CA2678875A1 - Prevention and treatment for osteonecrosis and osteoradionecrosis of the jaw - Google Patents
Prevention and treatment for osteonecrosis and osteoradionecrosis of the jaw Download PDFInfo
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- CA2678875A1 CA2678875A1 CA002678875A CA2678875A CA2678875A1 CA 2678875 A1 CA2678875 A1 CA 2678875A1 CA 002678875 A CA002678875 A CA 002678875A CA 2678875 A CA2678875 A CA 2678875A CA 2678875 A1 CA2678875 A1 CA 2678875A1
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- pdgf
- jaw
- biocompatible matrix
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- biocompatible
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- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89076307P | 2007-02-20 | 2007-02-20 | |
| US60/890,763 | 2007-02-20 | ||
| PCT/US2008/054354 WO2008103690A2 (en) | 2007-02-20 | 2008-02-20 | Prevention and treatment for osteonecrosis and osteoradionecrosis of the jaw using pdgf and a bone matrix |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2678875A1 true CA2678875A1 (en) | 2008-08-28 |
Family
ID=39710710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002678875A Abandoned CA2678875A1 (en) | 2007-02-20 | 2008-02-20 | Prevention and treatment for osteonecrosis and osteoradionecrosis of the jaw |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20100151025A1 (https=) |
| EP (1) | EP2125000A2 (https=) |
| JP (1) | JP2010518946A (https=) |
| AU (1) | AU2008218763B2 (https=) |
| CA (1) | CA2678875A1 (https=) |
| WO (1) | WO2008103690A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8114841B2 (en) | 2004-10-14 | 2012-02-14 | Biomimetic Therapeutics, Inc. | Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix |
| US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| ES2427993T3 (es) | 2006-02-09 | 2013-11-05 | Biomimetic Therapeutics, Llc | Composiciones y métodos para el tratamiento de hueso |
| US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| CA2656278C (en) | 2006-06-30 | 2016-02-09 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating rotator cuff injuries |
| US8106008B2 (en) | 2006-11-03 | 2012-01-31 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
| EP2259807B1 (en) * | 2008-02-07 | 2013-04-24 | Biomimetic Therapeutics, Inc. | Compositions for distraction osteogenesis |
| WO2012105223A1 (ja) * | 2011-01-31 | 2012-08-09 | オリンパス株式会社 | 免疫賦活剤 |
| MX2017004520A (es) | 2014-10-14 | 2018-03-15 | Lynch Samuel | Composiciones para tratar heridas. |
| GB2549714A (en) * | 2016-04-25 | 2017-11-01 | Pharmaceutical Business Consultants Ltd | Vascularity affinity precursor structure for musculo-skeletal tissue healing |
| JP7117724B2 (ja) * | 2018-01-18 | 2022-08-15 | 新田ゼラチン株式会社 | 歯肉および歯槽粘膜の再生促進作用に基づく顎骨壊死、顎骨骨髄炎または抜歯後治癒不全の予防に用いる予防剤 |
| WO2025024276A1 (en) * | 2023-07-21 | 2025-01-30 | Mercury Bio, Inc. | Production and delivery of therapeutic nucleic acids packaged in yeast extracellular vesicles embedded in biocompatible implant matrices |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1260391A (en) * | 1985-03-28 | 1989-09-26 | Karl A. Piez | Xenogeneic collagen/mineral preparations in bone repair |
| DE4120325A1 (de) * | 1991-06-20 | 1992-12-24 | Merck Patent Gmbh | Implantatwerkstoff |
| US5614206A (en) * | 1995-03-07 | 1997-03-25 | Wright Medical Technology, Inc. | Controlled dissolution pellet containing calcium sulfate |
| JP4809963B2 (ja) * | 1999-11-11 | 2011-11-09 | オリンパス株式会社 | 骨補填材 |
| JP2003019195A (ja) * | 2000-05-19 | 2003-01-21 | Mmt:Kk | 生体用部材 |
| AU2003210996A1 (en) * | 2002-02-11 | 2003-09-04 | Zymogenetics, Inc. | Materials and methods for preparing dimeric growth factors |
| WO2003094617A2 (en) * | 2002-05-06 | 2003-11-20 | Genentech, Inc. | Use of vegf for treating bone defects |
| AU2003245513A1 (en) * | 2002-06-14 | 2003-12-31 | Pierce Biotechnology, Inc. | Homogenous assay for enzymatic activity |
| JP2004159971A (ja) * | 2002-11-14 | 2004-06-10 | Hideki Yoshikawa | 骨形成用部材およびその製造方法 |
| EP1433489A1 (en) * | 2002-12-23 | 2004-06-30 | Degradable Solutions AG | Biodegradable porous bone implant with a barrier membrane sealed thereto |
| WO2004105825A1 (ja) * | 2003-01-10 | 2004-12-09 | Taki Chemical Co., Ltd. | 骨形成用生体材料、該材料を含む注入用製剤、及び該材料を調製するためのキット、並びにこれらを用いる骨形成方法 |
| ATE336270T1 (de) * | 2003-02-13 | 2006-09-15 | Synthes Ag | Injizierbare knochenersatzmischung |
| EP2399990B1 (en) * | 2003-06-27 | 2015-07-22 | DePuy Synthes Products, Inc. | Cells derived from post-partum umbilical cord for use in treatment of disease of the heart and circulatory system |
| EP2422814A1 (en) * | 2003-07-25 | 2012-02-29 | Ono Pharmaceutical Co., Ltd. | Remedy for cartilage-related diseases |
| JP2005111130A (ja) * | 2003-10-10 | 2005-04-28 | Olympus Corp | 骨補填材の製造方法 |
| US20080200372A1 (en) * | 2004-01-16 | 2008-08-21 | Institute Of Nutraceutical Research Pty Ltd. | Glycosaminoglycan Peptides Derived From Connective Tissues And Use Thereof In The Prevention Of Arthritis And Other Degenerative Medical Conditions |
| US7473678B2 (en) * | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| US8114841B2 (en) * | 2004-10-14 | 2012-02-14 | Biomimetic Therapeutics, Inc. | Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix |
| JP2006320442A (ja) * | 2005-05-18 | 2006-11-30 | Toshiba Ceramics Co Ltd | リン酸カルシウム系骨補填材 |
| ES2427993T3 (es) * | 2006-02-09 | 2013-11-05 | Biomimetic Therapeutics, Llc | Composiciones y métodos para el tratamiento de hueso |
| US7833270B2 (en) * | 2006-05-05 | 2010-11-16 | Warsaw Orthopedic, Inc | Implant depots to deliver growth factors to treat osteoporotic bone |
| US9161967B2 (en) * | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| CA2656278C (en) * | 2006-06-30 | 2016-02-09 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating rotator cuff injuries |
| US8106008B2 (en) * | 2006-11-03 | 2012-01-31 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
| US20080193424A1 (en) * | 2007-02-09 | 2008-08-14 | Biomet Biologics, Inc. | Treatment of tissue defects with a therapeutic composition |
| TR201815580T4 (tr) * | 2007-08-22 | 2018-11-21 | Noveome Biotherapeutics Inc | Yaraları iyileştirmeye yönelik çözelti bileşimleri ve bunların kullanımlarını içeren yeni selüler faktör. |
| EP2259807B1 (en) * | 2008-02-07 | 2013-04-24 | Biomimetic Therapeutics, Inc. | Compositions for distraction osteogenesis |
| KR20110067035A (ko) * | 2008-09-09 | 2011-06-20 | 바이오미메틱 세라퓨틱스, 인크. | 건 및 인대 손상의 치료를 위한 혈소판-유래 성장 인자 조성물 및 방법 |
| AU2009327377A1 (en) * | 2008-12-19 | 2011-07-14 | Biomimetic Therapeutics, Inc. | Bone grafts with reduced protease activity and methods of selection and use |
| WO2010102266A1 (en) * | 2009-03-05 | 2010-09-10 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects |
-
2008
- 2008-02-20 EP EP08743499A patent/EP2125000A2/en not_active Withdrawn
- 2008-02-20 US US12/527,692 patent/US20100151025A1/en not_active Abandoned
- 2008-02-20 JP JP2009550618A patent/JP2010518946A/ja active Pending
- 2008-02-20 AU AU2008218763A patent/AU2008218763B2/en not_active Ceased
- 2008-02-20 WO PCT/US2008/054354 patent/WO2008103690A2/en not_active Ceased
- 2008-02-20 CA CA002678875A patent/CA2678875A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2125000A2 (en) | 2009-12-02 |
| US20100151025A1 (en) | 2010-06-17 |
| AU2008218763B2 (en) | 2013-10-24 |
| WO2008103690A2 (en) | 2008-08-28 |
| JP2010518946A (ja) | 2010-06-03 |
| AU2008218763A1 (en) | 2008-08-28 |
| WO2008103690A3 (en) | 2009-09-03 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20140220 |