 2680842C
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Prior art keywords
acetyl mannosamine
derivative
leu
val
gly
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CA2680842A1 (fr
Inventor
Marjan Huizing
William A. Gahl
Irini Manoli
Enriko Klootwijk
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National Institutes of Health NIH
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National Institutes of Health NIH
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Priority to CA2903133A priority Critical patent/CA2903133C/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

L'invention concerne des compositions et des procédés pour traiter le dysfonctionnement d'un rein et d'un muscle qui comprennent l'utilisation de quantités thérapeutiques de mannosamine de N-acétyle.
CA2680842A 2007-05-31 2008-05-30 N-acetyl mannosamine ou derives de celui-ci pour le traitement d'une maladie renale chez un mammifere Active CA2680842C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2903133A CA2903133C (fr) 2007-05-31 2008-05-30 N-acetyl mannosamine ou derives de celui-ci pour le traitement d'une maladie renale chez un mammifere

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93245107P 2007-05-31 2007-05-31
US60/932,451 2007-05-31
PCT/US2008/006895 WO2008150477A2 (fr) 2007-05-31 2008-05-30 Mannosamine de n-acétyle en tant qu'agent thérapeutique

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2903133A Division CA2903133C (fr) 2007-05-31 2008-05-30 N-acetyl mannosamine ou derives de celui-ci pour le traitement d'une maladie renale chez un mammifere

Publications (2)

Publication Number Publication Date
CA2680842A1 CA2680842A1 (fr) 2008-12-11
CA2680842C true CA2680842C (fr) 2015-11-24

Family

ID=39952249

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2680842A Active CA2680842C (fr) 2007-05-31 2008-05-30 N-acetyl mannosamine ou derives de celui-ci pour le traitement d'une maladie renale chez un mammifere
CA2903133A Active CA2903133C (fr) 2007-05-31 2008-05-30 N-acetyl mannosamine ou derives de celui-ci pour le traitement d'une maladie renale chez un mammifere

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2903133A Active CA2903133C (fr) 2007-05-31 2008-05-30 N-acetyl mannosamine ou derives de celui-ci pour le traitement d'une maladie renale chez un mammifere

Country Status (6)

Country Link
US (5) US8410063B2 (fr)
EP (3) EP2155207A2 (fr)
JP (4) JP2010529021A (fr)
CA (2) CA2680842C (fr)
IL (3) IL268475B (fr)
WO (1) WO2008150477A2 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008150477A2 (fr) 2007-05-31 2008-12-11 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health Mannosamine de n-acétyle en tant qu'agent thérapeutique
US9018174B2 (en) * 2008-05-28 2015-04-28 Hibm Research Group, Inc. Mouse model and treatment of hereditary inclusion body myopathy
GB0813144D0 (en) 2008-07-17 2008-08-27 Glaxo Group Ltd Novel compounds
US8987232B2 (en) 2008-09-04 2015-03-24 The University Of Tokyo Agent for ameliorating brain hypofunction
JP5557243B2 (ja) * 2010-02-26 2014-07-23 国立大学法人 東京大学 睡眠の改善剤
US9241896B2 (en) 2008-12-19 2016-01-26 Ultragenyx Pharmaceutical Inc. Methods and formulations for treating sialic acid deficiencies
JP5626734B2 (ja) * 2009-05-15 2014-11-19 公益財団法人ヒューマンサイエンス振興財団 Ｇｎｅタンパク質の機能低下に起因する疾患の治療用医薬剤、食品組成物
UA110325C2 (en) * 2009-07-03 2015-12-25 Australian Biomedical Company Pty Ltd Medicinal carbohydrates for treating respiratory conditions
MX2012010533A (es) * 2010-03-12 2013-02-11 Dsm Ip Assets Bv Suplementacion materna de acido sialico.
US20110301103A1 (en) * 2010-06-05 2011-12-08 Chugh Sumant S Methods of Treatment
US9139629B2 (en) 2010-06-05 2015-09-22 The Uab Research Foundation Methods for treatment of nephrotic syndrome and related conditions
DK2575858T3 (en) * 2010-06-05 2018-03-12 Sumant S Chugh METHOD OF TREATING NEPHROTIC SYNDROME AND RELATED DISEASES
US9511015B2 (en) 2010-07-13 2016-12-06 Ultragenyx Pharmaceutical Inc. Methods and formulations for treating sialic acid deficiencies
WO2012082830A1 (fr) * 2010-12-14 2012-06-21 Hibm Research Group, Inc. Biomarqueurs du sérum pour hibm
EP2704597B1 (fr) * 2011-05-05 2021-04-07 Life Science Nutrition AS Compositions améliorant l'efficacité, et procédés d'utilisation
US20130058998A1 (en) * 2011-09-07 2013-03-07 United States Of America As Represented By The Secretary, Department Of Health And Human Services Encapsulated n-acetylmannosamine or n-acetylneuraminic acid to increase sialylation
US8840926B2 (en) 2011-10-24 2014-09-23 Ultragenyx Pharmaceutical Inc. Sialic acid analogs
WO2013109906A2 (fr) * 2012-01-18 2013-07-25 Ultragenyx Pharmaceutical Inc. Procédés et formulations permettant de traiter les déficiences en acide sialique
US20160025717A1 (en) 2013-03-14 2016-01-28 Emory University Hyposialylation disorders
AU2013408774B2 (en) * 2013-12-27 2017-06-29 Colgate-Palmolive Company Prebiotic oral care methods using a saccharide
US10493087B2 (en) 2015-02-25 2019-12-03 The United States of America, as represented by National Institute of Health Sialylation-increasing therapies for diseases associated with oxidative stress
TW201720803A (zh) 2015-09-14 2017-06-16 超基因克斯製藥公司 唾液酸或其鹽或溶劑合物之晶型
WO2017188692A1 (fr) * 2016-04-25 2017-11-02 경북대학교 산학협력단 Composition antimicrobienne contenant de l'acide 7,10- époxyoctadéca-7,9-diénoïque comme ingrédient actif
KR101792239B1 (ko) 2016-11-01 2017-10-31 경북대학교 산학협력단 7,10-에폭시옥타데카-7,9-다이에노산 및 항생제를 유효성분으로 포함하는 항균 조성물

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4051842A (en) 1975-09-15 1977-10-04 International Medical Corporation Electrode and interfacing pad for electrical physiological systems
DE2626348C3 (de) 1976-06-11 1980-01-31 Siemens Ag, 1000 Berlin Und 8000 Muenchen Implantierbare Dosiereinrichtung
US4383529A (en) 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
US4610868A (en) * 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
US4962091A (en) 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
DE3935906A1 (de) * 1989-10-27 1991-05-02 Reutter Werner Verwendung von galaktose zur (par)enteralen ernaehrung und versorgung in der intensivmedizin sowie hierzu geeignete praeparationen
WO1994007529A1 (fr) 1992-09-25 1994-04-14 Neorx Corporation Inhibiteur therapeutique de cellules des muscles vasculaires lisses
CA2155910C (fr) * 1995-08-11 1999-12-14 George Wu Solution aqueuse biocompatible pour utilisation en dialyse peritoneale ambulatoire continue
US6274568B1 (en) * 1998-08-06 2001-08-14 Ronald L. Schnaar Compounds for altering cell surface sialic acids and methods of use therefor
CA2442146A1 (fr) 2001-03-29 2002-10-10 The Scripps Research Institute Formulations comprenant des ingredients actifs pieges et utilisations de ces formulations
WO2003028709A2 (fr) * 2001-09-26 2003-04-10 Werner Reutter Utilisation de devrives de mannosamine pour la stimulation de la croissance des neurites
WO2003097073A1 (fr) * 2002-04-19 2003-11-27 Astion Development A/S Combinaison d'agonistes de recepteur adrenergique beta-2 et d'un sucre amine et leur utilisation pour le traitement de troubles immunomodulateurs
WO2004068970A2 (fr) 2003-01-31 2004-08-19 The Procter & Gamble Company Moyen pour ameliorer l'aspect de tissus keratiniques de mammiferes
US9315532B2 (en) * 2005-05-24 2016-04-19 The Johns Hopkins University Fatty acid carbohydrate hybrid molecules as therapeutic agents and methods thereof
WO2008150477A2 (fr) 2007-05-31 2008-12-11 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health Mannosamine de n-acétyle en tant qu'agent thérapeutique
JP5626734B2 (ja) 2009-05-15 2014-11-19 公益財団法人ヒューマンサイエンス振興財団 Ｇｎｅタンパク質の機能低下に起因する疾患の治療用医薬剤、食品組成物
US20110301103A1 (en) * 2010-06-05 2011-12-08 Chugh Sumant S Methods of Treatment
US20160025717A1 (en) 2013-03-14 2016-01-28 Emory University Hyposialylation disorders

Also Published As

Publication number Publication date
US20130196936A1 (en) 2013-08-01
EP3799874A1 (fr) 2021-04-07
EP3175859B1 (fr) 2020-09-23
IL268475B (en) 2022-08-01
IL200872A0 (en) 2010-05-17
JP2015042653A (ja) 2015-03-05
US8410063B2 (en) 2013-04-02
IL268475A (en) 2019-09-26
IL245026B (en) 2019-08-29
JP6283298B2 (ja) 2018-02-21
US20180117072A1 (en) 2018-05-03
JP2016196505A (ja) 2016-11-24
IL200872A (en) 2016-04-21
JP6694026B2 (ja) 2020-05-13
WO2008150477A3 (fr) 2009-11-26
US20150290229A1 (en) 2015-10-15
WO2008150477A2 (fr) 2008-12-11
CA2903133C (fr) 2021-10-19
US10335426B2 (en) 2019-07-02
JP2018184475A (ja) 2018-11-22
CA2903133A1 (fr) 2008-12-11
CA2680842A1 (fr) 2008-12-11
IL245026A0 (en) 2016-05-31
JP2010529021A (ja) 2010-08-26
EP2155207A2 (fr) 2010-02-24
US20190374561A1 (en) 2019-12-12
US20100249047A1 (en) 2010-09-30
EP3175859A1 (fr) 2017-06-07
US10953026B2 (en) 2021-03-23
US9095597B2 (en) 2015-08-04

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Effective date: 20130530