AU2007297754B2 - Heterocyclic inhibitors of c-MET and uses thereof - Google Patents

Heterocyclic inhibitors of c-MET and uses thereof Download PDF

Info

Publication number
AU2007297754B2
AU2007297754B2 AU2007297754A AU2007297754A AU2007297754B2 AU 2007297754 B2 AU2007297754 B2 AU 2007297754B2 AU 2007297754 A AU2007297754 A AU 2007297754A AU 2007297754 A AU2007297754 A AU 2007297754A AU 2007297754 B2 AU2007297754 B2 AU 2007297754B2
Authority
AU
Australia
Prior art keywords
aliphatic
optionally substituted
ring
pct
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007297754A
Other languages
English (en)
Other versions
AU2007297754A1 (en
Inventor
Alexander Aronov
Jon Come
John Court
David Deininger
David Lauffer
Pan Li
Kira Mcginty
Suganthini Nanthakumar
Dean Stamos
Kirk Tanner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of AU2007297754A1 publication Critical patent/AU2007297754A1/en
Application granted granted Critical
Publication of AU2007297754B2 publication Critical patent/AU2007297754B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2007297754A 2006-09-18 2007-09-18 Heterocyclic inhibitors of c-MET and uses thereof Ceased AU2007297754B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84535606P 2006-09-18 2006-09-18
US60/845,356 2006-09-18
PCT/US2007/020222 WO2008036272A1 (en) 2006-09-18 2007-09-18 HETEROCYCLIC INHIBITORS OF c-MET AND USES THEREOF

Publications (2)

Publication Number Publication Date
AU2007297754A1 AU2007297754A1 (en) 2008-03-27
AU2007297754B2 true AU2007297754B2 (en) 2012-05-17

Family

ID=39092942

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007297754A Ceased AU2007297754B2 (en) 2006-09-18 2007-09-18 Heterocyclic inhibitors of c-MET and uses thereof

Country Status (9)

Country Link
US (1) US8481538B2 (enExample)
EP (1) EP2066676A1 (enExample)
JP (1) JP2010519174A (enExample)
CN (1) CN101796056A (enExample)
AU (1) AU2007297754B2 (enExample)
CA (1) CA2663528A1 (enExample)
MX (1) MX2009002842A (enExample)
NZ (1) NZ575548A (enExample)
WO (1) WO2008036272A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2300455T1 (sl) * 2008-05-21 2017-12-29 Incyte Holdings Corporation Soli 2-fluoro-n-metil-4-(7-(kinolin-6-il-metil)-imidazo(1,2-b)1,2,4) triazin-2-il)benzamid in postopki v zvezi z njihovo pripravo
WO2010141275A1 (en) * 2009-06-01 2010-12-09 Merck Sharp & Dohme Corp. Pyrazine carboxamide orexin receptor antagonists
PT3511330T (pt) 2009-12-31 2020-12-24 Hutchison Medipharma Ltd Intermediário sintético útil na preparação de inibidores de triazolopiridina c-met
JP5960688B2 (ja) 2010-05-17 2016-08-02 インコゼン セラピューティクス プライベート リミテッド プロテインキナーゼ調節物質としての新規３，５−二置換−３ｈ−［１，２，３］トリアゾロ［４，５−ｂ］ピリジン化合物
CN104321322A (zh) 2012-03-30 2015-01-28 理森制药股份公司 作为c-met蛋白激酶调节剂的新型3,5-二取代-3h-咪唑并[4,5-b]吡啶和3,5-二取代-3h-[1,2,3]三唑并[4,5-b]吡啶化合物
WO2016004305A2 (en) * 2014-07-02 2016-01-07 Pharmacyclics Llc Inhibitors of bruton's tyrosine kinase
HUE057041T2 (hu) 2015-07-06 2022-04-28 Alkermes Inc Hiszton deacetiláz hetero-halogén gátlói
WO2017007755A1 (en) 2015-07-06 2017-01-12 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
HRP20220223T1 (hr) 2017-01-11 2022-04-29 Alkermes, Inc. Biciklički inhibitori histon deacetilaze
US11225475B2 (en) 2017-08-07 2022-01-18 Alkermes, Inc. Substituted pyridines as inhibitors of histone deacetylase
WO2020118683A1 (en) * 2018-12-14 2020-06-18 Lynk Pharmaceuticals Co. Ltd. Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
TR202010296A1 (tr) * 2020-06-30 2022-01-21 Anadolu Ueniversitesi Akt inhibisyonu aracılığıyla a549 hücrelerinde sitotoksik ve apoptotik etki gösteren yeni triazol ve triazolotiyadiazin türevleri

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007064797A2 (en) * 2005-11-30 2007-06-07 Vertex Pharmaceuticals Incorporated Inhibitors of c-met and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1277754B8 (en) * 2000-04-27 2005-09-28 Astellas Pharma Inc. Imidazopyridine derivatives
AU2003297161B8 (en) * 2002-12-18 2011-03-31 Vertex Pharmaceuticals Incorporated Triazolopyridazines as protein kinases inhibitors
US7122548B2 (en) * 2003-07-02 2006-10-17 Sugen, Inc. Triazolotriazine compounds and uses thereof
WO2008060578A2 (en) * 2006-11-15 2008-05-22 Cytovia, Inc. 3-aryl-6-aryl-[1,2,4] triazolo[3,4-b][1,3,4] thiadiazoles and related compounds as activators of caspases and inducers of apoptosis and the use thereof
EA201000051A1 (ru) * 2007-07-13 2010-08-30 ГЛАКСОСМИТКЛАЙН ЭлЭлСи Противовирусные соединения, композиции и способы использования
MY152040A (en) * 2008-02-05 2014-08-15 Sanofi Aventis Triazolopyridazines as par1 inhibitors, production thereof, and use as medicaments
CA2755285C (en) * 2009-03-20 2014-02-11 Yunxin Y. Bo Inhibitors of pi3 kinase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007064797A2 (en) * 2005-11-30 2007-06-07 Vertex Pharmaceuticals Incorporated Inhibitors of c-met and uses thereof

Also Published As

Publication number Publication date
WO2008036272A1 (en) 2008-03-27
CA2663528A1 (en) 2008-03-27
US20100144739A1 (en) 2010-06-10
NZ575548A (en) 2011-09-30
CN101796056A (zh) 2010-08-04
JP2010519174A (ja) 2010-06-03
AU2007297754A1 (en) 2008-03-27
MX2009002842A (es) 2009-05-27
US8481538B2 (en) 2013-07-09
EP2066676A1 (en) 2009-06-10

Similar Documents

Publication Publication Date Title
AU2006320580B2 (en) Inhibitors of c-Met and uses thereof
US8481538B2 (en) Heterocyclic inhibitors of c-Met and uses thereof
US8937064B2 (en) Pyrazolo[1,5-a]pyrimidines useful as JAK2 inhibitors
NZ575346A (en) 5- (2-furyl)-1, 3-thiazole derivatives useful as inhibitors of phosphatidylinositol 3-kinase
WO2007117494A1 (en) Deazapurines useful as inhibitors of janus kinases
AU2009281822A1 (en) cMET inhibitors
AU2010250055A1 (en) Tri-cyclic pyrazolopyridine kinase inhibitors
KR20110039278A (ko) 단백질 키나제 억제제
CA2681516A1 (en) Compounds useful as inhibitors of janus kinases
EP2032562A2 (en) Selective inhibitors of rock protein kinase and uses thereof
AU2010258903A1 (en) Inhibitors of phosphatidylinositol 3-kinase
US20110135603A1 (en) Inhibitors of phosphatidylinositol 3-kinase
AU2010216219A1 (en) Tetrahydrothiazolopyridine inhibitors of phosphatidylinositol 3-kinase
HK1146825A (en) Heterocyclic inhibitors of c-met and uses thereof
HK1161230A (en) Protein kinase inhibitors

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired