CA2664682C - N-substituted monomers and polymers - Google Patents
N-substituted monomers and polymers Download PDFInfo
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- CA2664682C CA2664682C CA2664682A CA2664682A CA2664682C CA 2664682 C CA2664682 C CA 2664682C CA 2664682 A CA2664682 A CA 2664682A CA 2664682 A CA2664682 A CA 2664682A CA 2664682 C CA2664682 C CA 2664682C
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- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 22
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- C08G64/08—Aromatic polycarbonates not containing aliphatic unsaturation containing atoms other than carbon, hydrogen or oxygen
- C08G64/12—Aromatic polycarbonates not containing aliphatic unsaturation containing atoms other than carbon, hydrogen or oxygen containing nitrogen
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
- C08G64/18—Block or graft polymers
- C08G64/183—Block or graft polymers containing polyether sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
- C08G64/18—Block or graft polymers
- C08G64/186—Block or graft polymers containing polysiloxane sequences
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G79/00—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
- C08G79/02—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule a linkage containing phosphorus
- C08G79/04—Phosphorus linked to oxygen or to oxygen and carbon
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L85/00—Compositions of macromolecular compounds obtained by reactions forming a linkage in the main chain of the macromolecule containing atoms other than silicon, sulfur, nitrogen, oxygen and carbon; Compositions of derivatives of such polymers
- C08L85/02—Compositions of macromolecular compounds obtained by reactions forming a linkage in the main chain of the macromolecule containing atoms other than silicon, sulfur, nitrogen, oxygen and carbon; Compositions of derivatives of such polymers containing phosphorus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
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- Polyamides (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
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Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1673109B1 (en) | 2003-09-25 | 2019-03-20 | Rutgers, The State University of New Jersey | Inherently radiopaque polymeric products for embolotherapy |
| US8702716B1 (en) * | 2009-09-21 | 2014-04-22 | Reva Medical Inc. | Devices, compositions and methods for bone and tissue augmentation |
| EP2079491B1 (en) | 2006-10-17 | 2013-02-27 | Reva Medical, Inc. | N-substituted monomers and polymers |
| MX2009014279A (es) * | 2007-06-21 | 2010-03-26 | Tyrx Pharma Inc | Cadenas laterales de ester de fenilo para incrementar la resortividad polimerica. |
| EP2334712A4 (en) * | 2008-09-16 | 2013-10-23 | Univ Rutgers | FROM MONOMERANALOGA OF NATURAL METABOLITES SYNTHETIZED BIORESORBABLE POLYMERS |
| CA2833960C (en) | 2008-09-22 | 2015-12-22 | Tyrx, Inc. | Linear polyesteramides from aminophenolic esters |
| US8551511B2 (en) * | 2008-10-11 | 2013-10-08 | Rutgers, The State University Of New Jersey | Phase-separated biocompatible polymer compositions for medical uses |
| DE102009016585A1 (de) * | 2009-04-06 | 2010-10-07 | Eos Gmbh Electro Optical Systems | Verfahren und Vorrichtung zum Kalibrieren einer Bestrahlungsvorrichtung |
| US9839628B2 (en) | 2009-06-01 | 2017-12-12 | Tyrx, Inc. | Compositions and methods for preventing sternal wound infections |
| CA2764134C (en) * | 2009-06-01 | 2014-04-15 | Tyrx, Inc. | Compositions and methods for preventing sternal wound infections |
| JP5847706B2 (ja) * | 2009-06-01 | 2016-01-27 | タイレックス・インコーポレイテッドＴｙｒｘ Ｉｎｃ． | 胸骨創感染症を予防するための組成物および方法 |
| US8105569B2 (en) * | 2009-06-29 | 2012-01-31 | Inolex Investment Corporation | Non-petrochemically derived cationic emulsifiers that are neutralized amino acid esters and related compositions and methods |
| US9080015B2 (en) | 2009-07-31 | 2015-07-14 | Rutgers, The State University Of New Jersey | Biocompatible polymers for medical devices |
| AU2010303170B2 (en) | 2009-10-11 | 2015-02-26 | Rutgers, The State University Of New Jersey | Biocompatible polymers for medical devices |
| US20110224770A1 (en) * | 2010-03-15 | 2011-09-15 | Boston Scientific Scimed, Inc. | Drug Eluting Stents and Methods of Making the Same |
| WO2012048298A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| AU2012283875B2 (en) * | 2011-07-20 | 2016-05-12 | Medtronic, Inc. | Drug eluting mesh to prevent infection of indwelling transdermal devices |
| WO2013116804A2 (en) * | 2012-02-03 | 2013-08-08 | Rutgers, The State Of University Of New Jersey | Polymeric biomaterials derived from phenolic monomers and their medical uses |
| US11472918B2 (en) | 2012-02-03 | 2022-10-18 | Rutgers, The State University Of New Jersey | Polymeric biomaterials derived from phenolic monomers and their medical uses |
| WO2015073918A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| US10150884B2 (en) * | 2014-08-14 | 2018-12-11 | The Secant Group, Llc | Composition, methods and devices useful for manufacturing of implantable articles |
| WO2016049421A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled feed |
| CN107108863B (zh) | 2014-12-23 | 2021-03-19 | 新泽西鲁特格斯州立大学 | 生物相容性的碘化二酚单体和聚合物 |
| US10774030B2 (en) | 2014-12-23 | 2020-09-15 | Rutgers, The State University Of New Jersey | Polymeric biomaterials derived from phenolic monomers and their medical uses |
| US9458353B1 (en) | 2015-04-15 | 2016-10-04 | International Business Machines Corporation | Additives for orientation control of block copolymers |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US10442757B2 (en) * | 2017-06-07 | 2019-10-15 | Medtronic, Inc. | Synthesis of tyrosine derived diphenol monomers |
| CN112533976A (zh) * | 2018-08-08 | 2021-03-19 | 雷瓦医药有限责任公司 | 交联的不透射线的生物可吸收的聚合物及由其制备的装置 |
| CA3110898A1 (en) | 2018-09-20 | 2020-03-26 | Reva Medical, Llc | Porous bioresorbable radiopaque embolic microspheres for drug delivery |
| RU2712117C1 (ru) * | 2019-08-20 | 2020-01-24 | Федеральное государственное бюджетное образовательное учреждение высшего образования"Волгоградский государственный технический университет" (ВолгГТУ) | Применение олигоэфиракрилата ((((1-галоген-3- (4- (2- (4- (3- (4- (2- (4- (3-галоген-2 - (((( 1-галоген-3- (метакрилоилокси))) пропан-2-ил) окси) ((1-галоген-3-феноксипропан-2-ил) окси) фосфино) окси) пропокси) фенил) пропан-2-ил) фенокси) -2-гидроксипропокси) фенил) пропан - 2-ил) фенокси) пропан-2-ил) окси) фосфиндиил) бис (окси)) бис (3-галогенпропан-2,1-диил) бис (2-метилакрилата) в качестве мономера для получения термо- и теплостойких полимеров с пониженной горючестью |
| GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
| TWI793863B (zh) * | 2021-11-17 | 2023-02-21 | 中國石油化學工業開發股份有限公司 | 脂環族聚碳酸酯之製備方法 |
| EP4460560A1 (en) * | 2022-01-04 | 2024-11-13 | Ronawk, Inc. | Cell cultivation methodology |
| US12209689B2 (en) | 2022-02-28 | 2025-01-28 | Terumo Kabushiki Kaisha | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
Family Cites Families (120)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3251806A (en) * | 1962-09-26 | 1966-05-17 | Armstrong Cork Co | Amide-containing polycarbonates |
| GB1164160A (en) | 1966-12-30 | 1969-09-17 | Shell Int Research | N,N-Disubstituted Amino Acid Derivatives and their use as Herbicides |
| JPS553446B2 (enExample) * | 1972-05-01 | 1980-01-25 | ||
| CH576495A5 (enExample) * | 1973-03-27 | 1976-06-15 | Ciba Geigy Ag | |
| US5876419A (en) | 1976-10-02 | 1999-03-02 | Navius Corporation | Stent and method for making a stent |
| EP0054231B1 (de) * | 1980-12-12 | 1984-02-15 | Bayer Ag | Leimungsmittel für Papier und Verfahren zu ihrer Herstellung |
| SE445884B (sv) | 1982-04-30 | 1986-07-28 | Medinvent Sa | Anordning for implantation av en rorformig protes |
| DE3442736C2 (de) | 1984-11-23 | 1987-03-05 | Tassilo Dr.med. 7800 Freiburg Bonzel | Dilatationskatheter |
| US5232445A (en) | 1984-11-23 | 1993-08-03 | Tassilo Bonzel | Dilatation catheter |
| US4638045A (en) | 1985-02-19 | 1987-01-20 | Massachusetts Institute Of Technology | Non-peptide polyamino acid bioerodible polymers |
| US4863735A (en) | 1985-02-19 | 1989-09-05 | Massachusetts Institute Of Technology | Biodegradable polymeric drug delivery system with adjuvant activity |
| US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
| US5040548A (en) | 1989-06-01 | 1991-08-20 | Yock Paul G | Angioplasty mehtod |
| US5350395A (en) | 1986-04-15 | 1994-09-27 | Yock Paul G | Angioplasty apparatus facilitating rapid exchanges |
| US5061273A (en) | 1989-06-01 | 1991-10-29 | Yock Paul G | Angioplasty apparatus facilitating rapid exchanges |
| US4740207A (en) | 1986-09-10 | 1988-04-26 | Kreamer Jeffry W | Intralumenal graft |
| US4748982A (en) | 1987-01-06 | 1988-06-07 | Advanced Cardiovascular Systems, Inc. | Reinforced balloon dilatation catheter with slitted exchange sleeve and method |
| US5527337A (en) | 1987-06-25 | 1996-06-18 | Duke University | Bioabsorbable stent and method of making the same |
| US5059211A (en) | 1987-06-25 | 1991-10-22 | Duke University | Absorbable vascular stent |
| US5192307A (en) | 1987-12-08 | 1993-03-09 | Wall W Henry | Angioplasty stent |
| US4877030A (en) | 1988-02-02 | 1989-10-31 | Andreas Beck | Device for the widening of blood vessels |
| US5140094A (en) | 1988-07-14 | 1992-08-18 | Rutgers, The State University | Polyiminocarbonate synthesis |
| US5264537A (en) | 1988-07-14 | 1993-11-23 | Rutgers, The State University | Polyiminocarbonate synthesis |
| US4980449A (en) | 1988-07-14 | 1990-12-25 | Rutgers, The State University | Polyiminocarbonate synthesis |
| US5092877A (en) | 1988-09-01 | 1992-03-03 | Corvita Corporation | Radially expandable endoprosthesis |
| US5151100A (en) | 1988-10-28 | 1992-09-29 | Boston Scientific Corporation | Heating catheters |
| US5230349A (en) | 1988-11-25 | 1993-07-27 | Sensor Electronics, Inc. | Electrical heating catheter |
| CH678393A5 (enExample) | 1989-01-26 | 1991-09-13 | Ulrich Prof Dr Med Sigwart | |
| US5007926A (en) | 1989-02-24 | 1991-04-16 | The Trustees Of The University Of Pennsylvania | Expandable transluminally implantable tubular prosthesis |
| US5035694A (en) | 1989-05-15 | 1991-07-30 | Advanced Cardiovascular Systems, Inc. | Dilatation catheter assembly with heated balloon |
| US5108416A (en) | 1990-02-13 | 1992-04-28 | C. R. Bard, Inc. | Stent introducer system |
| US5344426A (en) | 1990-04-25 | 1994-09-06 | Advanced Cardiovascular Systems, Inc. | Method and system for stent delivery |
| US5158548A (en) | 1990-04-25 | 1992-10-27 | Advanced Cardiovascular Systems, Inc. | Method and system for stent delivery |
| US5242399A (en) | 1990-04-25 | 1993-09-07 | Advanced Cardiovascular Systems, Inc. | Method and system for stent delivery |
| US5219564A (en) | 1990-07-06 | 1993-06-15 | Enzon, Inc. | Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon |
| US5660822A (en) | 1990-05-14 | 1997-08-26 | University Of Medicine & Dentistry Of N.J. | Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use |
| USRE37160E1 (en) | 1990-06-12 | 2001-05-01 | Rutgers, The State University | Synthesis of tyrosine derived diphenol monomers |
| US5587507A (en) | 1995-03-31 | 1996-12-24 | Rutgers, The State University | Synthesis of tyrosine derived diphenol monomers |
| US5198507A (en) | 1990-06-12 | 1993-03-30 | Rutgers, The State University Of New Jersey | Synthesis of amino acid-derived bioerodible polymers |
| US5099060A (en) | 1990-06-12 | 1992-03-24 | Rutgers, The State University Of New Jersey | Synthesis of amino acid-derived bioerodible polymers |
| US5216115A (en) | 1990-06-12 | 1993-06-01 | Rutgers, The State University Of New Jersey | Polyarylate containing derivatives of the natural amino acid L-tyrosine |
| US5242997A (en) | 1990-11-05 | 1993-09-07 | Rutgers, The State University Of New Jersey | Poly(N-phenyl urethane) from poly(N-substituted iminocarbonate) |
| US5194570A (en) | 1990-11-05 | 1993-03-16 | Rutgers, The State University Of New Jersey | Poly(N-substituted iminocarbonate) |
| DE59107815D1 (de) | 1991-01-18 | 1996-06-20 | Sulzer Medizinaltechnik Ag | Kniegelenkprothese |
| CA2068483A1 (en) | 1991-05-15 | 1992-11-16 | Motasim Mahmoud Sirhan | Low profile dilatation catheter |
| US5469867A (en) | 1992-09-02 | 1995-11-28 | Landec Corporation | Cast-in place thermoplastic channel occluder |
| US5263991A (en) | 1992-10-21 | 1993-11-23 | Biomet, Inc. | Method for heating biocompatible implants in a thermal packaging line |
| US5449382A (en) | 1992-11-04 | 1995-09-12 | Dayton; Michael P. | Minimally invasive bioactivated endoprosthesis for vessel repair |
| US5466439A (en) | 1992-11-12 | 1995-11-14 | Magnetic Research, Inc. | Polymeric contrast enhancing agents for magnetic resonance images |
| US5549556A (en) | 1992-11-19 | 1996-08-27 | Medtronic, Inc. | Rapid exchange catheter with external wire lumen |
| US5423321A (en) | 1993-02-11 | 1995-06-13 | Fontenot; Mark G. | Detection of anatomic passages using infrared emitting catheter |
| WO1994021196A2 (en) | 1993-03-18 | 1994-09-29 | C.R. Bard, Inc. | Endovascular stents |
| US5441515A (en) | 1993-04-23 | 1995-08-15 | Advanced Cardiovascular Systems, Inc. | Ratcheting stent |
| ES2157977T3 (es) | 1993-07-23 | 2001-09-01 | Cook Inc | Sonda flexible que tiene una configuracion conformada a partir de una hoja de material. |
| US5490962A (en) | 1993-10-18 | 1996-02-13 | Massachusetts Institute Of Technology | Preparation of medical devices by solid free-form fabrication methods |
| US5445646A (en) | 1993-10-22 | 1995-08-29 | Scimed Lifesystems, Inc. | Single layer hydraulic sheath stent delivery apparatus and method |
| US5989280A (en) | 1993-10-22 | 1999-11-23 | Scimed Lifesystems, Inc | Stent delivery apparatus and method |
| US5443477A (en) | 1994-02-10 | 1995-08-22 | Stentco, Inc. | Apparatus and method for deployment of radially expandable stents by a mechanical linkage |
| US5545138A (en) | 1994-02-28 | 1996-08-13 | Medtronic, Inc. | Adjustable stiffness dilatation catheter |
| US5836965A (en) | 1994-10-19 | 1998-11-17 | Jendersee; Brad | Stent delivery and deployment method |
| US5545135A (en) | 1994-10-31 | 1996-08-13 | Boston Scientific Corporation | Perfusion balloon stent |
| US5549662A (en) | 1994-11-07 | 1996-08-27 | Scimed Life Systems, Inc. | Expandable stent using sliding members |
| US5716358A (en) | 1994-12-02 | 1998-02-10 | Johnson & Johnson Professional, Inc. | Directional bone fixation device |
| US5755708A (en) | 1994-12-09 | 1998-05-26 | Segal; Jerome | Mechanical apparatus and method for deployment of expandable prosthesis |
| US6831116B2 (en) | 1995-03-07 | 2004-12-14 | Landec Corporation | Polymeric modifying agents |
| US5641861A (en) * | 1995-06-07 | 1997-06-24 | Torrey Pines Institute For Molecular Studies | μopioid receptor ligands: agonists and antagonists |
| WO1996040208A1 (en) * | 1995-06-07 | 1996-12-19 | Torrey Pines Institute For Molecular Studies | Novel mu opioid receptor ligands: agonists and antagonists |
| US5919897A (en) * | 1995-06-07 | 1999-07-06 | Torrey Pines Institute For Molecular Studies | MU opioid receptor ligands: agonists and antagonists |
| US5910816A (en) | 1995-06-07 | 1999-06-08 | Stryker Corporation | Imaging system with independent processing of visible an infrared light energy |
| FR2740035B1 (fr) * | 1995-10-20 | 1997-11-28 | Oreal | Procede de teinture des fibres keratiniques et composition mise en oeuvre au cours de ce procede |
| US5735872A (en) | 1995-11-13 | 1998-04-07 | Navius Corporation | Stent |
| US5658995A (en) | 1995-11-27 | 1997-08-19 | Rutgers, The State University | Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide) |
| US5741293A (en) | 1995-11-28 | 1998-04-21 | Wijay; Bandula | Locking stent |
| US6280473B1 (en) | 1996-08-19 | 2001-08-28 | Macropore, Inc. | Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration |
| US6096782A (en) | 1996-11-22 | 2000-08-01 | Athena Neurosciences, Inc. | N-(aryl/heteroaryl) amino acid derivatives pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6120491A (en) | 1997-11-07 | 2000-09-19 | The State University Rutgers | Biodegradable, anionic polymers derived from the amino acid L-tyrosine |
| US6319492B1 (en) * | 1996-11-27 | 2001-11-20 | Rutgers, The State University | Copolymers of tyrosine-based polyarylates and poly(alkylene oxides) |
| US6048521A (en) | 1997-11-07 | 2000-04-11 | Rutgers, The State University | Copolymers of tyrosine-based polyarlates and poly(alkylene oxides) |
| AU729552B2 (en) | 1997-02-18 | 2001-02-01 | Rutgers, The State University | Monomers derived from hydroxy acids and polymers prepared therefrom |
| US5800393A (en) | 1997-03-07 | 1998-09-01 | Sahota; Harvinder | Wire perfusion catheter |
| US5912225A (en) * | 1997-04-14 | 1999-06-15 | Johns Hopkins Univ. School Of Medicine | Biodegradable poly (phosphoester-co-desaminotyrosyl L-tyrosine ester) compounds, compositions, articles and methods for making and using the same |
| US6409755B1 (en) * | 1997-05-29 | 2002-06-25 | Scimed Life Systems, Inc. | Balloon expandable stent with a self-expanding portion |
| IT238354Y1 (it) | 1997-09-12 | 2000-10-16 | Invatec Srl | Catetere di dilatazione per l'introduzione di stent espandibili |
| US6475477B1 (en) * | 1997-11-07 | 2002-11-05 | Rutgers, The State University | Radio-opaque polymer biomaterials |
| US6602497B1 (en) | 1997-11-07 | 2003-08-05 | Rutgers, The State University | Strictly alternating poly(alkylene oxide ether) copolymers |
| RU2145966C1 (ru) * | 1997-11-11 | 2000-02-27 | Байкальский институт природопользования СО РАН | Способ получения поли-(n-фенилимино)карбофениленоксидов |
| US6562021B1 (en) | 1997-12-22 | 2003-05-13 | Micrus Corporation | Variable stiffness electrically conductive composite, resistive heating catheter shaft |
| US6492462B2 (en) | 1998-01-16 | 2002-12-10 | Landec Corporation | Side chain crystalline polymer as rheology modifier for crosslinked polymer |
| EP0930343A3 (en) | 1998-01-16 | 2000-05-31 | Landec Corporation | Low profile additives for crosslink resins |
| US6010245A (en) | 1998-01-25 | 2000-01-04 | Grayling Industries, Inc. | Bulk bag and method for producing same |
| US6224626B1 (en) | 1998-02-17 | 2001-05-01 | Md3, Inc. | Ultra-thin expandable stent |
| US6033436A (en) | 1998-02-17 | 2000-03-07 | Md3, Inc. | Expandable stent |
| US6623521B2 (en) | 1998-02-17 | 2003-09-23 | Md3, Inc. | Expandable stent with sliding and locking radial elements |
| AU751861B2 (en) * | 1998-02-23 | 2002-08-29 | Massachusetts Institute Of Technology | Biodegradable shape memory polymers |
| AU758800B2 (en) | 1998-02-23 | 2003-03-27 | Gkss-Forschungszentrum Geesthacht Gmbh | Shape memory polymers |
| US6015424A (en) | 1998-04-28 | 2000-01-18 | Microvention, Inc. | Apparatus and method for vascular embolization |
| US6562958B1 (en) | 1998-06-09 | 2003-05-13 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Acinetobacter baumannii for diagnostics and therapeutics |
| US6273909B1 (en) | 1998-10-05 | 2001-08-14 | Teramed Inc. | Endovascular graft system |
| US6200338B1 (en) | 1998-12-31 | 2001-03-13 | Ethicon, Inc. | Enhanced radiopacity of peripheral and central catheter tubing |
| US6689153B1 (en) | 1999-04-16 | 2004-02-10 | Orthopaedic Biosystems Ltd, Inc. | Methods and apparatus for a coated anchoring device and/or suture |
| US6103255A (en) | 1999-04-16 | 2000-08-15 | Rutgers, The State University | Porous polymer scaffolds for tissue engineering |
| US6447508B1 (en) | 1999-06-16 | 2002-09-10 | Hugh R. Sharkey | Stent inductive heating catheter |
| US6599448B1 (en) | 2000-05-10 | 2003-07-29 | Hydromer, Inc. | Radio-opaque polymeric compositions |
| US6550480B2 (en) | 2001-01-31 | 2003-04-22 | Numed/Tech Llc | Lumen occluders made from thermodynamic materials |
| US7918883B2 (en) * | 2002-02-25 | 2011-04-05 | Boston Scientific Scimed, Inc. | Non-invasive heating of implanted vascular treatment device |
| US6755868B2 (en) * | 2002-03-22 | 2004-06-29 | Ethicon, Inc. | Hernia repair device |
| US7271234B2 (en) | 2002-04-24 | 2007-09-18 | Rutgers, The State University Of New Jersey | Polyarylates for drug delivery and tissue engineering |
| US7455687B2 (en) | 2002-12-30 | 2008-11-25 | Advanced Cardiovascular Systems, Inc. | Polymer link hybrid stent |
| US6932930B2 (en) | 2003-03-10 | 2005-08-23 | Synecor, Llc | Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same |
| JP2006522744A (ja) * | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | グルココルチコイド受容体アゴニスト療法に伴う副作用を最小化するための、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤およびグルココルチコイド受容体アゴニストを使用する併用療法 |
| JP2006522750A (ja) * | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | 代謝性症候群ならびに関連の疾患および障害を治療するために、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤および抗高血圧剤を使用する併用療法 |
| EP1615698B1 (en) * | 2003-04-11 | 2010-09-29 | High Point Pharmaceuticals, LLC | New amide derivatives and pharmaceutical use thereof |
| EP1673109B1 (en) * | 2003-09-25 | 2019-03-20 | Rutgers, The State University of New Jersey | Inherently radiopaque polymeric products for embolotherapy |
| RU2383558C2 (ru) * | 2004-07-08 | 2010-03-10 | Рева Медикал, Инк. | Полимеры с кристаллизующимися боковыми цепями для медицинского применения |
| US7763065B2 (en) | 2004-07-21 | 2010-07-27 | Reva Medical, Inc. | Balloon expandable crush-recoverable stent device |
| WO2006023130A2 (en) * | 2004-08-12 | 2006-03-02 | Surmodics, Inc. | Biodegradable controlled release bioactive agent delivery device |
| EP1778761B1 (en) | 2004-08-13 | 2021-09-29 | Reva Medical, Inc. | Inherently radiopaque bioresorbable polymers for multiple uses |
| US20060034769A1 (en) | 2004-08-13 | 2006-02-16 | Rutgers, The State University | Radiopaque polymeric stents |
| US20060115449A1 (en) | 2004-11-30 | 2006-06-01 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable, biobeneficial, tyrosine-based polymers for use in drug eluting stent coatings |
| EP2079491B1 (en) | 2006-10-17 | 2013-02-27 | Reva Medical, Inc. | N-substituted monomers and polymers |
-
2007
- 2007-10-16 EP EP07872797A patent/EP2079491B1/en not_active Not-in-force
- 2007-10-16 US US11/873,362 patent/US8034365B2/en not_active Expired - Fee Related
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- 2007-10-16 AU AU2007347158A patent/AU2007347158B2/en not_active Ceased
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- 2007-10-16 EP EP07872322.8A patent/EP2083764B1/en not_active Not-in-force
- 2007-10-16 CA CA2664682A patent/CA2664682C/en not_active Expired - Fee Related
- 2007-10-16 RU RU2009112529/04A patent/RU2461582C2/ru not_active IP Right Cessation
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