CA2668961A1 - Spink1 as a prostate cancer marker and uses thereof - Google Patents

Spink1 as a prostate cancer marker and uses thereof Download PDF

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Publication number
CA2668961A1
CA2668961A1 CA 2668961 CA2668961A CA2668961A1 CA 2668961 A1 CA2668961 A1 CA 2668961A1 CA 2668961 CA2668961 CA 2668961 CA 2668961 A CA2668961 A CA 2668961A CA 2668961 A1 CA2668961 A1 CA 2668961A1
Authority
CA
Canada
Prior art keywords
spink1
overexpression
spinkl
erg
rna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2668961
Other languages
English (en)
French (fr)
Inventor
Arul M. Chinnaiyan
Scott A. Tomlins
Daniel R. Rhodes
Rohit Mehra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan System
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2668961A1 publication Critical patent/CA2668961A1/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8135—Kazal type inhibitors, e.g. pancreatic secretory inhibitor or ovomucoid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA 2668961 2006-11-08 2007-11-08 Spink1 as a prostate cancer marker and uses thereof Abandoned CA2668961A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US85775806P 2006-11-08 2006-11-08
US60/857,758 2006-11-08
US90687607P 2007-03-14 2007-03-14
US60/906,876 2007-03-14
PCT/US2007/084090 WO2008058239A2 (en) 2006-11-08 2007-11-08 Spink1 as a prostate cancer marker and uses thereof

Publications (1)

Publication Number Publication Date
CA2668961A1 true CA2668961A1 (en) 2008-05-15

Family

ID=39365376

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2668961 Abandoned CA2668961A1 (en) 2006-11-08 2007-11-08 Spink1 as a prostate cancer marker and uses thereof

Country Status (8)

Country Link
US (1) US20100129804A1 (https=)
EP (1) EP2079851B1 (https=)
JP (2) JP2010508855A (https=)
CN (2) CN101652484B (https=)
AU (1) AU2007317306B2 (https=)
CA (1) CA2668961A1 (https=)
IL (2) IL198526A (https=)
WO (1) WO2008058239A2 (https=)

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WO2011102999A2 (en) * 2010-02-19 2011-08-25 The Regents Of The University Of Michigan Spink1 targeted therapy
CN102939534A (zh) * 2010-04-02 2013-02-20 维里德克斯有限责任公司 用于临床局限性前列腺癌患者的基于基因的psa复发预测
WO2012078752A2 (en) * 2010-12-09 2012-06-14 Philadelphia Health & Education Corporation D/B/A Serine protease inhibitor kazal antibodies
EP3348652B1 (en) * 2011-05-12 2023-07-26 MDxHealth Research B.V. Molecular markers in prostate cancer
EP3492606B1 (en) * 2011-08-22 2023-10-04 Exosome Diagnostics, Inc. Urine biomarkers
WO2013036755A1 (en) * 2011-09-09 2013-03-14 Sloan-Kettering Institute For Cancer Research Etv1 antibodies and uses thereof
MX350807B (es) * 2011-11-29 2017-09-20 Genentech Inc Composiciones y metodos para el analisis de cancer de prostata.
CN103436594A (zh) * 2012-10-16 2013-12-11 科蒂亚(新乡)生物技术有限公司 一种bdna在尿液中检测pca3的应用
CN102968558B (zh) * 2012-11-14 2015-11-18 叶定伟 一种预测初诊前列腺癌骨转移风险的装置
EP3227460B1 (en) * 2014-12-01 2021-01-27 Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung e.V. Novel rna-biomarker signature for diagnosis of prostate cancer
CN104531878B (zh) * 2015-01-04 2017-11-10 上海市同济医院 一种联合lncRNA和AR3检测试剂盒及应用
CN105717082A (zh) * 2016-02-02 2016-06-29 管晓翔 一种用于检测三阴性乳腺癌瘤内异质性的方法
KR101948385B1 (ko) * 2016-09-01 2019-05-13 충북대학교 산학협력단 전립선암 예후 분석용 신규 바이오마커 및 그의 용도
CN109521457B (zh) * 2018-09-25 2022-10-21 中国辐射防护研究院 一种基于信息准则的γ辐射源项划分方法及系统
CN111110849B (zh) * 2018-10-11 2021-09-10 中国科学院上海营养与健康研究所 丝氨酸蛋白酶抑制因子Kazal 1型在制备细胞衰老及肿瘤诊断或调控制剂中的应用
CN109776679B (zh) * 2019-01-08 2022-06-17 灏灵赛奥（天津）生物科技有限公司 一种丝氨酸蛋白酶抑制因子spink1的抗体、其制备方法和应用
CN109678950B (zh) * 2019-01-08 2022-05-10 灏灵赛奥（天津）生物科技有限公司 spink1抗原、能够特异性结合spink1的抗体及其功能片段及其应用和产品
US11788091B2 (en) 2019-08-21 2023-10-17 University Of Virginia Patent Foundation Methods and compositions for diagnosing and treating prostate cancer based on long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth
US12319967B2 (en) 2019-08-21 2025-06-03 University Of Virginia Patent Foundation Methods and compositions for diagnosing and treating prostate cancer based on long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth
CN111308095A (zh) * 2020-03-04 2020-06-19 北京师范大学 用于诊断前列腺癌的尿液蛋白标记物
EP4232605A4 (en) * 2020-11-11 2024-09-25 University of Virginia Patent Foundation METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING PROSTATE CANCER BASED ON LONG NON-CODING RNA OVERLAPPING THE LCK GENE REGULATING PROSTATE CANCER CELL GROWTH
WO2023276768A1 (ja) * 2021-06-29 2023-01-05 国立大学法人京都大学 低酸素バイオマーカー及びその利用
CN115181801B (zh) * 2022-07-11 2026-03-31 中山大学附属第一医院 Bhlhe22在前列腺癌骨转移免疫治疗中的应用

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JP3448090B2 (ja) * 1994-02-16 2003-09-16 浜松ホトニクス株式会社 エネルギー移動検出法およびその装置
US20050214309A1 (en) * 1994-03-18 2005-09-29 Hinrichs Steven H Methods and compositions for modulating transcription factor activity
US5854206A (en) * 1995-08-25 1998-12-29 Corixa Corporation Compounds and methods for treatment and diagnosis of prostate cancer
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Also Published As

Publication number Publication date
WO2008058239A3 (en) 2008-11-06
JP2010508855A (ja) 2010-03-25
WO2008058239A9 (en) 2009-12-23
CN101652484A (zh) 2010-02-17
JP2014087335A (ja) 2014-05-15
IL198526A (en) 2012-10-31
EP2079851A4 (en) 2010-09-01
AU2007317306B2 (en) 2012-06-14
CN103233063A (zh) 2013-08-07
US20100129804A1 (en) 2010-05-27
EP2079851B1 (en) 2015-01-07
JP5850898B2 (ja) 2016-02-03
WO2008058239A2 (en) 2008-05-15
EP2079851A2 (en) 2009-07-22
IL215373A0 (en) 2011-11-30
IL215373A (en) 2013-07-31
AU2007317306A1 (en) 2008-05-15
CN101652484B (zh) 2013-03-20
IL198526A0 (en) 2010-02-17

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20171108