CA2663528A1 - Heterocyclic inhibitors of c-met and uses thereof - Google Patents
Heterocyclic inhibitors of c-met and uses thereof Download PDFInfo
- Publication number
- CA2663528A1 CA2663528A1 CA002663528A CA2663528A CA2663528A1 CA 2663528 A1 CA2663528 A1 CA 2663528A1 CA 002663528 A CA002663528 A CA 002663528A CA 2663528 A CA2663528 A CA 2663528A CA 2663528 A1 CA2663528 A1 CA 2663528A1
- Authority
- CA
- Canada
- Prior art keywords
- aliphatic
- optionally substituted
- ring
- cancer
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 125000000623 heterocyclic group Chemical group 0.000 title claims description 31
- 239000003112 inhibitor Substances 0.000 title abstract description 11
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- 238000000034 method Methods 0.000 claims abstract description 23
- 230000002062 proliferating effect Effects 0.000 claims abstract description 8
- 125000001931 aliphatic group Chemical group 0.000 claims description 115
- -1 1,2-methylenedioxy Chemical group 0.000 claims description 114
- 229910052757 nitrogen Inorganic materials 0.000 claims description 66
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- 125000001424 substituent group Chemical group 0.000 claims description 32
- 125000003118 aryl group Chemical group 0.000 claims description 31
- 125000001072 heteroaryl group Chemical group 0.000 claims description 29
- 229910052736 halogen Inorganic materials 0.000 claims description 27
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
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- 239000001257 hydrogen Substances 0.000 claims description 24
- 229910052717 sulfur Chemical group 0.000 claims description 24
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 23
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84535606P | 2006-09-18 | 2006-09-18 | |
| US60/845,356 | 2006-09-18 | ||
| PCT/US2007/020222 WO2008036272A1 (en) | 2006-09-18 | 2007-09-18 | HETEROCYCLIC INHIBITORS OF c-MET AND USES THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2663528A1 true CA2663528A1 (en) | 2008-03-27 |
Family
ID=39092942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002663528A Abandoned CA2663528A1 (en) | 2006-09-18 | 2007-09-18 | Heterocyclic inhibitors of c-met and uses thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8481538B2 (enExample) |
| EP (1) | EP2066676A1 (enExample) |
| JP (1) | JP2010519174A (enExample) |
| CN (1) | CN101796056A (enExample) |
| AU (1) | AU2007297754B2 (enExample) |
| CA (1) | CA2663528A1 (enExample) |
| MX (1) | MX2009002842A (enExample) |
| NZ (1) | NZ575548A (enExample) |
| WO (1) | WO2008036272A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2300455T1 (sl) * | 2008-05-21 | 2017-12-29 | Incyte Holdings Corporation | Soli 2-fluoro-n-metil-4-(7-(kinolin-6-il-metil)-imidazo(1,2-b)1,2,4) triazin-2-il)benzamid in postopki v zvezi z njihovo pripravo |
| WO2010141275A1 (en) * | 2009-06-01 | 2010-12-09 | Merck Sharp & Dohme Corp. | Pyrazine carboxamide orexin receptor antagonists |
| PT3511330T (pt) | 2009-12-31 | 2020-12-24 | Hutchison Medipharma Ltd | Intermediário sintético útil na preparação de inibidores de triazolopiridina c-met |
| JP5960688B2 (ja) | 2010-05-17 | 2016-08-02 | インコゼン セラピューティクス プライベート リミテッド | プロテインキナーゼ調節物質としての新規３，５−二置換−３ｈ−［１，２，３］トリアゾロ［４，５−ｂ］ピリジン化合物 |
| CN104321322A (zh) | 2012-03-30 | 2015-01-28 | 理森制药股份公司 | 作为c-met蛋白激酶调节剂的新型3,5-二取代-3h-咪唑并[4,5-b]吡啶和3,5-二取代-3h-[1,2,3]三唑并[4,5-b]吡啶化合物 |
| WO2016004305A2 (en) * | 2014-07-02 | 2016-01-07 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| HUE057041T2 (hu) | 2015-07-06 | 2022-04-28 | Alkermes Inc | Hiszton deacetiláz hetero-halogén gátlói |
| WO2017007755A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| HRP20220223T1 (hr) | 2017-01-11 | 2022-04-29 | Alkermes, Inc. | Biciklički inhibitori histon deacetilaze |
| US11225475B2 (en) | 2017-08-07 | 2022-01-18 | Alkermes, Inc. | Substituted pyridines as inhibitors of histone deacetylase |
| WO2020118683A1 (en) * | 2018-12-14 | 2020-06-18 | Lynk Pharmaceuticals Co. Ltd. | Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof |
| TR202010296A1 (tr) * | 2020-06-30 | 2022-01-21 | Anadolu Ueniversitesi | Akt inhibisyonu aracılığıyla a549 hücrelerinde sitotoksik ve apoptotik etki gösteren yeni triazol ve triazolotiyadiazin türevleri |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1277754B8 (en) * | 2000-04-27 | 2005-09-28 | Astellas Pharma Inc. | Imidazopyridine derivatives |
| AU2003297161B8 (en) * | 2002-12-18 | 2011-03-31 | Vertex Pharmaceuticals Incorporated | Triazolopyridazines as protein kinases inhibitors |
| US7122548B2 (en) * | 2003-07-02 | 2006-10-17 | Sugen, Inc. | Triazolotriazine compounds and uses thereof |
| US7728017B2 (en) | 2005-11-30 | 2010-06-01 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-Met and uses thereof |
| WO2008060578A2 (en) * | 2006-11-15 | 2008-05-22 | Cytovia, Inc. | 3-aryl-6-aryl-[1,2,4] triazolo[3,4-b][1,3,4] thiadiazoles and related compounds as activators of caspases and inducers of apoptosis and the use thereof |
| EA201000051A1 (ru) * | 2007-07-13 | 2010-08-30 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Противовирусные соединения, композиции и способы использования |
| MY152040A (en) * | 2008-02-05 | 2014-08-15 | Sanofi Aventis | Triazolopyridazines as par1 inhibitors, production thereof, and use as medicaments |
| CA2755285C (en) * | 2009-03-20 | 2014-02-11 | Yunxin Y. Bo | Inhibitors of pi3 kinase |
-
2007
- 2007-09-18 NZ NZ575548A patent/NZ575548A/en not_active IP Right Cessation
- 2007-09-18 CA CA002663528A patent/CA2663528A1/en not_active Abandoned
- 2007-09-18 CN CN200780039034A patent/CN101796056A/zh active Pending
- 2007-09-18 JP JP2009528341A patent/JP2010519174A/ja active Pending
- 2007-09-18 MX MX2009002842A patent/MX2009002842A/es unknown
- 2007-09-18 WO PCT/US2007/020222 patent/WO2008036272A1/en not_active Ceased
- 2007-09-18 US US12/441,187 patent/US8481538B2/en not_active Expired - Fee Related
- 2007-09-18 EP EP07838434A patent/EP2066676A1/en not_active Withdrawn
- 2007-09-18 AU AU2007297754A patent/AU2007297754B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008036272A1 (en) | 2008-03-27 |
| US20100144739A1 (en) | 2010-06-10 |
| NZ575548A (en) | 2011-09-30 |
| CN101796056A (zh) | 2010-08-04 |
| AU2007297754B2 (en) | 2012-05-17 |
| JP2010519174A (ja) | 2010-06-03 |
| AU2007297754A1 (en) | 2008-03-27 |
| MX2009002842A (es) | 2009-05-27 |
| US8481538B2 (en) | 2013-07-09 |
| EP2066676A1 (en) | 2009-06-10 |
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