CA2668508C - Process for regioselective mono-tosylation of diols - Google Patents

Process for regioselective mono-tosylation of diols Download PDF

Info

Publication number
CA2668508C
CA2668508C CA2668508A CA2668508A CA2668508C CA 2668508 C CA2668508 C CA 2668508C CA 2668508 A CA2668508 A CA 2668508A CA 2668508 A CA2668508 A CA 2668508A CA 2668508 C CA2668508 C CA 2668508C
Authority
CA
Canada
Prior art keywords
mol
formula
compound
mono
tosylation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2668508A
Other languages
English (en)
French (fr)
Other versions
CA2668508A1 (en
Inventor
Michel Joseph Maurice Andre Guillaume
Yolande Lydia Lang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of CA2668508A1 publication Critical patent/CA2668508A1/en
Application granted granted Critical
Publication of CA2668508C publication Critical patent/CA2668508C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/14—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of germanium, tin or lead
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
CA2668508A 2006-11-17 2007-11-09 Process for regioselective mono-tosylation of diols Active CA2668508C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06124292.1 2006-11-17
EP06124292 2006-11-17
PCT/EP2007/062109 WO2008058902A2 (en) 2006-11-17 2007-11-09 Process for regioselective mono-tosylation of diols

Publications (2)

Publication Number Publication Date
CA2668508A1 CA2668508A1 (en) 2008-05-22
CA2668508C true CA2668508C (en) 2014-05-13

Family

ID=37891804

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2668508A Active CA2668508C (en) 2006-11-17 2007-11-09 Process for regioselective mono-tosylation of diols

Country Status (9)

Country Link
US (1) US8143432B2 (https=)
EP (1) EP2084129B1 (https=)
JP (1) JP5586231B2 (https=)
KR (1) KR101400744B1 (https=)
CN (1) CN101535243B (https=)
CA (1) CA2668508C (https=)
ES (1) ES2595529T3 (https=)
IL (1) IL198764A0 (https=)
WO (1) WO2008058902A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5371090B2 (ja) * 2009-01-23 2013-12-18 三菱レイヨン株式会社 モノスルホン酸エステルの製造方法
JP5371091B2 (ja) * 2009-01-23 2013-12-18 三菱レイヨン株式会社 モノスルホン酸エステルの製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089608A (en) * 1990-03-23 1992-02-18 Mcneil-Ppc, Inc. Selective 6-acylation of sucrose mediated by cyclic adducts of dialkyltin oxides and diols
WO1998009942A1 (en) 1996-09-06 1998-03-12 Eli Lilly And Company Catalytic selective sulfonylation process

Also Published As

Publication number Publication date
KR20090091748A (ko) 2009-08-28
ES2595529T3 (es) 2016-12-30
WO2008058902A3 (en) 2008-07-31
US8143432B2 (en) 2012-03-27
JP5586231B2 (ja) 2014-09-10
EP2084129B1 (en) 2016-07-27
CA2668508A1 (en) 2008-05-22
CN101535243B (zh) 2012-10-03
KR101400744B1 (ko) 2014-05-29
JP2010510185A (ja) 2010-04-02
US20100016623A1 (en) 2010-01-21
EP2084129A2 (en) 2009-08-05
WO2008058902A2 (en) 2008-05-22
IL198764A0 (en) 2010-02-17
CN101535243A (zh) 2009-09-16

Similar Documents

Publication Publication Date Title
EP2716650A1 (en) Method for producing peptide
US9845315B2 (en) Method for preparing Afatinib and intermediate thereof
CA2668508C (en) Process for regioselective mono-tosylation of diols
CN107434772B (zh) 一种n，n-双（2-羟基乙基）甲基丙烯酰胺的制备方法
CN108752289B (zh) 2,2′-联氨-双（3-乙基苯并噻唑啉-6-磺酸）二铵盐的合成方法
TWI553012B (zh) The manufacturing method of the classics
US9981978B2 (en) Preparation of saturated ketone morphinan compounds by catalytic isomerisation
WO2022117071A1 (zh) 从多羟基酚合成苄基醚的方法
WO2008069451A1 (en) Improved process for the preparation of clevudine as anti-hbv agent
CN120004846B (zh) 一种小分子Id蛋白抑制剂AGX51的制备方法
KR860001496B1 (ko) 20-케토-델타^16-스테로이드류의 신규 제조방법과 이 방법에서 얻는 신규의 중간물류 제조방법
CN100451010C (zh) 一种合成(r)-3-氨基四氢呋喃的方法
CN115433097A (zh) 一种无金属制备4-丁氧基苯甲酸(2-二乙胺基乙基)酯的方法
CN111484534B (zh) 14-溴代蒽环类的制造方法
CN120247742A (zh) 一种mrgprx2激动剂及其中间体的制备方法
KR100288124B1 (ko) 조합화학합성 생성물의 정량분석방법
CN117304071A (zh) 一种手性n-烷基氨基酸衍生物的合成方法
CN1662517A (zh) 生产n－(2,6－二甲基苯基)－2－哌嗪－1－基乙酰胺的方法
EP1849761A1 (en) Process for production of 4-acetylpyrimidines and crystals thereof
CN102977042B (zh) 一种1-甲基苯骈三氮唑的制备方法
CN117466782A (zh) 一种n,n-双(2-羟乙基)-2-氨基乙磺酸的制备工艺
CN114315494A (zh) 一种(s)-2-甲基氮杂环丁烷盐酸盐的制备方法
JP2000103766A (ja) ２，６−ジイソプロピルアニリンの精製法およびトリまたはジアリールメタンの製造法
CN114685325A (zh) 一种含胺化合物及其制备方法和用途
OH 5.4 Experimental Procedures for Chapter 4

Legal Events

Date Code Title Description
EEER Examination request
W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20260106